The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives
Open accessAbstract
Persistent hyperglycemic state in type 2 diabetes mellitus leads to the initiation and progression of non-enzymatic glycation reaction with proteins and lipids and nucleic acids. Glycation reaction leads to the generation of a heterogeneous group of chemical moieties known as advanced glycated end products (AGEs), which play a central role in the pathophysiology of diabetic complications. The engagement of AGEs with its chief cellular receptor, RAGE, activates a myriad of signaling pathways such as MAPK/ERK, TGF-β, JNK, and NF-κB, leading to enhanced oxidative stress and inflammation. The downstream consequences of the AGEs/RAGE axis involve compromised insulin signaling, perturbation of metabolic homeostasis, RAGE-induced pancreatic beta cell toxicity, and epigenetic modifications. The AGEs/RAGE signaling instigated modulation of gene transcription is profoundly associated with the progression of type 2 diabetes mellitus and pathogenesis of diabetic complications. In this review, we will summarize the exogenous and endogenous sources of AGEs, their role in metabolic dysfunction, and current understandings of AGEs/RAGE signaling cascade. The focus of this review is to recapitulate the role of the AGEs/RAGE axis in the pathogenesis of type 2 diabetes mellitus and its associated complications. Furthermore, we present an overview of future perspectives to offer new therapeutic interventions to intervene with the AGEs/RAGE signaling pathway and to slow down the progression of diabetes-related complications.
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Cites
IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045
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The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
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Advanced glycation end-products: A review
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Understanding RAGE, the receptor for advanced glycation end products
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Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes
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Role of advanced glycation end products in cellular signaling
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Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095
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“A plethora of evidence suggests AGEs/RAGE signaling pathway, NFκB activation, inflammation, and ROS generation are directly related to the pathogenesis of insulin resistance by increased IRS-1serine phosphorylation and degradation, thus blocking the insulin signaling pathway [68,71,73,74].”
BackgroundThe Role of Advanced Glycation End Products in Progression and Complications of Diabetes
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“Maillard reaction generates highly reactive numerous intermediate carbonyl precursors of AGEs [20,29].”
Background
Cited by
Kropp, M., Golubnitschaja, O., Mazurakova, A., Koklesova, L., Sargheini, N., Vo, T.-T. K. S., de Clerck, E., Polivka, J., Potuznik, P., Polivka, J., et al. (2023) · EPMA Journal · doi:10.1007/s13167-023-00314-8 · Cited by 468
From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration
Li, S., Du, J., Huang, Y., Gao, S., Zhao, Z., Chang, Z., Zhang, X., & He, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1355503 · Cited by 32
Plant Foods, Healthy Plant-Based Diets, and Type 2 Diabetes: A Review of the Evidence
del Carmen Fernández-Fígares Jiménez, M. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuad099 · Cited by 20
Metadata
- Authors
- Khalid, M., Petroianu, G., & Adem, A.
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2022-04-04
- Volume
- 12
- Issue
- 4
- Pages
- 542
- ISSN
- 2218-273X (ISSN-L)
- OpenAlex
- W4224307827
- Cited by
- 879
- References
- 25
- FWCI
- 83.57
- Type
- journal article
- Language
- en
- Open access
- gold
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