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Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

Uddin, Md. Sahab, Stachowiak, Anna, Mamun, Abdullah Al, Tzvetkov, Nikolay T., Takeda, Shinya, Atanasov, Atanas G., Bergantin, Leandro B., Abdel-Daim, Mohamed M., Stankiewicz, Adrian M.·2018·Frontiers in Aging Neuroscience

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  • The role of autophagic/lysosomal dysfunction in Alzheimer pathology is evidenced by differential expression of key regulators of the pathway in individuals with Alzheimer's disease compared with control individuals.

    “The role of autophagic/lysosomal dysfunction in Alzheimer pathology is evidenced by differential expression of key regulators of the pathway in individuals with Alzheimer’s disease compared with control individuals [147].”

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Research works printed but not linked: 231

  1. Alberts, 2002, Transport from the Trans Golgi Network to Lysosomes.
  2. Armstrong, 2009, The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer’s disease., Folia Neuropathol., 47, 289
  3. Atkin, 2014, Ubiquitin pathways in neurodegenerative disease., Front. Mol. Neurosci., 7, 10.3389/fnmol.2014.00063 · DOI
  4. Bachhuber, 2015, Inhibition of amyloid-beta plaque formation by alpha-synuclein., Nat. Med., 21, 802, 10.1038/nm.3885 · DOI
  5. Bai, 2014, Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities., Alzheimer Dis. Assoc. Disord., 28, 226, 10.1097/WAD.0000000000000022 · DOI
  6. Baig, 2012, Clusterin mRNA and protein in Alzheimer’s disease., J. Alzheimers Dis., 28, 337, 10.3233/JAD-2011-110473 · DOI
  7. Bandyopadhyay, 2010, Identification of regulators of chaperone-mediated autophagy., Mol. Cell, 39, 535, 10.1016/j.molcel.2010.08.004 · DOI
  8. Barral, 2012, Genotype patterns at PICALM, CR1 BIN1 CLU, and APOE genes are associated with episodic memory., Neurology, 78, 1464, 10.1212/WNL.0b013e3182553c48 · DOI
  9. Basu, 2004, Interleukin-1: a master regulator of neuroinflammation., J. Neurosci. Res., 78, 151, 10.1002/jnr.20266 · DOI
  10. Bateman, 2006, Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo., Nat. Med., 12, 856, 10.1038/nm1438 · DOI · Paper page
  11. Bedse, 2014, Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer’s disease., J. Alzheimers Dis., 40, 701, 10.3233/JAD-131910 · DOI
  12. Bedse, 2015, The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer’s disease., J. Alzheimers Dis., 43, 1115, 10.3233/JAD-141635 · DOI
  13. Beeg, 2016, Clusterin binds to Abeta1-42 oligomers with high affinity and interferes with peptide aggregation by inhibiting primary and secondary nucleation., J. Biol. Chem., 291, 6958, 10.1074/jbc.M115.689539 · DOI
  14. Benito, 2003, Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer’s disease brains., J. Neurosci., 23, 11136, 10.1523/JNEUROSCI.23-35-11136.2003 · DOI
  15. Bian, 2002, Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice., J. Comp. Neurol., 446, 257, 10.1002/cne.10186 · DOI
  16. Blobel, 2013, Christian de Duve (1917-2013)., Nature, 498, 10.1038/498300a · DOI
  17. Bloom, 2014, Amyloid-beta and tau: the trigger and bullet in Alzheimer disease pathogenesis., JAMA Neurol., 71, 505, 10.1001/jamaneurol.2013.5847 · DOI
  18. Boland, 2008, Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer’s disease., J. Neurosci., 28, 6926, 10.1523/JNEUROSCI.0800-08.2008 · DOI · Paper page
  19. Braskie, 2011, Common Alzheimer’s disease risk variant within the CLU gene affects white matter microstructure in young adults., J. Neurosci., 31, 6764, 10.1523/JNEUROSCI.5794-10.2011 · DOI
  20. Caccamo, 2014, Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer’s disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature., J. Neurosci., 34, 7988, 10.1523/JNEUROSCI.0777-14.2014 · DOI
  21. Caccamo, 2013, mTOR regulates tau phosphorylation and degradation: implications for Alzheimer’s disease and other tauopathies., Aging Cell, 12, 370, 10.1111/acel.12057 · DOI · Paper page
  22. Caccamo, 2010, Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments., J. Biol. Chem., 285, 13107, 10.1074/jbc.M110.100420 · DOI · Paper page
