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Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling
Open accessAbstract
Dopamine is a neurotransmitter that plays a critical role both peripherally and centrally in vital functions such as cognition, reward, satiety, voluntary motor movements, pleasure, and motivation. Optimal dopamine bioavailability is essential for normal brain functioning and protection against the development of neurological diseases. Emerging evidence shows that gut microbiota have significant roles in maintaining adequate concentrations of dopamine via intricate, bidirectional communication known as the microbiota-gut-brain axis. The vagus nerve, immune system, hypothalamus–pituitary–adrenal axis, and microbial metabolites serve as important mediators of the reciprocal microbiota-gut-brain signaling. Furthermore, gut microbiota contain intrinsic enzymatic activity that is highly involved in dopamine metabolism, facilitating dopamine synthesis as well as its metabolite breakdown. This review examines the relationship between key genera of gut microbiota such as Prevotella, Bacteroides, Lactobacillus, Bifidobacterium, Clostridium,Enterococcus, and Ruminococcus and their effects on dopamine. The effects of gut dysbiosis on dopamine bioavailability and the subsequent impact on dopamine-related pathological conditions such as Parkinson’s disease are also discussed. Understanding the role of gut microbiota in modulating dopamine activity and bioavailability both in the periphery and in the central nervous system can help identify new therapeutic targets as well as optimize available methods to prevent, delay, or restore dopaminergic deficits in neurologic and metabolic disorders.
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Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208
Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease
Zhu, M., Liu, X., Ye, Y., Yan, X., Cheng, Y., Zhao, L., Chen, F., & Ling, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.937555 · Cited by 177
Brain modulation by the gut microbiota: From disease to therapy
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Gut Microbiota Restores Central Neuropeptide Deficits in Germ-Free Mice
Hamamah, S., & Covasa, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911756 · Cited by 25
Self-citation
Metadata
- Authors
- Hamamah, S., Aghazarian, A., Nazaryan, A., Hajnal, A., & Covasa, M.
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2022-02-13
- Volume
- 10
- Issue
- 2
- Pages
- 436
- ISSN
- 2227-9059 (ISSN-L)
- OpenAlex
- W4213012461
- Cited by
- 307
- References
- 50
- FWCI
- 16.37
- Type
- journal article
- Language
- en
- Open access
- gold
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