Cited by 135Glioma Diagnosis and TreatmentChronic Lymphocytic Leukemia ResearchPARP inhibition in cancer therapy

Glioblastoma under Siege: An Overview of Current Therapeutic Strategies

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Paolillo, Mayra, Boselli, Cinzia, Schinelli, Sergio·2018·Brain Sciences

Abstract

Glioblastoma is known to be one of the most lethal and untreatable human tumors. Surgery and radiotherapy in combination with classical alkylating agents such as temozolomide offer little hope to escape a poor prognosis. For these reasons, enormous efforts are currently devoted to refine in vivo and in vitro models with the specific goal of finding new molecular aberrant pathways, suitable to be targeted by a variety of therapeutic approaches, including novel pharmaceutical formulations and immunotherapy strategies. In this review, we will first discuss current molecular classification based on genomic and transcriptomic criteria. Also, the state of the art in current clinical practice for glioblastoma therapy in the light of the recent molecular classification, together with ongoing phases II and III clinical trials, will be described. Finally, new pharmaceutical formulations such as nanoparticles and viral vectors, together with new strategies entailing the use of monoclonal antibodies, vaccines and immunotherapy agents, such as checkpoint inhibitors, will also be discussed.

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Authors
Paolillo, M., Boselli, C., & Schinelli, S.
Affiliations
University of Pavia (IT)
Corresponding author
Paolillo, Mayra
Venue
Brain Sciences
Publisher
MDPI AG
Published
2018-01-16
Volume
8
Issue
1
Pages
15
ISSN
2076-3425 (ISSN-L)
OpenAlex
W2788894351
Cited by
135
References
68
Citations by year
2026: 7 · 2025: 9 · 2024: 10 · 2023: 4 · 2022: 17 · 2021: 24 · 2020: 25 · 2019: 27 · 2018: 12
FWCI
3.15
Type
journal article
Language
en
Open access
Locations
  • Brain Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Ministero dell’Istruzione, dell’Università e della Ricerca
Topics
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
  • Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords
glioblastoma, molecular classification, temozolomide, alkylating agents, combination therapy, clinical trials, nanoparticles, viral vectors, monoclonal antibodies, cancer vaccines, immunotherapy, immune checkpoint inhibitors

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