The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties
Open accessAbstract
This article reviews progress over the past three decades related to the role of dendrimer-based, branch cell symmetry in the development of advanced drug delivery systems, aqueous based compatibilizers/solubilizers/excipients and nano-metal cluster catalysts. Historically, it begins with early unreported work by the Tomalia Group (i.e., The Dow Chemical Co.) revealing that all known dendrimer family types may be divided into two major symmetry categories; namely: Category I: symmetrical branch cell dendrimers (e.g., Tomalia, Vögtle, Newkome-type dendrimers) possessing interior hollowness/porosity and Category II: asymmetrical branch cell dendrimers (e.g., Denkewalter-type) possessing no interior void space. These two branch cell symmetry features were shown to be pivotal in directing internal packing modes; thereby, differentiating key dendrimer properties such as densities, refractive indices and interior porosities. Furthermore, this discovery provided an explanation for unimolecular micelle encapsulation (UME) behavior observed exclusively for Category I, but not for Category II. This account surveys early experiments confirming the inextricable influence of dendrimer branch cell symmetry on interior packing properties, first examples of Category (I) based UME behavior, nuclear magnetic resonance (NMR) protocols for systematic encapsulation characterization, application of these principles to the solubilization of active approved drugs, engineering dendrimer critical nanoscale design parameters (CNDPs) for optimized properties and concluding with high optimism for the anticipated role of dendrimer-based solubilization principles in emerging new life science, drug delivery and nanomedical applications.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nearly 40% of newly developed APIs are rejected by the pharmaceutical industries without further development, mainly due to low water solubility.
“Nearly 40% of newly developed APIs are rejected by the pharmaceutical industries without further development, mainly due to the low water solubility.29”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Understanding biophysicochemical interactions at the nano–bio interface
Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083 · see citing works
A New Class of Polymers: Starburst-Dendritic Macromolecules
Tomalia, D. A., Baker, H., Dewald, J., Hall, M., Kallos, G. J., Martin, S., Roeck, J., Ryder, J., & Smith, P. B. (1985) · Polymer Journal · doi:10.1295/polymj.17.117 · Cited by 3,908 · see citing works
Self-citationTomalia, D. A., Naylor, A. M., & Goddard, W. A. (1990) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199001381 · Cited by 3,202 · see citing works
Self-citationCrooks, R. M., Zhao, M., Sun, L., Chechik, V., & Yeung, L. K. (2000) · Accounts of Chemical Research · doi:10.1021/ar000110a · Cited by 2,117 · see citing works
Astruc, D., Boisselier, É., & Ornelas, C. (2010) · Chemical Reviews · doi:10.1021/cr900327d · Cited by 1,842 · see citing works
Szejtli, J. (1988) · Topics in inclusion science · doi:10.1007/978-94-015-7797-7 · Cited by 1,762 · see citing works
Dendrimers and Other Dendritic Polymers
Fréchet, J. M. J., & Tomalia, D. A. (2001) · Wiley eBooks · doi:10.1002/0470845821 · Cited by 1,735 · see citing works
Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications
Esfand, R., & Tomalia, D. A. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(01)01757-3 · Cited by 1,562 · see citing works
Self-citation"Cascade"- and "Nonskid-Chain-like" Syntheses of Molecular Cavity Topologies
Buhleier, E., Wehner, W., & Vögtle, F. (1978) · Synthesis · doi:10.1055/s-1978-24702 · Cited by 1,287 · see citing works
Micelles. Part 1. Cascade molecules: a new approach to micelles. A [27]-arborol
Newkome, G. R., Yao, Z., Baker, G. R., & Gupta, V. K. (1985) · The Journal of Organic Chemistry · doi:10.1021/jo00211a052 · Cited by 1,199 · see citing works
Encapsulation of Guest Molecules into a Dendritic Box
Jansen, J. F. G. A., den Berg, E. M. M. D. B., & Meijer, E. W. (1994) · Science · doi:10.1126/science.266.5188.1226 · Cited by 1,168 · see citing works
Dendrimer as nanocarrier for drug delivery
Kesharwani, P., Jain, K., & Jain, N. K. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.07.005 · Cited by 1,163 · see citing works
Preparation of Cu Nanoclusters within Dendrimer Templates
Zhao, M., Sun, L., & Crooks, R. M. (1998) · Journal of the American Chemical Society · doi:10.1021/ja980438n · Cited by 933 · see citing works
Discovery of dendrimers and dendritic polymers: A brief historical perspective*
Tomalia, D. A., & Fréchet, J. M. J. (2002) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.10301 · Cited by 914 · see citing works
Self-citationDendritic macromolecules: synthesis of starburst dendrimers
Tomalia, D. A., Baker, H., Dewald, J., Hall, M., Kallos, G. J., Martin, S. J., Roeck, J., Ryder, J., & Smith, P. (1986) · Macromolecules · doi:10.1021/ma00163a029 · Cited by 877 · see citing works
Self-citationPolymer–drug conjugate therapeutics: advances, insights and prospects
Ekladious, I., Colson, Y. L., & Grinstaff, M. W. (2018) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0005-0 · Cited by 867 · see citing works
Poly(Amidoamine) Dendrimer-Templated Nanocomposites. 1. Synthesis of Zerovalent Copper Nanoclusters
Balogh, L. P., & Tomalia, D. A. (1998) · Journal of the American Chemical Society · doi:10.1021/ja980861w · Cited by 691 · see citing works
Self-citationNanopharmaceuticals and Nanomedicines Currently on the Market: Challenges and Opportunities
Farjadian, F., Ghasemi, A., Gohari, O., Roointan, A., Karimi, M., & Hamblin, M. R. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0120 · Cited by 678 · see citing works
Dendrimers as Carriers for Delivery of Chemotherapeutic Agents
Medina, S. H., & ElSayed, M. E. H. (2009) · Chemical Reviews · doi:10.1021/cr900174j · Cited by 672 · see citing works
Poly(propylene imine) Dendrimers: Large‐Scale Synthesis by Hetereogeneously Catalyzed Hydrogenations
den Berg, E. M. M. D. B., & Meijer, E. W. (1993) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199313081 · Cited by 664 · see citing works
