Tumour Progression Stage-Dependent Secretion of YB-1 Stimulates Melanoma Cell Migration and Invasion
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Secreted factors play an important role in intercellular communication. Therefore, they are not only indispensable for the regulation of various physiological processes but can also decisively advance the development and progression of tumours. In the context of inflammatory disease, Y-box binding protein 1 (YB-1) is actively secreted and the extracellular protein promotes cell proliferation and migration. In malignant melanoma, intracellular YB-1 expression increases during melanoma progression and represents an unfavourable prognostic marker. Here, we show active secretion of YB-1 from melanoma cells as opposed to benign cells of the skin. Intriguingly, YB-1 secretion correlates with the stage of melanoma progression and depends on a calcium- and ATP-dependent non-classical secretory pathway leading to the occurrence of YB-1 in the extracellular space as a free protein. Along with an elevated YB-1 secretion of melanoma cells in the metastatic growth phase, extracellular YB-1 exerts a stimulating effect on melanoma cell migration, invasion, and tumourigenicity. Collectively, these data suggest that secreted YB-1 plays a functional role in melanoma cell biology, stimulating metastasis, and may serve as a novel biomarker in malignant melanoma that reflects tumour aggressiveness.
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Melanoma cells promote growth and invasion through the secretion of protumorigenic factors.
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Tacke, F., Kanig, N., En‐Nia, A., Kaehne, T., Eberhardt, C. S., Shpacovitch, V. M., Trautwein, C., & Mertens, P. R. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-185 · Cited by 23 · see citing works
Self-citationRetractedHallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · cited 1× · see citing works
“dynamic interaction between cancer cells and various cell types of the tumour stroma or at distant sites can facilitate a growth-promoting local tumour microenvironment, on the one hand, and the establishment of a pre-metastatic niche, on the other, supporting metastases formation [2,6].”
BackgroundSignalP 5.0 improves signal peptide predictions using deep neural networks
Armenteros, J. J. A., Tsirigos, K. D., Sønderby, C. K., Petersen, T. N., Winther, O., Brunak, S., von HEIJNE, G., & Nielsen, H. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0036-z · Cited by 4,206 · see citing works
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
Hugo, W., Zaretsky, J. M., Sun, L., Song, C., Moreno, B. H., Hu-Lieskovan, S., Berent-Maoz, B., Pang, J., Chmielowski, B., Cherry, G., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.065 · Cited by 3,448 · see citing works
Pre-metastatic niches: organ-specific homes for metastases
Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889 · see citing works
Understanding the mechanism of IL-1β secretion
Lopez-Castejon, G., & Brough, D. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.10.001 · Cited by 1,519 · see citing works
Feature-based prediction of non-classical and leaderless protein secretion
Bendtsen, J. D., Jensen, L. J., Blom, N., von HEIJNE, G., & Brunak, S. (2004) · Protein Engineering Design and Selection · doi:10.1093/protein/gzh037 · Cited by 1,179 · see citing works
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
Wilson, T. R., Fridlyand, J., Yan, Y., Penuel, E., Burton, L., Chan, E., Peng, J., Lin, E., Wang, Y., Sosman, J., et al. (2012) · Nature · doi:10.1038/nature11249 · Cited by 1,134 · see citing works
A novel secretory pathway for interleukin‐1 beta, a protein lacking a signal sequence.