  23. Cai, 2015, Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of gamma-secretase complex., Neuropsychiatr. Dis. Treat., 11, 2091, 10.2147/NDT.S84755 · DOI
  24. Cataldo, 2004, Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology., J. Neuropathol. Exp. Neurol., 63, 821, 10.1093/jnen/63.8.821 · DOI
  25. Cerpa, 2010, The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer’s mouse model., Curr. Alzheimer Res., 7, 126, 10.2174/156720510790691218 · DOI
  26. Chan, 2016, Interference of alpha-synuclein uptake by monomeric beta-Amyloid1-40 and potential core acting site of the interference., Neurotox. Res., 30, 479, 10.1007/s12640-016-9644-2 · DOI
  27. Chang, 2012, Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death., J. Cell Sci., 125, 5124, 10.1242/jcs.108183 · DOI
  28. Chau, 2015, Latrepirdine for Alzheimer’s disease., Cochrane Database Syst. Rev., 4, 10.1002/14651858.CD009524.pub2 · DOI
  29. Chen, 2004, Content-rich biological network constructed by mining PubMed abstracts., BMC Bioinformatics, 5, 10.1186/1471-2105-5-147 · DOI
  30. Chen, 2013, Mass spectrometry assessment of ubiquitin carboxyl-terminal hydrolase L1 partitioning between soluble and particulate brain homogenate fractions., Anal. Chem., 85, 6011, 10.1021/ac400831z · DOI
  31. Cheng, 2017, Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice., J. Neurochem., 142, 297, 10.1111/jnc.14048 · DOI
  32. Cho, 2015, SUMO1 promotes Abeta production via the modulation of autophagy., Autophagy, 11, 100, 10.4161/15548627.2014.984283 · DOI
  33. Chu, 2013, Induction of autophagy by a novel small molecule improves a beta pathology and ameliorates cognitive deficits., PLOS ONE, 8, 10.1371/journal.pone.0065367 · DOI
  34. Ciechanover, 1998, The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death., Proc. Natl. Acad. Sci. U.S.A., 95, 2727, 10.1073/pnas.95.6.2727 · DOI
  35. Colasanti, 2014, Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes., Cell Death Dis., 5, 10.1038/cddis.2014.211 · DOI
  36. Corsetti, 2015, NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer’s disease., Hum. Mol. Genet., 24, 3058, 10.1093/hmg/ddv059 · DOI · Paper page
  37. Costes, 2014, UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in beta-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy., Autophagy, 10, 1004, 10.4161/auto.28478 · DOI
  38. Crews, 2011, Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer’s disease., Cell Death Dis., 2, 10.1038/cddis.2011.2 · DOI
  39. Crews, 2010, Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy., PLOS ONE, 5, 10.1371/journal.pone.0009313 · DOI
  40. de Duve, 2005, The lysosome turns fifty., Nat. Cell Biol., 7, 847, 10.1038/ncb0905-847 · DOI
  41. De Strooper, 1998, Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein., Nature, 391, 387, 10.1038/34910 · DOI · Paper page
  42. Dean, 1975, Direct evidence of importance of lysosomes in degradation of intracellular proteins., Nature, 257, 414, 10.1038/257414a0 · DOI
  43. Decuypere, 2012, Regulation of the autophagic bcl-2/beclin 1 interaction., Cells, 1, 284, 10.3390/cells1030284 · DOI
  44. Deng, 2016, beta-asarone improves learning and memory and reduces Acetyl Cholinesterase and Beta-amyloid 42 levels in APP/PS1 transgenic mice by regulating Beclin-1-dependent autophagy., Brain Res., 1652, 188, 10.1016/j.brainres.2016.10.008 · DOI
  45. Dickson, 1999, Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer’s disease., Exp. Neurol., 156, 100, 10.1006/exnr.1998.7010 · DOI
  46. Dolan, 2010, A caspase cleaved form of tau is preferentially degraded through the autophagy pathway., J. Biol. Chem., 285, 21978, 10.1074/jbc.M110.110940 · DOI
  47. Donovan, 2012, Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer’s disease., Proteomics Clin. Appl., 6, 201, 10.1002/prca.201100068 · DOI
  48. Du, 2017, Neuroinflammation contributes to autophagy flux blockage in the neurons of rostral ventrolateral medulla in stress-induced hypertension rats., J. Neuroinflammation, 14, 10.1186/s12974-017-0942-2 · DOI