Kojima, C., Kono, K., Maruyama, K., & Takagishi, T. (2000) · Bioconjugate Chemistry · doi:10.1021/bc0000583 · Cited by 663 · see citing works
Lee, C., Gillies, E. R., Fox, M. E., Guillaudeu, S. J., Fréchet, J. M. J., Dy, E. E., & Szoka, F. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607705103 · Cited by 648 · see citing works
Shape-Persistent Molecular Architectures of Nanoscale Dimension
Moore, J. S. (1997) · Accounts of Chemical Research · doi:10.1021/ar950232g · Cited by 616 · see citing works
Survey of Clinical Translation of Cancer Nanomedicines—Lessons Learned from Successes and Failures
He, H., Liu, L., Morin, E. E., Liu, M., & Schwendeman, A. A. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00228 · Cited by 592 · see citing works
D’Emanuele, A., & Attwood, D. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.012 · Cited by 570 · see citing works
Statistics of « starburst » polymers
de Gennes, P. G., & Hervet, H. (1983) · Journal de Physique Lettres · doi:10.1051/jphyslet:01983004409035100 · Cited by 556 · see citing works
Stimuli-Responsive Supramolecular Assemblies of Linear-Dendritic Copolymers
Gillies, E. R., Jonsson, T. B., & Fréchet, J. M. J. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0463738 · Cited by 549 · see citing works
Emerging concepts in dendrimer‐based nanomedicine: from design principles to clinical applications
Kannan, R., Nance, E. A., Kannan, S., & Tomalia, D. A. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12280 · Cited by 548 · see citing works
Self-citationA PEGylated dendritic nanoparticulate carrier of fluorouracil
Bhadra, D., Bhadra, S., Jain, S., & Jain, N. K. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(03)00132-7 · Cited by 544 · see citing works
Therapeutic and diagnostic applications of dendrimers for cancer treatment☆
Wolinsky, J. B., & Grinstaff, M. W. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.02.012 · Cited by 539 · see citing works
Biological applications of dendrimers
Cloninger, M. J. (2002) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(02)00400-3 · Cited by 516 · see citing works
Hawker, C. J., Wooley, K. L., & Fréchet, J. M. J. (1993) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/p19930001287 · Cited by 515 · see citing works
Starburst dendrimers. 5. Molecular shape control
Naylor, A. M., Goddard, W. A., Kiefer, G. E., & Tomalia, D. A. (1989) · Journal of the American Chemical Society · doi:10.1021/ja00188a079 · Cited by 513 · see citing works
Self-citationCavitands: Organic Hosts with Enforced Cavities
Cram, D. J. (1983) · Science · doi:10.1126/science.219.4589.1177 · Cited by 492 · see citing works
Water-soluble dendritic unimolecular micelles:
Liu, M., Kono, K., & Fréchet, J. M. J. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00245-x · Cited by 477 · see citing works
The Dendritic Box: Shape-Selective Liberation of Encapsulated Guests
Jansen, J. F. G. A., Meijer, E. W., & den Berg, E. M. M. D. B. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00120a032 · Cited by 461 · see citing works
Surface-Engineered Dendrimers in Gene Delivery
Jiepin, Y., Zhang, Q., Chang, H., & Cheng, Y. (2015) · Chemical Reviews · doi:10.1021/cr500542t · Cited by 432 · see citing works
Drug discovery beyond the ‘rule-of-five’
Zhang, M., & Wilkinson, B. M. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.10.005 · Cited by 421 · see citing works
Eaton, P. E., & Cole, T. W. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01059a072 · Cited by 420 · see citing works
Dendrimer-platinate: a novel approach to cancer chemotherapy.
Malik, N., Evagorou, E. G., & Duncan, R. (1999) · PubMed · Cited by 417 · see citing works
Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers
Kolhe, P. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(03)00225-4 · Cited by 416 · see citing works
Chen, H.-T., Neerman, M. F., Parrish, A. R., & Simanek, E. E. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048548j · Cited by 407 · see citing works
Cancer drug delivery in the nano era: An overview and perspectives
Li, Z., Tan, S., Li, S., Shen, Q., & Wang, K. (2017) · Oncology Reports · doi:10.3892/or.2017.5718 · Cited by 407 · see citing works
Malik, N., Evagorou, E. G., & Duncan, R. (1999) · Anti-Cancer Drugs · doi:10.1097/00001813-199909000-00010 · Cited by 402 · see citing works
Newkome, G. R., Moorefield, C. N., Baker, G. R., Saunders, M. J., & Grossman, S. H. (1991) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199111781 · Cited by 386 · see citing works
Dendrimers: Novel Polymeric Nanoarchitectures for Solubility Enhancement
Gupta, U. D., Agashe, H. B., Asthana, A., & Jain, N. K. (2006) · Biomacromolecules · doi:10.1021/bm050802s · Cited by 372 · see citing works
Peptide dendrimers: applications and synthesis
Sadler, K. E., & Tam, J. P. (2002) · Reviews in Molecular Biotechnology · doi:10.1016/s1389-0352(01)00061-7 · Cited by 366 · see citing works
Antimicrobial dendrimeric peptides
Tam, J. P., Lu, Y., & Yang, J. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02728.x · Cited by 343 · see citing works
Twyman, L. J., King, A. S. H., & Martin, I. K. (2002) · Chemical Society Reviews · doi:10.1039/b107812g · Cited by 342 · see citing works
Mignani, S. M., Kazzouli, S. E., Bousmina, M., & Majoral, J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.01.001 · Cited by 335 · see citing works
Role of Poly(amidoamine) Dendrimers for Preparing Nanoparticles of Gold, Platinum, and Silver
Esumi, K., Suzuki, A., Yamahira, A., & Torigoe, K. (2000) · Langmuir · doi:10.1021/la991291w · Cited by 326 · see citing works
Wang, Y., Cai, R., & Chen, C. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00126 · Cited by 304 · see citing works
Morgan, M. T., Nakanishi, Y., Kroll, D. J., Griset, A. P., Carnahan, M. A., Wathier, M., Oberlies, N. H., Manikumar, G., Wani, M. C., & Grinstaff, M. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2066 · Cited by 302 · see citing works
Alkane Cascade Polymers Possessing Micellar Topology: Micellanoic Acid Derivatives
Newkome, G. R., Moorefield, C. N., Baker, G. R., Johnson, A. L., & Behera, R. K. (1991) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199111761 · Cited by 265 · see citing works
Dendrimers of citric acid and poly (ethylene glycol) as the new drug-delivery agents
