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Cited by 87Cancer, Hypoxia, and MetabolismCardiac Ischemia and ReperfusionMitochondrial Function and Pathology

The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches

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Bouhamida, Esmaa, Morciano, Giampaolo, Perrone, Mariasole, Kahsay, Asrat E., Della Sala, Mario, Wieckowski, Mariusz R., Fiorica, Francesco, Pinton, Paolo +2 more·2022·Biology
DOI 10.3390/biology11020300PMC PMC8869508
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Abstract

Cardiovascular diseases (CVDs) and cancer continue to be the primary cause of mortality worldwide and their pathomechanisms are a complex and multifactorial process. Insufficient oxygen availability (hypoxia) plays critical roles in the pathogenesis of both CVDs and cancer diseases, and hypoxia-inducible factor 1 (HIF-1), the main sensor of hypoxia, acts as a central regulator of multiple target genes in the human body. Accumulating evidence demonstrates that mitochondria are the major target of hypoxic injury, the most common source of reactive oxygen species during hypoxia and key elements for inflammation regulation during the development of both CVDs and cancer. Taken together, observations propose that hypoxia, mitochondrial abnormality, oxidative stress, inflammation in CVDs, and cancer are closely linked. Based upon these facts, this review aims to deeply discuss these intimate relationships and to summarize current significant findings corroborating the molecular mechanisms and potential therapies involved in hypoxia and mitochondrial dysfunction in CVDs and cancer.

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  • Mitochondria undergo metabolic alterations to reduce hypoxia-induced damage, including exchanging or modifying respiratory chain subunits, decreasing OXPHOS, lowering TCA intermediates, adapting ROS production, and reducing fatty acid oxidation.

    “Thus, mitochondria undergo a variety of metabolic alterations to reduce hypoxia-induced damage, including by exchanging or modifying subunits of the respiratory chain, decreasing OXPHOS, lowering the TCA cycle intermediates, adapting ROS production, and reducing fatty acid oxidation (FAO) [41].”

    From The HIF Axes in Cancer - Angiogenesis, Metabolism and Immune-Modulation (2025) · cites this paper as [41]

    Section 3.1 describes a hypoxia-related shift away from OXPHOS and inhibited expression of respiratory-chain subunits; section 3.2.1 describes inhibition of the TCA cycle. But the paper does not establish that TCA intermediates generally decrease: section 4.3 reports that succinate rises during hypoxia. Nor does the located discussion establish reduced fatty acid oxidation as part of this mitochondrial response; section 4.5 instead discusses increased FAO during a T-cell transition. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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  1. [1]Masoudkabir F. Sarrafzadegan N. Gotay C. Ignaszewski A. Krahn A.D. Davis M.K. Franco C. Mani A. Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention Atherosclerosis 2017 263 343 351 10.1016/j.atherosclerosis.2017.06.001 28624099 PMC6207942 · DOI
  2. [2]Gernaat S.A.M. Boer J.M.A. Bongard D.V.D. Maas A.H.E.M. Van Der Pol C.C. Bijlsma R.M. Grobbee D.E. Verkooijen H.M. Peeters P.H. The risk of cardiovascular disease following breast cancer by Framingham risk score Breast Cancer Res. Treat. 2018 170 119 127 10.1007/s10549-018-4723-0 29492735 PMC5993849 · DOI
  3. [3]Coviello J.S. Cardiovascular and Cancer Risk: The Role of Cardio-oncology J. Adv. Pr. Oncol. 2018 9 160 176 PMC6303003 30588351
  4. [4]De Boer R.A. Meijers W.C. Van Der Meer P. Van Veldhuisen D.J. Cancer and heart disease: Associations and relations Eur. J. Hear. Fail. 2019 21 1515 1525 10.1002/ejhf.1539 31321851 PMC6988442 · DOI
  5. [5]Waypa G.B. Smith K.A. Schumacker P.T. O2 sensing, mitochondria and ROS signaling: The fog is lifting Mol. Asp. Med. 2016 47–48 76 89 10.1016/j.mam.2016.01.002 26776678 PMC4750107 · DOI
  6. [6]Liu M. Galli G. Wang Y. Fan Q. Wang Z. Wang X. Xiao W. Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1 Front. Physiol. 2020 11 774 10.3389/fphys.2020.00774 32760290 PMC7375027 · DOI
  7. [7]Bousquet P.A. Meltzer S. Sønstevold L. Esbensen Y. Dueland S. Flatmark K. Sitter B. Bathen T.F. Seierstad T. Redalen K.R. Markers of Mitochondrial Metabolism in Tumor Hypoxia, Systemic Inflammation, and Adverse Outcome of Rectal Cancer Transl. Oncol. 2019 12 76 83 10.1016/j.tranon.2018.09.010 30273860 PMC6170256 · DOI
  8. [8]Chen P.-S. Chiu W.-T. Hsu P.-L. Lin S.-C. Peng I.-C. Wang C.-Y. Tsai S.-J. Pathophysiological implications of hypoxia in human diseases J. Biomed. Sci. 2020 27 1 19 10.1186/s12929-020-00658-7 32389123 PMC7212687 · DOI · Paper page
  9. [9]Kim J.-W. Tchernyshyov I. Semenza G.L. Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia Cell Metab. 2006 3 177 185 10.1016/j.cmet.2006.02.002 16517405 · DOI · Paper page
  10. [10]McClelland G.B. Brooks G.A. Changes in MCT 1, MCT 4, and LDH expression are tissue specific in rats after long-term hypobaric hypoxia J. Appl. Physiol. 2002 92 1573 1584 10.1152/japplphysiol.01069.2001 11896024 · DOI
  11. [11]Tuder R.M. E Flook B. Voelkel N.F. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide J. Clin. Investig. 1995 95 1798 1807 10.1172/JCI117858 7706486 PMC295709 · DOI
  12. [12]Semenza G.L. Wang G.L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation Mol. Cell. Biol. 1992 12 5447 5454 10.1128/mcb.12.12.5447-5454.1992 1448077 PMC360482 · DOI
  13. [13]Melillo G. Musso T. Sica A. Taylor L.S. Cox G.W. Varesio L. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter J. Exp. Med. 1995 182 1683 1693 10.1084/jem.182.6.1683 7500013 PMC2192245 · DOI
  14. [14]Semenza G.L. Hypoxia-Inducible Factor 1 (HIF-1) Pathway Sci. STKE 2007 2007 cm8 10.1126/stke.4072007cm8 17925579 · DOI
  15. [15]Nakayama K. Kataoka N. Regulation of Gene Expression under Hypoxic Conditions Int. J. Mol. Sci. 2019 20 3278 10.3390/ijms20133278 PMC6651685 31277312 · DOI
  16. [16]Wang G.L. Semenza G.L. Purification and Characterization of Hypoxia-inducible Factor 1 J. Biol. Chem. 1995 270 1230 1237 10.1074/jbc.270.3.1230 7836384 · DOI
  17. [17]Semenza G.L. Hypoxia-Inducible Factors in Physiology and Medicine Cell 2012 148 399 408 10.1016/j.cell.2012.01.021 22304911 PMC3437543 · DOI · Paper page
