Molecular mechanisms of cognitive dysfunction following traumatic brain injury
Open accessAbstract
Traumatic brain injury (TBI) results in significant disability due to cognitive deficits particularly in attention, learning and memory, and higher-order executive functions. The role of TBI in chronic neurodegeneration and the development of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic Lateral Sclerosis (ALS) and most recently chronic traumatic encephalopathy (CTE) is of particular importance. However, despite significant effort very few therapeutic options exist to prevent or reverse cognitive impairment following TBI. In this review, we present experimental evidence of the known secondary injury mechanisms which contribute to neuronal cell loss, axonal injury, and synaptic dysfunction and hence cognitive impairment both acutely and chronically following TBI. In particular we focus on the mechanisms linking TBI to the development of two forms of dementia: AD and CTE. We provide evidence of potential molecular mechanisms involved in modulating Aβ and Tau following TBI and provide evidence of the role of these mechanisms in AD pathology. Additionally we propose a mechanism by which Aβ generated as a direct result of TBI is capable of exacerbating secondary injury mechanisms thereby establishing a neurotoxic cascade that leads to chronic neurodegeneration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adults experience chronic fatigue, loss of libido or amenorrhea, or overt gonadotropin deficiency in addition to a variety of neurocognitive complaints after TBI.
“Likewise, adults experience chronic fatigue, loss of libido or amenorrhea, or overt gonadotropin deficiency in addition to a variety of neurocognitive complaints [12,50].”
From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [12]
The “TBI a global health concern” section reports persistent post-TBI deficits in attention, learning, memory, and executive function. It does not report chronic fatigue, loss of libido, amenorrhea, or gonadotropin deficiency; searches for those terms and related endocrine terms found no supporting passage. Page numbers are unavailable in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSecondary injury typically develops within hours or days to weeks following the primary injury.
“Secondary injury typically develops within hours or days to weeks following the primary injury [12].”
From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [12]
Neuropsychological testing in post-concussive syndrome may reveal persistent, yet subtle, cognitive deficits, most often in the executive domain.
“Neuropsychological testing in PCS may reveal persistent, yet subtle, cognitive deficits, most often in the executive domain [192].”
From The neuropathology of sport (2014) · cites this paper as [192]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Ding, J. Y., Kreipke, C. W., Schafer, P. C., Schafer, S., Speirs, S. L., & Rafols, J. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.02.060 · Cited by 57 · see citing works
RetractedCorrespondence - Tranexamic acid for traumatic brain injury
(2005) · London School of Economics and Political Science Theses Online (London School of Economics and Political Science) · doi:10.1016/s0140-6736 · Cited by 11,894 · see citing works
(2015) · American Journal Of Pathology · doi:10.2353/ajpath · Cited by 4,961 · see citing works
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,044 · see citing works
What is cognitive reserve? Theory and research application of the reserve concept
STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951 · see citing works
National Center for Injury Prevention and Control (U.S.). Division of Injury Response., Faul, M., Wald, M. M., Wu, L., & Coronado, V. G. (2010) · doi:10.15620/cdc.5571 · Cited by 3,494 · see citing works
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382 · see citing works
Ghajar, J. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02689-1 · Cited by 2,244 · see citing works
Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2177-05.2005 · Cited by 2,140 · see citing works
Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
Niswender, C. M., & Conn, P. J. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145533 · Cited by 1,889 · see citing works
Pathophysiology of traumatic brain injury
Werner, C., & Engelhard, K. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem131 · Cited by 1,712 · see citing works
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687 · see citing works
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works
Epidemiology of Alzheimer disease
Reitz, C., Brayne, C., & Mayeux, R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.2 · Cited by 1,675 · see citing works
Animal models of traumatic brain injury
Xiong, Y., Mahmood, A., & Chopp, M. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3407 · Cited by 1,413 · see citing works
Axonal pathology in traumatic brain injury
Johnson, V. E., Stewart, W., & Smith, D. H. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.013 · Cited by 1,273 · see citing works
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265 · see citing works
Guskiewicz, K. M., Marshall, S. W., Bailes, J. E., McCrea, M., Cantu, R. C., RANDOLPH, C. C., & Jordan, B. D. (2005) · Neurosurgery · doi:10.1093/neurosurgery/57.4.719 · Cited by 1,197 · see citing works
Guskiewicz, K. M., Marshall, S. W., Bailes, J., McCrea, M., Cantu, R. C., Randolph, C., & Jordan, B. D. (2005) · Neurosurgery · doi:10.1227/01.neu.0000175725.75780.dd · Cited by 1,197 · see citing works
Classification of traumatic brain injury for targeted therapies
Saatman, K. E., Duhaime, A.-C., Bullock, R., Maas, A. I. R., Valadka, A., & Manley, G. T. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2008.0586 · Cited by 1,141 · see citing works
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions
Pearson, G. (2001) · Endocrine Reviews · doi:10.1210/er.22.2.153 · Cited by 1,060 · see citing works
