Curcumin and Resveratrol: Nutraceuticals with so Much Potential for Pseudoachondroplasia and Other ER-Stress Conditions

Bioavailability of curcumin: Problems and promises

Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543 · see citing works

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumPreprint

Marciniak, S. J., Yun, C. Y., Oyadomari, S., Novoa, I., Zhang, Y., Jungreis, R., Nagata, K., Harding, H. P., & Ron, D. (2004) · Genes & Development · doi:10.1101/gad.1250704 · Cited by 2,004 · see citing works

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

Berenbaum, F. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.11.012 · Cited by 1,718 · see citing works

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

Wojdasiewicz, P., Poniatowski, Ł. A., & Szukiewicz, D. (2014) · Mediators of Inflammation · doi:10.1155/2014/561459 · Cited by 1,608 · see citing works

Inflammation in osteoarthritis

Goldring, M. B., & Otero, M. (2011) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328349c2b1 · Cited by 1,462 · see citing works

Matrix Metalloproteinases: Role In Arthritis

Peter, S. B. (2006) · Frontiers in bioscience · doi:10.2741/1817 · Cited by 1,294 · see citing works

Methods Used to Evaluate Pain Behaviors in Rodents

Deuis, J. R., Dvorakova, L. S., & Vetter, I. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00284 · Cited by 1,269 · see citing works

Synovial tissue inflammation in early and late osteoarthritis

Benito, M. J., Veale, D. J., FitzGerald, O., van den Berg, W. B., & Bresnihan, B. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.025270 · Cited by 1,003 · see citing works

Regulation of SIRT1 in cellular functions: Role of polyphenols

Chung, S., Yao, H., Caito, S. W., Hwang, J., Arunachalam, G., & Rahman, I. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.003 · Cited by 651 · see citing works

Nosology and classification of genetic skeletal disorders: 2015 revision

Bonafe, L., Cormier‐Daire, V., Hall, C., Lachman, R., Mortier, G., Mundlos, S., Nishimura, G., Sangiorgi, L., Savarirayan, R., Sillence, D., et al. (2015) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37365 · Cited by 569 · see citing works

Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene

Briggs, M. D., Hoffman, S. M. G., King, L. M., Olsen, A. S., Mohrenweiser, H. W., Leroy, J. G., Mortier, G. R., Rimoin, D. L., Lachman, R. S., Gaines, E. S., et al. (1995) · Nature Genetics · doi:10.1038/ng0795-330 · Cited by 513 · see citing works

Pharmacokinetic and safety profile oftrans‐resveratrol in a rising multiple‐dose study in healthy volunteers

Almeida, L., Vaz‐da‐Silva, M., Falcão, A. C., Soares, E., Costa, R., Loureiro, A. I., Fernandes‐Lopes, C., Rocha, J., Nunes, T., Wright, L. C., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800177 · Cited by 427 · see citing works

Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death

Jang, J.-H. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00062-5 · Cited by 391 · see citing works

Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia

Hecht, J. T., Nelson, L. D., Crowder, E., Wang, Y., Elder, F. F. B., Harrison, W. R., Francomano, C. A., Prange, C. K., Lennon, G. G., Deere, M., et al. (1995) · Nature Genetics · doi:10.1038/ng0795-325 · Cited by 382 · see citing works

Immune modulation by curcumin: The role of interleukin-10

Mollazadeh, H., Cicero, A. F. G., Blesso, C. N., Pirro, M., Majeed, M. A., & Sahebkar, A. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1358139 · Cited by 382 · see citing works

Antidepressant activity of curcumin: involvement of serotonin and dopamine system

Kulkarni, S. K., Bhutani, M. K., & Bishnoi, M. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1300-y · Cited by 339 · see citing works

Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by MAP kinases, AP-1, and NF-κB transcription factors in articular chondrocytes

Liacini, A. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00180-0 · Cited by 312 · see citing works

Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

Coutinho, D. D. S., Pacheco, M. T., Frozza, R. L., & Bernardi, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061812 · Cited by 298 · see citing works

Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

Abrahams, S., Haylett, W. L., Johnson, G., Carr, J. A., & Bardien, S. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.02.020 · Cited by 297 · see citing works

Pseudoachondroplasia and multiple epiphyseal dysplasia: Mutation review, molecular interactions, and genotype to phenotype correlations

Briggs, M. D., & Chapman, K. L. (2002) · Human Mutation · doi:10.1002/humu.10066 · Cited by 290 · see citing works