  18. [18]Semenza G.L. Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning Biochim. Biophys. Acta 2011 1813 1263 1268 10.1016/j.bbamcr.2010.08.006 20732359 PMC3010308 · DOI
  19. [19]Lee D.C. Sohn H.A. Park Z.-Y. Oh S. Kang Y.K. Lee K.-M. Kang M. Jang Y.J. Yang S.-J. Hong Y.K. A Lactate-Induced Response to Hypoxia Cell 2015 161 595 609 10.1016/j.cell.2015.03.011 25892225 · DOI
  20. [20]Zheng J. Chen P. Zhong J. Cheng Y. Chen H. He Y. Chen C. HIF-1α in myocardial ischemia-reperfusion injury (Review) Mol. Med. Rep. 2021 23 1 9 10.3892/mmr.2021.11991 33760122 PMC7974458 · DOI
  21. [21]Ke Q. Costa M. Hypoxia-Inducible Factor-1 (HIF-1) Mol. Pharmacol. 2006 70 1469 1480 10.1124/mol.106.027029 16887934 · DOI
  22. [23]Wang G.L. Jiang B.-H. Rue E.A. Semenza G.L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Proc. Natl. Acad. Sci. USA 1995 92 5510 5514 10.1073/pnas.92.12.5510 7539918 PMC41725 · DOI · Paper page
  23. [24]Bruick R.K. McKnight S.L. A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF Science 2001 294 1337 1340 10.1126/science.1066373 11598268 · DOI · Paper page
  24. [25]Jaakkola P. Mole D.R. Tian Y.-M. Wilson M.I. Gielbert J. Gaskell S.J. von Kriegsheim A. Hebestreit H.F. Mukherji M. Schofield C.J. Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation Science 2001 292 468 472 10.1126/science.1059796 11292861 · DOI · Paper page
  25. [26]Luo W. Hu H. Chang R. Zhong J. Knabel M. O’Meally R. Cole R.N. Pandey A. Semenza G.L. Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1 Cell 2011 145 732 744 10.1016/j.cell.2011.03.054 21620138 PMC3130564 · DOI · Paper page
  26. [27]Tian X. Zhou N. Yuan J. Lu L. Zhang Q. Wei M. Zou Y. Yuan L. Heat shock transcription factor 1 regulates exercise-induced myocardial angiogenesis after pressure overload via HIF-1α/VEGF pathway J. Cell. Mol. Med. 2020 24 2178 2188 10.1111/jcmm.14872 31930683 PMC7011135 · DOI
  27. [28]Hölscher M. Schäfer K. Krull S. Farhat K. Hesse A. Silter M. Lin Y. Pichler B.J. Thistlethwaite P. El-Armouche A. Unfavourable consequences of chronic cardiac HIF-1α stabilization Cardiovasc. Res. 2012 94 77 86 10.1093/cvr/cvs014 22258630 · DOI
  28. [29]Zhang Y. Xu Y. Zhou K. Kao G. Yan M. Xiao J. Hypoxia-inducible transcription factor-1α inhibition by topotecan protects against lipopolysaccharide-induced inflammation and apoptosis of cardiomyocytes BioMed. Eng. OnLine 2021 20 88 10.1186/s12938-021-00923-2 34465337 PMC8407092 · DOI
  29. [30]Xie L. Pi X. Wang Z. He J. Willis M.S. Patterson C. Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis J. Mol. Cell. Cardiol. 2015 80 156 165 10.1016/j.yjmcc.2015.01.007 25633836 PMC4374643 · DOI
  30. [31]Neckar J. Hsu A. Khan A.H. Gross G.J. Nithipatikom K. Cyprova M. Benak D. Hlavackova M. Sotáková-Kašparová D. Falck J.R. Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3 Am. J. Physiol. Circ. Physiol. 2018 315 H1148 H1158 10.1152/ajpheart.00726.2017 PMC6734065 30074840 · DOI
  31. [32]Date T. Mochizuki S. Belanger A.J. Yamakawa M. Luo Z. Vincent K.A. Cheng S.H. Gregory R.J. Jiang C. Expression of constitutively stable hybrid hypoxia-inducible factor-1α protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury Am. J. Physiol. Physiol. 2005 288 C314 C320 10.1152/ajpcell.00374.2004 15496478 · DOI
  32. [33]Morand J. Arnaud C. Pépin J.L. Godin-Ribuot D. Chronic intermittent hypoxia promotes myocardial ischemia-related ventricular arrhythmias and sudden cardiac death Sci. Rep. 2018 8 1 8 10.1038/s41598-018-21064-y 29445096 PMC5813022 · DOI
  33. [34]Meerson F.Z. Beloshitskiĭ P.V. Vorontsova E.I. Ustinova E.E. Rozhitskaia I.I. Effect of adaptation to continuous and intermittent hypoxia on heart resistance to ischemic and reperfusion arrhythmias Patol. Fiziol. Eksp Ter. 1989 48 50 (In Russian) 2797899
  34. [35]Belaidi E. Béguin P.C. Lévy P. Ribuot C. Godin-Ribuot D. Prevention of HIF-1 activation and iNOS gene targeting by low-dose cadmium results in loss of myocardial hypoxic preconditioning in the rat Am. J. Physiol. Circ. Physiol. 2008 294 H901 H908 10.1152/ajpheart.00715.2007 18083903 · DOI
  35. [36]Xi L. Tekin D. Gursoy E. Salloum F. Levasseur J.E. Kukreja R.C. Evidence that NOS2 acts as a trigger and mediator of late preconditioning induced by acute systemic hypoxia Am. J. Physiol. Circ. Physiol. 2002 283 H5 H12 10.1152/ajpheart.00920.2001 12063268 · DOI
  36. [37]Ding H.-L. Zhu H.-F. Dong J.-W. Zhu W.-Z. Yang W.-W. Yang H.-T. Zhou Z.-N. Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury1 Acta Pharmacol. Sin. 2005 26 315 322 10.1111/j.1745-7254.2005.00046.x 15715927 · DOI
  37. [39]Zhang Y. Liu D. Hu H. Zhang P. Xie R. Cui W. HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury Biomed. Pharmacother. 2019 120 109464 10.1016/j.biopha.2019.109464 31590128 · DOI
  38. [40]Chen Y.-F. Pandey S. Day C.H. Chen Y.-F. Jiang A.-Z. Ho T.-J. Chen R.-J. Padma V.V. Kuo W.-W. Huang C.-Y. Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition J. Cell. Physiol. 2018 233 3660 3671 10.1002/jcp.26235 29030976 · DOI
  39. [41]Dorn G.W. Kirshenbaum L.A. Cardiac reanimation: Targeting cardiomyocyte death by BNIP3 and NIX/BNIP3L Oncogene 2008 27 S158 S167 10.1038/onc.2009.53 19641501 · DOI
  40. [42]Xin T. Lv W. Liu D. Jing Y. Hu F. Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control Front. Cell Dev. Biol. 2020 8 853 10.3389/fcell.2020.00853 32984338 PMC7483501 · DOI
  41. [43]Zhou H. Zhu P. Wang J. Zhu H. Ren J. Chen Y. Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy Cell Death Differ. 2018 25 1080 1093 10.1038/s41418-018-0086-7 29540794 PMC5988750 · DOI
  42. [44]Zhou H. Zhu P. Guo J. Hu N. Wang S. Li D. Hu S. Ren J. Cao F. Chen Y. Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury Redox Biol. 2017 13 498 507 10.1016/j.redox.2017.07.007 28732308 PMC5828768 · DOI
  43. [45]Feng Y. Zhao J. Hou H. Zhang H. Jiao Y. Wang J. Wang Y. Sun Y. WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation Acta Biochim. Biophys. Sin. 2016 48 1075 1084 10.1093/abbs/gmw104 27797717 · DOI
  44. [46]Zhao J.-F. Rodger C.E. Allen G.F.G. Weidlich S. Ganley I.G. HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation Cell Stress 2020 4 99 113 10.15698/cst2020.05.220 32420530 PMC7212530 · DOI · Paper page
  45. [47]Chowdhury A. Aich A. Jain G. Wozny K. Lüchtenborg C. Hartmann M. Bernhard O. Balleiniger M. Alfar E.A. Zieseniss A. Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia Cell Rep. 2018 25 561 570.e6 10.1016/j.celrep.2018.09.057 30332638 PMC6205837 · DOI