In-vivo measurement of activated microglia in dementia
Cagnin, A., Brooks, D. J., Kennedy, A. M., Gunn, R. N., Myers, R., Turkheimer, F. E., Jones, T., & Banati, R. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05625-2 · Cited by 1,054 · see citing works
Inflammation after trauma: Microglial activation and traumatic brain injury
Ramlackhansingh, A. F., Brooks, D. J., Greenwood, R. J., Bose, S. K., Turkheimer, F. E., Kinnunen, K. M., Gentleman, S., Heckemann, R. A., Gunanayagam, K., Gelosa, G., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22455 · Cited by 999 · see citing works
Kraus, M. F., Susmaras, T. M., Caughlin, B., Walker, C. J., Sweeney, J. A., & Little, D. M. (2007) · Brain · doi:10.1093/brain/awm216 · Cited by 994 · see citing works
Reddy, P. H., & Beal, M. F. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.002 · Cited by 975 · see citing works
Goldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X.-L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003716 · Cited by 958 · see citing works
Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias
Plassman, B. L., Havlik, R. J., Steffens, D. C., Helms, M. J., Newman, T. N., Drosdick, D., Phillips, C., Gau, B. A., Welsh–Bohmer, K. A., Burke, J. R., et al. (2000) · Neurology · doi:10.1212/wnl.55.8.1158 · Cited by 896 · see citing works
Metabolic Regulation of Brain Aβ by Neprilysin
Iwata, N., Tsubuki, S., Takaki, Y., Shirotani, K., Lu, B., Gerard, N., Gerard, C., Hama, E., Lee, H., & Saido, T. (2001) · Science · doi:10.1126/science.1059946 · Cited by 894 · see citing works
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J.-M., & Holtzman, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2801 · Cited by 880 · see citing works
Apolipoprotein E in Alzheimer’s disease and other neurological disorders
Verghese, P. B., Castellano, J. M., & Holtzman, D. M. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70325-2 · Cited by 857 · cited 1× · see citing works
“While, the role of APOε4 in modulating outcome following TBI appears to be much more complex, it is generally accepted that the presence of the APOε4 allele confers poor neurological outcome following TBI (see Verghese et al., 2011).”
BackgroundCorsellis, J. A. N., Bruton, C. J., & Freeman-Browne, D. (1973) · Psychological Medicine · doi:10.1017/s0033291700049588 · Cited by 836 · see citing works
Neuropathology of Alzheimer's Disease
Perl, D. P. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20157 · Cited by 825 · see citing works
Gervais, F. G., Xu, D., Robertson, G. S., Vaillancourt, J. P., Zhu, Y., Huang, J., LeBlanc, A. C., Smith, D., Rigby, M., Shearman, M. S., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80748-5 · Cited by 783 · see citing works
MARTLAND, H. S. (1928) · Journal of the American Medical Association · doi:10.1001/jama.1928.02700150029009 · Cited by 774 · see citing works
Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772 · see citing works
Necroptosis as an alternative form of programmed cell death
Christofferson, D. E., & Yuan, J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.003 · Cited by 771 · see citing works
Fleminger, S. (2003) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.7.857 · Cited by 719 · see citing works
Gavett, B. E., Stern, R. A., & McKee, A. C. (2011) · Clinics in Sports Medicine · doi:10.1016/j.csm.2010.09.007 · Cited by 696 · see citing works
β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease
Fukumoto, H. (2002) · Archives of Neurology · doi:10.1001/archneur.59.9.1381 · Cited by 694 · see citing works
Li, S., Jin, M., Koeglsperger, T., Shepardson, N. E., Shankar, G. M., & Selkoe, D. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0203-11.2011 · Cited by 673 · see citing works
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy
McKee, A. C., Gavett, B. E., Stern, R. A., Nowinski, C. J., Cantu, R. C., Kowall, N. W., Perl, D. P., Hedley-Whyte, E. T., Price, B., Sullivan, C., et al. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181ee7d85 · Cited by 659 · see citing works
Neurodegenerative causes of death among retired National Football League players
Lehman, E. J., Hein, M. J., Baron, S. L., & Gersic, C. M. (2012) · Neurology · doi:10.1212/wnl.0b013e31826daf50 · Cited by 638 · see citing works
Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury
Arundine, M., & Tymianski, M. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3319-x · Cited by 635 · see citing works
Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo
Cirrito, J. R., Kang, J.-E., Lee, J., Stewart, F. R., Verges, D. K., Silverio, L. M., Bu, G., Mennerick, S., & Holtzman, D. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.003 · Cited by 635 · see citing works
Diffuse Axonal Injury in Head Trauma
Smith, D. H., Meaney, D., & Shull, W. H. (2003) · The journal of head trauma rehabilitation · doi:10.1097/00001199-200307000-00003 · Cited by 627 · see citing works
Widespread tau and amyloid-beta pathology many years after a single traumatic brain injury in humans
Johnson, V. E., Stewart, W., & Smith, D. H. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00513.x · Cited by 620 · see citing works
Oxidative stress in the progression of Alzheimer disease in the frontal cortex
Ansari, M. A., & Scheff, S. W. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181cb5af4 · Cited by 605 · see citing works
Mortimer, J. A., Van Duijn, C. M., Chandra, V, Fratiglioni, L., Graves, A. B., Heyman, A., Jorm, A. F., Kokmen, E., Kondo, K., Rocca, W. A., et al. (1991) · International Journal of Epidemiology · doi:10.1093/ije/20.supplement_2.s28 · Cited by 594 · cited 1× · see citing works
“…head trauma is sufficient to cause chronic neurodegeneration and the development of a neurodegenerative disorder such as AD in some individuals (Mortimer et al., 1985, 1991; Graves et al., 1990; Molgaard et al., 1990; O’Meara et al., 1997; Salib and Hillier, 1997; Schofield et al., 1997; Guo…”
BackgroundTraumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?
