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Cited by 17Ethnobotanical and Medicinal Plants StudiesPhytochemistry Medicinal Plant ApplicationsMedicinal Plant Research

Zoopharmacology: A Way to Discover New Cancer Treatments

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Domínguez-Martín, Eva María, Tavares, Joana, Ríjo, Patrícia, Díaz-Lanza, Ana María·2020·Biomolecules
DOI 10.3390/biom10060817PMC PMC7356688
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Abstract

Zoopharmacognosy is the multidisciplinary approach of the self-medication behavior of many kinds of animals. Recent studies showed the presence of antitumoral secondary metabolites in some of the plants employed by animals and their use for the same therapeutic purposes in humans. Other related and sometimes confused term is Zootherapy, which consists on the employment of animal parts and/or their by-products such as toxins, venoms, etc., to treat different human ailments. Therefore, the aim of this work is to provide a brief insight for the use of Zoopharmacology (comprising Zoopharmacognosy and Zootherapy) as new paths to discover drugs studying animal behavior and/or using compounds derived from animals. This work is focused on the approaches related to cancer, in order to propose a new promising line of research to overcome multidrug resistance (MDR). This novel subject will encourage the use of new alternative prospective ways to find new medicines.

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  1. [2]Domínguez-Martin E.M. Díaz-Lanza A.M. Faustino C.M.C. Anticancer hybrid combinations: Mechanisms of action, implications and future perspectives Curr. Pharm. Des. 2018 24 4312 4333 10.2174/1381612825666190110162529 30636587 · DOI
  2. [3]Garcia-Mayea Y. Mir C. Masson F. Paciucci R. LLeonart M.E. Insights into new mechanisms and models of cancer stem cell multidrug resistance Semin. Cancer Biol. 2020 60 166 180 10.1016/j.semcancer.2019.07.022 31369817 · DOI
  3. [4]Stewart B.W. Wild C.P. World Cancer Report 2014 International Agency for Research on Cancer Lyon, France 2014 39432694
  4. [5]Ferreira R.J. dos Santos D.J. Ferreira M.J. P-glycoprotein and membrane roles in multidrug resistance Future Med. Chem. 2015 7 929 946 10.4155/fmc.15.36 26061109 · DOI
  5. [6]Reis M.A. Matos A.M. Duarte N. Ahmed O.B. Ferreira R.J. Lage H. Ferreira M. Epoxylathyrane Derivatives as MDR Selective Compounds for Disabling Multidrug Resistance in Cancer Front. Pharmacol. 2020 11 599 10.3389/fphar.2020.00599 32457612 PMC7226783 · DOI
  6. [7]Chaachouay H. Ohneseit P. Toulany M. Kehlbach R. Multhoff G. Rodemann H.P. Autophagy contributes to resistance of tumor cells to ionizing radiation Radiother. Oncol. 2011 99 287 292 10.1016/j.radonc.2011.06.002 21722986 · DOI
  7. [8]Efferth T. Saeed M.E.M. Kadioglu O. Seo E.J. Shirooie S. Mbaveng A.T. Nabavi S.M. Kuete V. Collateral sensitivity of natural products in drug-resistant cancer cells Biotechnol. Adv. 2020 38 107342 10.1016/j.biotechadv.2019.01.009 30708024 · DOI
  8. [9]Cragg G.M. Newman D.J. Natural products as sources of anticancer agents: Current approaches and perspectives Natural Products as Source of Molecules with Therapeutic Potential Filho V.C. Springer International Publishing Cham, Switzerland 2018 309 331
