Pre-metastatic niches: organ-specific homes for metastases
Open accessAbstract
It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.
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Cancer cells at the primary site can sculpt a pre-metastatic niche by releasing soluble factors and extracellular vesicles.
“Cancer cells at the primary site can sculpture a pre-metastatic niche by releasing soluble factors and extracellular vesicles (Liu & Cao, 2016;Peinado et al., 2017).”
From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Peinado et al., 2017
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- Authors
- Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., Bissell, M. J., Cox, T. R., Giaccia, A. J., Erler, J. T., Hiratsuka, S., Ghajar, C. M., & Lyden, D.
- Affiliations
- Spanish National Cancer Research Centre (ES)
- Children's Cancer and Blood Foundation (US)
- Hammersmith Hospital (GB)
- National Institutes of Health (US)
- Memorial Sloan Kettering Cancer Center (US)
- Princeton University (US)
- Lawrence Berkeley National Laboratory (US)
- Garvan Institute of Medical Research (AU)
- Stanford University (US)
- University of Copenhagen (DK)
- Tokyo Women's Medical University (JP)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Lyden, David
- ORCID
- Venue
- Nature Reviews Cancer
- Published
- 2017-03-17
- Volume
- 17
- Issue
- 5
- Pages
- 302-317
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2596133050
- Cited by
- 1,889
- References
- 214
- Citations by year
- 2026: 172 · 2025: 184 · 2024: 222 · 2023: 256 · 2022: 256 · 2021: 257 · 2020: 197 · 2019: 185 · 2018: 110 · 2017: 48 · 2012: 1
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- European Hematology Association (TRTH100)
- Wellcome Trust (107477/Z/15/Z)
- National Institute for Health and Care Research (CL-2012-21-004)
- Academy of Medical Sciences (AMS-SGCL10-Psaila)
- National Cancer Institute (U54CA193461, U01CA169538, P30CA008748)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- pre-metastatic niche, organ-specific metastasis, tumor microenvironment, extracellular vesicles, circulating tumor cells, niche formation
- MeSH terms
- Animals, Humans, Neoplastic Cells, Circulating, Neoplasm Metastasis, Neoplasms, Tumor Microenvironment
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