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Has-miR-129-5p’s Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases

Boicean, Adrian, Birsan, Sabrina, Ichim, Cristian, Boeras, Ioana, Roman-Filip, Iulian, Blanca, Grama, Bacila, Ciprian, Fleaca, Radu Sorin, Dura, Horatiu, Roman-Filip, Corina·2023·Biomedicines
DOI 10.3390/biomedicines11072058PMC PMC10377727
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Abstract

At present, it is necessary to identify specific biochemical, molecular, and genetic markers that can reliably aid in screening digestive cancer and correlate with the degree of disease development. Has-miR-129-5p is a small, non-coding molecule of RNA, circulating in plasma, gastric juice, and other biological fluids; it plays a protective role in tumoral growth, metastasis, etc. Furthermore, it is involved in various diseases, from the development of digestive cancer in cases of downregulation to neurodegenerative diseases and depression. Methods: We examined meta-analyses, research, and studies related to miR-129-5-p involved in digestive cancer and its implications in cancer processes, as well as metastasis, and described its implications in neurological diseases. Conclusions: Our review outlines that miR-129-5p is a significant controller of different pathways, genes, and proteins and influences different diseases. Some important pathways include the WNT and PI3K/AKT/mTOR pathways; their dysregulation results in digestive neoplasia and neurodegenerative diseases.

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Figure 1 Research strategy.
Figure 1 Research strategy.CC BY · PubMed Central
Figure 2 Protective role of miR-129-5p in preventing tumoral progression in different types of cancer. Overstimulation of miR129 targets WNT signaling pathway resulting in decreasing hepatoma-derived growth factor (HDGF) and HCC risk. Upregulation of miR-129-5p decreases COL1A1, ADAM 9 protein, and HMGB protein, lowering gastric cancer risk and decreasing IPO7 protein, resulting in suppressing pancreatic cancer proliferation.
Figure 2 Protective role of miR-129-5p in preventing tumoral progression in different types of cancer. Overstimulation of miR129 targets WNT signaling pathway resulting in decreasing hepatoma-derived growth factor (HDGF) and HCC risk. Upregulation of miR-129-5p decreases COL1A1, ADAM 9 protein, and HMGB protein, lowering gastric cancer risk and decreasing IPO7 protein, resulting in suppressing pancreatic cancer proliferation.CC BY · PubMed Central
Figure 3 Overstimulation of MiR-129-5p plays a protective role in reducing neural inflammation and preventing Alzheimer’s disease (AD) by reducing the expression of the SOX6 gene. Controlling the signaling pathway PI3K/AKT/mTOR represents a possible treatment in AD and PD. Upregulation of miR-129-5p targets genes and maintains neuronal homeostasis. Also, by lowering the activity of the mutant FMR1 gene, miR-129-5p reduces the risk for diseases in the autism spectrum and Fragile X Syndrome.
Figure 3 Overstimulation of MiR-129-5p plays a protective role in reducing neural inflammation and preventing Alzheimer’s disease (AD) by reducing the expression of the SOX6 gene. Controlling the signaling pathway PI3K/AKT/mTOR represents a possible treatment in AD and PD. Upregulation of miR-129-5p targets genes and maintains neuronal homeostasis. Also, by lowering the activity of the mutant FMR1 gene, miR-129-5p reduces the risk for diseases in the autism spectrum and Fragile X Syndrome.CC BY · PubMed Central

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Metadata

Authors
Boicean, A., Birsan, S., Ichim, C., Boeras, I., Roman-Filip, I., Blanca, G., Bacila, C., Fleaca, R. S., Dura, H., & Roman-Filip, C.
Affiliations
  • Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania
  • Molecular Biology Laboratory of the Applied Ecology Research Center, Faculty of Sciences, Lucian Blaga University of Sibiu, 550012 Sibiu, Romania
  • Department of Neurology, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540136 Targu Mures, Romania
  • Faculty of Social Sciences, Lucian Blaga University of Sibiu, 550012 Sibiu, Romania
ORCID
Venue
Biomedicines
Publisher
MDPI AG
Published
2023-07-21
Volume
11
Issue
7
Pages
2058
ISSN
2227-9059
DOI
10.3390/biomedicines11072058
PMC
PMC10377727
Cited by
23
References
3
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Ministry of Research, Innovation, and Digitization (28PFE/30.12.2021)
  • Lucian Blaga University of Sibiu (28PFE/30.12.2021)

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