Cited by 306Cannabis and Cannabinoid ResearchMedicinal Plant Extracts EffectsPsychedelics and Drug Studies

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Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders

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García-Gutiérrez, María S., Navarrete, Francisco, Gasparyan, Ani, Austrich-Olivares, Amaya, Sala, Francisco, Manzanares, Jorge·2020·Biomolecules

DOI 10.3390/biom10111575PMC PMC7699613

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Abstract

The potential therapeutic use of some Cannabis sativa plant compounds has been attracting great interest, especially for managing neuropsychiatric disorders due to the relative lack of efficacy of the current treatments. Numerous studies have been carried out using the main phytocannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD displays an interesting pharmacological profile without the potential for becoming a drug of abuse, unlike THC. In this review, we focused on the anxiolytic, antidepressant, and antipsychotic effects of CBD found in animal and human studies. In rodents, results suggest that the effects of CBD depend on the dose, the strain, the administration time course (acute vs. chronic), and the route of administration. In addition, certain key targets have been related with these CBD pharmacological actions, including cannabinoid receptors (CB1r and CB2r), 5-HT1A receptor and neurogenesis factors. Preliminary clinical trials also support the efficacy of CBD as an anxiolytic, antipsychotic, and antidepressant, and more importantly, a positive risk-benefit profile. These promising results support the development of large-scale studies to further evaluate CBD as a potential new drug for the treatment of these psychiatric disorders.

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Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Gaoni, Y., & Mechoulam, R. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01062a046 · Cited by 2,389
Psychological autopsy studies of suicide: a systematic review.
CAVANAGH, J. T. O., CARSON, A. J., SHARPE, M., & LAWRIE, S. M. (2003) · Psychological Medicine · doi:10.1017/s0033291702006943 · Cited by 2,207
The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: Δ 9 ‐tetrahydrocannabinol, cannabidiol and Δ 9 ‐tetrahydrocannabivarin
Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707442 · Cited by 2,047
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832
Endocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,595
Schizophrenia as a Disorder of Neurodevelopment
Lewis, D. A., & Levitt, P. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142754 · Cited by 1,163
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160
Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
Leweke, F. M., Piomelli, D., Pahlisch, F., Muhl, D., Gerth, C. W., Hoyer, C., Klosterkötter, J., Hellmich, M., & Koethe, D. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.15 · Cited by 1,059

Flagged first, then by citations

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Research works printed but not linked: 5

Patel, V., Laxminarayan, R., Medina-Mora, M.L., Dua, T., and Chisholm, D. (2016). Chapter 2 Global burden of mental, neurological and substance use disorder: An analysis from the global burden of disease study 2010. Mental, Neurological, and Substance Use Disorders: Disease Control Priorities, The International Bank for Reconstruction and Development. [3rd ed.].
Hawksworth, G.M.K. (2004). Metabolism and Pharmacokinetics of Cannabinoids, Pharmaceutical Press.
Sylantyev, S.J.T., Ross, R.A., and Rusakov, D.A. (2011, January 12–16). The enigmatic receptor GPR55 potentiates neurotransmitter release at central synapses. Proceedings of the Neuroscience Meeting Planner Washington, DC: Society for Neuroscience Online: Program, Washington, DC, USA. Program 653.01, Poster B28.
Heather, A., Church, A.C., and Lucey, J.V. (2012). Core Psychiatry, Elsevier. [3rd ed.].
Aragones, 2009, Comorbidity of major depression with other common mental disorders in primary care patients, Aten Primaria, 41, 545

Sorted by citations

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Authors: García-Gutiérrez, M. S., Navarrete, F., Gasparyan, A., Austrich-Olivares, A., Sala, F., & Manzanares, J.
Affiliations: Neurosciences Institute, University Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, Spain
Consejo Superior de Investigaciones Científicas (ES)
Corresponding author: Manzanares, Jorge
ORCID: Navarrete, Francisco
Gasparyan, Ani
Manzanares, Jorge
Venue: Biomolecules
Publisher: MDPI AG
Published: 2020-11-19
Volume: 10
Issue: 11
Pages: 1575
ISSN: 2218-273X (ISSN-L)
DOI: 10.3390/biom10111575
PMC: PMC7699613
OpenAlex: W3101299715
Cited by: 306
References: 213
Citations by year: 2026: 24 · 2025: 79 · 2024: 62 · 2023: 66 · 2022: 46 · 2021: 29
FWCI: 4.62
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomolecules (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Keywords: cannabidiol, anxiety, depression, psychosis, anxiolytic effects, antidepressant effects, antipsychotic effects, tetrahydrocannabinol, phytocannabinoids, cannabinoid receptors, CB1 receptor, CB2 receptor, 5-HT1A receptor, neurogenesis, dose-dependent effects, route of administration, clinical trials, risk-benefit profile
MeSH terms: Animals, Anxiety, Cannabidiol, Depression, Dose-Response Relationship, Drug, Drug Administration Routes, Humans, Psychotic Disorders, Treatment Outcome

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Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders

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