  49. Du, 2013, Trehalose rescues Alzheimer’s disease phenotypes in APP/PS1 transgenic mice., J. Pharm. Pharmacol., 65, 1753, 10.1111/jphp.12108 · DOI
  50. Ferreiro, 2007, Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells., J. Alzheimers Dis., 12, 223, 10.3233/JAD-2007-12303 · DOI
  51. Forlenza, 2012, Does lithium prevent Alzheimer’s disease?, Drugs Aging, 29, 335, 10.2165/11599180-000000000-00000 · DOI
  52. Francois, 2014, Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice., J. Neuroinflammation, 11, 10.1186/s12974-014-0139-x · DOI
  53. Francois, 2013, Involvement of interleukin-1beta in the autophagic process of microglia: relevance to Alzheimer’s disease., J. Neuroinflammation, 10, 10.1186/1742-2094-10-151 · DOI · Paper page
  54. Frederick, 2015, Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice., J. Alzheimers Dis., 44, 1145, 10.3233/JAD-142097 · DOI
  55. Funakoshi, 1997, Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae., Gene, 192, 207, 10.1016/S0378-1119(97)00031-0 · DOI
  56. Funderburk, 2010, Cell “self-eating” (autophagy) mechanism in Alzheimer’s disease., Mt. Sinai J. Med., 77, 59, 10.1002/msj.20161 · DOI · Paper page
  57. Garcia-Arencibia, 2010, Autophagy, a guardian against neurodegeneration., Semin. Cell Dev. Biol., 21, 691, 10.1016/j.semcdb.2010.02.008 · DOI
  58. Glick, 2010, Autophagy: cellular and molecular mechanisms., J. Pathol., 221, 3, 10.1002/path.2697 · DOI
  59. Gong, 2006, Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory., Cell, 126, 775, 10.1016/j.cell.2006.06.046 · DOI
  60. Gong, 2013, Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models., Neurobiol. Aging, 34, 1581, 10.1016/j.neurobiolaging.2012.12.005 · DOI · Paper page
  61. Grill, 2017, Nicotinamide as an Early Alzheimer’s Disease Treatment (NEAT).
  62. Grossi, 2013, The polyphenol oleuropein aglycone protects TgCRND8 mice against Ass plaque pathology., PLOS ONE, 8, 10.1371/journal.pone.0071702 · DOI
  63. Guglielmotto, 2012, Abeta1-42-mediated down-regulation of Uch-L1 is dependent on NF-kappaB activation and impaired BACE1 lysosomal degradation., Aging Cell, 11, 834, 10.1111/j.1474-9726.2012.00854.x · DOI
  64. Hiebel, 2014, Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex., J. Neurochem., 131, 484, 10.1111/jnc.12839 · DOI
  65. Higuchi, 2010, The cannabinoid 1-receptor silent antagonist O-2050 attenuates preference for high-fat diet and activated astrocytes in mice., J. Pharmacol. Sci., 112, 369, 10.1254/jphs.09326SC · DOI
  66. Hiltunen, 2006, Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion., J. Biol. Chem., 281, 32240, 10.1074/jbc.M603106200 · DOI
  67. Huber, 2016, Lysosomal signaling in control of degradation pathways., Curr. Opin. Cell Biol., 39, 8, 10.1016/j.ceb.2016.01.006 · DOI
  68. Hubert, 2016, LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes., Biol. Open, 5, 1516, 10.1242/bio.018648 · DOI
  69. Iijima, 2000, Neuron-specific phosphorylation of Alzheimer’s beta-amyloid precursor protein by cyclin-dependent kinase 5., J. Neurochem., 75, 1085, 10.1046/j.1471-4159.2000.0751085.x · DOI
  70. Ikeda, 2013, Cerebrospinal fluid levels of phosphorylated tau and Abeta1-38/Abeta1-40/Abeta1-42 in Alzheimer’s disease with PS1 mutations., Amyloid, 20, 107, 10.3109/13506129.2013.790810 · DOI
  71. Inestrosa, 2011, Tetrahydrohyperforin prevents cognitive deficit, A beta deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1DeltaE9 model of Alzheimer’s disease: a possible effect on APP processing., Transl. Psychiatry, 1, 10.1038/tp.2011.19 · DOI
  72. Inoue, 2012, Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway., Mol. Neurodegener., 7, 10.1186/1750-1326-7-48 · DOI · Paper page
  73. Iqbal, 2010, Tau in Alzheimer disease and related tauopathies., Curr. Alzheimer Res., 7, 656, 10.2174/156720510793611592 · DOI
  74. Irvine, 2008, Protein aggregation in the brain: the molecular basis for Alzheimer’s and Parkinson’s diseases., Mol. Med., 14, 451, 10.2119/2007-00100.Irvine · DOI
  75. Jellinger, 2010, Basic mechanisms of neurodegeneration: a critical update., J. Cell Mol. Med., 14, 457, 10.1111/j.1582-4934.2010.01010.x · DOI