Namazi, H., & Adeli, M. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.04.014 · Cited by 265 · see citing works
Dendrimers, Dendrons, and Dendritic Polymers
Tomalia, D. A., Christensen, J. B., & Boas, U. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139048859 · Cited by 257 · see citing works
Self-citationIn quest of a systematic framework for unifying and defining nanoscience
Tomalia, D. A. (2009) · Journal of Nanoparticle Research · doi:10.1007/s11051-009-9632-z · Cited by 256 · see citing works
Self-citationDendritic Molecular Capsules for Hydrophobic Compounds
Morgan, M. T., Carnahan, M. A., Immoos, C. E., Ribeiro, A. A., Finkelstein, S., Lee, S. J., & Grinstaff, M. W. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0347383 · Cited by 252 · see citing works
Polynitrile‐ and Polyamine‐Functional Poly(trimethylene imine) Dendrimers
Wörner, C., & Mülhaupt, R. (1993) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199313061 · Cited by 246 · see citing works
Dendrimeric micelles for controlled drug release and targeted delivery
Ambade, A. V., Savariar, E. N., & Thayumanavan, S. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050020d · Cited by 245 · see citing works
Total synthesis of dodecahedrane
Paquette, L. A., Ternansky, R. J., Balogh, D. W., & Kentgen, G. (1983) · Journal of the American Chemical Society · doi:10.1021/ja00354a043 · Cited by 240 · see citing works
New Horizon of Nanoparticle and Cluster Catalysis with Dendrimers
Yamamoto, K., Imaoka, T., Tanabe, M., & Kambe, T. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00188 · Cited by 240 · see citing works
Tomalia, D. A., & Khanna, S. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00367 · Cited by 236 · see citing works
Self-citationBeezer, A. E., King, A. S. H., Martin, I. K., Mitchel, J. C., Twyman, L. J., & Wain, C. F. (2003) · Tetrahedron · doi:10.1016/s0040-4020(03)00437-x · Cited by 231 · see citing works
Polyamidoamine Starburst® dendrimers as solubility enhancers
Milhem, O. M., Myles, C., McKeown, N. B., Attwood, D., & D’Emanuele, A. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00463-9 · Cited by 227 · see citing works
Yiyun, C., Na, M., Tongwen, X., Rongqiang, F., Xueyuan, W., Xiaomin, W., & Longping, W. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20745 · Cited by 225 · see citing works
Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules
Choudhary, S., Gupta, L. K., Rani, S., Dave, K., & Gupta, U. D. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00261 · Cited by 223 · see citing works
Devarakonda, B., HILL, R., & DeVilliers, M. M. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.07.006 · Cited by 217 · see citing works
Tomalia, D. A., Berry, V., Hall, M., & Hedstrand, D. M. (1987) · Macromolecules · doi:10.1021/ma00171a051 · Cited by 215 · see citing works
Self-citationKesharwani, P., Xie, L., Banerjee, S., Mao, G., Padhyé, S., Sarkar, F. H., & Iyer, A. K. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.09.043 · Cited by 211 · see citing works
Cheng, Y., Qu, H., Ma, M., Xu, Z., Xu, P., Fang, Y., & Xu, T. (2007) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2006.12.035 · Cited by 206 · see citing works
Tomalia, D. A. (2009) · Soft Matter · doi:10.1039/b917370f · Cited by 204 · see citing works
Self-citationElectrostatic Multilayer Deposition of a Gold−Dendrimer Nanocomposite
He, J., Valluzzi, R., Yang, K., Dolukhanyan, T., Sung, C., Kumar, J., Tripathy, S. K., Samuelson, L. A., Balogh, L. P., & Tomalia, D. A. (1999) · Chemistry of Materials · doi:10.1021/cm990311c · Cited by 203 · see citing works
Self-citationHydraamphiphiles: Novel Linear Dendritic Block Copolymer Surfactants
Chapman, T. M., Hillyer, G. L., Mahan, E. J., & Shaffer, K. A. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00103a060 · Cited by 199 · see citing works
Ma, M., Cheng, Y., Xu, Z., Xu, P., Qu, H., Fang, Y., Xu, T., & Wen, L. (2006) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2006.07.015 · Cited by 190 · see citing works
Yang, H., Morris, J. J., & Lopina, S. T. (2004) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2003.12.023 · Cited by 185 · see citing works
Endocytosis and Interaction of Poly (Amidoamine) Dendrimers with Caco-2 Cells
Kitchens, K. M., Foraker, A. B., Kolhatkar, R. B., Swaan, P. W., & Ghandehari, H. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9415-0 · Cited by 182 · see citing works
Host-Guest Chemistry of Dendritic Molecules
Baars, M. W. P. L., & Meijer, E. W. (2000) · Topics in current chemistry · doi:10.1007/3-540-46577-4_3 · Cited by 182 · see citing works
Ooya, T. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.07.001 · Cited by 180 · see citing works
Sun, X., Dong, S., & Wang, E. (2004) · Macromolecules · doi:10.1021/ma048847t · Cited by 177 · see citing works
Formation of Silver and Gold Dendrimer Nanocomposites
Balogh, L. P., Valluzzi, R., Laverdure, K. S., Gido, S. P., Hagnauer, G. L., & Tomalia, D. A. (1999) · Journal of Nanoparticle Research · doi:10.1023/a:1010060404024 · Cited by 175 · see citing works
Self-citationRen, Y. T., Kang, C., Yuan, X.-B., Zhou, X., Xu, P., Han, L., Wang, G. X., Jia, Z., Zhong, Y., Yu, S., et al. (2010) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856209x415828 · Cited by 175 · see citing works
Ottaviani, M. F., Montalti, F., Turro, N. J., & Tomalia, D. A. (1997) · The Journal of Physical Chemistry B · doi:10.1021/jp962857h · Cited by 170 · see citing works
Self-citationYiyun, C., & Xu, T. (2005) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2005.06.010 · Cited by 168 · see citing works
Poly(amidoamine) dendrimers: covalent and supramolecular synthesis
Lyu, Z., Ding, L., Huang, A. Y., Kao, C., & Peng, L. (2019) · Materials Today Chemistry · doi:10.1016/j.mtchem.2019.04.004 · Cited by 166 · see citing works
Enhanced Oral Bioavailability of Doxorubicin in a Dendrimer Drug Delivery System
Ke, W., Zhao, Y., Huang, R., Jiang, C., & Pei, Y. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21155 · Cited by 165 · see citing works
Devarakonda, B., Hill, R. A., Liebenberg, W., Brits, M., & de Villiers, M. M. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.07.023 · Cited by 163 · see citing works
Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?