  9. [10]Schmidt B. Ribnicky D.M. Poulev A. Logendra S. Cefalu W.T. Raskin I. A natural history of botanical therapeutics Metabolism 2008 57 S3 S9 10.1016/j.metabol.2008.03.001 18555851 PMC2981029 · DOI
  10. [11]Dhami N. Trends in Pharmacognosy: A modern science of natural medicines J. Herb. Med. 2013 3 123 131 10.1016/j.hermed.2013.06.001 · DOI
  11. [12]Heinrich M. Ethnopharmacology: Quo vadis? Challenges for the future Rev. Bras. Farm. 2014 24 99 102 10.1016/j.bjp.2013.11.019 · DOI · Paper page
  12. [13]Tasdemir D. MacIntosh A.J.J. Stergiou P. Kaiser M. Mansour N.R. Bickle Q. Huffman M.A. Antiprotozoal and antihelminthic properties of plants ingested by wild Japanese macaques (Macaca fuscata yakui) in Yakushima Island J. Ethnopharmacol. 2020 247 112270 10.1016/j.jep.2019.112270 31589965 · DOI
  13. [15]Huffman M.A. Animal self-medication and ethno-medicine: Exploration and exploitation of the medicinal properties of plants Proc. Nutr. Soc. 2003 62 371 381 10.1079/PNS2003257 14506884 · DOI
  14. [16]Costa-Neto E.M. Zoopharmacognosy, the self-medication behavior of animals Interfaces Cient. Saúde Ambiente 2012 1 61 72 10.17564/2316-3798.2012v1n1p61-72 · DOI
  15. [18]Abbott J. Self-medication in insects: Current evidence and future perspectives Ecol. Entomol. 2014 39 273 280 10.1111/een.12110 · DOI
  16. [19]Huffman M.A. Primate self-medication, passive prevention and active treatment—A brief review IJMS 2016 3 1 10 10.4038/ijms.v3i2.1 · DOI
  17. [22]Villalba J.J. Miller J. Ungar E.D. Landau S.Y. Glendinning J. Ruminant self-medication against gastrointestinal nematodes: Evidence, mechanism, and origins Parasite 2014 21 31 10.1051/parasite/2014032 24971486 PMC4073621 · DOI
  18. [23]Lisonbee L.D. Villalba J.J. Provenza F.D. Hall J.O. Tannins and self-medication: Implications for sustainable parasite control in herbivores Behav. Process. 2009 82 184 189 10.1016/j.beproc.2009.06.009 19576969 · DOI
  19. [24]Johnson W. Tchounwou P.B. Yedjou C.G. Therapeutic mechanisms of Vernonia amygdalina delile in the treatment of prostate cancer Molecules 2017 22 1594 10.3390/molecules22101594 28937624 PMC5661957 · DOI
  20. [26]Wong F.C. Woo C.C. Hsu A. Tan B.K. The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways PLoS ONE 2013 8 e78021 10.1371/journal.pone.0078021 24205071 PMC3812032 · DOI
  21. [27]Toyang N.J. Verpoorte R. A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae) J. Ethnopharmacol. 2013 146 681 723 10.1016/j.jep.2013.01.040 23395623 · DOI
  22. [28]Tambour M. La Zoopharmacognosie ou L’étude de L’automédication chez les Animaux: Voie D’avenir Pour de Nouveaux Médicaments Ph.D. Thesis Université de Lille Lille, France 2016 (In French)
  23. [29]Omosa L.K. Midiwo J.O. Masila V.M. Gisacho B.M. Munayi R. Kamakama F. Chemutai K.P. Elhaboob G. Saeed M.E. Hamdoun S. Cytotoxicity of 91 Kenyan indigenous medicinal plants towards human CCRF-CEM leukemia cells J. Ethnopharmacol. 2016 179 177 196 10.1016/j.jep.2015.12.028 26721219 · DOI