Resveratrol for Alzheimer's disease

Sawda, C. N., Moussa, C., & Turner, R. S. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13431 · Cited by 281 · see citing works

Resveratrol: review on therapeutic potential and recent advances in drug delivery

Pangeni, R., Sahni, J. K., Ali, J., Sharma, S., & Baboota, S. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.919253 · Cited by 255 · see citing works

The effects of curcumin on depressive-like behaviors in mice

Xu, Y., Ku, B., Yao, H.-Y., Lin, Y., Ma, X., Zhang, Y., & Li, X.-J. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.06.002 · Cited by 245 · see citing works

Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation

Kao, C.-L., Chen, L., Chang, Y.-L., Yung, M.-C., Hsu, C.-C., Chen, Y., Lo, W., Chen, S., Ku, H., & Hwang, S.-J. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.4333 · Cited by 241 · see citing works

Resveratrol increases vascular oxidative stress resistance

Ungvari, Z. I., Orosz, Z. Z., Rivera, A., Labinskyy, N., Xiangmin, Z., Olson, S. C., Podlutsky, A. J., & Csiszár, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01258.2006 · Cited by 239 · see citing works

Mutations in Cartilage Oligomeric Matrix Protein Causing Pseudoachondroplasia and Multiple Epiphyseal Dysplasia Affect Binding of Calcium and Collagen I, II, and IX

Thur, J., Rosenberg, K., Nitsche, D. P., Pihlajamaa, T., Ala‐Kokko, L., Heinegård, D. K., Paulsson, M., & Maurer, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009512200 · Cited by 234 · see citing works

Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is the Solution?

Smoliga, J. M., & Blanchard, O. L. (2014) · Molecules · doi:10.3390/molecules191117154 · Cited by 231 · see citing works

Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial

Panahi, Y., Alishiri, G. H., Parvin, S., & Sahebkar, A. (2015) · Journal of Dietary Supplements · doi:10.3109/19390211.2015.1008611 · Cited by 229 · see citing works

Mechanisms of Osteoarthritic Pain. Studies in Humans and Experimental Models

Eitner, A., Hofmann, G., & Schaible, H. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00349 · Cited by 229 · see citing works

Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence

Ameye, L., & Chee, W. S. S. (2006) · Arthritis Research & Therapy · doi:10.1186/ar2016 · Cited by 225 · see citing works

Cartilage Oligomeric Matrix Protein Interacts with Type IX Collagen, and Disruptions to These Interactions Identify a Pathogenetic Mechanism in a Bone Dysplasia Family

Holden, P. K., Meadows, R. S., Chapman, K. L., Grant, M. E., Kadler, K. E., & Briggs, M. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009507200 · Cited by 222 · see citing works

Resveratrol Improves Endothelial Function

Zhang, H., Zhang, J., Ungvari, Z. I., & Zhang, C. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.187146 · Cited by 211 · see citing works

Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model

Zhang, Z., Leong, D. J., Xu, L., He, Z., Wang, A. Y., Navati, M. S., Kim, S. J., Hirsh, D. M., Hardin, J., COBELLI, N. J., et al. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1025-y · Cited by 211 · see citing works

Functional Foods: A Survey of Health Claims, Pros and Cons, and Current Legislation

Arvanitoyannis, I. S., & van Houwelingen-Koukaliaroglou, M. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390590967667 · Cited by 208 · see citing works

Resveratrol suppresses interleukin-1β-induced inflammatory signaling and apoptosis in human articular chondrocytes: Potential for use as a novel nutraceutical for the treatment of osteoarthritis

Shakibaei, M., Buhrmann, C., Nebrich, S., & Mobasheri, A. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.05.029 · Cited by 203 · see citing works

Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro

Buhrmann, C., Keshishzadeh, N., Fischer, K., & Shakibaei, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.09.014 · Cited by 198 · see citing works

REGULATION OF COX AND LOX BY CURCUMIN

Rao, C. V. (2007) · Springer eBooks · doi:10.1007/978-0-387-46401-5_9 · Cited by 197 · see citing works

The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis

Chin, K. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s117432 · Cited by 187 · see citing works

Neuroprotective Properties and Mechanisms of Resveratrol in in Vitro and in Vivo Experimental Cerebral Stroke Models

Singh, N., Agrawal, M., & Doré, S. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400094w · Cited by 184 · see citing works

Protective Effects of Resveratrol and Quercetin Against MPP+ -Induced Oxidative Stress Act by Modulating Markers of Apoptotic Death in Dopaminergic Neurons