Johnson, V. E., Stewart, W., & Smith, D. H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2808 · Cited by 587 · see citing works
Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
D'Amelio, M., Cavallucci, V., Middei, S., Marchetti, C., Pacioni, S., Ferri, A., Diamantini, A., De Zio, D., Carrara, P., Battistini, L., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2709 · Cited by 572 · see citing works
Roberts, G. W., Gentleman, S. M., Lynch, A., Murray, L., Landon, M., & Graham, D. I. (1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.419 · Cited by 569 · see citing works
Long‐term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy
Stern, R. A., Riley, D., Daneshvar, D. H., Nowinski, C. J., Cantu, R. C., & McKee, A. C. (2011) · PM&R · doi:10.1016/j.pmrj.2011.08.008 · Cited by 564 · see citing works
Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease
Holsinger, R. M. D., McLean, C. A., Beyreuther, K., Masters, C. L., & Evin, G. (2002) · Annals of Neurology · doi:10.1002/ana.10208 · Cited by 562 · see citing works
Wu, A., Ying, Z., & Gomez-Pinilla, F. (2004) · Journal of Neurotrauma · doi:10.1089/neu.2004.21.1457 · Cited by 518 · see citing works
Caspase activation precedes and leads to tangles
de Calignon, A., Fox, L. M., Pitstick, R., Carlson, G. A., Bacskai, B. J., Spires-Jones, T. L., & Hyman, B. T. (2010) · Nature · doi:10.1038/nature08890 · Cited by 517 · see citing works
Synaptic degeneration in Alzheimer's disease
Arendt, T. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0536-x · Cited by 517 · see citing works
Head injury and the risk of AD in the MIRAGE study
Guo, Z., Cupples, L. A., Kurz, A., Auerbach, S. H., Volicer, L., Chui, H., Green, R. C., Sadovnick, A. D., Duara, R., DeCarli, C., et al. (2000) · Neurology · doi:10.1212/wnl.54.6.1316 · Cited by 506 · see citing works
Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury
Yi, J., & Hazell, A. S. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.001 · Cited by 477 · see citing works
Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease
Masliah, E., Hansen, L., Alford, M., Deteresa, R., & Mallory, M. (1996) · Annals of Neurology · doi:10.1002/ana.410400512 · Cited by 476 · see citing works
Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407963200 · Cited by 474 · see citing works
Neurobiological consequences of traumatic brain injury
McAllister, T. W. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.2/tmcallister · Cited by 472 · see citing works
Cognitive Outcome Following Traumatic Brain Injury
DIKMEN, S. S., Corrigan, J. D., Levin, H. S., Machamer, J., Stiers, W. M., & Weisskopf, M. G. (2009) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3181c133e9 · Cited by 466 · see citing works
Mitochondrial Dysfunction and Calcium Perturbation Induced by Traumatic Brain Injury
Xiong, Y., GU, Q., Peterson, P. L., Muizelaar, J. P., & Lee, C. P. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.23 · Cited by 447 · see citing works
βA4 amyloid protein deposition in brain after head trauma
Roberts, G., Gentleman, S., Lynch, A., & Graham, D. I. (1991) · The Lancet · doi:10.1016/0140-6736(91)92724-g · Cited by 440 · see citing works
Guillaume, D. J., Doolittle, N. D., Gahramanov, S., et al. (2010) · PubMed · doi:10.1227/01.neu.0000363152.37594.f7 · Cited by 420 · see citing works
Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin
Shao, W., Zhang, S., Tang, M., Zhang, X., Zhou, Z., Yin, Y., Zhou, Q., Huang, Y., Liu, Y., Wawrousek, E. F., et al. (2012) · Nature · doi:10.1038/nature11748 · Cited by 418 · see citing works
Traumatic Brain Injury‐Induced Excitotoxicity Assessed in a Controlled Cortical Impact Model
Palmer, A. M., Marion, D. W., Botscheller, M. L., Swedlow, P. E., Styren, S. D., & DeKosky, S. T. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb07437.x · Cited by 412 · see citing works
Actions of TNF‐α on glutamatergic synaptic transmission in the central nervous system
Pickering, M., Cumiskey, D., & O'Connor, J. J. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.030734 · Cited by 411 · see citing works
Caspase‐3 Mediated Neuronal Death After Traumatic Brain Injury in Rats
Clark, R. S. B., Kochanek, P. M., Watkins, S. C., Chen, M., Dixon, C. E., Seidberg, N. A., Melick, J. A., Loeffert, J. E., Nathaniel, P. D., Jin, K. L., et al. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740740.x · Cited by 406 · see citing works