  46. [48]Papandreou I. Cairns R.A. Fontana L. Lim A.L. Denko N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption Cell Metab. 2006 3 187 197 10.1016/j.cmet.2006.01.012 16517406 · DOI · Paper page
  47. [49]Gomes A.P. Price N.L. Ling A.J.Y. Moslehi J.J. Montgomery M.K. Rajman L. White J.P. Teodoro J.S. Wrann C.D. Hubbard B.P. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging Cell 2013 155 1624 1638 10.1016/j.cell.2013.11.037 24360282 PMC4076149 · DOI · Paper page
  48. [50]Fuhrmann D. Brüne B. Mitochondrial composition and function under the control of hypoxia Redox Biol. 2017 12 208 215 10.1016/j.redox.2017.02.012 28259101 PMC5333533 · DOI
  49. [51]Koutnikova H. Campuzano V. Foury F. Dollé P. Cazzalini O. Koenig M. Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin Nat. Genet. 1997 16 345 351 10.1038/ng0897-345 9241270 · DOI
  50. [52]Nanayakkara G. Alasmari A. Mouli S. Eldoumani H. Quindry J.C. McGinnis G. Fu X. Berlin A. Peters B. Zhong J. Cardioprotective HIF-1α-frataxin signaling against ischemia-reperfusion injury Am. J. Physiol. Circ. Physiol. 2015 309 H867 H879 10.1152/ajpheart.00875.2014 26071548 · DOI
  51. [53]Rane S. He M. Sayed D. Vashistha H. Malhotra A. Sadoshima J. Vatner D.E. Vatner S.F. Abdellatif M. Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes Circ. Res. 2009 104 879 886 10.1161/CIRCRESAHA.108.193102 19265035 PMC3332328 · DOI
  52. [54]Briston T. Yang J. Ashcroft M. HIF-1α localization with mitochondria Cell Cycle 2011 10 4170 4171 10.4161/cc.10.23.18565 22101263 PMC3272295 · DOI
  53. [55]Mylonis I. Kourti M. Samiotaki M. Panayotou G. Simos G. Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia J. Cell Sci. 2017 130 466 479 10.1242/jcs.195339 27909249 · DOI
  54. [56]Li H.-S. Zhou Y.-N. Li L. Li S.-F. Long D. Chen X.-L. Zhang J.-B. Feng L. Li Y.-P. HIF-1α protects against oxidative stress by directly targeting mitochondria Redox Biol. 2019 25 101109 10.1016/j.redox.2019.101109 30686776 PMC6859547 · DOI
  55. [57]Du Y. Ge Y. Xu Z.-H. Aa N. Gu X. Meng H. Lin Z. Zhu N. Shi J. Zhuang R. Hypoxia-Inducible Factor 1 alpha (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Pathway Participates in Angiogenesis of Myocardial Infarction in Muscone-Treated Mice: Preliminary Study Med. Sci. Monit. 2018 24 8870 8877 10.12659/MSM.912051 30531686 PMC6295139 · DOI
  56. [58]Ikeda M. Ide T. Tadokoro T. Miyamoto H.D. Ikeda S. Okabe K. Ishikita A. Sato M. Abe K. Furusawa S. Excessive Hypoxia-Inducible Factor-1α Expression Induces Cardiac Rupture via p53-Dependent Apoptosis After Myocardial Infarction J. Am. Hear. Assoc. 2021 10 020895 10.1161/JAHA.121.020895 PMC8649270 34472375 · DOI
  57. [59]Liu Y. Zeng L. Yang Y. Chen C. Wang D. Wang H. Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition Cell Death Dis. 2020 11 756 10.1038/s41419-020-02948-2 32934217 PMC7492260 · DOI
  58. [60]Wei H. Bedja D. Koitabashi N. Xing D. Chen J. Fox-Talbot K. Rouf R. Chen S. Steenbergen C. Harmon J.W. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF- signaling Proc. Natl. Acad. Sci. 2012 109 E841 E850 10.1073/pnas.1202081109 22403061 PMC3325701 · DOI
  59. [61]Stamati K. Mudera V. Cheema U. Evolution of oxygen utilization in multicellular organisms and implications for cell signalling in tissue engineering J. Tissue Eng. 2011 2 2041731411432365 10.1177/2041731411432365 22292107 PMC3258841 · DOI
  60. [62]Wolff M. Kosyna F.K. Dunst J. Jelkmann W. Depping R. Impact of hypoxia inducible factors on estrogen receptor expression in breast cancer cells Arch. Biochem. Biophys. 2017 613 23 30 10.1016/j.abb.2016.11.002 27823907 · DOI
  61. [63]Nadtochiy S.M. Schafer X. Fu D. Nehrke K. Munger J. Brookes P.S. Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling J. Biol. Chem. 2016 291 20188 20197 10.1074/jbc.M116.738799 27510037 PMC5025701 · DOI · Paper page
  62. [64]Miska J. Lee-Chang C. Rashidi A. Muroski M.E. Chang A.L. Lopez-Rosas A. Zhang P. Panek W.K. Cordero A. Han Y. HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma Cell Rep. 2019 27 226 237.e4 10.1016/j.celrep.2019.03.029 30943404 PMC6461402 · DOI
  63. [65]Fukuda R. Zhang H. Kim J.-W. Shimoda L. Dang C.V. Semenza G.L. HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells Cell 2007 129 111 122 10.1016/j.cell.2007.01.047 17418790 · DOI · Paper page
  64. [66]Rodríguez-Enríquez S. Carreño-Fuentes L. Gallardo-Pérez J.C. Saavedra E. Quezada H. Vega A. Marín-Hernández A. Olín-Sandoval V. Torres-Márquez M.E. Moreno-Sánchez R. Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma Int. J. Biochem. Cell Biol. 2010 42 1744 1751 10.1016/j.biocel.2010.07.010 20654728 · DOI · Paper page
  65. [68]Guarino F. Zinghirino F. Mela L. Pappalardo X.G. Ichas F. De Pinto V. Messina A. NRF-1 and HIF-1α contribute to modulation of human VDAC1 gene promoter during starvation and hypoxia in HeLa cells Biochim. Biophys. Acta 2020 1861 148289 10.1016/j.bbabio.2020.148289 32810507 · DOI
  66. [69]Zhang H. Gao P. Fukuda R. Kumar G. Krishnamachary B. Zeller K.I. Dang C. Semenza G.L. HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity Cancer Cell 2007 11 407 420 10.1016/j.ccr.2007.04.001 17482131 · DOI · Paper page
  67. [70]Tohme S. Yazdani H.O. Liu Y. Loughran P. Van Der Windt D.J. Huang H. Simmons R.L. Shiva S. Tai S. Tsung A. Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction Hepatol. 2017 66 182 197 10.1002/hep.29184 PMC5481489 28370295 · DOI
  68. [71]Jin J. Qiu S. Wang P. Liang X. Huang F. Wu H. Zhang B. Zhang W. Tian X. Xu R. Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming J. Exp. Clin. Cancer Res. 2019 38 1 16 10.1186/s13046-019-1351-4 31455352 PMC6712736 · DOI
  69. [72]Lu H. Samanta D. Xiang L. Zhang H. Hu H. Chen I. Bullen J.W. Semenza G.L. Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype Proc. Natl. Acad. Sci. 2015 112 E4600 E4609 10.1073/pnas.1513433112 26229077 PMC4547233 · DOI
  70. [73]Chourasia A.H. Tracy K. Frankenberger C. Boland M.L. Sharifi M. E Drake L. Sachleben J.R. Asara J.M. Locasale J. Karczmar G.S. Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis EMBO Rep. 2015 16 1145 1163 10.15252/embr.201540759 26232272 PMC4576983 · DOI
  71. [74]Castelli S. Ciccarone F. Tavian D. Ciriolo M.R. ROS-dependent HIF1α activation under forced lipid catabolism entails glycolysis and mitophagy as mediators of higher proliferation rate in cervical cancer cells J. Exp. Clin. Cancer Res. 2021 40 1 18 10.1186/s13046-021-01887-w 33706793 PMC7948341 · DOI
