The DOI matches its Crossref record; 239 of the 239 references it cites were found in a registry or an index.
The Warburg Effect 97 Years after Its Discovery
Open accessAbstract
The deregulation of the oxidative metabolism in cancer, as shown by the increased aerobic glycolysis and impaired oxidative phosphorylation (Warburg effect), is coordinated by genetic changes leading to the activation of oncogenes and the loss of oncosuppressor genes. The understanding of the metabolic deregulation of cancer cells is necessary to prevent and cure cancer. In this review, we illustrate and comment the principal metabolic and molecular variations of cancer cells, involved in their anomalous behavior, that include modifications of oxidative metabolism, the activation of oncogenes that promote glycolysis and a decrease of oxygen consumption in cancer cells, the genetic susceptibility to cancer, the molecular correlations involved in the metabolic deregulation in cancer, the defective cancer mitochondria, the relationships between the Warburg effect and tumor therapy, and recent studies that reevaluate the Warburg effect. Taken together, these observations indicate that the Warburg effect is an epiphenomenon of the transformation process essential for the development of malignancy.
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Cites
1 retracted
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Cited by
Revisiting the Warburg effect: historical dogma versus current understanding
Vaupel, P., & Multhoff, G. (2021) · The Journal of Physiology · doi:10.1113/jp278810 · Cited by 830
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation
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Metadata
- Authors
- Pascale, R. M., Calvisi, D. F., Simile, M. M., Feo, C. F., & Feo, F.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2020-09-30
- Volume
- 12
- Issue
- 10
- Pages
- 2819
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W3091700828
- Cited by
- 300
- References
- 239
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pascale, R. M., Calvisi, D. F., Simile, M. M., Feo, C. F., & Feo, F. (2020). The Warburg Effect 97 Years after Its Discovery. Cancers. https://doi.org/10.3390/cancers12102819
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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