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
Ikonomovic, M. D., Uryu, K., Abrahamson, E. E., Ciallella, J. R., Trojanowski, J. Q., Lee, V. M.-Y., Clark, R. S., Marion, D. W., Wisniewski, S. R., & DeKosky, S. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.011 · Cited by 399 · see citing works
Schindowski, K., Bretteville, A., Leroy, K., Bégard, S., Brion, J., Hamdane, M., & Buée, L. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060002 · Cited by 396 · see citing works
Sheng, J. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00069-x · Cited by 388 · see citing works
Pierce, J. E. S., Smith, D. H., Trojanowski, J. Q., & McIntosh, T. K. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00142-0 · Cited by 385 · cited 9× · see citing works
“In view of the repetitive nature of many TBI’s it is possible that a reduction in cognitive reserve following the first injury can lead to the brain becoming “primed” and any further insults to their brain may amplify the deleterious effects of the original injury.”
BackgroundInfluentialCalpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration
Vosler, P. S., Brennan, C. S., & Chen, J. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8036-x · Cited by 381 · see citing works
Xia, P., Chen, H.-S. V., Zhang, D., & Lipton, S. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2488-10.2010 · Cited by 380 · see citing works
Wang, X., Jung, J., Asahi, M., Chwang, W. B., Russo, L. A., Moskowitz, M. A., Dixon, C. E., Fini, M. E., & Lo, E. H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-07037.2000 · Cited by 371 · see citing works
Zhao, J. J., O’Connor, T., & Vassar, R. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-150 · Cited by 370 · see citing works
Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice
Trinchese, F., Liu, S., Battaglia, F., Walter, S., Mathews, P. M., & Arancio, O. (2004) · Annals of Neurology · doi:10.1002/ana.20101 · Cited by 369 · see citing works
Wu, H.-Y., Hudry, E., Hashimoto, T., Kuchibhotla, K., Rozkalne, A., Fan, Z., Spires-Jones, T., Xie, H., Arbel-Ornath, M., Grosskreutz, C. L., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4456-09.2010 · Cited by 367 · see citing works
Alberdi, E. M., Sánchez‐Gómez, M. V., Cavaliere, F., Pérez‐Samartín, A., Zugaza, J. L., Trullás, R., Domercq, M., & Matute, C. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.010 · Cited by 364 · see citing works
Uryu, K., Chen, X.-H., Martinez, D., Browne, K. D., Johnson, V. E., Graham, D. I., Lee, V. M.-Y., Trojanowski, J. Q., & Smith, D. H. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.018 · Cited by 360 · see citing works
Yasojima, K., Akiyama, H., McGeer, E. G., & McGeer, P. L. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01675-x · Cited by 357 · see citing works
Synaptic slaughter in Alzheimer's disease
Coleman, P. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.001 · Cited by 351 · see citing works
Cheng, G., Kong, R., Zhang, L., & Zhang, J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02025.x · Cited by 345 · see citing works
Cyclosporin A Attenuates Acute Mitochondrial Dysfunction Following Traumatic Brain Injury
Sullivan, P. G., Thompson, M. B., & Scheff, S. W. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7197 · Cited by 344 · see citing works
LI, S., MALLORY, M., ALFORD, M., TANAKA, S., & MASLIAH, E. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199708000-00008 · Cited by 343 · see citing works
Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity
Tesco, G., Koh, Y. H., Kang, E. L., Cameron, A. N., Das, S., Sena-Esteves, M., Hiltunen, M., Yang, S.-H., Zhong, Z., Shen, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.012 · Cited by 337 · see citing works
Self-citationOxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury
Ansari, M. A., Roberts, K. N., & Scheff, S. W. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.038 · Cited by 327 · see citing works
Traumatic brain injury: A risk factor for Alzheimer's disease
Sivanandam, T. M., & Thakur, M. K. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.013 · Cited by 326 · see citing works
Abdul, H. M., Sama, M. A., Furman, J. L., Mathis, D. M., Beckett, T. L., Weidner, A. M., Patel, E., Baig, I., Murphy, M. P., LeVine, H., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1064-09.2009 · Cited by 323 · see citing works
A mouse model of human repetitive mild traumatic brain injury