Rubartelli, A., Cozzolino, F., Talio, M., & Sitia, R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08268.x · Cited by 780 · see citing works
PI(3,4,5)P 3 and PI(4,5)P 2 Lipids Target Proteins with Polybasic Clusters to the Plasma Membrane
Heo, W. D., Inoue, T., Park, W. S., Kim, M. L., Park, B. O., Wandless, T. J., & Meyer, T. (2006) · Science · doi:10.1126/science.1134389 · Cited by 775 · see citing works
Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction
Shurtleff, M. J., Karfilis, K. V., Temoche-Diaz, M. M., Ri, S., & Schekman, R. W. (2016) · eLife · doi:10.7554/elife.19276 · Cited by 648 · see citing works
Pathways of Unconventional Protein Secretion
Rabouille, C. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.007 · Cited by 573 · see citing works
Therapy-induced tumour secretomes promote resistance and tumour progression
Obenauf, A. C., Zou, Y., Ji, A. L., Vanharanta, S., Shu, W., Shi, H., Kong, X., Bosenberg, M., Wiesner, T., Rosen, N. X., et al. (2015) · Nature · doi:10.1038/nature14336 · Cited by 485 · see citing works
Evdokimova, V. E., Tognon, C. E., Ng, T., Ruzanov, P., Melnyk, N., Fink, D., Sorokin, A. V., Ovchinnikov, L. P., Davicioni, E., Triche, T. J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.017 · Cited by 444 · see citing works
Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis
El-Naggar, A. M., Veinotte, C. J., Cheng, H., Grünewald, T. G. P., Negri, G. L., Somasekharan, S. P., Corkery, D., Tirode, F., Mathers, J. A., Khan, D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.003 · Cited by 280 · see citing works
YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1
Somasekharan, S. P., El-Naggar, A. M., Leprivier, G., Cheng, H., Hajee, S., Grünewald, T. G. P., Zhang, F., Ng, T., Delattre, O., Evdokimova, V. E., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201411047 · Cited by 279 · see citing works
Flieger, O., Engling, A., Bucala, R., Lue, H., Nickel, W., & Bernhagen, J. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00900-1 · Cited by 232 · see citing works
Human Melanoma Progression in Skin Reconstructs
Meier, F. E., Nesbit, M., Hsu, M., Martin, B. G., Belle, P. A. V., Elder, D. E., Schaumburg‐Lever, G., Garbe, C., Walz, T. M., DONATIEN, P. D., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64719-0 · Cited by 226 · see citing works
Self-citationQuantitative export of FGF‐2 occurs through an alternative, energy‐dependent, non‐ER/Golgi pathway
Florkiewicz, R. Z., Majack, R. A., Buechler, R. D., & Florkiewicz, E. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041620311 · Cited by 213 · see citing works
Cancer secretomics reveal pathophysiological pathways in cancer molecular oncology
Karagiannis, G. S., Pavlou, M. P., & Diamandis, E. P. (2010) · Molecular Oncology · doi:10.1016/j.molonc.2010.09.001 · Cited by 159 · see citing works
The secretome in cancer progression
Paltridge, J. L., Belle, L., & Khew‐Goodall, Y. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.03.014 · Cited by 142 · see citing works
Frye, B. C., Halfter, S., Djudjaj, S., Muehlenberg, P., Weber, S., Raffetseder, U., En‐Nia, A., Knott, H., Baron, J. M., Dooley, S., et al. (2009) · EMBO Reports · doi:10.1038/embor.2009.81 · Cited by 134 · see citing works
Self-citationBRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth
Wang, T., Xiao, M., Ge, Y., Krepler, C., Belser, E., López-Coral, A., Xu, X., Zhang, G., Azuma, R., Liu, Q., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1554 · Cited by 130 · see citing works
Temmerman, K., Ebert, A., Müller, H., Sinning, I., Tews, I., & Nickel, W. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00749.x · Cited by 124 · see citing works
Growth and invasion of human melanomas in human skin grafted to immunodeficient mice.
Juhász, I., Albelda, S. Μ., Elder, D. E., Murphy, G. F., Adachi, M., Herlyn, D., Valyi-Nagy, I. T., & Herlyn, M. (1993) · PubMed Central · Cited by 122 · see citing works
Steringer, J. P., Bleicken, S., Andreas, H., Zacherl, S., Laußmann, M., Temmerman, K., Contreras, F. ‐., Bharat, T. A. M., Lechner, J., Müller, H., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.381939 · Cited by 119 · see citing works
Class I HDAC inhibitors enhance YB‐1 acetylation and oxidative stress to block sarcoma metastasis
El-Naggar, A. M., Somasekharan, S. P., Wang, Y., Cheng, H., Negri, G. L., Pan, M., Wang, X. Q., Delaidelli, A., Rafn, B., Cran, J., et al. (2019) · EMBO Reports · doi:10.15252/embr.201948375 · Cited by 113 · see citing works