  24. [30]Singh G. Passsari A.K. Leo V.V. Mishra V.K. Subbarayan S. Singh B.P. Kumar B. Kumar S. Gupta V.K. Lalhlenmawia H. Evaluation of phenolic content variability along with antioxidant, antimicrobial, and cytotoxic potential of selected traditional medicinal plants from india Front. Plant Sci. 2016 7 407 10.3389/fpls.2016.00407 27066046 PMC4815358 · DOI
  25. [31]Desai T.H. Joshi S.V. Anticancer activity of saponin isolated from Albizia lebbeck using various in vitro models J. Ethnopharmacol. 2019 231 494 502 10.1016/j.jep.2018.11.004 30408535 · DOI
  26. [32]Simo L.M. Noté O.P. Mbing J.N. Aouazou S.A. Guillaume D. Muller C.D. Pegnyemb D.E. Lobstein A. New cytotoxic triterpenoid saponins from the roots of Albizia gummifera (J.F.Gmel.) C.A.Sm Chem. Biodivers. 2017 14 10.1002/cbdv.201700260 28877411 · DOI
  27. [33]Noté O.P. Kamto E.L.D. Toukea D.D. Aouazou S.A. Mbing J.N. Muller C.D. Guillaume D. Pegnyemb D.E. Pro-apoptotic activity of new triterpenoid saponins from the roots of Albizia adianthifolia (Schumach.) W.Wight Fitoterapia 2018 129 34 41 29906557
  28. [34]Noté O.P. Jihu D. Antheaume C. Zeniou M. Pegnyemb D.E. Guillaume D. Chneiwess H. Kilhoffer M.C. Lobstein A. Triterpenoid saponins from Albizia lebbeck (L.) Benth and their inhibitory effect on the survival of high grade human brain tumor cells Carbohydr. Res. 2015 404 26 33 25662738
  29. [36]Han Q. Qian Y. Wang X. Zhang Q. Cui J. Tu P. Liang H. Cytotoxic oleanane triterpenoid saponins from Albizia julibrissin Fitoterapia 2017 121 183 193 10.1016/j.fitote.2017.07.015 28764915 · DOI
  30. [37]Zhang J. Akihisa T. Kurita M. Kikuchi T. Zhu W.F. Ye F. Dong Z.H. Liu W.Y. Feng F. Xu J. Melanogenesis-inhibitory and cytotoxic activities of triterpene glycoside constituents from the bark of Albizia procera J. Nat. Prod. 2018 81 2612 2620 10.1021/acs.jnatprod.8b00167 30520635 · DOI
  31. [38]Lacaille-Dubois M.A. Pegnyemb D.E. Note O.P. Mitaine-Offer A.C. A review of acacic acid-type saponins from Leguminosae-Mimosoideae as potent cytotoxic and apoptosis inducing agents Phytochem. Rev. 2011 10 565 584 10.1007/s11101-011-9218-0 · DOI
  32. [39]Fotso G.W. Kamga J. Ngameni B. Uesugi S. Ohno M. Kimura K.I. Momma H. Kwon E. Furuno H. Shiono Y. Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae) Nat. Prod. Res. 2017 31 1981 1987 10.1080/14786419.2016.1269097 28103742 · DOI
  33. [40]Kuete V. Tchinda C.F. Mambe F.T. Beng V.P. Efferth T. Cytotoxicity of methanol extracts of 10 Cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines BMC Complement. Altern. Med. 2016 16 267 10.1186/s12906-016-1253-3 27484842 PMC4970256 · DOI
  34. [41]Petroni L.M. Huffman M.A. Rodrigues E. Medicinal plants in the diet of woolly spider monkeys (Brachyteles arachnoides, E. Geoffroy, 1806)—A bio-rational for the search of new medicines for human use? Rev. Bras. Farm. 2017 27 135 142 10.1016/j.bjp.2016.09.002 · DOI
  35. [42]Dubost J. Lamxay V. Krief S. Falshaw M. Manithip C. Deharo E. From plant selection by elephants to human and veterinary pharmacopeia of mahouts in Laos J. Ethnopharmacol. 2019 244 112157 10.1016/j.jep.2019.112157 31415849 · DOI
  36. [43]Krief S. Hladik C.M. Haxaire C. Ethnomedicinal and bioactive properties of plants ingested by wild chimpanzees in Uganda J. Ethnopharmacol. 2005 101 1 15 10.1016/j.jep.2005.03.024 15913933 · DOI