Kane, M. J., Angoa‐Pérez, M., Briggs, D. I., Viano, D. C., Kreipke, C. W., & Kuhn, D. M. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.09.003 · Cited by 322 · see citing works
Traumatic Brain Injury — Football, Warfare, and Long-Term Effects
DeKosky, S. T., Ikonomović, M. D., & Gandy, S. (2010) · New England Journal of Medicine · doi:10.1056/nejmp1007051 · Cited by 322 · see citing works
Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease
Furman, J. L., Sama, D. M., Gant, J. C., Beckett, T. L., Murphy, M. P., Bachstetter, A. D., Van Eldik, L. J., & Norris, C. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2323-12.2012 · Cited by 313 · see citing works
Hippocampal volume in normal aging and traumatic brain injury.
Bigler, E. D., Blatter, D. D., Anderson, C. V., Johnson, S. C., Gale, S. D., Hopkins, R. O., & Burnett, B. (1997) · PubMed Central · Cited by 311 · see citing works
Heneka, M. T., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T., & Van Leuven, F. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-22 · Cited by 309 · see citing works
Head injury as a risk factor for Alzheimer's disease
Mortimer, J. A., French, L., Hutton, J. T., & Schuman, L. M. (1985) · Neurology · doi:10.1212/wnl.35.2.264 · Cited by 308 · see citing works
Shitaka, Y., Tran, H., Bennett, R. E., Sanchez, L., Levy, M. A., Dikranian, K. T., & Brody, D. L. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31821f891f · Cited by 307 · see citing works
Dixon, C. E., Kochanek, P. M., Yan, H. Q., Schiding, J. K., GRIFFITH, R. G., Baum, E., Marion, D. W., & DeKosky, S. T. (1999) · Journal of Neurotrauma · doi:10.1089/neu.1999.16.109 · Cited by 303 · see citing works
Age- and region-dependent alterations in Aβ-degrading enzymes: implications for Aβ-induced disorders
Caccamo, A., Oddo, S., Sugarman, M. C., Akbari, Y., & LaFerla, F. M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.013 · Cited by 299 · see citing works
Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease
Knobloch, M., & Mansuy, I. M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8018-z · Cited by 296 · see citing works
Amyloid-β Dynamics Correlate with Neurological Status in the Injured Human Brain
Brody, D. L., Magnoni, S., Schwetye, K. E., Spinner, M. L., Esparza, T. J., Stocchetti, N., Zipfel, G. J., & Holtzman, D. M. (2008) · Science · doi:10.1126/science.1161591 · Cited by 295 · see citing works
Traumatic brain injury and time to onset of Alzheimer’s disease: a population-based study
Nemetz, P. N., Leibson, C., Naessens, J. M., Beard, M., Kokmen, E., Annegers, J. F., & Kurland, L. T. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009724 · Cited by 295 · see citing works
Mouzon, B., Chaytow, H., Crynen, G. C., Bachmeier, C. J., Stewart, J., MULLAN, M. J., Stewart, W. B., Jr., & Crawford, F. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2498 · Cited by 294 · see citing works
Revett, T. J., Baker, G. B., Jhamandas, J. H., & Kar, S. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110190 · Cited by 294 · see citing works
Wu, A., Ying, Z., & Gómez‐Pinilla, F. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.09.004 · Cited by 292 · see citing works
(2001) · PubMed Central · Cited by 289 · see citing works
Increases in Bcl‐2 and cleavage of caspase‐1 and caspase‐3 in human brain after head injury
Clark, R. S. B., Kochanek, P. M., Chen, M., Watkins, S. C., Marion, D. W., Chen, J., Hamilton, R. L., Loeffert, J. E., & Graham, S. H. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.8.813 · Cited by 281 · see citing works
Cell Death Mechanisms and Modulation in Traumatic Brain Injury
Stoica, B. A., & Faden, A. I. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2009.10.023 · Cited by 277 · see citing works
Chen, X.-H., Siman, R., Iwata, A., Meaney, D. F., Trojanowski, J. Q., & Smith, D. H. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63303-2 · Cited by 271 · see citing works
Chen, X., Johnson, V. E., Uryu, K., Trojanowski, J. Q., & Smith, D. H. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00176.x · Cited by 267 · see citing works
Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis
Bales, J. W., Wagner, A. K., Kline, A. E., & Dixon, C. E. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.03.011 · Cited by 267 · see citing works
You, Z., Savitz, S. I., Yang, J., Degterev, A., Yuan, J., Cuny, G. D., Moskowitz, M. A., & Whalen, M. J. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.44 · Cited by 266 · see citing works