Bournival, J., Quessy, P., & Martinoli, M. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9411-5 · Cited by 182 · see citing works

Diverse Mutations in the Gene for Cartilage Oligomeric Matrix Protein in the Pseudoachondroplasia–Multiple Epiphyseal Dysplasia Disease Spectrum

Briggs, M. D., Mortier, G. R., Cole, W. G., King, L. M., Golik, S. S., Bonaventure, J., Nuytinck, L., Paepe, A. D., Leroy, J. G., Biesecker, L. G., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301713 · Cited by 179 · see citing works

The Unfolded Protein Response in Secretory Cell Function

Moore, K. A., & Hollien, J. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155644 · Cited by 178 · see citing works

Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: Descending monoamine system and opioid receptors are differentially involved

Zhao, X., Xu, Y., Zhao, Q. C., Chen, C.-R., Liu, A., & Huang, Z. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.050 · Cited by 177 · see citing works

Pleiotropic mechanisms facilitated by resveratrol and its metabolites

Calamini, B., Ratia, K. M., Malkowski, M. G., Cuendet, M., Pezzuto, J. M., Santarsiero, B. D., & Mesecar, A. D. (2010) · Biochemical Journal · doi:10.1042/bj20091857 · Cited by 176 · see citing works

Anti‐inflammatory effects of polyphenols in arthritis

Oliviero, F., Scanu, A., Zamudio-Cuevas, Y. E., Punzi, L., & Spinella, P. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8664 · Cited by 168 · see citing works

Structure of a thrombospondin C‐terminal fragment reveals a novel calcium core in the type 3 repeats

Kvansakul, M., Adams, J. C., & Hohenester, E. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600166 · Cited by 166 · see citing works

Interactions between the Cartilage Oligomeric Matrix Protein and Matrilins

Mann, H. H., Özbek, S., Engel, J., Paulsson, M., & Wagener, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403778200 · Cited by 165 · see citing works

Articular Cartilage Degradation in Osteoarthritis

Goldring, M. B. (2012) · HSS Journal® The Musculoskeletal Journal of Hospital for Special Surgery · doi:10.1007/s11420-011-9250-z · Cited by 155 · see citing works

Curcumin Inhibits the PERK-eIF2 α -CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model

Feng, K., Ge, Y., Chen, Z., Li, X., Liu, Z., Li, X., Li, H., Tang, T., Yang, F., & Wang, X. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8574386 · Cited by 145 · see citing works

Sirtuin activators

Alcaín, F. J., & Villalba, J. M. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770902762893 · Cited by 137 · see citing works

The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production

Dave, M. N., Attur, M. G., Palmer, G. D., Al-Mussawir, H., Kennish, L., Patel, J., & Abramson, S. B. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23799 · Cited by 135 · see citing works

Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy

Li, X., Feng, K., Li, J., Yu, D., Fan, Q., Tang, T., Yao, X., & Wang, X. (2017) · Nutrients · doi:10.3390/nu9040414 · Cited by 135 · see citing works

Resveratrol Protects C6 Astrocyte Cell Line against Hydrogen Peroxide-Induced Oxidative Stress through Heme Oxygenase 1

Quincozes‐Santos, A., Bobermin, L. D., Latini, A., Wajner, M., Souza, D. O., Gonçalves, C., & Gottfried, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064372 · Cited by 132 · see citing works

Matrix–matrix interaction of cartilage oligomeric matrix protein and fibronectin

Cesare, P. E. D., Chen, F. S., Moergelin, M., Carlson, C. S., Leslie, M. P., Perris, R., & Fang, C. (2002) · Matrix Biology · doi:10.1016/s0945-053x(02)00015-x · Cited by 130 · see citing works

Effect of trans-resveratrol on induced oxidative stress in human sperm and in rat germinal cells

Collodel, G., Federico, M. G., Geminiani, M., Martini, S., Bonechi, C., Rossi, C., Figura, N., & Moretti, E. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.11.010 · Cited by 128 · see citing works

Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial

Rahimnia, A., Panahi, Y., Alishiri, G. H., Sharafi, M., & Sahebkar, A. (2014) · Drug Research · doi:10.1055/s-0034-1384536 · Cited by 120 · see citing works

Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin

Maiti, P., Manna, J., Veleri, S., & Frautschy, S. A. (2014) · BioMed Research International · doi:10.1155/2014/495091 · Cited by 119 · see citing works

Intra‐articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF‐2α

Li, W., Cai, L., Zhang, Y., Cui, L., & Shen, G. (2015) · Journal of Orthopaedic Research® · doi:10.1002/jor.22859 · Cited by 117 · see citing works

Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction

Ito, M., Yurube, T., Kakutani, K., Maeno, K., Takada, T., Terashima, Y., Kakiuchi, Y., Takeoka, Y., Miyazaki, S., Kuroda, R., et al. (2017) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2017.08.019 · Cited by 115 · see citing works

Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat.