  37. [44]Omara T. Kiprop A.K. Ramkat R.C. Cherutoi J. Kagoya S. Moraa Nyangena D. Azeze Tebo T. Nteziyaremye P. Nyambura Karanja L. Jepchirchir A. Medicinal plants used in traditional management of cancer in Uganda: A review of ethnobotanical surveys, phytochemistry, and anticancer studies Evid. Based Complement. Altern. Med. 2020 2020 3529081 10.1155/2020/3529081 PMC7102457 32256639 · DOI
  38. [45]Ochwang’i D.O. Kimwele C.N. Oduma J.A. Gathumbi P.K. Mbaria J.M. Kiama S.G. Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya J. Ethnopharmacol. 2014 151 1040 1055 10.1016/j.jep.2013.11.051 24362078 · DOI
  39. [46]Farombi E.O. Owoeye O. Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid Int. J. Environ. Res. Public Health 2011 8 2533 2555 10.3390/ijerph8062533 21776245 PMC3138040 · DOI
  40. [47]Rodríguez E. Richard W. Zoopharmacognosy: The use of medicinal plants by animals Phytochemical Potential of Tropical Plants 1st ed. Downum K.R. Romeo J.T. Stafford H.A. Springer New York, NY, USA 1993 89 105
  41. [48]Messner E.J. Wrangham R.W. In vitro testing of the biological activity of Rubia cordifolia leaves on primate strongyloides species Primates 1996 37 105 108 10.1007/BF02382927 · DOI
  42. [49]Xu K. Wang P. Yuan B. Cheng Y. Li Q. Lei H. Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia Chem. Cent. J. 2013 7 81 10.1186/1752-153X-7-81 23642144 PMC3698108 · DOI
  43. [50]Wang Z. Li M.Y. Mi C. Wang K.S. Ma J. Jin X. Mollugin has an anti-cancer therapeutic effect by inhibiting TNF-alpha-induced NF-kappaB activation Int. J. Mol. Sci. 2017 18 1619 10.3390/ijms18081619 28933726 PMC5578011 · DOI
  44. [51]Zhang L. Wang H. Zhu J. Xu J. Ding K. Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K and ERK signaling pathways Biochem. Biophys. Res. Commun. 2014 450 247 254 10.1016/j.bbrc.2014.05.101 24887566 · DOI
  45. [52]Kim S.M. Park H.S. Jun D.Y. Woo H.J. Woo M.H. Yang C.H. Kim Y.H. Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL Toxicol. Appl. Pharmacol. 2009 241 210 220 10.1016/j.taap.2009.08.024 19716835 · DOI
  46. [53]Chen X.Q. Zhao S.M. Wang Z. Zeng G.Z. Huang M.B. Tan N.H. Rubicordins A-C, new cyclopeptides from Rubia cordifolia with cytotoxicity and inhibiting NF-kB signaling pathway Tetrahedron 2015 71 9673 9678 10.1016/j.tet.2015.10.044 · DOI
  47. [54]Lee Y.M. Auh Q.S. Lee D.W. Kim J.Y. Jung H.J. Lee S.H. Kim E.C. Involvement of Nrf2-mediated upregulation of heme oxygenase-1 in mollugin-induced growth inhibition and apoptosis in human oral cancer cells BioMed Res. Int. 2013 2013 210604 10.1155/2013/210604 23738323 PMC3659465 · DOI
  48. [55]Wang J. Li L. Wang J. Song L. Tan N. Wang Z. Natural naphthohydroquinone dimer rubioncolin C exerts anti-tumor activity by inducing apoptotic and autophagic cell death and inhibiting the NF-kappaB and Akt/mTOR/P70S6K pathway in human cancer cells Cells 2019 8 1593 10.3390/cells8121593 PMC6953124 31817918 · DOI
  49. [56]van Asseldonk T. Kleijer G. Lans C. Ethnoveterinary herb use in the Netherlands-between ethnobotany and zoopharmacognosy Proceedings of the Conference: BASEL VET Preconference GA Basel, Switzerland 3 September 2017 1 6