Cole, S. L., & Vassar, R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800015200 · Cited by 262 · see citing works
Su, J. H., Zhao, M., Anderson, A. J., Srinivasan, A. N., & Cotman, C. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02018-2 · Cited by 260 · see citing works
Amyloid β-peptide induces apoptosis-related events in synapses and dendrites
Mattson, M. P., Partin, J. V., & Begley, J. G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00763-x · Cited by 260 · see citing works
Alzheimer’s disease after remote head injury: an incidence study
Schofield, P. W., Tang, M., Marder, K., Bell, K., Dooneief, G., Chun, M., Sano, M., Stern, Y., & Mayeux, R. (1997) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.2.119 · Cited by 260 · see citing works
THE ASSOCIATION BETWEEN HEAD TRAUMA AND ALZHEIMER'S DISEASE
Graves, A. B., White, E., Koepsell, T. D., Reifler, B. V., van Belle, G., Larson, E. B., & Raskind, M. A. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115523 · Cited by 257 · see citing works
Tran, H. T., LaFerla, F. M., Holtzman, D. M., & Brody, D. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0858-11.2011 · Cited by 255 · see citing works
Marklund, N., & Hillered, L. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01163.x · Cited by 254 · see citing works
Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
Decuypere, J.-P., Parys, J. B., & Bultynck, G. (2012) · Cells · doi:10.3390/cells1030284 · Cited by 251 · see citing works
Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury
Loane, D. J., Pocivavsek, A., Moussa, C. E.-H., Thompson, R., Matsuoka, Y., Faden, A. I., Rebeck, G. W., & Burns, M. P. (2009) · Nature Medicine · doi:10.1038/nm.1940 · Cited by 246 · see citing works
Cognitive decline in older adults with a history of traumatic brain injury
Moretti, L., Cristofori, I., Weaver, S. M., Chau, A., Tremont, J. N. P., & Grafman, J. H. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70226-0 · Cited by 244 · see citing works
Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer’s disease.
Lorenzl, S. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(03)00004-4 · Cited by 243 · see citing works
Reddy, P. H., Mańczak, M., Mao, P., Calkins, M. J., Reddy, A. P., & Shirendeb, U. P. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100504 · Cited by 240 · see citing works
Biegon, A. R., Fry, P. A., Paden, C. M., Alexandrovich, A. G., Tsenter, J., & Shohami, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305741101 · Cited by 240 · see citing works
Rao, V. L. R., Başkaya, M. K., Dog⫧an, A., Rothstein, J. D., & Dempsey, R. J. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052020.x · Cited by 231 · see citing works
Scheff, S. W., & Sullivan, P. G. (1999) · Journal of Neurotrauma · doi:10.1089/neu.1999.16.783 · Cited by 227 · see citing works
Cell death induction by TNF: a matter of self control
Wallach, D. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01015-3 · Cited by 226 · see citing works
Witgen, B. M., Lifshitz, J., Smith, M. L., Schwarzbach, E., Liang, S., Grady, M. S., & Cohen, A. S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.052 · Cited by 225 · see citing works
Yasojima, K., McGeer, E. G., & McGeer, P. L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03008-6 · Cited by 224 · see citing works
Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury
Zhang, X., Chen, Y.-M., Jenkins, L., Kochanek, P., & Clark, R. (2004) · Critical Care · doi:10.1186/cc2950 · Cited by 223 · see citing works
Gao, X., Deng, P., Xu, Z. C., & Chen, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024566 · Cited by 218 · see citing works
Calpain as a Therapeutic Target in Traumatic Brain Injury
Saatman, K. E., Creed, J. A., & Raghupathi, R. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2009.11.002 · Cited by 218 · see citing works
Molecular mechanisms in the pathogenesis of traumatic brain injury.
Ray, S. K., Dixon, C. E., & Banik, N. L. (2002) · PubMed · doi:10.14670/hh-17.1137 · Cited by 215 · see citing works
Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease
Louneva, N., Cohen, J. W., Han, L., Talbot, K., Wilson, R. S., Bennett, D. A., Trojanowski, J. Q., & Arnold, S. E. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080434 · Cited by 207 · see citing works
Closed-head minimal traumatic brain injury produces long-term cognitive deficits in mice.