  76. Jiang, 2014, Temsirolimus promotes autophagic clearance of amyloid-beta and provides protective effects in cellular and animal models of Alzheimer’s disease., Pharmacol. Res., 81, 54, 10.1016/j.phrs.2014.02.008 · DOI
  77. Jourquin, 2012, GLAD4U: deriving and prioritizing gene lists from PubMed literature., BMC Genomics, 10.1186/1471-2164-13-S8-S20 · DOI
  78. Jung, 2010, mTOR regulation of autophagy., FEBS Lett., 584, 1287, 10.1016/j.febslet.2010.01.017 · DOI · Paper page
  79. Kamada, 2000, Tor-mediated induction of autophagy via an Apg1 protein kinase complex., J. Cell Biol., 150, 1507, 10.1083/jcb.150.6.1507 · DOI · Paper page
  80. Kamphuis, 2014, Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer’s disease., Neurobiol. Aging, 35, 492, 10.1016/j.neurobiolaging.2013.09.035 · DOI
  81. Kanehisa, 2017, KEGG: new perspectives on genomes, pathways, diseases and drugs., Nucleic Acids Res., 45, D353, 10.1093/nar/gkw1092 · DOI · Paper page
  82. Karch, 2015, Alzheimer’s disease risk genes and mechanisms of disease pathogenesis., Biol. Psychiatry, 77, 43, 10.1016/j.biopsych.2014.05.006 · DOI · Paper page
  83. Karigar, 2005, The Nobel Prize in Chemistry 2004., Resonance, 10, 41, 10.1007/BF02835891 · DOI
  84. Katona, 2012, Multiple functions of endocannabinoid signaling in the brain., Annu. Rev. Neurosci., 35, 529, 10.1146/annurev-neuro-062111-150420 · DOI · Paper page
  85. Kaushik, 2012, Chaperone-mediated autophagy: a unique way to enter the lysosome world., Trends Cell Biol., 22, 407, 10.1016/j.tcb.2012.05.006 · DOI
  86. Kickstein, 2010, Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling., Proc. Natl. Acad. Sci. U.S.A., 107, 21830, 10.1073/pnas.0912793107 · DOI · Paper page
  87. Klionsky, 2008, Autophagy revisited: a conversation with Christian de Duve., Autophagy, 4, 740, 10.4161/auto.6398 · DOI
  88. Klionsky, 2003, A unified nomenclature for yeast autophagy-related genes., Dev. Cell, 5, 539, 10.1016/S1534-5807(03)00296-X · DOI
  89. Korff, 2013, alpha-Synuclein in cerebrospinal fluid of Alzheimer’s disease and mild cognitive impairment., J. Alzheimers Dis., 36, 679, 10.3233/JAD-130458 · DOI · Paper page
  90. Korolainen, 2005, Proteomic analysis of glial fibrillary acidic protein in Alzheimer’s disease and aging brain., Neurobiol. Dis., 20, 858, 10.1016/j.nbd.2005.05.021 · DOI
  91. Kruger, 2012, Autophagic degradation of tau in primary neurons and its enhancement by trehalose., Neurobiol. Aging, 33, 2291, 10.1016/j.neurobiolaging.2011.11.009 · DOI · Paper page
  92. Larson, 2012, Soluble alpha-synuclein is a novel modulator of Alzheimer’s disease pathophysiology., J. Neurosci., 32, 10253, 10.1523/JNEUROSCI.0581-12.2012 · DOI · Paper page
  93. Lee, 2007, ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration., Curr. Biol., 17, 1561, 10.1016/j.cub.2007.07.029 · DOI
  94. Lee, 2010, Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations., Cell, 141, 1146, 10.1016/j.cell.2010.05.008 · DOI · Paper page
  95. Letronne, 2016, ADAM30 downregulates APP-linked defects through cathepsin D activation in Alzheimer’s disease., EBioMedicine, 9, 278, 10.1016/j.ebiom.2016.06.002 · DOI
  96. Li, 2012, Metformin attenuates Alzheimer’s disease-like neuropathology in obese, leptin-resistant mice., Pharmacol. Biochem. Behav., 101, 564, 10.1016/j.pbb.2012.03.002 · DOI · Paper page
  97. Li, 2013, Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-beta pathology in a mouse model of Alzheimer’s disease., Curr. Alzheimer Res., 10, 433, 10.2174/1567205011310040008 · DOI
  98. Li, 2009, The yeast lysosome-like vacuole: endpoint and crossroads., Biochim. Biophys. Acta, 1793, 650, 10.1016/j.bbamcr.2008.08.003 · DOI
  99. Li, 2006, Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta., Biochemistry, 45, 3134, 10.1021/bi051635j · DOI
  100. Li, 2008, Polyubiquitin chains: functions, structures, and mechanisms., Cell Mol. Life. Sci., 65, 2397, 10.1007/s00018-008-8090-6 · DOI
  101. Lilienbaum, 2013, Relationship between the proteasomal system and autophagy., Int. J. Biochem. Mol. Biol., 4, 1