Baumann, A., Tuerck, D., Prabhu, S., Dickmann, L. J., & Sims, J. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.06.002 · Cited by 163 · see citing works
Alibolandi, M., Taghdisi, S. M., Ramezani, P., Shamili, F. H., Farzad, S. A., Abnous, K., & Ramezani, M. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.01.044 · Cited by 163 · see citing works
NMR Insights into Dendrimer-Based Host–Guest Systems
Hu, J., Xu, T., & Cheng, Y. (2012) · Chemical Reviews · doi:10.1021/cr200333h · Cited by 160 · see citing works
Tomalia, D. A., Hall, M. B., & Hedstrand, D. M. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00239a068 · Cited by 159 · see citing works
Self-citationYang, Y., Sunoqrot, S., Stowell, C. E. T., Ji, J., Lee, C.-W., Kim, J. W., Khan, S. A., & Hong, S. (2012) · Biomacromolecules · doi:10.1021/bm300545b · Cited by 158 · see citing works
Wong, A. D., DeWit, M. A., & Gillies, E. R. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.09.012 · Cited by 156 · see citing works
Tomalia, D. A. (2011) · New Journal of Chemistry · doi:10.1039/c1nj20501c · Cited by 154 · see citing works
Self-citationRecent development of unimolecular micelles as functional materials and applications
Fan, X., Li, Z., & Loh, X. J. (2016) · Polymer Chemistry · doi:10.1039/c6py01006g · Cited by 152 · see citing works
Dendrimer nanohybrid carrier systems: an expanding horizon for targeted drug and gene delivery
Kesharwani, P., Gothwal, A., Iyer, A. K., Jain, K., Chourasia, M. K., & Gupta, U. D. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.06.009 · Cited by 148 · see citing works
Dendrimers for Enhanced Drug Solubilization
Svenson, S., & Chauhan, A. S. (2008) · Nanomedicine · doi:10.2217/17435889.3.5.679 · Cited by 146 · see citing works
Silver Nanoparticles by PAMAM-Assisted Photochemical Reduction of Ag+
Kéki, S., Török, J., Deák, G., Daróczi, L., & Zsuga, M. (2000) · Journal of Colloid and Interface Science · doi:10.1006/jcis.2000.7011 · Cited by 143 · see citing works
Venuganti, V. V. K., & Perumal, O. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21603 · Cited by 142 · see citing works
Kaminskas, L. M., McLeod, V. M., Porter, C. J. H., & Boyd, B. J. (2012) · Molecular Pharmaceutics · doi:10.1021/mp2005966 · Cited by 141 · see citing works
Ooya, T., Lee, J., & Park, K. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049814l · Cited by 140 · see citing works
Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis
Sapra, R., Verma, R. P., Maurya, G. P., Dhawan, S., Babu, J., & Haridas, V. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00153 · Cited by 131 · see citing works
Taratula, O. R., Schumann, C., Duong, T., Taylor, K. L., & Taratula, O. (2014) · Nanoscale · doi:10.1039/c4nr06050d · Cited by 129 · see citing works
Dimensional Evolution of Polyphenylenes: Expanding in All Directions
Hammer, B. A. G., & Müllen, K. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00515 · Cited by 128 · see citing works
Size and solution properties of globular tert-butyloxycarbonyl-poly(α,iε-L-lysine)
Aharoni, S. M., Crosby, C., & Walsh, E. K. (1982) · Macromolecules · doi:10.1021/ma00232a026 · Cited by 123 · see citing works
Dextran conjugated dendritic nanoconstructs as potential vectors for anti-cancer agent
Agarwal, A., Gupta, U. D., Asthana, A., & Jain, N. K. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.03.016 · Cited by 119 · see citing works
Papagiannaros, A., Dimas, K., Papaioannou, G. T., & Demetzos, C. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.05.039 · Cited by 116 · see citing works
Precision Synthesis of Subnanoparticles Using Dendrimers as a Superatom Synthesizer
Yamamoto, K., & Imaoka, T. (2014) · Accounts of Chemical Research · doi:10.1021/ar400257s · Cited by 116 · see citing works
Gupta, L. K., Sharma, A. K., Gothwal, A., Khan, M. S., Khinchi, M. P., Qayum, A., Singh, S. K., & Gupta, U. D. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.04.073 · Cited by 114 · see citing works
Dendrimers with Both Polar and Apolar Nanocontainer Characteristics
Vutukuri, D. R., Basu, S., & Thayumanavan, S. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0449628 · Cited by 107 · see citing works
Ligand anchored dendrimers based nanoconstructs for effective targeting to cancer cells
Gupta, U. D., Dwivedi, S. K. D., Bid, H. K., Konwar, R., & Jain, N. K. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.04.002 · Cited by 107 · see citing works
Reduction of Drug Toxicity Using Dendrimers Based on Melamine
Neerman, M. F., Chen, H., Parrish, A. R., & Simanek, E. E. (2004) · Molecular Pharmaceutics · doi:10.1021/mp049957p · Cited by 107 · see citing works
Pentek, T., Newenhouse, E., O’Brien, B., & Chauhan, A. S. (2017) · Molecules · doi:10.3390/molecules22010137 · Cited by 107 · see citing works
Cheng, Y., Shao, S., Zhang, Hu, Zhang, & Zhang (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s27028 · Cited by 106 · see citing works
Šebestı́k, J., Niederhafner, P., & Ježek, J. (2010) · Amino Acids · doi:10.1007/s00726-010-0707-z · Cited by 102 · see citing works
Durairaj, C., Sistla, R., Ahmad, F. J., Khar, R. K., & Diwan, P. V. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31122 · Cited by 96 · see citing works
Facile Synthesis of Polyester Dendrimers as Drug Delivery Carriers
Ma, X., Zhou, Z., Jin, E., Sun, Q., Zhang, B., Tang, J., & Shen, Y. (2012) · Macromolecules · doi:10.1021/ma301849a · Cited by 93 · see citing works
Boas, U., Karlsson, A. J., de Waal, B. F. M., & Meijer, E. W. (2001) · The Journal of Organic Chemistry · doi:10.1021/jo001573x · Cited by 89 · see citing works
The synthesis of pentaprismane
Eaton, P. E., Or, Y. S., Branca, S. J., & Shankar, B. K. R. (1986) · Tetrahedron · doi:10.1016/s0040-4020(01)87579-7 · Cited by 89 · see citing works
Targeted nanosystems: Advances in targeted dendrimers for cancer therapy
Yang, H. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.11.012 · Cited by 86 · see citing works
Dhanikula, R. S., & Hildgen, P. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050184c · Cited by 85 · see citing works
Jain, N. K., Tare, M., Mishra, V. K., & Tripathi, P. K. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.09.006 · Cited by 82 · see citing works
Recker, J., Tomcik, D. J., & Parquette, J. R. (2000) · Journal of the American Chemical Society · doi:10.1021/ja001225c · Cited by 81 · see citing works
Cheng, Y., Li, M., & Xu, T. (2008) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2007.09.030 · Cited by 80 · see citing works
Luong, D., Kesharwani, P., Killinger, B. A., Moszczyńska, A., Sarkar, F. H., Padhyé, S., Rishi, A. K., & Iyer, A. K. (2016) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2016.08.061 · Cited by 80 · see citing works
Mignani, S. M., Kazzouli, S. E., Bousmina, M., & Majoral, J. (2013) · Chemical Reviews · doi:10.1021/cr400362r · Cited by 78 · see citing works
Dendrimer‐Based Drug Delivery Systems
Najlah, M., Zhou, Z., & DEmanuele, A. (2012) · Wiley eBooks · doi:10.1002/9781118275238 · Cited by 77 · see citing works
Pegylated lysine based copolymeric dendritic micelles for solubilization and delivery of artemether.
Bhadra, D., Bhadra, S., & Jain, N. K. (2005) · PubMed · Cited by 72 · see citing works
Cao, W., & Zhu, L. J. (2011) · Macromolecules · doi:10.1021/ma1021242 · Cited by 72 · see citing works
Kaanumalle, L. S., Nithyanandhan, J., Pattabiraman, M., Jayaraman, N., & Ramamurthy, V. (2004) · Journal of the American Chemical Society · doi:10.1021/ja049492w · Cited by 70 · see citing works
Dendrimer-mediated drug delivery to the skin
Sun, M., Fan, A., Wang, Z., & Zhao, Y. (2012) · Soft Matter · doi:10.1039/c2sm07280g · Cited by 69 · see citing works
Drug Delivery Systems from Self-Assembly of Dendron-Polymer Conjugates †
Bolu, B. S., Sanyal, R., & Sanyal, A. (2018) · Molecules · doi:10.3390/molecules23071570 · Cited by 68 · see citing works
Fluorescence Imaging of Bacterial Killing by Antimicrobial Peptide Dendrimer G3KL
Gan, B., Siriwardena, T. N., Javor, S., Darbre, T., & Reymond, J. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00299 · Cited by 67 · see citing works
Lipid-dendrimer hybrid nanosystem as a novel delivery system for paclitaxel to treat ovarian cancer
Liu, Y., Ng, Y., Toh, M. R., & Chiu, G. N. C. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.11.004 · Cited by 63 · see citing works
Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library
Armstrong, J. I., Portley, A. R., Chang, Y., Nierengarten, D. M., Cook, B. N., Bowman, K. G., Bishop, A., Gray, N. S., Shokat, K. M., Schultz, P. G., et al. (2000) · Angewandte Chemie International Edition · doi:10.1002/(sici)1521-3773(20000403)39:7 · Cited by 61 · see citing works
Dendrimer grafts for delivery of 5-fluorouracil.
