Cited by 1,889Cancer Cells and MetastasisMechanisms of cancer metastasisExtracellular vesicles in disease

Pre-metastatic niches: organ-specific homes for metastases

Open access
Peinado, Héctor, Zhang, Haiying, Matei, Irina R., Costa-Silva, Bruno, Hoshino, Ayuko, Rodrigues, Goncalo, Psaila, Bethan, Kaplan, Rosandra N. +9 more·2017·Nature Reviews Cancer

Abstract

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

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Crossref · 10.1038/nrc.2017.6

Cites

214 of 214 references verified0 citation errors · 0 not checkable

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  • Cancer cells at the primary site can sculpt a pre-metastatic niche by releasing soluble factors and extracellular vesicles.

    “Cancer cells at the primary site can sculpture a pre-metastatic niche by releasing soluble factors and extracellular vesicles (Liu & Cao, 2016;Peinado et al., 2017).”

    From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Peinado et al., 2017

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Authors
Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., Bissell, M. J., Cox, T. R., Giaccia, A. J., Erler, J. T., Hiratsuka, S., Ghajar, C. M., & Lyden, D.
Affiliations
  • Spanish National Cancer Research Centre (ES)
  • Children's Cancer and Blood Foundation (US)
  • Hammersmith Hospital (GB)
  • National Institutes of Health (US)
  • Memorial Sloan Kettering Cancer Center (US)
  • Princeton University (US)
  • Lawrence Berkeley National Laboratory (US)
  • Garvan Institute of Medical Research (AU)
  • Stanford University (US)
  • University of Copenhagen (DK)
  • Tokyo Women's Medical University (JP)
  • Fred Hutch Cancer Center (US)
Corresponding author
Lyden, David
Venue
Nature Reviews Cancer
Published
2017-03-17
Volume
17
Issue
5
Pages
302-317
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2596133050
Cited by
1,889
References
214
Citations by year
2026: 172 · 2025: 184 · 2024: 222 · 2023: 256 · 2022: 256 · 2021: 257 · 2020: 197 · 2019: 185 · 2018: 110 · 2017: 48 · 2012: 1
FWCI
15.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • European Hematology Association (TRTH100)
  • Wellcome Trust (107477/Z/15/Z)
  • National Institute for Health and Care Research (CL-2012-21-004)
  • Academy of Medical Sciences (AMS-SGCL10-Psaila)
  • National Cancer Institute (U54CA193461, U01CA169538, P30CA008748)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
pre-metastatic niche, organ-specific metastasis, tumor microenvironment, extracellular vesicles, circulating tumor cells, niche formation
MeSH terms
Animals, Humans, Neoplastic Cells, Circulating, Neoplasm Metastasis, Neoplasms, Tumor Microenvironment

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