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MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways
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miR-132 can ameliorate AD pathology at multiple levels, through its involvement in TAU metabolism and hyperphosphorylation, amyloidosis, neuronal survival, adult neurogenesis and memory formation.
“miR-132 can ameliorate AD pathology at multiple levels, through its involvement in TAU metabolism and hyperphosphorylation, amyloidosis, neuronal survival, adult neurogenesis and memory formation [18, 20–34].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [20]
miR-132 has numerous neuroprotective and neurotrophic regulatory effects in AD.
“Such an approach could also be envisioned for miR-132, considering the numerous neuroprotective and neurotrophic regulatory effects it has in AD [20, 24, 30–32, 34, 92–95].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [20]
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Exosome Processing and Characterization Approaches for Research and Technology Development
Lai, J. J., Chau, Z. L., Chen, S., Hill, J. J., Korpany, K. V., Liang, N., Lin, L., Lin, Y., Liu, J. K., Liu, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202103222 · Cited by 623
Khezri, M. R., & Ghasemnejad-Berenji, M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220873 · Cited by 12
Penning, A., Snoeck, S., Ormaechea, O. R., Ayyildiz, D., Polzer, O., Buitrago-Arango, M., Capobianco, R., de Winter, F., Balusu, S., Verhaagen, J., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02228-8 · Cited by 6
Metadata
- Authors
- El Fatimy, R., Li, S., Chen, Z., Mushannen, T., Gongala, S., Wei, Z., Balu, D. T., Rabinovsky, R., Cantlon, A., Elkhal, A., Selkoe, D. J., Sonntag, K. C., Walsh, D. M., & Krichevsky, A. M.
- Venue
- Acta Neuropathologica
- Published
- 2018-07-07
- Volume
- 136
- Issue
- 4
- Pages
- 537-555
- ISSN
- 0001-6322
- 1432-0533
- PMC
- PMC6132948
- Cited by
- 161
- References
- 17
- Language
- en
- Funders
- Alzheimer's Association (NIRG-09-132844)
- Rainwater Foundation
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