Effect of Roux-en-Y bariatric bypass surgery on subclinical atherosclerosis and oxidative stress markers in leukocytes of obese patients: a one-year follow-up study
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Little is known about the mechanisms underlying the cardioprotective effect of Roux en-Y gastric bypass (RYGB) surgery. Therefore, the aim of the present study was to investigate whether weight loss associated with RYGB improves the oxidative status of leukocytes and ameliorates subclinical atherosclerotic markers. This is an interventional study of 57 obese subjects who underwent RYGB surgery. We determined biochemical parameters and qualitative analysis of cholesterol, leukocyte and systemic oxidative stress markers —superoxide production, glutathione peroxidase 1 (GPX1), superoxide dismutase (SOD) activity and protein carbonylation—, soluble cellular adhesion molecules —sICAM-1 and sP-selectin—, myeloperoxidase (MPO) and leukocyte-endothelium cell interactions—rolling flux, velocity and adhesion. RYGB induced an improvement in metabolic parameters, including hsCRP and leukocyte count (p < 0.001, for both). This was associated with an amelioration in oxidative stress, since superoxide production and protein carbonylation were reduced (p < 0.05 and p < 0.01, respectively) and antioxidant systems were enhanced (GPX1; p < 0.05 and SOD; p < 0.01). In addition, a significant reduction of the following parameters was observed one year after RYGB: MPO and sICAM (p < 0.05, for both), sPselectin and pattern B of LDL particles (p < 0.001, for both), and rolling flux and adhesion of leukocytes (p < 0.05 and p < 0.01, respectively). Our results suggest that patients undergoing RYGB benefit from an amelioration of the prooxidant status of leukocytes, metabolic outcomes, and subclinical markers of atherosclerosis.
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A small interventional bariatric study found a 17% decrease in leukocytes by 52 weeks.
“and a small interventional bariatric study found a 17% decrease in leukocytes by 52 weeks. 23”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [23]
The Discussion reports a significant decrease in total leukocyte count after Roux-en-Y gastric bypass and describes the study population as relatively small. The Methods place blood collection at baseline and one year after surgery, approximately 52 weeks. The passages in our copy do not give a 17% decrease, so the claimed magnitude is not verified. (LLM, conf=0.84)
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Self-citation
- Authors
- Abad-Jiménez, Z., López-Domènech, S., Gómez-Abril, S. Á., Periañez-Gómez, D., de Marañón, A. M., Bañuls, C., Morillas, C., Víctor, V. M., & Rocha, M.
- Affiliations
- Department of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain
- Department of General and Digestive System Surgery, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Universitat de València (ES)
- Corresponding author
- Víctor, Víctor M.
- Rocha, Milagros
- ORCID
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2020-08-11
- Volume
- 9
- Issue
- 8
- Pages
- 734
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC7464524
- OpenAlex
- W3048457501
- Cited by
- 17
- References
- 44
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 5
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Instituto de Salud Carlos III (PI19/00437, PI18/00932, PI19/00838)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Roux-en-Y gastric bypass, bariatric surgery, obesity, subclinical atherosclerosis, oxidative stress, leukocytes, superoxide production, protein carbonylation, glutathione peroxidase 1, superoxide dismutase, myeloperoxidase, soluble ICAM-1, soluble P-selectin, leukocyte-endothelial adhesion, cardioprotection, weight loss
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