  50. [57]Saad B. Said O. Natural drugs in greco-arabic and Islamic medicine Greco-Arab and Islamic Herbal Medicine Saad B. Said O. John Wiley & Sons, Inc. Hoboken, NJ, USA 2011 101 121
  51. [58]Alves R.R.N. Rosa I.L. Why study the use of animal products in traditional medicines? J. Ethnobiol. Ethnomed. 2005 1 5 10.1186/1746-4269-1-5 16270931 PMC1277085 · DOI
  52. [59]Kaufmann A. Greten H.J. Efferth T. Animals and animal toxins in traditional and modern medicine Br. J. Appl. Sci. Technol. 2014 4 578 593 10.9734/BJAST/2014/5639 · DOI
  53. [60]Borah M.P. Prasad S.B. Ethnozoological study of animals based medicine used by traditional healers and indigenous inhabitants in the adjoining areas of Gibbon Wildlife Sanctuary, Assam, India J. Ethnobiol. Ethnomed. 2017 13 39 10.1186/s13002-017-0167-6 28666483 PMC5493085 · DOI
  54. [61]Dhakal P. Chettri B. Lepcha S. Acharya B.K. Rich yet undocumented ethnozoological practices of socio-culturally diverse indigenous communities of Sikkim Himalaya, India J. Ethnopharmacol. 2020 249 112386 10.1016/j.jep.2019.112386 31730891 · DOI
  55. [62]Das K.S. Choudhury S. Nonglait K. Zootherapy among the ethnic groups of North Eastern Region of India-A Critical Review J. Crit. Rev. 2017 4 1 9 10.22159/jcr.2017v4i2.14698 · DOI
  56. [63]Alves R.R. Alves H.N. The faunal drugstore: Animal-based remedies used in traditional medicines in Latin America J. Ethnobiol. Ethnomed. 2011 7 9 10.1186/1746-4269-7-9 21385357 PMC3060860 · DOI
  57. [64]Solís L. Casas A. Cuicatec ethnozoology: Traditional knowledge, use, and management of fauna by people of San Lorenzo Pápalo, Oaxaca, Mexico J. Ethnobiol. Ethnomed. 2019 15 58 10.1186/s13002-019-0340-1 31775811 PMC6882361 · DOI
  58. [65]Mahomoodally F. Samoisy A.K. Suroowan S. Ethnozoological practices in Rodrigues Island of the Mascarene archipelago J. Ethnopharmacol. 2019 245 112163 10.1016/j.jep.2019.112163 31419503 · DOI
  59. [66]Khusro A. Aarti C. Barbabosa-Pliego A. Rivas-Cáceres R.R. Cipriano-Salazar M. Venom as therapeutic weapon to combat dreadful diseases of 21st century: A systematic review on cancer, TB, and HIV/AIDS Microb. Pathog. 2018 125 96 107 10.1016/j.micpath.2018.09.003 30195644 · DOI
  60. [67]Jang A. Jo C. Kang K. Lee M. Antimicrobial and human cancer cell cytotoxic effect of synthetic angiotensin-converting enzyme (ACE) inhibitory peptides Food Chem. 2008 107 327 336 10.1016/j.foodchem.2007.08.036 · DOI
  61. [68]Yu Z.J. Xu Y. Peng W. Liu Y.J. Zhang J.M. Li J.S. Sun T. Wang P. Calculus bovis: A review on traditional usages, origin, chemistry, pharmacological activities and toxicology J. Ethnopharmacol. 2020 254 112649 10.1016/j.jep.2020.112649 32068140 · DOI
  62. [69]Wang L. Dong C. Li X. Han W. Su X. Anticancer potential of bioactive peptides from animal sources (Review) Oncol. Rep. 2017 38 637 651 10.3892/or.2017.5778 28677775 · DOI
  63. [70]Sánchez-Pedraza R. Gamba-Rincón M.R. González-Rangel A.L. Use of black vulture (Coragyps atratus) in complementary and alternative therapies for cancer in Colombia: A qualitative study J. Ethnobiol. Ethnomed. 2012 8 20 10.1186/1746-4269-8-20 22651097 PMC3473314 · DOI
  64. [71]Jeyamogan S. Khan N.A. Siddiqui R. Animals living in polluted environments are a potential source of anti-tumor molecule(s) Cancer Chemother. Pharmacol. 2017 80 919 924 10.1007/s00280-017-3410-x 28795217 · DOI