Pk, T., Khopade, A. J., Nagaich, S., Shrivastava, S. K., Jain, S., & Nk, J. (2002) · PubMed · Cited by 61 · see citing works
Dendritic core–shell systems as soft drug delivery nanocarriers
Lukowiak, M. C., Thota, B. N. S., & Haag, R. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.03.014 · Cited by 60 · see citing works
Zhao, L., Cheng, Y., Hu, J., Wu, Q., & Xu, T. (2009) · The Journal of Physical Chemistry B · doi:10.1021/jp907437e · Cited by 58 · see citing works
Molecular interactions between dimethoxycurcumin and Pamam dendrimer carriers
Markatou, E., Vassilis Gionis, B., Chryssikos, G. D., Hatziantoniou, S., Georgopoulos, A., & Demetzos, C. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.02.037 · Cited by 57 · see citing works
Xu, X., Lü, S., Gao, C., Wang, X., Bai, X. F., Gao, N., & Liu, M. (2014) · Chemical Engineering Journal · doi:10.1016/j.cej.2014.12.075 · Cited by 56 · see citing works
Wang, F., Hu, K., & Cheng, Y. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.10.034 · Cited by 55 · see citing works
Hyperbranched copolymer micelles as delivery vehicles of doxorubicin in breast cancer cells
Zeng, X., Zhang, Y., Wu, Z., Lundberg, P., Malkoch, M., & Nyström, A. M. (2011) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.25027 · Cited by 53 · see citing works
Synthesis of silica-PAMAM dendrimer nanoparticles as promising carriers in Neuro blastoma cells
Yeşil-Çeliktaş, Ö., Pala, C., Çetin, E. Ö., & Sevimli-Gür, C. (2016) · Analytical Biochemistry · doi:10.1016/j.ab.2016.12.004 · Cited by 53 · see citing works
Shadrack, D. M., Swai, H., Munissi, J. J. E., Mubofu, E. B., & Nyandoro, S. S. (2018) · Molecules · doi:10.3390/molecules23061419 · Cited by 50 · see citing works
dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction
Kaminskas, L. M., Pires, D. E. V., & Ascher, D. B. (2019) · Scientific Reports · doi:10.1038/s41598-019-51789-3 · Cited by 47 · see citing works
Partially PEGylated PAMAM dendrimers as solubility enhancers of Silybin
Díaz, C. F., Guzmán, J., Jiménez, V. A., & Alderete, J. B. (2017) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2017.1315134 · Cited by 45 · see citing works
Devarakonda, B., Li, N., & de Villiers, M. M. (2005) · AAPS PharmSciTech · doi:10.1208/pt060363 · Cited by 44 · see citing works
The polar side of polyphenylene dendrimers
Hammer, B. A. G., Moritz, R., Stangenberg, R., Baumgarten, M., & Müllen, K. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00245h · Cited by 42 · see citing works
Development and Characterization of Triazine Based Dendrimers for Delivery of Antitumor Agent
Bansal, K. K., Kakde, D. D., Gupta, U. D., & Jain, N. K. (2010) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2010.3003 · Cited by 42 · see citing works
Reul, R., Renette, T., Bege, N., & Kissel, T. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.01.028 · Cited by 41 · see citing works
Shadrack, D. M., Mubofu, E. B., & Nyandoro, S. S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125956 · Cited by 41 · see citing works
Study of Poly(propylene imine) Dendrimers in Water, by Exciplex Formation
Pistolis, G., & Malliaris, A. (2001) · Langmuir · doi:10.1021/la010859+ · Cited by 38 · see citing works
Interactions and Encapsulation of Vitamins C, B3, and B6 with Dendrimers in Water
Boisselier, É., Liang, L., Dalko‐Csiba, M., Ruiz, J., & Astruc, D. (2010) · Chemistry - A European Journal · doi:10.1002/chem.200902995 · Cited by 38 · see citing works
Chooi, K. W., Gray, A. I., Tetley, L., Fan, Y., & Uchegbu, I. F. (2009) · Langmuir · doi:10.1021/la9027282 · Cited by 37 · see citing works
Phosphorus dendrimers as new tools to deliver active substances
Göller, R., Vors, J., Caminade, A., & Majoral, J. (2001) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)00509-3 · Cited by 37 · see citing works
Abdou, E. M., & Masoud, M. M. (2017) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2017.1344994 · Cited by 37 · see citing works
Singh, M. K., Pooja, D., Kulhari, H., Jain, S., Sistla, R., & Chauhan, A. S. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.09.005 · Cited by 36 · see citing works
Solubility of aceclofenac in polyamidoamine dendrimer solutions
Patel, J., Basu, B., Dharamsi, A. T., Garala, K., & Raval, M. K. (2011) · International Journal of Pharmaceutical Investigation · doi:10.4103/2230-973x.85962 · Cited by 35 · see citing works
Nabavizadeh, F., Fanaei, H., Imani, A., Vahedian, J., Amoli, F. A., Ghorbi, J., Sohanaki, H., Mohammadi, S. M., & Golchoobian, R. (2016) · PubMed · Cited by 34 · see citing works
Precision host–guest chemistry of polyphenylene dendrimers
Bauer, R. E., Clark, C. G., & Müllen, K. (2007) · New Journal of Chemistry · doi:10.1039/b617666f · Cited by 30 · see citing works
In Vitro Evaluation of Third Generation PAMAM Dendrimer Conjugates
Najlah, M., Freeman, S., Khoder, M., Attwood, D., & D’Emanuele, A. (2017) · Molecules · doi:10.3390/molecules22101661 · Cited by 30 · see citing works
Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection
Heitz, M., Javor, S., Darbre, T., & Reymond, J. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00403 · Cited by 30 · see citing works
Bellis, E., Hajba, L., Kovács, B., Sándor, K., Kollár, L., & Kokotos, G. (2006) · Journal of Biochemical and Biophysical Methods · doi:10.1016/j.jbbm.2006.02.006 · Cited by 29 · see citing works
HIV-1 antiviral behavior of anionic PPI metallo-dendrimers with EDA core
García‐Gallego, S., Díaz, L., Jiménez, J. L., Gómez, R., de la Mata, F. J., & Muñoz‐Fernández, M. Á. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.05.026 · Cited by 28 · see citing works
Burnett, J. L., King, A. S. H., Martin, I. K., & Twyman, L. J. (2002) · Tetrahedron Letters · doi:10.1016/s0040-4039(02)00113-2 · Cited by 28 · see citing works
Buczkowski, A., Olesinski, T., Zbicinska, E., Urbaniak, P., & Palecz, B. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.05.033 · Cited by 26 · see citing works
