The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Lipid Peroxidation and Antioxidant Protection
Open accessAbstract
Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins. The chemistry of LP and its biological consequences are reviewed with focus on the kinetics of the various processes, which helps understand the mechanisms and efficacy of antioxidant strategies. The main types of antioxidants are discussed in terms of structure–activity rationalization, with focus on mechanism and kinetics, as well as on their potential role in modulating ferroptosis. Phenols, pyri(mi)dinols, antioxidants based on heavy chalcogens (Se and Te), diarylamines, ascorbate and others are addressed, along with the latest unconventional antioxidant strategies based on the double-sided role of the superoxide/hydroperoxyl radical system.
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Citations
Cites
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
Yang, W. S., Kim, K. J., Gaschler, M. M., Patel, M., Shchepinov, M. S., & Stockwell, B. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603244113 · Cited by 2,329
Lipid peroxidation and ferroptosis: The role of GSH and GPx4
Ursini, F., & Maiorino, M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.027 · Cited by 1,954 · cited 4×
“…phospholipid hydroperoxide glutathione peroxidase that differs from other GPXs preferably reducing hydrogen peroxide—would cause cell death by inducing massive ferroptosis, which would be inhibited by liproxstatin-1, allowed recognizing the key role of GPX4 as a controller of ferroptosis [14,85].”
InfluentialRole of Glutathione in Cancer: From Mechanisms to Therapies
Kennedy, L., Sandhu, J. K., Harper, M.-E., & Cuperlovic-Culf, M. (2020) · Biomolecules · doi:10.3390/biom10101429 · Cited by 880
Antioxidant Activity of Essential Oils
Amorati, R., Foti, M. C., & Valgimigli, L. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf403496k · Cited by 803
Self-citationResolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis
Shah, R., Shchepinov, M. S., & Pratt, D. A. (2018) · ACS Central Science · doi:10.1021/acscentsci.7b00589 · Cited by 782
Ito, F., Sono, Y., & Ito, T. (2019) · Antioxidants · doi:10.3390/antiox8030072 · Cited by 535
Pratt, D. A., Tallman, K. A., & Porter, N. A. (2011) · Accounts of Chemical Research · doi:10.1021/ar200024c · Cited by 352 · cited 4×
“…s − 1 at 37 ◦ C) and the corresponding hydroperoxide would never be formed in the absence of a much faster H-atom donor such as α -tocopherol ( α -TOH) or other antioxidants; therefore, they used this radical clock to measure the rate constant of inhibition k inh for antioxidants (vide infra) [39].”
InfluentialFormation and signaling actions of electrophilic lipids
Schopfer, F. J., Cipollina, C., & Freeman, B. A. (2011) · Chemical Reviews · doi:10.1021/cr200131e · Cited by 299
Miyamoto, S., Martinez, G. R., Rettori, D., Augusto, O., Medeiros, M. H. G., & Di Mascio, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508170103 · Cited by 137
Cited by
Oxidative Stress: Signaling Pathways, Biological Functions, and Disease
Liu, S., Liu, J., Wang, Y., Deng, F., & Deng, Z. (2025) · MedComm · doi:10.1002/mco2.70268 · Cited by 359
Metadata
- Authors
- Valgimigli, L.
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2023-08-24
- Volume
- 13
- Issue
- 9
- Pages
- 1291
- ISSN
- 2218-273X (ISSN-L)
- OpenAlex
- W4386142300
- Cited by
- 335
- References
- 10
- FWCI
- 32.83
- Type
- journal article
- Language
- en
- Open access
- gold
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