  65. [72]Song W. Shen D.Y. Kang J.H. Li S.S. Zhan H.W. Shi Y. Xiong Y.X. Liang G. Chen Q.X. Apoptosis of human cholangiocarcinoma cells induced by ESC-3 from Crocodylus siamensis bile World J. Gastroenterol. 2012 18 704 711 10.3748/wjg.v18.i7.704 22363144 PMC3281230 · DOI
  66. [73]Wu X. Chen D. Xie G.R. Effects of Gekko sulfated polysaccharide on the proliferation and differentiation of hepatic cancer cell line Cell Biol. Int. 2006 30 659 664 10.1016/j.cellbi.2006.04.005 16757189 · DOI
  67. [74]Ding X.L. Man Y.N. Hao J. Zhu C.H. Liu C. Yang X. Wu X.Z. The antitumor effect of gekko sulfated glycopeptide by inhibiting bFGF-induced lymphangiogenesis BioMed Res. Int. 2016 2016 7396392 10.1155/2016/7396392 27190997 PMC4844873 · DOI
  68. [75]He S. Mao X. Zhang T. Guo X. Ge Y. Ma C. Zhang X. Separation and nanoencapsulation of antitumor peptides from Chinese three-striped box turtle (Cuora trifasciata) J. Microencapsul. 2016 33 344 354 10.1080/02652048.2016.1194904 27292913 · DOI
  69. [76]El Ouar I. Braicu C. Naimi D. Irimie A. Berindan-Neagoe I. Effect of Helix aspersa extract on TNFα, NF-κB and some tumor suppressor genes in breast cancer cell line Hs578T Pharmacol. Mag. 2017 13 281 285 10.4103/0973-1296.204618 PMC5421427 28539722 · DOI · Paper page
  70. [77]Ruiz-Torres V. Encinar J.A. Herranz-Lopez M. Perez-Sanchez A. Galiano V. Barrajon-Catalan E. Micol V. An updated review on marine anticancer compounds: The use of virtual screening for the discovery of small-molecule cancer drugs Molecules 2017 22 1037 10.3390/molecules22071037 PMC6152364 28644406 · DOI
  71. [78]Newman D.J. From natural products to drugs Phys. Sci. Rev. 2018 4 20180111 10.1515/psr-2018-0111 · DOI
  72. [79]Abraham I. El Sayed K. Chen Z.S. Guo H. Current status on marine products with reversal effect on cancer multidrug resistance Mar. Drugs 2012 10 2312 2321 10.3390/md10102312 23170086 PMC3497025 · DOI
  73. [80]Lopez D. Martinez-Luis S. Marine natural products with P-glycoprotein inhibitor properties Mar. Drugs 2014 12 525 546 10.3390/md12010525 24451193 PMC3917285 · DOI
  74. [81]Liu C.C. Yang H. Zhang L.L. Zhang Q. Chen B. Wang Y. Biotoxins for cancer therapy Asian Pac. J. Cancer Prev. 2014 15 4753 4758 10.7314/APJCP.2014.15.12.4753 24998537 · DOI
  75. [82]Abdelfatah S. Lu X. Schmeda-Hirschmann G. Efferth T. Cytotoxicity and antimitotic activity of Rhinella schneideri and Rhinella marina venoms J. Ethnopharmacol. 2019 242 112049 10.1016/j.jep.2019.112049 31265888 · DOI
  76. [83]Wei W.L. Hou J.J. Wang X. Yu Y. Li H.J. Li Z.W. Feng Z.J. Qu H. Wu W.Y. Guo D.A. Venenum bufonis: An overview of its traditional use, natural product chemistry, pharmacology, pharmacokinetics and toxicology J. Ethnopharmacol. 2019 237 215 235 10.1016/j.jep.2019.03.042 30905791 · DOI
  77. [84]Zhao J. Zhang Q. Zou G. Gao G. Yue Q. Arenobufagin, isolated from toad venom, inhibited epithelial-to-mesenchymal transition and suppressed migration and invasion of lung cancer cells via targeting IKKβ/NFκβ signal cascade J. Ethnopharmacol. 2020 250 112492 10.1016/j.jep.2019.112492 31866511 · DOI
