Antioxidant and Cytoprotective Effect of Quinoa (Chenopodium quinoa Willd.) with Pressurized Hot Water Extraction (PHWE)
Open accessAbstract
Quinoa is widely noted for its nutritional value. The seed is the main edible part of the plant and exists in at least three different colors: white, red and black. This study utilized a pressurized hot water extraction (PHWE) for the extraction of phytochemicals from quinoa. Chemical fingerprints with LC/UV and LC/MS using a targeted approach and pattern recognition tools were used to evaluate the quinoa extracts. The antioxidant properties for various types of quinoa were evaluated using DPPH assay, ABTS assay and the cytoprotective effect of quinoa extracts were investigated in HMEC-1 cell line. Distinctive chemical profiles obtained from black and red quinoa were well correlated with the antioxidant activities and cytoprotective effects. The combination of PHWE, chemical standardization with LC/UV and LC/MS, pattern recognition tools and biological assay provided an approach for the evaluation and eventual production of quinoa extracts for functional food.
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Quinoa has pronounced antioxidant activity, as shown in in vitro studies.
“Quinoa has pronounced antioxidant activity, as shown in in vitro studies [10,11] or in in vivo experiments, where quinoa consumption showed antihyperlipidemic action against the background of a high-fat diet, leading to increased superoxide dismutase and glutathione peroxidase activities and to decreased levels of malondialdehyde [12] and inflammatory cytokines [13,14].”
From Anxiolytic and Antioxidant Effect of Phytoecdysteroids and Polyphenols from Chenopodium quinoa on an In Vivo Restraint Stress Model (2022) · cites this paper as [10]
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- Authors
- Ong, E. S., Pek, C. J. N., Tan, J. C. W., & Leo, C. H.
- Affiliations
- Singapore University of Technology and Design (SG)
- Corresponding author
- Ong, Eng Shi
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2020-11-11
- Volume
- 9
- Issue
- 11
- Pages
- 1110
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC7697190
- OpenAlex
- W3100126728
- Cited by
- 31
- References
- 39
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 6 · 2021: 3
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- SUTD-MIT International Design Center Pilot Research Grant (IDG11900102) ((IDG11900102))
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Seed and Plant Biochemistry
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
- Keywords
- quinoa, subcritical water extraction, antioxidant activity, cytoprotection, phytochemicals, HMEC-1 cells, chemical fingerprinting, LC-MS, functional foods
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