Suryanarayana, P., Satyanarayana, A., Balakrishna, N., Kumar, P. U., & Reddy, G. B. (2007) · PubMed · Cited by 114 · see citing works

Challenges of Translating Basic Research Into Therapeutics: Resveratrol as an Example

Smoliga, J. M., Vang, O., & Baur, J. A. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr062 · Cited by 111 · see citing works

Resveratrol Protects HUVECs from Oxidized-LDL Induced Oxidative Damage by Autophagy Upregulation via the AMPK/SIRT1 Pathway

Guo, H., Chen, Y.-L., Liao, L.-Z., & Wu, W.-K. (2013) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-013-6442-4 · Cited by 106 · see citing works

Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes

Liu, F., Hung, L., Wu, W., Chang, D., Huang, C., Lai, J., & Ho, L. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3127 · Cited by 106 · see citing works

Cartilage oligomeric matrix protein: Isolation and characterization from human articular cartilage

DiCesare, P. E., Mörgelin, M., Carlson, C. S., et al. (1995) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100130316 · Cited by 106 · see citing works

The role of sirtuin 1 and its activator, resveratrol in osteoarthritis

Deng, Z., Li, Y.-S., Liu, H., Xiao, S., Li, L.-J., Tian, J., Cheng, C., Zhang, G., & Zhang, F.-J. (2019) · Bioscience Reports · doi:10.1042/bsr20190189 · Cited by 96 · see citing works

Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro

Shakibaei, M., Mobasheri, A., & Buhrmann, C. (2010) · Genes & Nutrition · doi:10.1007/s12263-010-0179-5 · Cited by 94 · see citing works

The peripheral antinociceptive effect of resveratrol is associated with activation of potassium channels

Granados‐Soto, V., Argüelles, C. F., & Ortiz, M. I. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00130-2 · Cited by 93 · see citing works

Local intra-articular injection of resveratrol delays cartilage degeneration in C57BL/6 mice by inducing autophagy via AMPK/mTOR pathway

Qin, N., Wei, L., Li, W., Yang, W., Cai, L., Qian, Z., & Wu, S. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.06.002 · Cited by 93 · see citing works

Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitrite

Olas, B., Nowak, P., Kołodziejczyk-Czepas, J., Ponczek, M. B., & Wachowicz, B. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.05.010 · Cited by 89 · see citing works

Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis

Wei, Y., Jia, J., Jin, X., et al. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8036 · Cited by 89 · see citing works

Neuroprotective effects of curcumin through autophagy modulation

Forouzanfar, F., Read, M. I., Barreto, G. E., & Sahebkar, A. (2019) · IUBMB Life · doi:10.1002/iub.2209 · Cited by 89 · see citing works

Avoidance and management of intra-articular complications of anterior cruciate ligament reconstruction.

Cooper, R. R., Ponseti, I. V., & Maynard, J. A. (1973) · PubMed · Cited by 86 · see citing works

Novel and recurrent COMP (cartilage oligomeric matrix protein) mutations in pseudoachondroplasia and multiple epiphyseal dysplasia

Ikegawa, S., Ohashi, H., Nishimura, G., Kim, K. C., Sannohe, A., Kimizuka, M., Fukushima, Y., Nagai, T., & Nakamura, Y. (1998) · Human Genetics · doi:10.1007/s004390050883 · Cited by 84 · see citing works

Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction

Kakiuchi, Y., Yurube, T., Kakutani, K., Takada, T., Ito, M., Takeoka, Y., Kanda, Y., Miyazaki, S., Kuroda, R., & Nishida, K. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.01.009 · Cited by 83 · see citing works

Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health

Mobasheri, A., Henrotin, Y. E., Biesalski, H. K., & Shakibaei, M. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13044202 · Cited by 79 · see citing works

Efficacy and safety of co-administration of resveratrol with meloxicam in patients with knee osteoarthritis: a pilot interventional study

Hussain, S. A., Marouf, B. H., Ali, Z. S., & Ahmmad, R. S. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s172758 · Cited by 77 · see citing works