Schittek, B., Psenner, K., Sauer, B., Meier, F. E., Iftner, T., & Garbe, C. (2007) · International Journal of Cancer · doi:10.1002/ijc.22512 · Cited by 113 · see citing works
Self-citationY-box binding protein 1 – A prognostic marker and target in tumour therapy
Kosnopfel, C., Sinnberg, T. W., & Schittek, B. (2014) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2013.11.007 · Cited by 110 · see citing works
Self-citationKhan, M. I., Adhami, V. M., Lall, R. K., Sechi, M., Joshi, D. C., Haidar, O., Syed, D. N., Siddiqui, I. A., Chiu, S. Y., & Mukhtar, H. (2014) · Oncotarget · doi:10.18632/oncotarget.1790 · Cited by 108 · see citing works
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro‐invasive exosomes
Guo, D., Lui, G. Y. L., Lai, S. L., Wilmott, J. S., Tikoo, S., Jackett, L. A., Quek, C. Y. J., Brown, D. L., Sharp, D. M., Kwan, R. Y. Q., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.32064 · Cited by 107 · see citing works
BRAF Inhibition Generates a Host–Tumor Niche that Mediates Therapeutic Escape
Smalley, I., Wargo, J. A., Flaherty, K. T., Messina, J. L., & Smalley, K. S. M. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.329 · Cited by 105 · see citing works
Kossinova, O. A., Gopanenko, A. V., TAMKOVICH, S. N., Krasheninina, O. A., Tupikin, A. E., Владимировна, К. Е., Yanshina, D. D., Malygin, A. A., Ven'yaminova, A. G., Kabilov, M. R., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2017.03.010 · Cited by 97 · see citing works
Ohanna, M., Cheli, Y., Bonet, C., Bonazzi, V. F., Allegra, M., Giuliano, S., Bille, K., Bahadoran, P., Giacchero, D., Lacour, J. P., et al. (2013) · Oncotarget · doi:10.18632/oncotarget.1143 · Cited by 78 · see citing works
Detection of Proteins on Blot Membranes
Goldman, A. R., Harper, S. L., & Speicher, D. W. (2016) · Current Protocols in Protein Science · doi:10.1002/cpps.15 · Cited by 71 · see citing works
Sinnberg, T. W., Sauer, B., Holm, P. S., Spangler, B., Kuphal, S., Bosserhoff, A., & Schittek, B. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01448.x · Cited by 68 · see citing works
Self-citationYB-1 Is an Early and Central Mediator of Bacterial and Sterile Inflammation In Vivo
Hanssen, L., Alidousty, C., Djudjaj, S., Frye, B. C., Rauen, T., Boor, P., Mertens, P. R., van Roeyen, C. R. C., Tacke, F., Heymann, F., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300416 · Cited by 68 · see citing works
Self-citationLim, J. P., Nair, S., Shyamasundar, S., Chua, P. J., Muniasamy, U., Matsumoto, K., Gunaratne, J., & Bay, B. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.03.014 · Cited by 63 · see citing works
In-depth proteomic profiling of the uveal melanoma secretome
Angi, M., Kalirai, H., Prendergast, S., Simpson, D. M., Hammond, D. E., Madigan, M. C., Beynon, R. J., & Coupland, S. E. (2016) · Oncotarget · doi:10.18632/oncotarget.10418 · Cited by 62 · see citing works
Detection of Proteins on Blot Membranes
Harper, S. L., & Speicher, D. W. (1995) · Current Protocols in Protein Science · doi:10.1002/0471140864.ps1008s00 · Cited by 57 · see citing works
Kosnopfel, C., Sinnberg, T. W., Sauer, B., Busch, C., Niessner, H., Schmitt, A., Forchhammer, S., Grimmel, C., Mertens, P. R., Hailfinger, S., et al. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0528 · Cited by 57 · see citing works
Self-citationYB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis
Lovett, D. H., Cheng, S., Cape, L., Pollock, A. S., & Mertens, P. R. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.104 · Cited by 48 · see citing works
Self-citationSomasekharan, S. P., Stoynov, N., Rotblat, B., Leprivier, G., Galpin, J. D., Ahern, C. A., Foster, L. J., & Sorensen, P. H. B. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.08.019 · Cited by 46 · see citing works
Torrado, L. C., Temmerman, K., Müller, H., Mayer, M. P., Seelenmeyer, C., Backhaus, R., & Nickel, W. (2009) · Journal of Cell Science · doi:10.1242/jcs.049791 · Cited by 39 · see citing works
Kosnopfel, C., Sinnberg, T. W., Sauer, B., Niessner, H., Schmitt, A., Makino, E., Forschner, A., Hailfinger, S., Garbe, C., & Schittek, B. (2017) · Oncotarget · doi:10.18632/oncotarget.16204 · Cited by 39 · see citing works
Self-citationGuarino, A. M., Troiano, A., Pizzo, E., Bosso, A., Vivo, M., Pinto, G., Amoresano, A., Pollice, A., Mantia, G. L., & Calabrò, V. (2018) · Genes · doi:10.3390/genes9100513 · Cited by 39 · see citing works