Zohar, O., Schreiber, S., Getslev, V., Schwartz, J. P., Mullins, P. G., & Pick, C. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00048-4 · Cited by 205 · see citing works
Trinchese, F., Fà, M., Liu, S., Zhang, H., Hidalgo, A., Schmidt, S. D., Yamaguchi, H., Yoshii, N., Mathews, P. M., Nixon, R. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34254 · Cited by 205 · see citing works
Inflammatory changes parallel the early stages of Alzheimer disease
Parachikova, A., Agadjanyan, M. G., Cribbs, D. H., Blurton-Jones, M., Perreau, V., Rogers, J., Beach, T. G., & Cotman, C. W. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.014 · Cited by 203 · see citing works
Blaylock, R. L., & Maroon, J. C. (2011) · Surgical Neurology International · doi:10.4103/2152-7806.83391 · Cited by 202 · see citing works
Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease
Scott, H. A., Gebhardt, F. M., Mitrovic, A. D., Vandenberg, R. J., & Dodd, P. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.008 · Cited by 202 · see citing works
Apolipoprotein E and the CNS Response to Injury
Laskowitz, D. T., Horsburgh, K., & Roses, A. D. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199805000-00001 · Cited by 201 · see citing works
NMDA Receptor Activation Inhibits α-Secretase and Promotes Neuronal Amyloid-β Production
Lesné, S., Ali, C., Gabriel, C., Croci, N., MacKenzie, E. T., Glabe, C. G., Plotkine, M., Marchand‐Leroux, C., Vivien, D., & Buisson, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0849-05.2005 · Cited by 198 · see citing works
Amyloid β accumulation in axons after traumatic brain injury in humans
Smith, D. H., Chen, X.-H., Iwata, A., & Graham, D. (2003) · Journal of neurosurgery · doi:10.3171/jns.2003.98.5.1072 · Cited by 196 · see citing works
Bordji, K., Becerril-Ortega, J., Nicole, O., & Buisson, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3021-10.2010 · Cited by 195 · see citing works
Luo, C., Li, B.-X., Li, Q.-Q., Chen, X.-P., Sun, Y., Bao, H., Dai, D.-K., Shen, Y., Xu, H., Ni, H., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.021 · Cited by 194 · see citing works
Acosta, S. A., Tajiri, N., Shinozuka, K., Ishikawa, H., Grimmig, B. A., Diamond, D. M., Sanberg, P. R., Bickford, P. C., Kaneko, Y., & Borlongan, C. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053376 · Cited by 194 · see citing works
Dragicevic, N., Mamcarz, M. B., Zhu, Y., Buzzeo, R. W., Tan, J., Arendash, G. W., & Bradshaw, P. C. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100342 · Cited by 193 · see citing works
Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain.
Brugg, B., Lemaigre‐Dubreuil, Y., Huber, G., Wollman, E. E., Delhaye‐Bouchaud, N., & Mariani, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.3032 · Cited by 191 · see citing works
α- and β-secretase: profound changes in Alzheimer’s disease
Tyler, S., Dawbarn, D., Wilcock, G. K., & Allen, S. J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02635-9 · Cited by 188 · see citing works
Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury
Sandhir, R., Onyszchuk, G., & Berman, N. E. J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.06.013 · Cited by 184 · see citing works
Posmantur, R. M., Kampfl, A., Siman, R., Liu, S. J., Zhao, X., Clifton, G. L., & Hayes, R. L. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00483-6 · Cited by 183 · see citing works
Blasko, I., Beer, R., Bigl, M., Apelt, J., Franz, G., Rudzki, D., Ransmayr, G. N., Kampfl, A., & Schliebs, R. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0095-6 · Cited by 183 · see citing works
Clausen, F., Hånell, A., Björk, M., Hillered, L., Mir, A., Gram, H., & Marklund, N. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06820.x · Cited by 181 · see citing works
Lloyd, E., Somera-Molina, K., Eldik, L. J. V., Watterson, D. M., & Wainwright, M. S. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-28 · Cited by 180 · see citing works
All-you-can-eat: autophagy in neurodegeneration and neuroprotection
Jaeger, P. A., & Wyss‐Coray, T. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-16 · Cited by 175 · see citing works
Fitz, N. F., Cronican, A., Pham, T., Fogg, A., Fauq, A. H., Chapman, R., Lefterov, I., & Koldamova, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1051-10.2010 · Cited by 175 · see citing works
Interactions between APP secretases and inflammatory mediators
Sastre, M., Walter, J., & Gentleman, S. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-25 · Cited by 172 · see citing works
Truncation and Activation of Calcineurin A by Calpain I in Alzheimer Disease Brain