A Cartilage Oligomeric Matrix Protein Mutation Associated with Pseudoachondroplasia Changes the Structural and Functional Properties of the Type 3 Domain

Maddox, B. K., Mokashi, A., Keene, D. R., & Bächinger, H. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11412 · Cited by 76 · see citing works

Pseudoachondroplastic Dwarfism

Cooper, R. R., Ponseti, I. V., & Maynard, J. A. (1973) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197355030-00003 · Cited by 76 · see citing works

Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review

Nguyen, C., Savouret, J., Widerak, M., Corvol, M. T., & Rannou, F. (2017) · Nutrients · doi:10.3390/nu9010045 · Cited by 75 · see citing works

Resveratrol, a natural antioxidant, protects monosodium iodoacetate-induced osteoarthritic pain in rats.

Wang, Z., Chen, Y., & Wang, D.-P. (2016) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2016.06.050 · Cited by 73 · see citing works

Various Extraction Techniques of Curcumin─A Comprehensive Review

Manasa, P., Kamble, A. D., & Chilakamarthi, U. (2023) · ACS Omega · doi:10.1021/acsomega.3c04205 · Cited by 73 · see citing works

Bradykinin Induces Interleukin-6 Production in Human Airway Smooth Muscle Cells

Huang, C., Tliba, O., Panettieri, R. A., & Amrani, Y. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0040oc · Cited by 70 · see citing works

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways

Dinser, R., Zaucke, F., Kreppel, F., Hultenby, K. R., Kochanek, S., Paulsson, M., & Maurer, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14386 · Cited by 69 · see citing works

A Comparative Pharmacokinetic Assessment of a Novel Highly Bioavailable Curcumin Formulation with 95% Curcumin: A Randomized, Double-Blind, Crossover Study

STOHS, S. J., Ji, J., Bucci, L. R., et al. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1358118 · Cited by 68 · see citing works

A unique rough surfaced endoplasmic reticulum inclusion in pseudoachondroplasia.

Maynard, J. A., Cooper, R. R., & Ponseti, I. V. (1972) · PubMed · Cited by 67 · see citing works

An Inducible Cartilage Oligomeric Matrix Protein Mouse Model Recapitulates Human Pseudoachondroplasia Phenotype

Posey, K. L., Veerisetty, A. C., Liu, P., Wang, H. R., Poindexter, B. J., Bick, R. J., Alcorn, J. L., & Hecht, J. T. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090184 · Cited by 64 · see citing works

The Effect of Curcumin (Active Substance of Turmeric)on the Acetic Acid-Induced Visceral Nociception in Rats

Tajik, H., Tamaddonfa, E., & Hamzeh-Goo, N. (2008) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2008.312.314 · Cited by 64 · see citing works

Genotype to phenotype correlations in cartilage oligomeric matrix protein associated chondrodysplasias

Briggs, M. D., Brock, J., Ramsden, S., & Bell, P. A. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.30 · Cited by 60 · see citing works

Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study

Marouf, B. H., Hussain, S., Ali, Z. S., & Ahmmad, R. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2017.4176 · Cited by 58 · see citing works

A Next Generation Formulation of Curcumin Ameliorates Experimentally Induced Osteoarthritis in Rats via Regulation of Inflammatory Mediators

Yabas, M., Orhan, C., Er, B., Tuzcu, M., Durmuş, A., Ozercan, I., Şahin, N., Bhanuse, P., Morde, A. A., Padigaru, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.609629 · Cited by 58 · see citing works

Role of TSP-5/COMP in Pseudoachondroplasia

Posey, K. L., Hayes, E., Haynes, R., et al. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.01.011 · Cited by 55 · see citing works

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways

Dinser, R., Zaucke, F., Kreppel, F., Hultenby, K. R., Kochanek, S., Paulsson, M., & Maurer, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214386 · Cited by 55 · see citing works

Inflammation-Related Disorders in the Tryptophan Catabolite Pathway in Depression and Somatization

Anderson, G., Maes, M. H. J., & Berk, M. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-398314-5.00002-7 · Cited by 54 · see citing works

IL-6 Increases MMP-13 Expression and Motility in Human Chondrosarcoma Cells

Tang, C., Chen, C., Chen, W., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204081 · Cited by 50 · see citing works

The Combination Treatment of Curcumin and Probucol Protects Chondrocytes from TNF‐α Induced Inflammation by Enhancing Autophagy and Reducing Apoptosis via the PI3K‐Akt‐mTOR Pathway