  102. Liu, 2014, The CLU gene rs11136000 variant is significantly associated with Alzheimer’s disease in Caucasian and Asian populations., Neuromolecular Med., 16, 52, 10.1007/s12017-013-8250-1 · DOI
  103. Liu, 2005, Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42., Neurobiol. Dis., 20, 74, 10.1016/j.nbd.2005.02.003 · DOI
  104. Liu, 2016, Neuroprotective effect of beta-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1., Drug Des. Devel. Ther., 10, 1461, 10.2147/DDDT.S93559 · DOI
  105. Luccarini, 2015, Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ss toxicity: biochemical, epigenetic and functional correlates., Neurobiol. Aging, 36, 648, 10.1016/j.neurobiolaging.2014.08.029 · DOI
  106. Majd, 2013, Reciprocal induction between alpha-synuclein and beta-amyloid in adult rat neurons., Neurotox. Res., 23, 69, 10.1007/s12640-012-9330-y · DOI
  107. Manuel, 2014, Type-1 cannabinoid receptor activity during Alzheimer’s disease progression., J. Alzheimers Dis., 42, 761, 10.3233/JAD-140492 · DOI
  108. Maroof, 2013, Endocannabinoid signalling in Alzheimer’s disease., Biochem. Soc. Trans., 41, 1583, 10.1042/BST20130140 · DOI
  109. Martorell, 2016, Potential therapeutic effects of oleuropein aglycone in Alzheimer’s disease., Curr. Pharm. Biotechnol., 17, 994, 10.2174/1389201017666160725120656 · DOI
  110. Marzella, 1981, Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation., Virchows Arch. B Cell Pathol. Incl. Mol. Pathol., 36, 219, 10.1007/BF02912068 · DOI
  111. Matsubara, 2001, Genetic association between Alzheimer disease and the alpha-synuclein gene., Dement. Geriatr. Cogn. Disord., 12, 106, 10.1159/000051243 · DOI
  112. Matsunaga, Lithium as a treatment for Alzheimer’s disease: a systematic review and meta-analysis., J. Alzheimers Dis., 48, 403, 10.3233/JAD-150437 · DOI
  113. Matsunaga, Memantine monotherapy for Alzheimer’s disease: a systematic review and meta-analysis., PLOS ONE, 10, 10.1371/journal.pone.0123289 · DOI
  114. Matsuura, 1997, Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae., Gene, 192, 245, 10.1016/S0378-1119(97)00084-X · DOI
  115. McDermott, 1996, Degradation of Alzheimer’s beta-amyloid protein by human cathepsin D., Neuroreport, 7, 2163, 10.1097/00001756-199609020-00021 · DOI
  116. Meijer, 2015, Regulation of autophagy by amino acids and MTOR-dependent signal transduction., Amino Acids, 47, 2037, 10.1007/s00726-014-1765-4 · DOI
  117. Melendez, 2008, The cell biology of autophagy in metazoans: a developing story., Development, 135, 2347, 10.1242/dev.016105 · DOI
  118. Messai, 2014, ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy., Cancer Res., 74, 6820, 10.1158/0008-5472.CAN-14-0303 · DOI · Paper page
  119. Metcalf, 2012, Autophagy and misfolded proteins in neurodegeneration., Exp. Neurol., 238, 22, 10.1016/j.expneurol.2010.11.003 · DOI · Paper page
  120. Miners, 2017, Clusterin levels are increased in Alzheimer’s disease and influence the regional distribution of Abeta., Brain Pathol., 27, 305, 10.1111/bpa.12392 · DOI
  121. Mirnics, 2008, Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice., Mol. Neurodegener., 3, 10.1186/1750-1326-3-14 · DOI · Paper page
  122. Mizushima, 2011, Autophagy: renovation of cells and tissues., Cell, 147, 728, 10.1016/j.cell.2011.10.026 · DOI
  123. Mizushima, 2004, In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker., Mol. Biol. Cell, 15, 1101, 10.1091/mbc.E03-09-0704 · DOI · Paper page
  124. Mo, 2014, Lack of association between cathepsin D C224T polymorphism and Alzheimer’s disease risk: an update meta-analysis., BMC Neurol., 14, 10.1186/1471-2377-14-13 · DOI
  125. Mohammadi, 2016, Reduction of autophagy markers mediated protective effects of JNK inhibitor and bucladesine on memory deficit induced by A beta in rats., Naunyn Schmiedebergs Arch. Pharmacol., 389, 501, 10.1007/s00210-016-1222-x · DOI
  126. Mulder, 2014, Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro., Glia, 62, 493, 10.1002/glia.22619 · DOI
  127. Mullan, 2013, Plasma clusterin levels and the rs11136000 genotype in individuals with mild cognitive impairment and Alzheimer’s disease., Curr. Alzheimer Res., 10, 973, 10.2174/15672050113106660162 · DOI