  78. [85]Calderon L.A. Sobrinho J.C. Zaqueo K.D. De Moura A.A. Grabner A.N. Mazzi M.V. Marcussi S. Nomizo A. Fernandes C.F.C. Zuliani J.P. Antitumoral activity of snake venom proteins: New trends in cancer therapy BioMed Res. Int. 2014 2014 203639 10.1155/2014/203639 24683541 PMC3943284 · DOI
  79. [86]Urra F.A. Araya-Maturana R. Targeting metastasis with snake toxins: Molecular mechanisms Toxins (Basel) 2017 9 390 10.3390/toxins9120390 PMC5744110 29189742 · DOI
  80. [87]Cohen-Inbar O. Zaaroor M. Glioblastoma multiforme targeted therapy: The Chlorotoxin story J. Clin. Neurosci. 2016 33 52 58 10.1016/j.jocn.2016.04.012 27452128 · DOI
  81. [88]Ding J. Chua P.J. Bay B.H. Gopalakrishnakone P. Scorpion venoms as a potential source of novel cancer therapeutic compounds Exp. Biol. Med. (Maywood) 2014 239 387 393 10.1177/1535370213513991 24599885 · DOI
  82. [89]Verma A.K. Prasad S.B. Antitumor effect of blister beetles: An ethno-medicinal practice in Karbi community and its experimental evaluation against a murine malignant tumor model J. Ethnopharmacol. 2013 148 869 879 10.1016/j.jep.2013.05.032 23707211 · DOI
  83. [90]Deng Y. Zhang W. Li N. Lei X. Gong X. Zhang D. Wang L. Ye W. Cantharidin derivatives from the medicinal insect Mylabris phalerata Tetrahedron 2017 73 5932 5939 10.1016/j.tet.2017.08.034 · DOI
  84. [91]Akef H.M. Anticancer, antimicrobial, and analgesic activities of spider venoms Toxicol. Res. 2018 7 381 395 10.1039/C8TX00022K 30090588 PMC6060684 · DOI
  85. [92]Ma R. Mahadevappa R. Kwok H.F. Venom-based peptide therapy: Insights into anti-cancer mechanism Oncotarget 2017 8 100908 100930 10.18632/oncotarget.21740 29246030 PMC5725072 · DOI
  86. [93]Balamurugan E. Reddy B.V. Menon V.P. Antitumor and antioxidant role of Chrysaora quinquecirrha (sea nettle) nematocyst venom peptide against Ehrlich ascites carcinoma in Swiss Albino mice Mol. Cell. Biochem. 2010 338 69 76 10.1007/s11010-009-0339-3 20012161 · DOI
  87. [94]Lyu C. Fang F. Li B. Anti-tumor effects of melittin and its potential applications in clinic Curr. Protein Pept. Sci. 2018 20 240 250 10.2174/1389203719666180612084615 29895240 · DOI
  88. [95]Huerta-Reyes M. Anselme C. Cherqui A. Decocq G. Exploration through the venoms from hymenoptera as potential therapeutic agents in cancer therapy Int. J. Pharmacol. 2017 13 507 515 10.3923/ijp.2017.507.515 · DOI
  89. [96]El-Tantawy N.L. Helminthes and insects: Maladies or therapies Parasitol. Res. 2015 114 359 377 10.1007/s00436-014-4260-7 25547076 · DOI
  90. [97]Olgac A. Orhan I.E. Banoglu E. The potential role of in silico approaches to identify novel bioactive molecules from natural resources Future Med. Chem. 2017 9 1665 1686 10.4155/fmc-2017-0124 28841048 · DOI
  91. [98]Rifaioglu A.S. Atas H. Martin M.J. Cetin-Atalay R. Atalay V. Dogan T. Recent applications of deep learning and machine intelligence on in silico drug discovery: Methods, tools and databases Brief Bioinform. 2019 20 1878 1912 10.1093/bib/bby061 30084866 PMC6917215 · DOI
  92. [99]Chen B. Harrison R.F. Papadatos G. Willett P. Wood D.J. Lewell X.Q. Greenidge P. Stiefl N. Evaluation of machine-learning methods for ligand-based virtual screening J. Comput. Aided Mol. Des. 2007 21 53 62 10.1007/s10822-006-9096-5 17205373 · DOI