Han, G., Zhang, Y., & Li, H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5558066 · Cited by 50 · see citing works

Chronic resveratrol treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with mononeuropathy: Involvement of serotonergic system

Zhao, X., Yu, C., Wang, C., Zhang, J., Zhou, W., Cui, W., Ye, F., & Xu, Y. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.04.021 · Cited by 49 · see citing works

The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis

Dvir‐Ginzberg, M., Mobasheri, A., & Kumar, A. (2016) · Current Rheumatology Reports · doi:10.1007/s11926-016-0591-y · Cited by 49 · see citing works

Curcumin ameliorates IL‐1β‐induced apoptosis by activating autophagy and inhibiting the NF‐κB signaling pathway in rat primary articular chondrocytes

Chen, T., Zhou, R., Chen, Y., Fu, W., Wei, X., Ma, G., Hu, W. M., & Lu, C. (2020) · Cell Biology International · doi:10.1002/cbin.11541 · Cited by 49 · see citing works

Analgesic and Anti‐Inflammatory Activities of Resveratrol through Classic Models in Mice and Rats

Wang, G., Hu, Z., Song, X., Cui, Q., Fu, Q., Jia, R., Zou, Y., Li, L., & Yin, Z. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/5197567 · Cited by 48 · see citing works

Effects of curcumin and curcumin analogues on TRP channels

Nalli, M., Ortar, G., Moriello, A. S., et al. (2017) · Fitoterapia · doi:10.1016/j.fitote.2017.09.007 · Cited by 43 · see citing works

Curcumin acts via transient receptor potential vanilloid‐1 receptors to inhibit gut nociception and reverses visceral hyperalgesia

Zhi, L., Dong, L., Kong, D., Sun, B., Sun, Q., Grundy, D., Zhang, G., & Rong, W. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12145 · Cited by 42 · see citing works

D469del-COMP Retention in Chondrocytes Stimulates Caspase-Independent Necroptosis

Coustry, F., Posey, K. L., Liu, P., Alcorn, J. L., & Hecht, J. T. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.10.033 · Cited by 42 · see citing works

Protective effect of resveratrol and vitamin E against ethanol-induced oxidative damage in mice: biochemical and immunological basis.

Das, S. K., Mukherjee, S., Gupta, G., et al. (2010) · PubMed · Cited by 42 · see citing works

DDIT3/CHOP promotes autophagy in chondrocytes via SIRT1-AKT pathway

Yang, C., Xu, X., Dong, X., Yang, B., Dong, W., Luo, Y., Liu, X., Wu, Y., & Wang, J. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119074 · Cited by 42 · see citing works

Nutritional Supplements for the Treatment of Neuropathic Pain

Abdelrahman, K. M., & Hackshaw, K. V. (2021) · Biomedicines · doi:10.3390/biomedicines9060674 · Cited by 42 · see citing works

Chop (Ddit3) Is Essential for D469del-COMP Retention and Cell Death in Chondrocytes in an Inducible Transgenic Mouse Model of Pseudoachondroplasia

Posey, K. L., Coustry, F., Veerisetty, A. C., Liu, P., Alcorn, J. L., & Hecht, J. T. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.10.035 · Cited by 40 · see citing works

Increased Classical Endoplasmic Reticulum Stress Is Sufficient to Reduce Chondrocyte Proliferation Rate in the Growth Plate and Decrease Bone Growth

Kung, L. H. W., Rajpar, M. H., Preziosi, R. F., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117016 · Cited by 40 · see citing works

Resveratrol, an activator of SIRT1, improves ER stress by increasing clusterin expression in HepG2 cells

Lee, J., Hong, S., Kwon, H., Park, S. E., Rhee, E., Park, C., Oh, K.-W., Park, S., & Lee, W. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-019-01012-z · Cited by 39 · see citing works

Primary Osteoarthritis Early Joint Degeneration Induced by Endoplasmic Reticulum Stress Is Mitigated by Resveratrol

Hecht, J. T., Veerisetty, A. C., Wu, J., et al. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.05.016 · Cited by 39 · see citing works

Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia

Posey, K. L., Coustry, F., Veerisetty, A. C., Hossain, M. S., Alcorn, J. L., & Hecht, J. T. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv122 · Cited by 38 · see citing works

Curcumin-Alleviated Osteoarthritic Progression in Rats Fed a High-Fat Diet by Inhibiting Apoptosis and Activating Autophagy via Modulation of MicroRNA-34a