  128. Nah, 2013, BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid beta 42., Autophagy, 9, 2009, 10.4161/auto.26118 · DOI
  129. Nakatogawa, 2013, Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy., Essays Biochem., 55, 39, 10.1042/bse0550039 · DOI
  130. Nakatogawa, 2007, Atg8 a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion., Cell, 130, 165, 10.1016/j.cell.2007.05.021 · DOI
  131. Natunen, 2016, Relationship between ubiquilin-1 and BACE1 in human Alzheimer’s disease and APdE9 transgenic mouse brain and cell-based models., Neurobiol. Dis., 85, 187, 10.1016/j.nbd.2015.11.005 · DOI
  132. Neely, 2011, Presenilins mediate efficient proteolysis via the autophagosome-lysosome system., Autophagy, 7, 664, 10.4161/auto.7.6.15448 · DOI
  133. Nilsson, 2014, Dual roles for autophagy: degradation and secretion of Alzheimer’s disease Abeta peptide., Bioessays, 36, 570, 10.1002/bies.201400002 · DOI
  134. Nilsson, 2015, Autophagy-related protein 7 deficiency in amyloid beta (A beta) precursor protein transgenic mice decreases Abeta in the multivesicular bodies and induces Abeta accumulation in the Golgi., Am. J. Pathol., 185, 305, 10.1016/j.ajpath.2014.10.011 · DOI
  135. Nixon, 2007, Autophagy, amyloidogenesis and Alzheimer disease., J. Cell Sci., 120, 4081, 10.1242/jcs.019265 · DOI · Paper page
  136. Nixon, 2005, Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study., J. Neuropathol. Exp. Neurol., 64, 113, 10.1093/jnen/64.2.113 · DOI · Paper page
  137. 2017, The Nobel Prize in Physiology or Medicine 2016 [Online]. Nobel Media AB 2014.
  138. Noble, 2003, Cdk5 is a key factor in tau aggregation and tangle formation in vivo., Neuron, 38, 555, 10.1016/S0896-6273(03)00259-9 · DOI
  139. Nowacek, 2009, Neurodegenerative disorders and nanoformulated drug development., Nanomedicine (Lond), 4, 541, 10.2217/nnm.09.37 · DOI
  140. Ntais, 2004, Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer’s disease: a HuGE gene-disease association review., Am. J. Epidemiol., 159, 527, 10.1093/aje/kwh069 · DOI
  141. Ohsumi, 2014, Historical landmarks of autophagy research., Cell Res., 24, 9, 10.1038/cr.2013.169 · DOI
  142. Oikawa, 2016, alpha-Synuclein fibrils exhibit gain of toxic function, promoting tau aggregation and inhibiting microtubule assembly., J. Biol. Chem., 291, 15046, 10.1074/jbc.M116.736355 · DOI
  143. Oksman, 2013, Transduced wild-type but not P301S mutated human tau shows hyperphosphorylation in transgenic mice overexpressing A30P mutated human alpha-synuclein., Neurodegener. Dis., 12, 91, 10.1159/000341596 · DOI
  144. Okuma, 1998, A history of investigation on the mood stabilizing effect of carbamazepine in Japan., Psychiatry Clin. Neurosci., 52, 3, 10.1111/j.1440-1819.1998.tb00966.x · DOI
  145. Olah, 2015, Proteomic analysis of cerebrospinal fluid in Alzheimer’s disease: wanted dead or alive., J. Alzheimers Dis., 44, 1303, 10.3233/JAD-140141 · DOI
  146. Onodera, 2005, Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation., J. Biol. Chem., 280, 31582, 10.1074/jbc.M506736200 · DOI
  147. Pacheco, 2009, Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis., Hum. Mol. Genet., 18, 956, 10.1093/hmg/ddn423 · DOI
  148. Parenti, 2013, New strategies for the treatment of lysosomal storage diseases (review)., Int. J. Mol. Med., 31, 11, 10.3892/ijmm.2012.1187 · DOI
  149. Paroni, 2014, FOXO1 locus and acetylcholinesterase inhibitors in elderly patients with Alzheimer’s disease., Clin. Interv. Aging, 9, 1783, 10.2147/CIA.S64758 · DOI
  150. Paz-Y-Miño, 2015, Positive association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer’s disease., Am. J. Med. Sci., 350, 296, 10.1097/MAJ.0000000000000555 · DOI
  151. Perez, 2009, Tau–an inhibitor of deacetylase HDAC6 function., J. Neurochem., 109, 1756, 10.1111/j.1471-4159.2009.06102.x · DOI · Paper page
  152. Perez, 2015, Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer’s disease., Biol. Psychiatry, 77, 693, 10.1016/j.biopsych.2013.12.016 · DOI