Proteomic identification of a marker signature for MAPKi resistance in melanoma
Paulitschke, V., Eichhoff, O. M., Gerner, C., Paulitschke, P., Bileck, A., Mohr, T. T., Cheng, P. F., Leitner, A., Guenova, E., Saulīte, I., et al. (2019) · The EMBO Journal · doi:10.15252/embj.201695874 · Cited by 36 · see citing works
The major mRNP protein YB-1: Structural and association properties in solution
Guryanov, S. G., Filimonov, V. V., Timchenko, A. A., Melnik, B. S., Kihara, H., Kutyshenko, V. P., Ovchinnikov, L. P., & Semisotnov, G. V. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2012.11.007 · Cited by 31 · see citing works
Tacke, F., Galm, O., Kanig, N., Yagmur, E., Brandt, S., Lindquist, J. A., Eberhardt, C. S., Raffetseder, U., & Mertens, P. R. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-33 · Cited by 28 · see citing works
Self-citationFerreira, A. R., Bettencourt, M., Alho, I., Costa, A. L., Sousa, A. R., Mansinho, A., Abreu, C., Pulido, C., Macedo, D., Vendrell, I., et al. (2017) · Journal of bone oncology · doi:10.1016/j.jbo.2017.01.002 · Cited by 27 · see citing works
Y‐box binding protein 1 is correlated with lymph node metastasis in intestinal‐type gastric cancer
Guo, T., Yu, Y., Yip, G. W. C., Baeg, G. H., Thike, A. A., Lim, T. K., Tan, P. H., Matsumoto, K., & Bay, B. (2014) · Histopathology · doi:10.1111/his.12570 · Cited by 25 · see citing works
Unconventional protein secretion: Diversity and consensus
Nickel, W., & Rabouille, C. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.03.007 · Cited by 25 · see citing works
Proteomic Profiling of Human Melanoma Metastatic Cell Line Secretomes
Rocco, M., Malorni, L., Cozzolino, R., Palmieri, G., Rozzo, C., Manca, A., Parente, A., & Chambery, A. (2011) · Journal of Proteome Research · doi:10.1021/pr200511f · Cited by 21 · see citing works
Larribère, L., Kuphal, S., Sachpekidis, C., Sachindra, Hüser, L., Bosserhoff, A., & Utikal, J. S. (2018) · Cancers · doi:10.3390/cancers10110451 · Cited by 16 · see citing works
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A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance
Alkrekshi, A., Wang, W., Rana, P. S., Marković, V. G., & Sossey‐Alaoui, K. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110073 · Cited by 104 · see citing works
Yin, Q., Zheng, M. J., Luo, Q., Jiang, D., Zhang, H., & Chen, C. (2022) · Cells · doi:10.3390/cells11071217 · Cited by 63 · see citing works
The role of mitochondria in the resistance of melanoma to PD-1 inhibitors
Du, F., Yang, L.-H., Liu, J., Wang, J., Fan, L., Duangmano, S., Liu, H., Liu, M., Wang, J., Zhong, X., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04200-9 · Cited by 48 · see citing works
The Role of Calcium Signaling in Melanoma
Zhang, H., Chen, Z., Zhang, A., Gupte, A. A., & Hamilton, D. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031010 · Cited by 41 · see citing works
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis
Suman, S., & Markovic, S. N. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.07.002 · Cited by 31 · see citing works
Zhou, X., Zhang, Y., & Wang, N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.915784 · Cited by 30 · see citing works
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More, S., Bonnereau, J., Wouters, D., Spotbeen, X., Karras, P., Rizzollo, F., Killian, T., Venken, T., Naulaerts, S., Vervoort, E., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp6164 · Cited by 25 · see citing works
Tiwari, A., Iida, M., Kosnopfel, C., Abbariki, M., Menegakis, A., Fehrenbacher, B., Maier, J., Schaller, M., Brucker, S. Y., Wheeler, D. L., et al. (2020) · Cancers · doi:10.3390/cancers12102795 · Cited by 22 · see citing works
Self-citationHessman, C. L., Hildebrandt, J., Shah, A., Brandt, S., Bock, A., Frye, B. C., Raffetseder, U., Geffers, R., Brunner-Weinzierl, M. C., Isermann, B., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197076 · Cited by 21 · see citing works
Self-citationLi, M., Zhou, S., Zhang, S., Xie, X., Nie, J., Wang, Q., Ma, L., Cheng, Y., & Luo, J. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03523-7 · Cited by 18 · see citing works
Stojanovska, V., Shah, A., Woidacki, K., Fischer, F., Bauer, M., Lindquist, J. A., Mertens, P. R., & Zenclussen, A. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137226 · Cited by 14 · see citing works