Yao, J., Liu, X., Sun, Y., Dong, X., Liu, L., & Gu, H. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s312139 · Cited by 37 · see citing works

Natural Products and some Semi-synthetic Analogues as Potential TRPV1 Ligands for Attenuating Neuropathic Pain

Naik, G. G., Uniyal, A., Chouhan, D., et al. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210719155931 · Cited by 37 · see citing works

Curcuma as an anti-inflammatory component in treating osteoarthritis

Koroljević, Z. D., Jordan, K., Ivković, J., Bender, D. V., & Perić, P. (2022) · Rheumatology International · doi:10.1007/s00296-022-05244-8 · Cited by 35 · see citing works

Chondrocyte-Specific Pathology During Skeletal Growth and Therapeutics in a Murine Model of Pseudoachondroplasia

Posey, K. L., Coustry, F., Veerisetty, A. C., Liu, P., Alcorn, J. L., & Hecht, J. T. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2139 · Cited by 33 · see citing works

The fallacy of enzymatic hydrolysis for the determination of bioactive curcumin in plasma samples as an indication of bioavailability: a comparative study

STOHS, S. J., Chen, C. Y. O., Preuss, H. G., et al. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2699-x · Cited by 31 · see citing works

Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis

Kung, L. H. W., Mullan, L., Soul, J., et al. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1988-6 · Cited by 29 · see citing works

Curcumin prevents tension-induced endplate cartilage degeneration by enhancing autophagy

Liang, X., Ding, B., Gao, J., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118213 · Cited by 29 · see citing works

Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis

Sethi, V. S., Garg, M. L., Herve, M., et al. (2022) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x221124545 · Cited by 29 · see citing works

Pseudoachondroplasia and painful sequelae

Gamble, C., Nguyen, J., Hashmi, S. S., & Hecht, J. T. (2015) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37253 · Cited by 26 · see citing works

Anti-Nociceptive Effect of Resveratrol During Inflammatory Hyperalgesia via Differential Regulation of pro-Inflammatory Mediators

Singh, A. K., & Vinayak, M. (2016) · Phytotherapy Research · doi:10.1002/ptr.5624 · Cited by 26 · see citing works

Novel therapeutic interventions for pseudoachondroplasia

Posey, K. L., & Hecht, J. T. (2017) · Bone · doi:10.1016/j.bone.2017.03.045 · Cited by 25 · see citing works

REVIEW OF NUTRITIONAL SUPPLEMENTS FOR THE TREATMENT OF BIPOLAR DEPRESSION

Rakofsky, J. J., & Dunlop, B. W. (2013) · Depression and Anxiety · doi:10.1002/da.22220 · Cited by 24 · see citing works

Effects of Intra-Articular Resveratrol Injections on Cartilage Destruction and Synovial Inflammation in Experimental Temporomandibular Joint Osteoarthritis

Yuce, P., Hoşgör, H., Rençber, S. F., et al. (2020) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2020.09.015 · Cited by 23 · see citing works

Resveratrol Reduces COMPopathy in Mice Through Activation of Autophagy

Hecht, J. T., Coustry, F., Veerisetty, A. C., Hossain, M. G., & Posey, K. L. (2020) · JBMR Plus · doi:10.1002/jbm4.10456 · Cited by 20 · see citing works

Mechanisms of Inflammatory Pain

Mackey, S. (2004) · JCR Journal of Clinical Rheumatology · doi:10.1097/01.rhu.0000130684.35729.55 · Cited by 19 · see citing works

Suppression of knee joint osteoarthritis induced secondary to type 2 diabetes mellitus in rats by resveratrol: role of glycated haemoglobin and hyperlipidaemia and biomarkers of inflammation and oxidative stress

Ebrahim, H. A., AlZamil, N. M., Al‐Ani, B., et al. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1771378 · Cited by 19 · see citing works

Joint Degeneration in a Mouse Model of Pseudoachondroplasia: ER Stress, Inflammation, and Block of Autophagy

Hecht, J. T., Veerisetty, A. C., Hossain, M. G., Patra, D., Chiu, F., Coustry, F., & Posey, K. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179239 · Cited by 17 · see citing works

Novel mTORC1 Mechanism Suggests Therapeutic Targets for COMPopathies

Posey, K. L., Coustry, F., Veerisetty, A. C., Hossain, M. G., Gambello, M. J., & Hecht, J. T. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.09.008 · Cited by 16 · see citing works