  153. Phelan, 2017, Phase II clinical trial of nicotinamide for the treatment of mild to moderate Alzheimer’s disease., J. Geriatr. Med. Gerontol., 3, 10.23937/2469-5858/1510021 · DOI
  154. Pickford, 2008, The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice., J. Clin. Invest., 118, 2190, 10.1172/JCI33585 · DOI · Paper page
  155. Piyanova, 2013, Loss of CB1 receptors leads to decreased cathepsin D levels and accelerated lipofuscin accumulation in the hippocampus., Mech. Ageing Dev., 134, 391, 10.1016/j.mad.2013.08.001 · DOI
  156. Poon, 2013, beta-Amyloid (A beta) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1., J. Biol. Chem., 288, 16937, 10.1074/jbc.M113.463711 · DOI
  157. Porquet, 2014, Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer’s disease., J. Alzheimers Dis., 42, 1209, 10.3233/JAD-140444 · DOI
  158. Portbury, 2017, Trehalose improves cognition in the transgenic Tg2576 mouse model of Alzheimer’s disease., J. Alzheimers Dis., 60, 549, 10.3233/JAD-170322 · DOI
  159. Posada-Duque, 2015, p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing., J. Neurochem., 134, 354, 10.1111/jnc.13127 · DOI
  160. Qu, 2011, S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide., Proc. Natl. Acad. Sci. U.S.A., 108, 14330, 10.1073/pnas.1105172108 · DOI
  161. Quinn, 2012, alpha-Synuclein mRNA and soluble alpha-synuclein protein levels in post-mortem brain from patients with Parkinson’s disease, dementia with Lewy bodies, and Alzheimer’s disease., Brain Res., 1459, 71, 10.1016/j.brainres.2012.04.018 · DOI
  162. Rademakers, 2005, Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer’s disease., Neurobiol. Aging, 26, 1145, 10.1016/j.neurobiolaging.2004.10.003 · DOI
  163. Ramirez, 2005, Prevention of Alzheimer’s disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation., J. Neurosci., 25, 1904, 10.1523/JNEUROSCI.4540-04.2005 · DOI
  164. Riemenschneider, 2006, The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease., Hum. Mutat., 27, 532, 10.1002/humu.20326 · DOI
  165. Roberts, 2017, alpha-Synuclein increases beta-amyloid secretion by promoting beta-/gamma-secretase processing of APP., PLOS ONE, 12, 10.1371/journal.pone.0171925 · DOI
  166. Rogel, 2010, The role of the ubiquitin proteasome pathway in keratin intermediate filament protein degradation., Proc. Am. Thorac. Soc., 7, 71, 10.1513/pats.200908-089JS · DOI
  167. Rubinsztein, 2011, Autophagy and aging., Cell, 146, 682, 10.1016/j.cell.2011.07.030 · DOI · Paper page
  168. Rusten, 2009, How do ESCRT proteins control autophagy?, J. Cell Sci., 122, 2179, 10.1242/jcs.050021 · DOI
  169. Sadleir, 2012, Cdk5 protein inhibition and Abeta42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease., J. Biol. Chem., 287, 7224, 10.1074/jbc.M111.333914 · DOI
  170. Santulli, 2015, Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging., Curr. Mol. Pharmacol., 8, 206, 10.2174/1874467208666150507105105 · DOI
  171. Sarkar, 2007, Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein., J. Biol. Chem., 282, 5641, 10.1074/jbc.M609532200 · DOI · Paper page
  172. Sarkar, 2005, Lithium induces autophagy by inhibiting inositol monophosphatase., J. Cell Biol., 170, 1101, 10.1083/jcb.200504035 · DOI · Paper page
  173. Satoh, 2013, Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer’s disease brains., Neuropathol. Appl. Neurobiol., 39, 817, 10.1111/nan.12036 · DOI
  174. Schuur, 2011, Cathepsin D gene and the risk of Alzheimer’s disease: a population-based study and meta-analysis., Neurobiol. Aging, 32, 1607, 10.1016/j.neurobiolaging.2009.10.011 · DOI
  175. Settembre, 2013, Signals from the lysosome: a control centre for cellular clearance and energy metabolism., Nat. Rev. Mol. Cell Biol., 14, 283, 10.1038/nrm3565 · DOI
  176. Seyb, 2007, p35/Cyclin-dependent kinase 5 is required for protection against beta-amyloid-induced cell death but not tau phosphorylation by ceramide., J. Mol. Neurosci., 31, 23, 10.1007/BF02686115 · DOI
  177. Shao, 2014, Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelitis via activation of autophagy and inhibiting NLRP3 inflammasome., CNS Neurosci. Ther., 20, 1021, 10.1111/cns.12349 · DOI
