The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
Open accessAbstract
Autophagy is an intracellular degradation process responsible for the delivery of cellular material to the lysosomes. One of the key mechanisms for control of autophagy is the modulation of the interaction between the autophagic protein Beclin 1 and the members of the anti-apoptotic Bcl-2 family (e.g., Bcl-2, Bcl-XL and Mcl-1). This binding is regulated by a variety of proteins and compounds that are able to enhance or inhibit the Bcl-2/Beclin 1 interaction in order to repress or activate autophagy, respectively. In this review we will focus on this interaction and discuss its characteristics, relevance and regulation.
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1 retracted
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J., & Semenza, G. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800102200 · Cited by 1,601
RetractedAutophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Autophagy in immunity and inflammation
Levine, B., Mizushima, N., & Virgin, H. W. (2011) · Nature · doi:10.1038/nature09782 · Cited by 3,289
The Beclin 1 network regulates autophagy and apoptosis
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
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Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116
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Autophagic cell death: the story of a misnomer
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Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
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Cited by
Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications
Uddin, M. S., Stachowiak, A., Mamun, A. A., Tzvetkov, N. T., Takeda, S., Atanasov, A. G., Bergantin, L. B., Abdel-Daim, M. M., & Stankiewicz, A. M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00004 · Cited by 395
Molecular mechanisms of cognitive dysfunction following traumatic brain injury
Walker, K. R., & Tesco, G. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00029 · Cited by 265
La Rovere, R. M. L., Roest, G., Bultynck, G., & Parys, J. B. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.04.005 · Cited by 257
Self-citationThe lifecycle of skeletal muscle mitochondria in obesity
Pileggi, C. A., Parmar, G., & Harper, M. (2021) · Obesity Reviews · doi:10.1111/obr.13164 · Cited by 61
Resistance to hormone therapy in breast cancer cells promotes autophagy and EGFR signaling pathway
Siatis, K. E., Giannopoulou, E., Manou, D., Sarantis, P., Karamouzis, M. V., Raftopoulou, S., Fasseas, K., Alzahrani, F. M., Kalofonos, H. P., & Theocharis, A. D. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00199.2023 · Cited by 23
Metadata
- Authors
- Decuypere, J.-P., Parys, J. B., & Bultynck, G.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2012-07-06
- Volume
- 1
- Issue
- 3
- Pages
- 284-312
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W2059182725
- Cited by
- 249
- References
- 31
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- gold
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- Decuypere, J.-P., Parys, J. B., & Bultynck, G. (2012). Regulation of the Autophagic Bcl-2/Beclin 1 Interaction. Cells. https://doi.org/10.3390/cells1030284
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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