Downregulation of epithelial sodium channel (ENaC) activity in cystic fibrosis cells by epigenetic targeting

Blaconà, G., Raso, R., Castellani, S., Pierandrei, S., Porto, P. D., Ferraguti, G., Ascenzioni, F., Conese, M., & Lucarelli, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04190-9 · Cited by 15 · see citing works

Resveratrol Differently Modulates Group I Metabotropic Glutamate Receptors Depending on Age in SAMP8 Mice

Sánchez-Melgar, A., Albasanz, J. L., Pallàs, M., & Martı́n, M. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00067 · Cited by 14 · see citing works

[Inflammatory cytokines and oxidative stress markers in the inhibition of osteoarthritis by curcumin].

Liu, J., He, X., Zhen, P., et al. (2016) · PubMed · doi:10.3785/j.issn.1008-9292.2016.09.03 · Cited by 12 · see citing works

Pseudoachondroplasia.

Hall, J. G. (1975) · PubMed · Cited by 12 · see citing works

Health consequences of mutant cartilage oligomeric matrix protein and its relationship to abnormal growth and joint degeneration

Hecht, J. T., Chiu, F., Veerisetty, A. C., Hossain, M. S., & Posey, K. L. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.03.008 · Cited by 10 · see citing works

Early Resveratrol Treatment Mitigates Joint Degeneration and Dampens Pain in a Mouse Model of Pseudoachondroplasia (PSACH)

Hecht, J. T., Veerisetty, A. C., Patra, D., Hossain, M. S., Chiu, F., Mobed, C., Gannon, F. H., & Posey, K. L. (2023) · Biomolecules · doi:10.3390/biom13101553 · Cited by 9 · see citing works

Urinary bile acids and peroxisomal bifunctional enzyme deficiency

Natowicz, M. R., Evans, J. E., Kelley, R. I., Moser, A. B., Watkins, P. A., & Moser, H. W. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960517)63:2 · Cited by 8 · see citing works

The Effects of Dietary Supplements, Nutraceutical Agents, and Physical Exercise on Myostatin Levels: Hope or Hype?

Santos, H. O., Cerqueira, H. S. C., & Tinsley, G. M. (2022) · Metabolites · doi:10.3390/metabo12111146 · Cited by 8 · see citing works

The Additive Antinociceptive Effect of Resveratrol and Ketorolac in the Formalin Test in Mice

Rojas-Aguilar, F. A., Briones-Aranda, A., Jaramillo‐Morales, O. A., Romero‐Nava, R., Esquinca-Avilés, H. A., & Espinosa‐Juárez, J. V. (2023) · Pharmaceuticals · doi:10.3390/ph16081078 · Cited by 7 · see citing works

CurQ+, a Next-Generation Formulation of Curcumin, Ameliorates Growth Plate Chondrocyte Stress and Increases Limb Growth in a Mouse Model of Pseudoachondroplasia

Hecht, J. T., Veerisetty, A. C., Hossain, M. G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043845 · Cited by 5 · see citing works

Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound?

Zádor, E. (2025) · Cells · doi:10.3390/cells14060431 · Cited by 9 · see citing works

Metabolic Fate of Curcumin in the Gastrointestinal Tract in Mice

Li, Z., Sun, Y., Song, M., et al. (2016) · The FASEB Journal · doi:10.1096/fasebj.30.1_supplement.690.9 · Cited by 1 · see citing works

Anti Oxidant Potential of “Cureit”- A Novel BioAvailable Curcumin Formulation

Gopia, S., Georgea, R., & .Sriraamb, V. T. (2014) · Asian Journal of Pharmaceutical Technology and Innovation · Cited by 5 · see citing works

Evaluation of Curcumin Nanoparticles against Rabbit Skin Infection

Fatthi, D. A. (2023) · E3S Web of Conferences · doi:10.1051/e3sconf/202339101119

Biocompatible Lipid Nanoparticles as Carriers To Improve Curcumin Efficacy in Ovarian Cancer Treatment

Bondı̀, M. L., Emma, M. R., Botto, C., Augello, G., Azzolina, A., Gaudio, F. D., Craparo, E. F., Cavallaro, G., Bachvarov, D. R., & Cervello, M. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04409 · Cited by 65 · see citing works

Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4-phenoxyphenol derivatives

Parsai, S., Keck, R. W., Skrzypczak‐Jankun, E., & Jankun, J. (2013) · Oncology Letters · doi:10.3892/ol.2013.1679 · Cited by 24 · see citing works