  93. [100]Duran-Frigola M. Pauls E. Guitart-Pla Bertoni M. Alcalde V. Amat D. Juan-Blanco T. Aloy P. Extending the small-molecule similarity principle to all levels of biology with the chemical checker Nat. Biotechnol. 2020 10.1038/s41587-020-0502-7 32440005 PMC7616951 · DOI · Paper page
  94. [101]Acevedo C.H. Scotti L. Scotti M.T. In silico studies designed to select sesquiterpene lactones with potential antichagasic activity from an in-house Asteraceae database ChemMedChem 2018 13 634 645 10.1002/cmdc.201700743 29323468 · DOI
  95. [102]Chagas-Paula D.A. Oliveira T.B. Zhang T. Edrada-Ebel R. Da Costa F.B. Prediction of anti-inflammatory plants and discovery of their biomarkers by machine learning algorithms and metabolomic studies Planta Med. 2015 81 450 458 10.1055/s-0034-1396206 25615275 · DOI
  96. [103]Blondeau S. Do Q.T. Scior T. Bernard P. Morin-Allory L. Reverse pharmacognosy: Another way to harness the generosity of nature Curr. Pharm. Des. 2010 16 1682 1696 10.2174/138161210791164036 20222859 · DOI
  97. [104]Xiong Y. Yang Y. Xiong W. Yao Y. Wu H. Zhang M. Network pharmacology-based research on the active component and mechanism of the antihepatoma effect of Rubia cordifolia L. J. Cell. Biochem. 2019 120 12461 12472 10.1002/jcb.28513 30816612 · DOI
  98. [105]Zhao L.J. Zhao H.Y. Wei X.L. Guo F.F. Wei J.Y. Wang H.J. Yang J. Yang Z.G. Si N. Bian B.L. The lipid homeostasis regulation study of arenobufagin in zebrafish HepG2 xenograft model and HepG2 cells using integrated lipidomics-proteomics approach J. Ethnopharmacol. 2020 10.1016/j.jep.2020.112943 32422359 · DOI
  99. [106]Sen T. Samanta S.K. Medicinal plants, human health and biodiversity: A broad review Adv. Biochem. Eng. Biotechnol. 2015 147 59 110 25001990

Cited by

Sorted by citations

Authors
Domínguez-Martín, E. M., Tavares, J., Ríjo, P., & Díaz-Lanza, A. M.
Affiliations
  • Universidad de Alcalá (ES)
  • Universidade Lusófona de Humanidades e Tecnologias (PT)
  • CBIOS-Center for Research in Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologías, Campo Grande 376, 1749-024 Lisbon, Portugal
  • Department of Biomedical Sciences, Faculty of Pharmacy, University of Alcalá, Carretera Madrid-Barcelona, Km 33.100, 28805 Alcalá de Henares, Madrid, Spain
ORCID
Venue
Biomolecules
Publisher
MDPI AG
Published
2020-05-26
Volume
10
Issue
6
Pages
817
ISSN
2218-273X (ISSN-L)
DOI
10.3390/biom10060817
PMC
PMC7356688
OpenAlex
W3030276530
Cited by
17
References
0
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2
FWCI
0.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomolecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • e_Buah (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Fundação para a Ciência e a Tecnologia (UID/DTP/04567/2020)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Ethnobotanical and Medicinal Plants Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
zootherapy, animal self-medication, animal-derived compounds, drug discovery, cancer therapy, multidrug resistance
MeSH terms
Animals, Antineoplastic Agents, Neoplasms, Drug Resistance, Neoplasm, Drug Discovery

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

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