Expanding the limits of synthetic macromolecular chemistry through Polyphenylene Dendrimers
Hammer, B. A. G., & Müllen, K. (2018) · Journal of Nanoparticle Research · doi:10.1007/s11051-018-4364-6 · Cited by 26 · see citing works
Zheng, K., Ren, J., & He, J. (2019) · Macromolecules · doi:10.1021/acs.macromol.9b00920 · Cited by 26 · see citing works
Sowińska, M., Laskowska, A. K., Guśpiel, A., Solecka, J., Bochyńska-Czyż, M., Lipkowski, A. W., Trzeciak, K., & Urbańczyk-Lipkowska, Z. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00544 · Cited by 25 · see citing works
García‐Gallego, S., Cangiotti, M., Fiorani, L., Fattori, A., Muñoz‐Fernández, M. Á., Gómez, R., Ottaviani, M. F., & de la Mata, F. J. (2013) · Dalton Transactions · doi:10.1039/c3dt32870h · Cited by 24 · see citing works
Pavan, G. M., & Danani, A. (2010) · Physical Chemistry Chemical Physics · doi:10.1039/c0cp01124j · Cited by 21 · see citing works
Gothwal, A., Khan, I., Kumar, P., Raza, K., Kaul, A., Mishra, A. K., & Gupta, U. D. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00625 · Cited by 20 · see citing works
IN QUEST OF A SYSTEMATIC FRAMEWORK FOR UNIFYING AND DEFINING NANOSCIENCE
Tomalia, D. A., & Khanna, S. N. (2014) · Modern Physics Letters B · doi:10.1142/s0217984914300026 · Cited by 19 · see citing works
Self-citationPolcyn, P., Zielińska, P., Zimnicka, M., Troć, A., Kalicki, P., Solecka, J., Laskowska, A. K., & Urbańczyk-Lipkowska, Z. (2013) · Molecules · doi:10.3390/molecules18067120 · Cited by 19 · see citing works
Chauhan, A. S., & Kaul, M. (2018) · Journal of Nanoparticle Research · doi:10.1007/s11051-018-4318-z · Cited by 18 · see citing works
Wang, Z., Chen, C., Liu, R., Fan, A., Kong, D., & Zhao, Y. (2014) · Chemical Communications · doi:10.1039/c4cc06621a · Cited by 15 · see citing works
PAMAM dendrimer hydrogel film—biocompatible material to an efficient dermal delivery of drugs
Magalhães, T. M., Guerra, R. C., Gil, R. A. D. S. S., Valente, A. P., Simão, R. A., Soares, B. G., Mendes, T. D. C., Pyrrho, A. D. S., de Sousa, V. P., & Rodrigues-Furtado, V. L. (2017) · Journal of Nanoparticle Research · doi:10.1007/s11051-017-3965-9 · Cited by 15 · see citing works
Rahman, A., Rahman, A., & Tomalia, D. A. (2017) · Nanoscale Horizons · doi:10.1039/c7nh00010c · Cited by 12 · see citing works
Self-citationRecent Patents in Dendrimers for Nanomedicine: Evolution 2014
Shcharbin, D., Shcharbina, N., & Bryszewska, M. J. (2014) · Current Nanomedicine · doi:10.2174/1877912304666140609233256 · Cited by 9 · see citing works
Guest-Host Chemistry with Dendrimers—Binding of Carboxylates in Aqueous Solution
Ficker, M., Petersen, J. F., Hansen, J. S., & Christensen, J. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138706 · Cited by 8 · see citing works
Tang, S., Tomalia, D. A., Orr, B. G., Baker, J. R., & Huang, B. (2012) · New Journal of Chemistry · doi:10.1039/c2nj41002h · Cited by 7 · see citing works
Self-citationUnique features of the nano-scale
Fonash, S. J. (2018) · Journal of Nanoparticle Research · doi:10.1007/s11051-018-4405-1 · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 183 references couldn’t be matched to a known paper.
Research works printed but not linked: 12
- [5]Cram D.J. Cram J.M. Container Molecules and Their Guests The Royal Society of Chemistry Cambridge, UK 1994
- [12]Tomalia D.A. Dewald J.R. Hall M.J. Martin S.J. Smith P.B. Preprints: 1st SPSJ International Polymer Conference, Kyoto, Japan, 20–24 August 1984 Society of Polymer Science Kyoto, Japan 1984 65
- [13]Tomalia D.A. Starburst Macromolecules Proceedings of the Flory-Pauling Macromolecular Conference (Gordon Conference)—Frontiers in Synthetic Polymer Chemistry Santa Barbara, CA, USA 10–14 January 1983
- [14]Tomalia D.A. Starburst/Dendritic Macromolecules Proceedings of the Akron Polymer Lecture Series Akron, OH, USA 26 April 1984
- [15]Tomalia D.A. A New Class of Polymers: Starburst/Dendritic Macromolecules Proceedings of the Sixth Biennial Carl S. Marvel Symposium—Advances in Synthetic Polymer Chemistry Tucson, AZ, USA 19 March 1985
- [16]Tomalia D.A. A New Class of Polymers: Starburst/Dendritic Macromolecules Proceedings of the ACS Great Lakes/Central Regional Meeting Kalamazoo, MI, USA 23–25 May 1984
- [38]Balogh L. Swanson D.R. Spindler R. Tomalia D.A. Formation and characterization of dendrimer-based water soluble inorganic nanocomposites Proc. Am. Chem. Soc. Polym. Mater. Sci. Eng. 1997 77 118 119
- [82]Tomalia D.A. Rookmaker M. Poly(propylene imine) Dendrimers In Polymer Data Handbook 2nd ed. Mark J.E. Oxford University Press New York, NY, USA 2009 979 982
- [180]Tomalia D.A. Nixon L.S. Hedstrand D.M. Engineering critical nanoscale design parameters (CNDPs): A strategy for developing effective nanomedicine therapies and assessing (QNSARs) Pharmaceutical Applications of Dendrimers Chauhan A. Hitesh K. Elsevier Inc. Amsterdam, The Netherlands 2020
- [185]Tomalia D.A. Khanna S.N. Progress in the Development of a Systematic Nanoperiodic Framework for Unifying Nanoscience Taylor & Francis Abingdon, UK 2019
- [186]Tomalia D.A. Christensen J.B. Boas U. Dendrimers, Dendrons, and Dendritic Polymers: Discovery, Applications and the Future Cambridge University Press New York, NY, USA 2012 412
- [197]Grand View Research Nanomedicine market size worth $350.8 billion by 2025 |CAGR: 11.2% (2017) Available online: https://www.grandviewresearch.com/press-release/global-nanomedicine-market (accessed on 30 March 2020)
Cited by
Sorted by citations
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Recent Advances in Targeted Drug Delivery Strategy for Enhancing Oncotherapy
Li, J.-M., Wang, Q., Xia, G., Adilijiang, N., Li, Y., Hou, Z., Fan, Z., & Li, J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092233 · Cited by 292 · see citing works
Mukherjee, S., Mukherjee, S., Abourehab, M. A. S., Sahebkar, A., & Kesharwani, P. (2022) · European Polymer Journal · doi:10.1016/j.eurpolymj.2022.111471 · Cited by 111 · see citing works