  72. [75]Wu Z. Zuo M. Zeng L. Cui K. Liu B. Yan C. Chen L. Dong J. Shangguan F. Hu W. OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development EMBO Rep. 2021 22 e50827 10.15252/embr.202050827 33314701 PMC7788456 · DOI
  73. [76]Chiche J. Rouleau M. Gounon P. Brahimi-Horn M.C. Pouyssã©Gur J. Mazure N.M. Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli J. Cell. Physiol. 2009 222 648 657 10.1002/jcp.21984 19957303 · DOI
  74. [77]Devine R. Bicer S. Reiser P.J. Wold L.E. Increased hypoxia-inducible factor-1α in striated muscle of tumor-bearing mice Am. J. Physiol. Circ. Physiol. 2017 312 H1154 H1162 10.1152/ajpheart.00090.2016 28341633 PMC5495928 · DOI
  75. [78]Wu C.-S. Chang I.Y.-F. Hung J.-L. Liao W.-C. Lai Y.-R. Chang K.-P. Li H.-P. Chang Y.-S. ASC modulates HIF-1α stability and induces cell mobility in OSCC Cell Death Dis. 2020 11 1 11 10.1038/s41419-020-02927-7 32883954 PMC7471912 · DOI
  76. [79]Coimbra-Costa D. Alva N. Duran M. Carbonell T. Rama R. Oxidative stress and apoptosis after acute respiratory hypoxia and reoxygenation in rat brain Redox Biol. 2017 12 216 225 10.1016/j.redox.2017.02.014 28259102 PMC5334548 · DOI
  77. [80]Liberti M.V. Locasale J.W. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem. Sci. 2016 41 211 218 10.1016/j.tibs.2015.12.001 26778478 PMC4783224 · DOI · Paper page
  78. [81]Akkol E. Tatlı I. Karatoprak G. Ağar O. Yücel Ç. Sobarzo-Sánchez E. Capasso R. Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin Cancers 2021 13 2733 10.3390/cancers13112733 34073059 PMC8198870 · DOI
  79. [82]Hu L. Cui R. Liu H. Wang F. Emodin and rhein decrease levels of hypoxia-inducible factor-1α in human pancreatic cancer cells and attenuate cancer cachexia in athymic mice carrying these cells Oncotarget 2017 8 88008 88020 10.18632/oncotarget.21330 29152137 PMC5675689 · DOI
  80. [84]Gao Y.-H. Li C.-X. Shen S.-M. Li H. Chen G.-Q. Wei Q. Wang L.-S. Hypoxia-inducible factor 1α mediates the down-regulation of superoxide dismutase 2 in von Hippel–Lindau deficient renal clear cell carcinoma Biochem. Biophys. Res. Commun. 2013 435 46 51 10.1016/j.bbrc.2013.04.034 23611775 · DOI
  81. [85]Patergnani S. Missiroli S. Morciano G. Perrone M. Mantovani C.M. Anania G. Fiorica F. Pinton P. Giorgi C. Understanding the Role of Autophagy in Cancer Formation and Progression Is a Real Opportunity to Treat and Cure Human Cancers Cancers 2021 13 5622 10.3390/cancers13225622 34830777 PMC8616104 · DOI
  82. [86]Patergnani S. Bonora M. Ingusci S. Previati M. Marchi S. Zucchini S. Perrone M. Wieckowski M.R. Castellazzi M. Pugliatti M. Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis Proc. Natl. Acad. Sci. 2021 118 2020078118 10.1073/pnas.2020078118 34099564 PMC8214668 · DOI
  83. [87]Song M. Franco A. Fleischer J.A. Zhang L. Dorn G.W. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence Cell Metab. 2017 26 872 883.e5 10.1016/j.cmet.2017.09.023 29107503 PMC5718956 · DOI · Paper page
  84. [88]Torrano V. Valcarcel-Jimenez L. Cortazar A.R. Liu X. Urosevic J. Castillo-Martin M. Fernández-Ruiz S. Morciano G. Caro-Maldonado A. Guiu M. The metabolic co-regulator PGC1α suppresses prostate cancer metastasis Nat. Cell Biol. 2016 18 645 656 10.1038/ncb3357 27214280 PMC4884178 · DOI
  85. [89]Sebastian D. Hernandez-Alvarez M.I. Segales J. Sorianello E. Muñoz J.P. Sala D. Waget A. Liesa M. Paz J.C. Gopalacharyulu P. Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis Proc. Natl. Acad. Sci. 2012 109 5523 5528 10.1073/pnas.1108220109 22427360 PMC3325712 · DOI · Paper page
  86. [90]Kim H. Scimia M.C. Wilkinson D. Trelles R.D. Wood M.R. Bowtell D. Dillin A. Mercola M. Ronai Z.A. Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia Mol. Cell 2011 44 532 544 10.1016/j.molcel.2011.08.045 22099302 PMC3360955 · DOI
  87. [91]LeBleu V.S. O’Connell J.T. Gonzalez Herrera K.N.G. Wikman H. Pantel K. Haigis M.C. De Carvalho F.M. Damascena A. Domingos Chinen L.T. Rocha R.M. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis Nat. Cell Biol. 2014 16 992 1003 10.1038/ncb3039 25241037 PMC4369153 · DOI
  88. [92]Palikaras K. Lionaki E. Tavernarakis N. Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis Cell Death Differ. 2015 22 1399 1401 10.1038/cdd.2015.86 26256515 PMC4532782 · DOI
  89. [94]Bellot G. Garcia-Medina R. Gounon P. Chiche J. Roux D. Pouysségur J. Mazure N.M. Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains Mol. Cell. Biol. 2009 29 2570 2581 10.1128/MCB.00166-09 19273585 PMC2682037 · DOI · Paper page
  90. [95]Sowter H.M. Ratcliffe P.J. Watson P. Greenberg A.H. Harris A.L. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors Cancer Res. 2001 61 6669 6673 11559532
  91. [96]Liu L. Feng D. Chen G. Chen M. Zheng Q. Song P. Ma Q. Zhu C. Wang R. Qi W. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells Nat. Cell Biol. 2014 14 177 185 10.1038/ncb2422 22267086 · DOI
  92. [97]Araki K. Kawauchi K. Sugimoto W. Tsuda D. Oda H. Yoshida R. Ohtani K. Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells Commun. Biol. 2019 2 3 10.1038/s42003-018-0246-9 30740539 PMC6318215 · DOI
  93. [98]Di Meo S. Reed T.T. Venditti P. Victor V.M. Role of ROS and RNS Sources in Physiological and Pathological Conditions Oxid. Med. Cell. Longev. 2016 2016 1245049 10.1155/2016/1245049 27478531 PMC4960346 · DOI
  94. [100]Münzel T. Camici G.G. Maack C. Bonetti N.R. Fuster V. Kovacic J.C. Impact of Oxidative Stress on the Heart and Vasculature J. Am. Coll. Cardiol. 2017 70 212 229 10.1016/j.jacc.2017.05.035 28683969 PMC5663297 · DOI
  95. [101]Lenaz G. The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology IUBMB Life 2001 52 159 164 10.1080/15216540152845957 11798028 · DOI · Paper page
  96. [102]Lambertucci R.H. Hirabara S.M. Silveira L.D.R. Levada-Pires A.C. Curi R. Pithon-Curi T.C. Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells J. Cell. Physiol. 2008 216 796 804 10.1002/jcp.21463 18446788 · DOI
  97. [103]Di Lisa F. Kaludercic N. Carpi A. Menabò R. Giorgio M. Mitochondrial pathways for ROS formation and myocardial injury: The relevance of p66Shc and monoamine oxidase Basic Res. Cardiol. 2009 104 131 139 10.1007/s00395-009-0008-4 19242637 · DOI
  98. [104]Starkov A. Fiskum G. Chinopoulos C. Lorenzo B.J. Browne S.E. Patel M.S. Beal M.F. Mitochondrial -Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species J. Neurosci. 2004 24 7779 7788 10.1523/JNEUROSCI.1899-04.2004 15356189 PMC6729932 · DOI