  178. Shen, 2014, At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy., Trends Biochem. Sci., 39, 61, 10.1016/j.tibs.2013.12.001 · DOI
  179. Sheng, 2016, Cdk5 is a new rapid synaptic homeostasis regulator capable of initiating the early Alzheimer-like pathology., Cereb. Cortex, 26, 2937, 10.1093/cercor/bhv032 · DOI
  180. Shibata, 2012, Lack of genetic association of the UCHL1 gene with Alzheimer’s disease and Parkinson’s disease with dementia., Dement. Geriatr. Cogn. Disord., 33, 250, 10.1159/000339357 · DOI
  181. Shilling, 2014, Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer’s disease pathogenesis., J. Neurosci., 34, 6910, 10.1523/JNEUROSCI.5441-13.2014 · DOI
  182. Shuai, 2015, Genetic associations of CLU rs9331888 polymorphism with Alzheimer’s disease: a meta-analysis., Neurosci. Lett., 591, 160, 10.1016/j.neulet.2015.02.040 · DOI
  183. Shukla, 2013, A truncated peptide from p35 a Cdk5 activator, prevents Alzheimer’s disease phenotypes in model mice., FASEB J., 27, 174, 10.1096/fj.12-217497 · DOI
  184. Singh, 2016, Effect of low-dose rapamycin on senescence markers and physical functioning in older adults with coronary artery disease: results of a pilot study., J Frailty Aging, 5, 204
  185. Solas, 2013, CB2 receptor and amyloid pathology in frontal cortex of Alzheimer’s disease patients., Neurobiol. Aging, 34, 805, 10.1016/j.neurobiolaging.2012.06.005 · DOI
  186. Somavarapu, 2016, Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer’s disease., J. Neurochem., 137, 101, 10.1111/jnc.13535 · DOI
  187. Song, 2015, Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer’s disease via mammalian target of rapamycin-dependent and -independent pathways., Mol. Med. Rep., 12, 7615, 10.3892/mmr.2015.4382 · DOI
  188. Song, 2015, Enhancement of BACE1 activity by p25/Cdk5-mediated phosphorylation in Alzheimer’s disease., PLOS ONE, 10, 10.1371/journal.pone.0136950 · DOI · Paper page
  189. Steele, 2013, Modulation of autophagy as a therapeutic target for Alzheimer’s disease., Postdoc. J., 1, 21, 10.14304/SURYA.JPR.V1N2.3 · DOI
  190. Steele, 2013, Latrepirdine (Dimebon(R)), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model., Autophagy, 9, 617, 10.4161/auto.23487 · DOI
  191. Stevens, 2014, A gene-brain-cognition pathway for the effect of an Alzheimers risk gene on working memory in young adults., Neuropsychologia, 61, 143, 10.1016/j.neuropsychologia.2014.06.021 · DOI
  192. Stieren, 2011, Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein., J. Biol. Chem., 286, 35689, 10.1074/jbc.M111.243147 · DOI
  193. Sun, 2014, Differential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer’s disease., J. Alzheimers Dis., 38, 437, 10.3233/JAD-131124 · DOI
  194. Takeshige, 1992, Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction., J. Cell Biol., 119, 301, 10.1083/jcb.119.2.301 · DOI
  195. Tanaka, 2004, Ubiquitin, proteasome and parkin., Biochim. Biophys. Acta, 1695, 235, 10.1016/j.bbamcr.2004.09.026 · DOI
  196. 2016, Scientific Background Discoveries of Mechanisms for Autophagy.
  197. Tian, 2014, Decreased expression of cathepsin D in monocytes is related to the defective degradation of amyloid-beta in Alzheimer’s disease., J. Alzheimers Dis., 42, 511, 10.3233/JAD-132192 · DOI
  198. Tian, 2011, A small-molecule enhancer of autophagy decreases levels of A beta and APP-CTF via Atg5-dependent autophagy pathway., FASEB J., 25, 1934, 10.1096/fj.10-175158 · DOI
  199. Tsukada, 1993, Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae., FEBS Lett., 333, 169, 10.1016/0014-5793(93)80398-E · DOI
  200. Turner, 2015, A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease., Neurology, 85, 1383, 10.1212/WNL.0000000000002035 · DOI

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Metadata

Authors
Uddin, M. S., Stachowiak, A., Mamun, A. A., Tzvetkov, N. T., Takeda, S., Atanasov, A. G., Bergantin, L. B., Abdel-Daim, M. M., & Stankiewicz, A. M.
Venue
Frontiers in Aging Neuroscience
Published
2018-01-30
Volume
10
ISSN
1663-4365
Cited by
395
References
33

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