Kaurav, M., Ruhi, S., Al-Goshae, H. A. A., Jeppu, A. K., Ramachandran, D., Sahu, R. K., Sarkar, A. K., Khan, J., & Ikbal, A. M. A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1159131 · Cited by 100 · see citing works
Mignani, S. M., Shi, X., Karpus, A. O., & Majoral, J. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112905 · Cited by 92 · see citing works
Amphiphilic Dendrimer Vectors for RNA Delivery: State-of-the-Art and Future Perspective
Chen, J., Zhu, D., Liu, X., & Peng, L. (2022) · Accounts of Materials Research · doi:10.1021/accountsmr.1c00272 · Cited by 83 · see citing works
Wang, J., Li, B., Huang, D., Norat, P., Grannonico, M., Cooper, R. C., Gui, Q., Chow, W. N., Liu, X., & Yang, H. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130498 · Cited by 77 · see citing works
Recent Advances and Challenges in Nanodelivery Systems for Antimicrobial Peptides (AMPs)
Tang, Z., Ma, Q., Chen, X., Chen, T., Ying, Y., Xi, X., Wang, L., Ma, C., Shaw, C., & Zhou, M. (2021) · Antibiotics · doi:10.3390/antibiotics10080990 · Cited by 77 · see citing works
Neuroinflammation Treatment via Targeted Delivery of Nanoparticles
Cerqueira, S. R., Ayad, N. G., & Lee, J. K. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.576037 · Cited by 67 · see citing works
Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases
Ortega, M. A., Merino, A. G., Fraile‐Μartinez, O., Recio-Ruiz, J., Pekarek, L., Guijarro, L. G., García‐Honduvilla, N., Álvarez‐Mon, M., Buján, J., & García‐Gallego, S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090874 · Cited by 64 · see citing works
Dendrimers toward Translational Nanotherapeutics: Concise Key Step Analysis
Mignani, S. M., Shi, X., Rodrigues, J., Roy, R., Muñoz‐Fernández, M. Á., Ceña, V., & Majoral, J. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00395 · Cited by 56 · see citing works
Dendrimer-Mediated Delivery of DNA and RNA Vaccines
Kisakova, L. A., Apartsin, E. K., Nizolenko, L. F., & Карпенко, Л. И. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041106 · Cited by 52 · see citing works
Cutting-edge development in dendritic polymeric materials for biomedical and energy applications
Thalji, M. R., Ibrahim, A. A., & Ali, G. A. M. (2021) · European Polymer Journal · doi:10.1016/j.eurpolymj.2021.110770 · Cited by 49 · see citing works
Bacha, K., Chemotti, C., Mbakidi, J., Deleu, M., & Bouquillon, S. (2023) · Macromol—A Journal of Macromolecular Research · doi:10.3390/macromol3020022 · Cited by 41 · see citing works
Tsujimoto, A., Uehara, H., Yoshida, H., Nishio, M., Furuta, K., Inui, T., Matsumoto, A., Morita, S., Tanaka, M., & Kojima, C. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112159 · Cited by 39 · see citing works
Devadas, B., Periasamy, A. P., & Bouzek, K. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214062 · Cited by 37 · see citing works
Tomalia, D. A. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16121530 · Cited by 36 · see citing works
Self-citationMoradi, F., & Dashti, N. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02196-x · Cited by 37 · see citing works
Heterogeneous Dendrimer-Based Catalysts
Karakhanov, E. A., Maximov, A. L., & Zolotukhina, A. V. (2022) · Polymers · doi:10.3390/polym14050981 · Cited by 35 · see citing works
Dendritic Macromolecular Architectures: Dendrimer-Based Polyion Complex Micelles
Mignani, S. M., Shi, X., Zabłocka, M., & Majoral, J. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.0c01645 · Cited by 26 · see citing works
Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An Opportunity
Mignani, S. M., Shi, X., Karpus, A. O., Lentini, G., & Majoral, J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091513 · Cited by 25 · see citing works
Application of Dendrimers for Treating Parasitic Diseases
Folliero, V., Zannella, C., Chianese, A., Stelitano, D., Ambrosino, A., Filippis, A. D., Galdiero, M., Franci, G., & Galdiero, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030343 · Cited by 25 · see citing works
Studzian, M., Działak, P., Pułaski, Ł., Hedstrand, D. M., Tomalia, D. A., & Klajnert‐Maculewicz, B. (2020) · Molecules · doi:10.3390/molecules25194406 · Cited by 22 · see citing works
Self-citationDendrimer nanoplatforms for veterinary medicine applications: A concise overview
Mignani, S. M., Shi, X., Rodrigues, J., Tomás, H., & Majoral, J. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.01.001 · Cited by 19 · see citing works
Sowińska, M., Szeliga, M., Morawiak, M., Zabłocka, B., & Urbańczyk-Lipkowska, Z. (2022) · Biomolecules · doi:10.3390/biom12081116 · Cited by 17 · see citing works
Bezrodnyi, V. V., Mikhtaniuk, S. E., Shavykin, O. V., Михайлович, Н. И., Sheveleva, N. N., & Markelov, D. A. (2021) · Molecules · doi:10.3390/molecules26216552 · Cited by 15 · see citing works
Ma, X., & Poma, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-823994-0.00004-9 · Cited by 15 · see citing works
Bonardd, S., Díaz, D. D., Leiva, Á., & Saldías, C. (2021) · Polymers · doi:10.3390/polym13244404 · Cited by 14 · see citing works
England, R., Sonzini, S., Buttar, D., Treacher, K. E., & Ashford, M. B. (2022) · Polymer Chemistry · doi:10.1039/d2py00080f · Cited by 14 · see citing works
Zloh, M., & Barata, T. S. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1769597 · Cited by 13 · see citing works
Kojima, C., Suzuki, Y., Ikemoto, Y., Tanaka, M., & Matsumoto, A. (2022) · Polymer Journal · doi:10.1038/s41428-022-00700-5 · Cited by 11 · see citing works
Bañales-Leal, Y., García-Rodríguez, A., Cuétara‐Guadarrama, F., Vonlanthen, M., Sorroza-Martínez, K., Morales‐Morales, D., & Rivera, E. (2021) · Dyes and Pigments · doi:10.1016/j.dyepig.2021.109382 · Cited by 11 · see citing works
Kojima, C., Fu, Y., & Tamaki, M. (2022) · Polymers · doi:10.3390/polym14122426 · Cited by 10 · see citing works