  99. [105]St-Pierre J. Buckingham J.A. Roebuck S.J. Brand M. Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain J. Biol. Chem. 2002 277 44784 44790 10.1074/jbc.M207217200 12237311 · DOI · Paper page
  100. [106]Vásquez-Vivar J. Kalyanaraman B. Kennedy M.C. Mitochondrial Aconitase Is a Source of Hydroxyl Radical J. Biol. Chem. 2000 275 14064 14069 10.1074/jbc.275.19.14064 10799480 · DOI
  101. [107]Weyemi U. Dupuy C. The emerging role of ROS-generating NADPH oxidase NOX4 in DNA-damage responses Mutat. Res. Mutat. Res. 2012 751 77 81 10.1016/j.mrrev.2012.04.002 22580379 · DOI
  102. [108]Giorgio M. Migliaccio E. Orsini F. Paolucci D. Moroni M. Contursi C. Pelliccia G. Luzi L. Minucci S. Marcaccio M. Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis Cell 2005 122 221 233 10.1016/j.cell.2005.05.011 16051147 · DOI · Paper page
  103. [109]Giorgi C. Marchi S. Simoes I.C. Ren Z. Morciano G. Perrone M. Patalas-Krawczyk P. Borchard S. Jędrak P. Pierzynowska K. Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases Int. Rev. Cell Mol. Biol. 2018 340 209 344 10.1016/bs.ircmb.2018.05.006 30072092 PMC8127332 · DOI
  104. [110]Arnaiz S.L. Coronel M.F. Boveris A. Nitric Oxide, Superoxide, and Hydrogen Peroxide Production in Brain Mitochondria after Haloperidol Treatment Nitric Oxide 1999 3 235 243 10.1006/niox.1999.0229 10442855 · DOI
  105. [111]Tewari S. Santos J.M. Kowluru R.A. Damaged Mitochondrial DNA Replication System and the Development of Diabetic Retinopathy Antioxid. Redox Signal. 2012 17 492 504 10.1089/ars.2011.4333 22229649 PMC3365359 · DOI
  106. [112]Tewari S. Zhong Q. Santos J.M. A Kowluru R. Mitochondria DNA Replication and DNA Methylation in the Metabolic Memory Associated with Continued Progression of Diabetic Retinopathy Investig. Ophthalmol. Vis. Sci. 2012 53 4881 4888 10.1167/iovs.12-9732 22743328 PMC3415280 · DOI
  107. [113]Morciano G. Naumova N. Koprowski P. Valente S. Sardão V.A. Potes Y. Rimessi A. Wieckowski M.R. Oliveira P.J. The mitochondrial permeability transition pore: An evolving concept critical for cell life and death Biol. Rev. 2021 96 2489 2521 10.1111/brv.12764 34155777 · DOI
  108. [114]Radi R. Turrens J. Chang L. Bush K. Crapo J. Freeman B. Detection of catalase in rat heart mitochondria J. Biol. Chem. 1991 266 22028 22034 10.1016/S0021-9258(18)54740-2 1657986 · DOI · Paper page
  109. [115]Zhou R. Yazdi A.S. Menu P. Tschopp J. A role for mitochondria in NLRP3 inflammasome activation Nature 2011 469 221 225 10.1038/nature09663 21124315 · DOI · Paper page
  110. [116]Zorov D.B. Juhaszova M. Sollott S.J. Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release Physiol. Rev. 2014 94 909 950 10.1152/physrev.00026.2013 24987008 PMC4101632 · DOI · Paper page
  111. [117]Patergnani S. Bouhamida E. Leo S. Pinton P. Rimessi A. Mitochondrial Oxidative Stress and “Mito-Inflammation”: Actors in the Diseases Biomedicines 2021 9 216 10.3390/biomedicines9020216 33672477 PMC7923430 · DOI
  112. [118]Bonora M. Wieckowski M. Sinclair D. Kroemer G. Pinton P. Galluzzi L. Targeting mitochondria for cardiovascular disorders: Therapeutic potential and obstacles Nat. Rev. Cardiol. 2019 16 33 55 10.1038/s41569-018-0074-0 30177752 PMC6349394 · DOI
  113. [119]Bonora M. Pinton P. A New Current for the Mitochondrial Permeability Transition Trends Biochem. Sci. 2019 44 559 561 10.1016/j.tibs.2019.04.009 31076251 · DOI
  114. [120]Zhong Z. Liang S. Sanchez-Lopez E. He F. Shalapour S. Lin X.-J. Wong J. Ding S. Seki E. Schnabl B. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation Nature 2018 560 198 203 10.1038/s41586-018-0372-z 30046112 PMC6329306 · DOI · Paper page
  115. [121]Idzko M. Hammad H. Van Nimwegen M. Kool M. Willart M.A.M. Muskens F. Hoogsteden H.C. Luttmann W. Ferrari D. Di Virgilio F. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells Nat. Med. 2007 13 913 919 10.1038/nm1617 17632526 · DOI
  116. [122]Wang P. Chaung W.W. Wu R. Ji Y. Dong W. Mitochondrial transcription factor A is a proinflammatory mediator in hemorrhagic shock Int. J. Mol. Med. 2012 30 199 203 10.3892/ijmm.2012.959 22469910 PMC3981640 · DOI
  117. [124]Nakahira K. Hisata S. Choi A.M. The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases Antioxid. Redox Signal. 2015 23 1329 1350 10.1089/ars.2015.6407 26067258 PMC4685486 · DOI
  118. [125]Tuominen A. Miller Y.I. Hansen L.F. Kesäniemi Y.A. Witztum J.L. Hörkkö S. A Natural Antibody to Oxidized Cardiolipin Binds to Oxidized Low-Density Lipoprotein, Apoptotic Cells, and Atherosclerotic Lesions Arter. Thromb. Vasc. Biol. 2006 26 2096 2102 10.1161/01.ATV.0000233333.07991.4a 16794225 · DOI · Paper page
  119. [126]Misawa T. Takahama M. Kozaki T. Lee H. Zou J. Saitoh T. Akira S. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome Nat. Immunol. 2013 14 454 460 10.1038/ni.2550 23502856 · DOI
  120. [127]Senoner T. Dichtl W. Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target? Nutrients 2019 11 2090 10.3390/nu11092090 PMC6769522 31487802 · DOI
  121. [128]Morciano G. Vitto V. Bouhamida E. Giorgi C. Pinton P. Mitochondrial Bioenergetics and Dynamism in the Failing Heart Life 2021 11 436 10.3390/life11050436 34066065 PMC8151847 · DOI
  122. [129]Parathath S. Mick S.L. Feig J.E. Joaquin V. Grauer L. Habiel D.M. Gassmann M. Gardner L. Fisher E.A. Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism Circ. Res. 2011 109 1141 1152 10.1161/CIRCRESAHA.111.246363 21921268 PMC3208906 · DOI
  123. [130]Jin Y. Fu J. Novel Insights Into the NLRP3 Inflammasome in Atherosclerosis J. Am. Hear. Assoc. 2019 8 e012219 10.1161/JAHA.119.012219 PMC6645652 31184236 · DOI
  124. [131]Proudfoot D. Skepper J.N. Hegyi L. Bennett M.R. Shanahan C. Weissberg P.L. Apoptosis Regulates Human Vascular Calcification In Vitro Circ. Res. 2000 87 1055 1062 10.1161/01.RES.87.11.1055 11090552 · DOI · Paper page
  125. [133]Harrison C.M. Pompilius M. Pinkerton K.E. Ballinger S.W. Mitochondrial Oxidative Stress Significantly Influences Atherogenic Risk and Cytokine-Induced Oxidant Production Environ. Heal. Perspect. 2011 119 676 681 10.1289/ehp.1002857 PMC3094420 21169125 · DOI
  126. [134]Orsini F. Migliaccio E. Moroni M. Contursi C. Raker V.A. Piccini D. Martin-Padura I. Pelliccia G. Trinei M. Bono M. The Life Span Determinant p66Shc Localizes to Mitochondria Where It Associates with Mitochondrial Heat Shock Protein 70 and Regulates Trans-membrane Potential J. Biol. Chem. 2004 279 25689 25695 10.1074/jbc.M401844200 15078873 · DOI