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Self-citationLi, B., Li, F., Gu, T., Guo, Y., Shen, B., Xu, X., Shen, Z., Chen, L., Zhang, Q., Dong, H., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174866 · Cited by 11 · see citing works
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Eliseeva, I. A., Sogorina, E. M., Smolin, E. A., Kulakovskiy, I. V., & Lyabin, D. N. (2022) · Biochemistry (Moscow) · doi:10.1134/s000629792214005x · Cited by 7 · see citing works
Maurus, K., Kosnopfel, C., Kneitz, H., Appenzeller, S., Schrama, D., Glutsch, V., Roth, S., Gerhard‐Hartmann, E., Rosenfeldt, M. T., Möhrmann, L., et al. (2021) · British Journal of Dermatology · doi:10.1111/bjd.20869 · Cited by 6 · see citing works
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Cykowska, A., Hofmann, U. K., Tiwari, A., Kosnopfel, C., Riester, R., & Danalache, M. (2023) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2023.1050487 · Cited by 4 · see citing works
Self-citationFischer, F., Schumacher, A., Meyer, N., Fink, B., Bauer, M., Stojanovska, V., & Zenclussen, A. C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1039206 · Cited by 1 · see citing works
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Self-citationKosnopfel, C., Wendlinger, S., Niessner, H., Siewert, J., Sinnberg, T. W., Hofmann, A., Wohlfarth, J., Schrama, D., Berthold, M., Siedel, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23706986
Self-citationKosnopfel, C., Wendlinger, S., Niessner, H., Siewert, J., Sinnberg, T. W., Hofmann, A., Wohlfarth, J., Schrama, D., Berthold, M., Siedel, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23706989
Self-citationKosnopfel, C., Wendlinger, S., Niessner, H., Siewert, J., Sinnberg, T. W., Hofmann, A., Wohlfarth, J., Schrama, D., Berthold, M., Siedel, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23706983
Self-citationKosnopfel, C., Wendlinger, S., Niessner, H., Siewert, J., Sinnberg, T. W., Hofmann, A., Wohlfarth, J., Schrama, D., Berthold, M., Siedel, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23706992
Self-citationKosnopfel, C., Wendlinger, S., Niessner, H., Siewert, J., Sinnberg, T. W., Hofmann, A., Wohlfarth, J., Schrama, D., Berthold, M., Siedel, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23706998
Self-citationKosnopfel, C., Wendlinger, S., Niessner, H., Siewert, J., Sinnberg, T. W., Hofmann, A., Wohlfarth, J., Schrama, D., Berthold, M., Siedel, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23706980
Self-citationKosnopfel, C., Wendlinger, S., Niessner, H., Siewert, J., Sinnberg, T. W., Hofmann, A., Wohlfarth, J., Schrama, D., Berthold, M., Siedel, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23706974
Self-citationKosnopfel, C., Wendlinger, S., Niessner, H., Siewert, J., Sinnberg, T. W., Hofmann, A., Wohlfarth, J., Schrama, D., Berthold, M., Siedel, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23706971
Self-citationTu, F., Chen, S., Lu, Y., Ge, Y., Zhang, F., & Wang, Q. (2026) · ACS Sensors · doi:10.1021/acssensors.6c00702
- Authors
- Kosnopfel, C., Sinnberg, T., Sauer, B., Niessner, H., Muenchow, A., Fehrenbacher, B., Schaller, M., Mertens, P. R., Garbe, C., Thakur, B. K., & Schittek, B.
- Affiliations
- Universitätsklinikum Würzburg (DE)
- University of Tübingen (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Essen University Hospital (DE)
- Corresponding author
- Kosnopfel, Corinna
- Schittek, Birgit
- ORCID
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2020-08-18
- Volume
- 12
- Issue
- 8
- Pages
- 2328
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC7464723
- OpenAlex
- W3067247909
- Cited by
- 31
- References
- 56
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 13 · 2022: 7 · 2021: 5 · 2020: 2
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Online Publication Service of Würzburg University (Würzburg University) (submittedVersion, cc-by)
- Funders
- Hiege Stiftung gegen Hautkrebs (-)
- Deutsche Forschungsgemeinschaft (SCHI 510/11-1, Germany’s Excellence Strategy - EXC 2180 – 390900677, ME-1365/7-2, ME-1365/9-2, 97850925 - SFB 854)
- University of Tübingen, intramural funding programme “fortüne" (2505-0-0)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- YB-1, melanoma, tumor progression, extracellular secretion, non-classical secretion, calcium-dependent secretion, cell migration, cell invasion, metastasis, tumor aggressiveness, prognostic factors, intercellular communication
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