Workie, Y. A., Kuo, C.-Y., Riskawati, J. H., Krathumkhet, N., Imae, T., Ujihara, M., & Krafft, M. P. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c09812 · Cited by 9 · see citing works
Nandhabala, S., Hemalatha, J., Senthamil, C., Sakthivel, C., Nivetha, A., & Prabha, I. (2023) · ChemistrySelect · doi:10.1002/slct.202204490 · Cited by 6 · see citing works
Kojima, C., Xia, H., Yamamoto, Y., & Shiigi, H. (2021) · ChemNanoMat · doi:10.1002/cnma.202100442 · Cited by 6 · see citing works
Potential of Dendrimers in Drug Delivery: An Updated Review
Vardhan, H., Jain, A., & Singhai, A. K. (2024) · Asian Journal of Pharmaceutical Research · doi:10.52711/2231-5691.2024.00038 · Cited by 6 · see citing works
Sowińska, M., Szeliga, M., Morawiak, M., Ziemińska, E., Zabłocka, B., & Urbańczyk-Lipkowska, Z. (2021) · Biomolecules · doi:10.3390/biom11030435 · Cited by 6 · see citing works
Advanced bis-MPA hyperbranched dendritic nanocarriers of artemisinin with anticancer potential
Halevas, E. G., Mavroidi, B., Kokotidou, C., Mitraki, A., Pelecanou, M., & Sagnou, M. (2021) · Journal of Nanoparticle Research · doi:10.1007/s11051-021-05250-0 · Cited by 5 · see citing works
Direct 129 Xe-NMR spectroscopy evidence of a mesogenic dendrimer with free void space
Lu, Y.-C., Anedda, R., Chen, H., Hsu, H., Hsu, S., Ratcliffe, C. I., Lai, L., Ripmeester, J. A., & Hsu, H. (2023) · Journal of Materials Chemistry C · doi:10.1039/d3tc00486d · Cited by 5 · see citing works
Braga, C. B., Perli, G., Wang, Q., Wylie, L., Bertuzzi, D. L., Soares, M. C. P., Ramos, M. D., Ruiz, J., Pádua, A. A. H., Astruc, D., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402888 · Cited by 4 · see citing works
Dendrimer nanoplatforms for oral drug delivery applications
Kim, D., Kim, S., & Na, D. H. (2024) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-024-00716-4 · Cited by 4 · see citing works
Xie, Q., Lei, C., Chen, W., & Huang, B. (2021) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c01041 · Cited by 4 · see citing works
Organic nanocarriers for targeted delivery of anticancer agents
Dahiya, S., & Dahiya, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85503-7.00010-9 · Cited by 4 · see citing works
Gamma-irradiation induced nonconventional fluorescence enhancement in silicone foams
Huang, Z., Liu, Q., Jiang, B., Dou, R., Dai, B., Huang, W., & Chen, H. (2025) · Polymer Testing · doi:10.1016/j.polymertesting.2025.108846 · Cited by 3 · see citing works
Dhar, I., Bhatt, S., Gupta, S., Singh, S. K., & Dadhich, A. (2026) · Next Nanotechnology · doi:10.1016/j.nxnano.2026.100557 · Cited by 3 · see citing works
Kojima, C., & Xia, H. (2025) · ACS Applied Nano Materials · doi:10.1021/acsanm.5c01945 · Cited by 3 · see citing works
Cyclophane-Based Dendrimers: Today and Tomorrow
Mostovaya, O. A., Vavilova, A. A., Gazizova, A. F., & Stoikov, I. I. (2025) · Molecules · doi:10.3390/molecules30214211 · Cited by 3 · see citing works
Yuliana, A., Rahmiyani, I., & Kartika, C. (2023) · Journal Of Tropical Pharmacy And Chemistry · doi:10.25026/jtpc.v7i1.432 · Cited by 2 · see citing works
Muduli, A., Satapathy, B. S., Pattnaik, S., & Maharana, L. (2025) · Current Nanomaterials · doi:10.2174/0124054615358881250131070918 · Cited by 2 · see citing works
Dendrimer-assisted nanotechnological ways for glioblastoma drug delivery
Panchpuri, M., Sahu, V., Tomar, R., & Rath, S. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33319-4.00011-2 · Cited by 1 · see citing works
Amphiphilic dendron-polymer conjugates: Self-assembled nanocarriers for drug delivery
Demirkol, D., Sanyal, R., & Sanyal, A. (2026) · Polymer · doi:10.1016/j.polymer.2026.130073 · Cited by 1 · see citing works
Dendrimers in precision oncology: advances in therapy, diagnostics, and translational prospects
Zaeifi, D., Jamialahmadi, K., & Karimi, G. (2026) · Biomaterials Science · doi:10.1039/d6bm00242k · Cited by 1 · see citing works
Buczkowski, A., Malinowska-Michalak, M., Stępniak, A., Tokarz, P., Urbaniak, P., & Palecz, B. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2021.116118 · Cited by 1 · see citing works
Hood, D. K., Ananthraman, S., & Musa, O. M. (2021) · doi:10.1002/9781119468769.hpcbm024
Design, synthesis and self-assembly of amide-linked dendron-based non-ionic amphiphiles
Kumar, A., Singh, R., & Tyagi, Y. K. (2021) · Journal of the Iranian Chemical Society · doi:10.1007/s13738-021-02370-1
Tailor-made dendrimers in drug delivery and targeting
Aswal, A., Rohit, N., & Gupta, U. D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33304-0.00051-4
Smart and Sustainable Nanomaterials for Digital Healthcare: Application in Drug Delivery
Pal, R., Kumar, R., Kumar, T., Singh, D., & Kumar, K. (2026) · Springer eBooks · doi:10.1007/978-981-95-9386-6_5
Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality
Ghonaim, A. H., El-Naka, M. A., Nageeb, W. M., Khan, A. U., Seleem, N. M., Abdelghafar, A., Zamel, D., Liu, Y., He, Q., & Li, W. (2026) · BMEMat · doi:10.1002/bmm2.70133
- Authors
- Tomalia, D. A., Nixon, L. S., & Hedstrand, D. M.
- Affiliations
- Virginia Commonwealth University (US)
- National Dendrimer and Nanotechnology Center, NanoSynthons LLC, 1200 N. Fancher Avenue, Mt. Pleasant, MI 48858, USA
- Corresponding author
- Tomalia, Donald A.
- ORCID
- Tomalia, Donald A.
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2020-04-21
- Volume
- 10
- Issue
- 4
- Pages
- 642
- ISSN
- 2218-273X (ISSN-L)
- PMC
- PMC7226492
- OpenAlex
- W3019703663
- Cited by
- 60
- References
- 183
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 19 · 2020: 6
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Biomolecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
- Keywords
- dendrimers, dendrimer encapsulation, unimolecular micelles, drug solubilization, drug delivery systems
- MeSH terms
- Drug Compounding, Micelles, Magnetic Resonance Spectroscopy, Dendrimers, Nanoparticles, Hydrophobic and Hydrophilic Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review