  127. [135]Graiani G. Lagrasta C. Migliaccio E. Spillmann F. Meloni M. Madeddu P. Quaini F. Padura I.M. Lanfrancone L. Pelicci P. Genetic Deletion of the p66 Shc Adaptor Protein Protects from Angiotensin II–Induced Myocardial Damage Hypertension 2005 46 433 440 10.1161/01.HYP.0000174986.73346.ba 15998704 · DOI
  128. [137]Kaludercic N. Takimoto E. Nagayama T. Feng N. Lai E.W. Bedja D. Chen K. Gabrielson K.L. Blakely R.D. Shih J.C. Monoamine Oxidase A–Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts with Pressure Overload Circ. Res. 2010 106 193 202 10.1161/CIRCRESAHA.109.198366 19910579 PMC2804073 · DOI
  129. [138]Kaludercic N. Carpi A. Nagayama T. Sivakumaran V. Zhu G. Lai E.W. Bedja D. De Mario A. Chen K. Gabrielson K.L. Monoamine Oxidase B Prompts Mitochondrial and Cardiac Dysfunction in Pressure Overloaded Hearts Antioxid. Redox Signal. 2014 20 267 280 10.1089/ars.2012.4616 23581564 PMC3887464 · DOI
  130. [139]Kuroda J. Ago T. Matsushima S. Zhai P. Schneider M. Sadoshima J. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart Proc. Natl. Acad. Sci. 2010 107 15565 15570 10.1073/pnas.1002178107 20713697 PMC2932625 · DOI · Paper page
  131. [140]Ikegami T. Suzuki Y.-I. Shimizu T. Isono K. Koseki H. Shirasawa T. Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene Biochem. Biophys. Res. Commun. 2002 296 729 736 10.1016/S0006-291X(02)00933-6 12176043 · DOI
  132. [141]Sharma S. Bhattarai S. Ara H. Sun G. Clair D.K.S. Bhuiyan S. Kevil C. Watts M.N. Dominic P. Shimizu T. SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy Redox Biol. 2020 37 101740 10.1016/j.redox.2020.101740 33049519 PMC7559509 · DOI
  133. [142]Souiden Y. Mallouli H. Meskhi S. Chaabouni Y. Rebai A. Chéour F. Mahdouani K. MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity Biol. Res. 2016 49 22 10.1186/s40659-016-0083-6 27067415 PMC4828869 · DOI
  134. [143]Faraci F.M. Didion S.P. Vascular Protection Arter. Thromb. Vasc. Biol. 2004 24 1367 1373 10.1161/01.ATV.0000133604.20182.cf 15166009 · DOI
  135. [144]Ardanaz N. Yang X.-P. Cifuentes M.E. Haurani M.J. Jackson K.W. Liao T.-D. Carretero O.A. Pagano P.J. Lack of Glutathione Peroxidase 1 Accelerates Cardiac-Specific Hypertrophy and Dysfunction in Angiotensin II Hypertension Hypertension 2010 55 116 123 10.1161/HYPERTENSIONAHA.109.135715 19917877 PMC3061336 · DOI
  136. [145]Chen Z. Chua C.C. Gao J. Chua K.-W. Ho Y.-S. Hamdy R.C. Chua B.H.L. Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1 J. Pineal Res. 2009 46 235 241 10.1111/j.1600-079X.2008.00654.x 19141089 PMC2752734 · DOI
  137. [146]Matsushima S. Ide T. Yamato M. Matsusaka H. Hattori F. Ikeuchi M. Kubota T. Sunagawa K. Hasegawa Y. Kurihara T. Overexpression of Mitochondrial Peroxiredoxin-3 Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice Circulation 2006 113 1779 1786 10.1161/CIRCULATIONAHA.105.582239 16585391 · DOI
  138. [147]Huang Q. Zhou H.J. Zhang H. Huang Y. Hinojosa-Kirschenbaum F. Fan P. Yao L. Belardinelli L. Tellides G. Giordano F.J. Thioredoxin-2 Inhibits Mitochondrial Reactive Oxygen Species Generation and Apoptosis Stress Kinase-1 Activity to Maintain Cardiac Function Circulation 2015 131 1082 1097 10.1161/CIRCULATIONAHA.114.012725 25628390 PMC4374031 · DOI
  139. [148]Flores-Mateo G. Carrillo-Santisteve P. Elosua R. Guallar E. Marrugat J. Bleys J. Covas M.-I. Antioxidant Enzyme Activity and Coronary Heart Disease: Meta-analyses of Observational Studies Am. J. Epidemiol. 2009 170 135 147 10.1093/aje/kwp112 19465742 · DOI
  140. [149]Tonet E. Bernucci D. Morciano G. Campo G. Pharmacological protection of reperfusion injury in ST-segment elevation myocardial infarction. Gone with the wind? Postepy Kardiol Interwencyjnej 2018 14 5 8 10.5114/aic.2018.74349 29743898 PMC5939539 · DOI
  141. [150]Calbet J.A. Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans J. Physiol. 2003 551 379 386 10.1113/jphysiol.2003.045112 12844510 PMC2343162 · DOI
  142. [151]Lee S.H. Wolf P.L. Escudero R. Deutsch R. Jamieson S.W. Thistlethwaite P.A. Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction New Engl. J. Med. 2000 342 626 633 10.1056/NEJM200003023420904 10699162 · DOI
  143. [152]Liu Y. Luo Q. Su Z. Xing J. Wu J. Xiang L. Huang Y. Pan H. Wu X. Zhang X. Suppression of Myocardial Hypoxia-Inducible Factor-1α Compromises Metabolic Adaptation and Impairs Cardiac Function in Patients with Cyanotic Congenital Heart Disease During Puberty Circulation 2021 143 2254 2272 10.1161/CIRCULATIONAHA.120.051937 33663226 · DOI
  144. [153]Murry C.E. Jennings R.B. Reimer K.A. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium Circulation 1986 74 1124 1136 10.1161/01.CIR.74.5.1124 3769170 · DOI
  145. [154]Morciano G. Giorgi C. Bonora M. Punzetti S. Pavasini R. Wieckowski M. Campo G. Pinton P. Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury J. Mol. Cell. Cardiol. 2015 78 142 153 10.1016/j.yjmcc.2014.08.015 25172387 · DOI
  146. [155]Giorgi C. Marchi S. Pinton P. The machineries, regulation and cellular functions of mitochondrial calcium Nat. Rev. Mol. Cell Biol. 2018 19 713 730 10.1038/s41580-018-0052-8 30143745 · DOI · Paper page
  147. [156]Bonora M. Giorgi C. Pinton P. Molecular mechanisms and consequences of mitochondrial permeability transition Nat. Rev. Mol. Cell Biol. 2021 1 20 10.1038/s41580-021-00433-y 34880425 · DOI
  148. [157]Modesti L. Danese A. Vitto V.A.M. Ramaccini D. Aguiari G. Gafà R. Lanza G. Giorgi C. Pinton P. Mitochondrial Ca2+ Signaling in Health, Disease and Therapy Cells 2021 10 1317 10.3390/cells10061317 34070562 PMC8230075 · DOI
  149. [159]Kwong J.Q. Lu X. Correll R.N. Schwanekamp J. Vagnozzi R.J. Sargent M.A. York A.J. Zhang J. Bers D. Molkentin J.D. The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart Cell Rep. 2015 12 15 22 10.1016/j.celrep.2015.06.002 26119742 PMC4497842 · DOI
  150. [162]Mezzaroma E. Toldo S. Farkas D. Seropian I.M. Van Tassell B.W. Salloum F. Kannan H.R. Menna A.C. Voelkel N.F. Abbate A. The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse Proc. Natl. Acad. Sci. 2011 108 19725 19730 10.1073/pnas.1108586108 22106299 PMC3241791 · DOI
  151. [163]Sandanger Ø. Ranheim T. Vinge L.E. Bliksøen M. Alfsnes K. Finsen A.V. Dahl C.P. Askevold E.T. Florholmen G. Christensen G. The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury Cardiovasc. Res. 2013 99 164 174 10.1093/cvr/cvt091 23580606 · DOI
