Impact of Statin Use on Dementia Incidence in Elderly Men and Women with Ischemic Heart Disease
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This study aimed to determine the association between statins and the prevention of dementia according to sex differences in elderly patients with ischemic heart disease (IHD). We performed a nationwide retrospective cohort study using the Korean Health Insurance Review and Assessment Service database (2007–2015). Among the 264,036 eligible patients aged ≥65 years with IHD, statin users were compared with non–users by propensity score matching at a 1:1 ratio (71,587 in each group). The primary outcome was dementia risk by estimating hazard ratios (HRs) and 95% confidence intervals (CIs). Differential risks of dementia were assessed by sex in the subgroups of statin types, exposure duration, and patient age, implying that sex is an influential factor for the link between statin use and dementia incidence. Among seven commonly prescribed statins, rosuvastatin was associated with the greatest preventive effect on dementia incidence, with an adjusted HR of 0.82 (95% CI = 0.78–0.87). In a subgroup analysis organized by sex, the differential risk of dementia incidence was assessed in each statin group, implying that sex is an influential factor for the link between statin and dementia. This study suggests that appropriate statin use considering sex differences may have beneficial effects on the development of dementia.
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One reason women are more susceptible to insomnia than men is changes in body hormones due to menstruation and menopause.
“One of the reasons that women are more susceptible to insomnia than men is the changes in body hormones due to menstruation and menopause [60].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [60]
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“lipophilicity [32], both lipophilic statin (atorvastatin) and hydrophilic statins (rosuvastatin, pitavastatin, pravastatin, and fluvastatin) were associated with a reduced risk of dementia in patients with IHD in the present study.”
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“One of the reasons that women are more susceptible to insomnia than men is the changes in body hormones due to menstruation and menopause [60].”
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- Authors
- Kim, M.-Y., Jung, M., Noh, Y., Shin, S., Hong, C. H., Lee, S., & Jung, Y.-S.
- Affiliations
- Department of Pathophysiology, College of Pharmacy, Ajou University, Suwon 16499, Korea
- Ajou University (KR)
- Corresponding author
- Lee, Sukhyang
- Jung, Yi-Sook
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2020-02-09
- Volume
- 8
- Issue
- 2
- Pages
- 30
- ISSN
- 2227-9059 (ISSN-L)
- PMC
- PMC7168191
- OpenAlex
- W3005355607
- Cited by
- 23
- References
- 52
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 1
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Biomedicines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- AJOU Open Repository (Ajou University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation
- Korea Health Industry Development Institute (HI18C0920)
- National Research Foundation of Korea (2019H1C3A1032224)
- Ministry of Science and ICT, South Korea (2019H1C3A1032224)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- statins, dementia incidence, ischemic heart disease, sex differences, elderly patients, rosuvastatin, dementia prevention, cardiovascular risk factors
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