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Cited by 210Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsInflammasome and immune disorders

Microglia Mediated Neuroinflammation: Focus on PI3K Modulation

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Cianciulli, Antonia, Porro, Chiara, Calvello, Rosa, Trotta, Teresa, Lofrumento, Dario Domenico, Panaro, Maria Antonietta·2020·Biomolecules
DOI 10.3390/biom10010137PMC PMC7022557
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Abstract

Immune activation in the central nervous system involves mostly microglia in response to pathogen invasion or tissue damage, which react, promoting a self-limiting inflammatory response aimed to restore homeostasis. However, prolonged, uncontrolled inflammation may result in the production by microglia of neurotoxic factors that lead to the amplification of the disease state and tissue damage. In particular, specific inducers of inflammation associated with neurodegenerative diseases activate inflammatory processes that result in the production of a number of mediators and cytokines that enhance neurodegenerative processes. Phosphoinositide 3-kinases (PI3Ks) constitute a family of enzymes regulating a wide range of activity, including signal transduction. Recent studies have focused attention on the intracellular role of PI3K and its contribution to neurodegenerative processes. This review illustrates and discusses recent findings about the role of this signaling pathway in the modulation of microglia neuroinflammatory responses linked to neurodegeneration. Finally, we discuss the modulation of PI3K as a potential therapeutic approach helpful for developing innovative therapeutic strategies in neurodegenerative diseases.

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Authors
Cianciulli, A., Porro, C., Calvello, R., Trotta, T., Lofrumento, D. D., & Panaro, M. A.
Affiliations
  • University of Bari Aldo Moro (IT)
  • University of Foggia (IT)
  • University of Salento (IT)
Corresponding author
Panaro, Maria Antonietta
ORCID
Venue
Biomolecules
Publisher
MDPI AG
Published
2020-01-14
Volume
10
Issue
1
Pages
137
ISSN
2218-273X (ISSN-L)
DOI
10.3390/biom10010137
PMC
PMC7022557
OpenAlex
W2999235182
Cited by
210
References
139
Citations by year
2026: 43 · 2025: 36 · 2024: 33 · 2023: 30 · 2022: 23 · 2021: 36 · 2020: 9
FWCI
2.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomolecules (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • AIRUS (submittedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords
microglia, neuroinflammation, phosphatidylinositol 3-kinase, PI3K signaling, neurodegenerative diseases, cytokines
MeSH terms
Animals, Humans, Inflammation, Signal Transduction, Microglia, Neurodegenerative Diseases, Phosphatidylinositol 3-Kinases, Drug Discovery

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