  152. [164]Malhotra R. Tyson D.W. Rosevear H.M. Brosius F.C. Hypoxia-inducible factor-1alpha is a critical mediator of hypoxia induced apoptosis in cardiac H9c2 and kidney epithelial HK-2 cells BMC Cardiovasc. Disord. 2008 8 9 10.1186/1471-2261-8-9 18447926 PMC2387135 · DOI
  153. [165]Moslehi J. Minamishima Y.A. Shi J. Neuberg D. Charytan D. Padera R.F. Signoretti S. Liao R. Kaelin W.G. Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy Circulation 2010 122 1004 1016 10.1161/CIRCULATIONAHA.109.922427 20733101 PMC2971656 · DOI
  154. [166]Loor G. Schumacker P.T. Role of hypoxia-inducible factor in cell survival during myocardial ischemia–reperfusion Cell Death Differ. 2008 15 686 690 10.1038/cdd.2008.13 18259200 · DOI
  155. [167]Li B. Li M. Li X. Li H. Lai Y. Huang S. He X. Si X. Zheng H. Liao W. Sirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation Aging 2019 11 12546 12567 10.18632/aging.102587 31881009 PMC6949046 · DOI
  156. [168]Luo G. Jian Z. Zhu Y. Chen B. Ma R. Tang F. Xiao Y. Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress Int. J. Mol. Med. 2019 43 2033 2043 10.3892/ijmm.2019.4125 30864731 PMC6443335 · DOI
  157. [169]Robador P.A. José G.S. Rodríguez C. Guadall A. Moreno M.U. Beaumont J. Fortuño A. Díez J. Martínez-González J. Zalba G. HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia Cardiovasc. Res. 2011 92 247 255 10.1093/cvr/cvr202 21771897 · DOI
  158. [170]Tennant D. Howell N.J. The role of HIFs in ischemia-reperfusion injury Hypoxia 2014 2 107 115 10.2147/HP.S49720 27774470 PMC5045060 · DOI
  159. [171]Wan D.-Y. Zhang Z. Yang H.-H. Cardioprotective effect of miR-214 in myocardial ischemic postconditioning by down-regulation of hypoxia inducible factor 1, alpha subunit inhibitor Cell. Mol. Biol. 2015 61 1 6 26025394
  160. [172]Stanley M. Crowcroft N. Quigley J. Parkinson E. Responses of human cervical keratinocytes in vitro to tumour promoters and diethylstilboestrol Carcinogenesis 1985 6 1011 1015 10.1093/carcin/6.7.1011 2410159 · DOI
  161. [173]Chaudhuri R.D. Banik A. Mandal B. Sarkar S. Cardiac-specific overexpression of HIF-1α during acute myocardial infarction ameliorates cardiomyocyte apoptosis via differential regulation of hypoxia-inducible pro-apoptotic and anti-oxidative genes Biochem. Biophys. Res. Commun. 2021 537 100 108 10.1016/j.bbrc.2020.12.084 33388412 · DOI
  162. [174]Yang B. He K. Zheng F. Wan L. Yu X. Wang X. Zhao D. Bai Y. Chu W. Sun Y. Over-expression of hypoxia-inducible factor-1 alpha in vitro protects the cardiac fibroblasts from hypoxia-induced apoptosis J. Cardiovasc. Med. 2014 15 579 586 10.2459/JCM.0b013e3283629c52 24583668 · DOI
  163. [175]Zhu H. Sun A. Programmed necrosis in heart disease: Molecular mechanisms and clinical implications J. Mol. Cell. Cardiol. 2018 116 125 134 10.1016/j.yjmcc.2018.01.018 29426003 · DOI
  164. [176]Piamsiri C. Maneechote C. Siri-Angkul N. Chattipakorn S.C. Chattipakorn N. Targeting necroptosis as therapeutic potential in chronic myocardial infarction J. Biomed. Sci. 2021 28 1 13 10.1186/s12929-021-00722-w 33836761 PMC8034148 · DOI
  165. [178]Zhang T. Zhang Y. Cui M. Jin L. Wang Y. Lv F. Liu Y. Zheng W. Shang H. Zhang J. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis Nat. Med. 2016 22 175 182 10.1038/nm.4017 26726877 · DOI · Paper page
  166. [179]Karshovska E. Wei Y. Subramanian P. Mohibullah R. Geißler C. Baatsch I. Popal A. Campos J.C. Exner N. Schober A. HIF-1α (Hypoxia-Inducible Factor-1α) Promotes Macrophage Necroptosis by Regulating miR-210 and miR-383 Arter. Thromb. Vasc. Biol. 2020 40 583 596 10.1161/ATVBAHA.119.313290 31996026 · DOI
  167. [180]Liu B. Zhao C. Li H. Chen X. Ding Y. Xu S. Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis Biochem. Biophys. Res. Commun. 2018 497 233 240 10.1016/j.bbrc.2018.02.061 29427658 · DOI
  168. [181]Chen X. Xu S. Zhao C. Liu B. Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure Biochem. Biophys. Res. Commun. 2019 516 37 43 10.1016/j.bbrc.2019.06.015 31196626 · DOI
  169. [182]Yoshimura C. Nagasaka A. Kurose H. Nakaya M. Efferocytosis during myocardial infarction J. Biochem. 2020 168 1 6 10.1093/jb/mvaa051 32302392 · DOI
  170. [183]Davis C.K. Jain S.A. Bae O.-N. Majid A. Rajanikant G.K. Hypoxia Mimetic Agents for Ischemic Stroke Front. Cell Dev. Biol. 2019 6 175 10.3389/fcell.2018.00175 30671433 PMC6331394 · DOI
  171. [184]Yu Y. Yan Y. Niu F. Wang Y. Chen X. Su G. Liu Y. Zhao X. Qian L. Liu P. Ferroptosis: A cell death connecting oxidative stress, inflammation and cardiovascular diseases Cell Death Discov. 2021 7 1 10 10.1038/s41420-021-00579-w 34312370 PMC8313570 · DOI
  172. [185]Li W. Li W. Leng Y. Xiong Y. Xia Z. Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress DNA Cell Biol. 2020 39 210 225 10.1089/dna.2019.5097 31809190 · DOI
  173. [186]Gao M. Monian P. Quadri N. Ramasamy R. Jiang X. Glutaminolysis and Transferrin Regulate Ferroptosis Mol. Cell 2015 59 298 308 10.1016/j.molcel.2015.06.011 26166707 PMC4506736 · DOI · Paper page
  174. [187]Tang L.-J. Luo X.-J. Tu H. Chen H. Xiong X.-M. Li N.-S. Peng J. Ferroptosis occurs in phase of reperfusion but not ischemia in rat heart following ischemia or ischemia/reperfusion Naunyn-Schmiedebergs Arch. fur Exp. Pathol. Pharmakol. 2021 394 401 410 10.1007/s00210-020-01932-z 32621060 · DOI
  175. [188]Tay W.T. Fang Y.-H. Beh S.T. Liu Y.-W. Hsu L.-W. Yen C.-J. Liu P.-Y. Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro Int. J. Mol. Sci. 2020 21 2399 10.3390/ijms21072399 PMC7177768 32244307 · DOI
  176. [192]Shi L.Z. Wang R. Huang G. Vogel P. Neale G. Green D.R. Chi H. HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells J. Exp. Med. 2011 208 1367 1376 10.1084/jem.20110278 21708926 PMC3135370 · DOI · Paper page
  177. [194]Gualdoni G.A. Mayer K.A. Göschl L. Boucheron N. Ellmeier W. Zlabinger G.J. The AMP analog AICAR modulates the T reg /T h 17 axis through enhancement of fatty acid oxidation FASEB J. 2016 30 3800 3809 10.1096/fj.201600522R 27492924 · DOI
  178. [195]Sun Y. Tian T. Gao J. Liu X. Hou H. Cao R. Li B. Quan M. Guo L. Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice J. Neuroimmunol. 2016 292 58 67 10.1016/j.jneuroim.2016.01.014 26943960 · DOI
  179. [196]Rolf J. Zarrouk M. Finlay D.K. Foretz M. Viollet B. Cantrell D.A. AMPKα1: A glucose sensor that controls CD8 T-cell memory Eur. J. Immunol. 2013 43 889 896 10.1002/eji.201243008 23310952 PMC3734624 · DOI · Paper page
  180. [197]Pearce E.L. Walsh M.C. Cejas P.J. Harms G.M. Shen H. Wang L.-S. Jones R.G. Choi Y. Enhancing CD8 T-cell memory by modulating fatty acid metabolism Nature 2009 460 103 107 10.1038/nature08097 19494812 PMC2803086 · DOI · Paper page
  181. [198]Putignani L. Raffa S. Pescosolido R. Aimati L. Signore F. Torrisi M.R. Grammatico P. Alteration of expression levels of the oxidative phosphorylation system (OXPHOS) in breast cancer cell mitochondria Breast Cancer Res. Treat. 2007 110 439 452 10.1007/s10549-007-9738-x 17899367 · DOI
  182. [199]Simonnet H. Alazard N. Pfeiffer K. Gallou C. Beroud C. Demont J. Bouvier R. Schägger H. Godinot C. Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma Carcinog. 2002 23 759 768 10.1093/carcin/23.5.759 12016148 · DOI
  183. [200]Bonora E. Porcelli A.M. Gasparre G. Biondi A. Ghelli A. Carelli V. Baracca A. Tallini G. Martinuzzi A. Lenaz G. Defective Oxidative Phosphorylation in Thyroid Oncocytic Carcinoma Is Associated with Pathogenic Mitochondrial DNA Mutations Affecting Complexes I and III Cancer Res. 2006 66 6087 6096 10.1158/0008-5472.CAN-06-0171 16778181 · DOI
  184. [201]Robles A.I. Traverso G. Zhang M. Roberts N.J. Khan M.A. Joseph C. Lauwers G.Y. Selaru F.M. Popoli M. Pittman M.E. Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease−Associated Colorectal Cancers Gastroenterology 2016 150 931 943 10.1053/j.gastro.2015.12.036 26764183 PMC5270616 · DOI
  185. [202]Dmitrieva-Posocco O. Dzutsev A. Posocco D.F. Hou V. Yuan W. Thovarai V. Mufazalov I. Gunzer M. Shilovskiy I. Khaitov M. Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer Immunity 2019 50 166 180 10.1016/j.immuni.2018.11.015 30650375 PMC6490968 · DOI
  186. [203]Grivennikov S. Karin E. Terzic J. Mucida D. Yu G.-Y. Vallabhapurapu S. Scheller J. Rose-John S. Cheroutre H. Eckmann L. IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer Cancer Cell 2009 15 103 113 10.1016/j.ccr.2009.01.001 19185845 PMC2667107 · DOI · Paper page
  187. [204]Joshi A.U. Minhas P.S. Liddelow S.A. Haileselassie B. Andreasson K.I. Dorn G.W. II Mochly-Rosen D. Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration Nat. Neurosci. 2019 22 1635 1648 10.1038/s41593-019-0486-0 31551592 PMC6764589 · DOI · Paper page
  188. [205]Panchanathan R. Liu H. Choubey D. Hypoxia primes human normal prostate epithelial cells and cancer cell lines for the NLRP3 and AIM2 inflammasome activation Oncotarget 2016 7 28183 28194 10.18632/oncotarget.8594 27058421 PMC5053719 · DOI
  189. [206]Li X. Zhang X. Xia J. Zhang L. Chen B. Lian G. Yun C. Yang J. Yan Y. Wang P. Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance Cell Rep. 2021 36 109607 10.1016/j.celrep.2021.109607 34433035 · DOI
  190. [207]Moon J.-S. Nakahira K. Chung K.-P. DeNicola G. Koo M.J. Pabón M.A. Rooney K.T. Yoon J.-H. Ryter S.W. Stout-Delgado H. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages Nat. Med. 2016 22 1002 1012 10.1038/nm.4153 27455510 PMC5204248 · DOI · Paper page
  191. [208]Missiroli S. Perrone M. Boncompagni C. Borghi C. Campagnaro A. Marchetti F. Anania G. Greco P. Fiorica F. Pinton P. Targeting the NLRP3 Inflammasome as a New Therapeutic Option for Overcoming Cancer Cancers 2021 13 2297 10.3390/cancers13102297 34064909 PMC8151587 · DOI
  192. [209]Guo B. Fu S. Zhang J. Liu B. Li Z. Targeting inflammasome/IL-1 pathways for cancer immunotherapy Sci. Rep. 2016 6 36107 10.1038/srep36107 27786298 PMC5082376 · DOI · Paper page
  193. [210]Kaplanov I. Carmi Y. Kornetsky R. Shemesh A. Shurin G.V. Shurin M.R. Dinarello C.A. Voronov E. Apte R.N. Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation Proc. Natl. Acad. Sci. USA 2018 116 1361 1369 10.1073/pnas.1812266115 30545915 PMC6347724 · DOI
  194. [211]Wang Y. Kong H. Zeng X. Liu W. Wang Z. Yan X. Wang H. Xie W. Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells Oncol. Rep. 2016 35 2053 2064 10.3892/or.2016.4569 26782741 · DOI · Paper page
  195. [213]Ahmad I. Muneer K.M. Tamimi I.A. Chang M.E. Ata M.O. Yusuf N. Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome Toxicol. Appl. Pharmacol. 2013 270 70 76 10.1016/j.taap.2013.03.027 23583630 · DOI
  196. [214]Zaki H. Vogel P. Body-Malapel M. Lamkanfi M. Kanneganti T.-D. IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation J. Immunol. 2010 185 4912 4920 10.4049/jimmunol.1002046 20855874 PMC3104023 · DOI · Paper page
  197. [215]Huber S. Gagliani N. Zenewicz L. Huber F.J. Bosurgi L. Hu B. Hedl M. Zhang W. O’connor W. Murphy A. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine Nature 2012 491 259 263 10.1038/nature11535 23075849 PMC3493690 · DOI
  198. [216]Wei Q. Mu K. Li T. Zhang Y. Yang Z. Jia X. Zhao W. Huai W. Guo P. Han L. Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression Lab. Investig. 2013 94 52 62 10.1038/labinvest.2013.126 24166187 · DOI
  199. [217]Ayala A. Muñoz M.F. Argüelles S. Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal Oxid. Med. Cell. Longev. 2014 2014 360438 10.1155/2014/360438 24999379 PMC4066722 · DOI
  200. [219]Todisco S. Convertini P. Iacobazzi V. Infantino V. TCA Cycle Rewiring as Emerging Metabolic Signature of Hepatocellular Carcinoma Cancers 2019 12 68 10.3390/cancers12010068 PMC7016696 31881713 · DOI

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Authors
Bouhamida, E., Morciano, G., Perrone, M., Kahsay, A. E., Della Sala, M., Wieckowski, M. R., Fiorica, F., Pinton, P., Giorgi, C., & Patergnani, S.
Affiliations
  • University of Ferrara (IT)
  • Department of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy
  • Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
  • Azienda ULSS 9 Scaligera (IT)
Corresponding author
  • Giorgi, Carlotta
  • Patergnani, Simone
ORCID
Venue
Biology
Publisher
MDPI AG
Published
2022-02-12
Volume
11
Issue
2
Pages
300
ISSN
2079-7737 (ISSN-L)
DOI
10.3390/biology11020300
PMC
PMC8869508
OpenAlex
W4213248429
Cited by
87
References
258
Citations by year
2026: 20 · 2025: 29 · 2024: 17 · 2023: 16 · 2022: 5
FWCI
2.02
Type
journal article
Language
en
Open access
Licence
Locations
  • Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
Funders
  • Italian Association for Cancer Research (IG23670, IG-19803)
  • Telethon Foundation (GGP11139B)
  • European Research Council (853057)
  • Associazione Ricerca Oncologica Sperimentale Estense (A-ROSE), (.)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
hypoxia signaling, mitochondrial dysfunction, inflammation, cardiovascular disease, cancer, HIF-1, reactive oxygen species, oxidative stress, treatment options

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