Liu, F., Grundke, I., Iqbal, K., Oda, Y., Tomizawa, K., & Gong, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507475200 · Cited by 171 · see citing works
Opposing Roles for Reactive Astrocytes following Traumatic Brain Injury
Laird, M. D., Vender, J. R., & Dhandapani, K. M. (2008) · Neurosignals · doi:10.1159/000111560 · Cited by 171 · see citing works
Animal models of traumatic brain injury: A critical evaluation
O'Connor, W. T., Smyth, A., & Gilchrist, M. D. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.001 · Cited by 170 · see citing works
Synaptogenesis in the Hippocampal CA1 Field following Traumatic Brain Injury
Scheff, S., Price, D., Hicks, R., Baldwin, S. A., Robinson, S., & Brackney, C. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.719 · Cited by 167 · see citing works
Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice
Ojo, J.-O., Mouzon, B., Greenberg, M. B., Bachmeier, C., Mullan, M., & Crawford, F. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182814cdf · Cited by 166 · see citing works
Head Injury and Risk of Alzheimer's Disease by Apolipoprotein E Genotype
O’Meara, E. S., Kukull, W. A., Sheppard, L. A., Bowen, J., McCormick, W. C., Teri, L. L., Pfanschmidt, M. L., Thompson, J. D., Schellenberg, G. D., & Larson, E. B. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009290 · Cited by 165 · see citing works
Apoptotic and Antiapoptotic Mechanisms after Traumatic Brain Injury
Keane, R. W., Kraydieh, S., Lotocki, G., Alonso, O. F., Aldana, P. M. H., & Dietrich, W. D. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00007 · Cited by 165 · see citing works
Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease
Supnet, C. B., & Борисович, Б. И. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100306 · Cited by 160 · see citing works
Sauerbeck, A. D., Gao, J., Readnower, R. D., Liu, M., Pauly, J. R., Bing, G., & Sullivan, P. G. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.10.003 · Cited by 156 · see citing works
LeBlanc, A. C. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07837.1995 · Cited by 156 · see citing works
DeKosky, S. T., Abrahamson, E. E., Ciallella, J. R., Paljug, W. R., Wisniewski, S. R., Clark, R. S. B., & Ikonomovic, M. D. (2007) · Archives of Neurology · doi:10.1001/archneur.64.4.541 · Cited by 152 · see citing works
Decreased Expression of Glutamate Transporters in Astrocytes after Human Traumatic Brain Injury
van Landeghem, F. K. H., Weiss, T., Oehmichen, M., & von Deimling, A. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.1518 · Cited by 151 · see citing works
Baldwin, S. A., Gibson, T. R., CALLIHAN, C. T., Sullivan, P. G., PALMER, E., & Scheff, S. W. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.385 · Cited by 140 · see citing works
Experimental traumatic brain injury
Albert-Weißenberger, C., & Sirén, A. (2010) · Experimental & Translational Stroke Medicine · doi:10.1186/2040-7378-2-16 · Cited by 139 · see citing works
Enduring suppression of hippocampal long-term potentiation following traumatic brain injury in rat
Miyazaki, S., Katayama, Y., Lyeth, B. G., Jenkins, L. W., DeWitt, D. S., Goldberg, S. J., Newlon, P. G., & Hayes, R. L. (1992) · Brain Research · doi:10.1016/0006-8993(92)91232-4 · Cited by 138 · see citing works
Proteolytic mechanisms in necrotic cell death and neurodegeneration
Artal‐Sanz, M., & Tavernarakis, N. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.052 · Cited by 138 · see citing works
Fitz, N. F., Cronican, A. A., Saleem, M., Fauq, A. H., Chapman, R., Lefterov, I. M., & Koldamova, R. P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1937-12.2012 · Cited by 138 · see citing works
Marklund, N., Blennow, K., Zetterberg, H., Ronne-Engström, E., Enblad, P., & Hillered, L. (2009) · Journal of Neurosurgery · doi:10.3171/2008.9.jns08584 · Cited by 135 · see citing works
Rao, V. L. R., Dog⫧an, A., Todd, K. G., Bowen, K. K., & Dempsey, R. J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02617-8 · Cited by 135 · see citing works
Osteen, C. L., Moore, A. H., Prins, M., & Hovda, D. (2001) · Journal of Neurotrauma · doi:10.1089/08977150150502587 · Cited by 131 · see citing works
A Role for Calcineurin in Alzheimers Disease
Reese, L. C., & Taglialatela, G. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376316 · Cited by 131 · see citing works
D’Ambrosio, R., Maris, D. O., Grady, M. S., Winn, H. R., & Janigro, D. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01412-1 · Cited by 131 · see citing works
Long-term potentiation deficits and excitability changes following traumatic brain injury
Reeves, T. M., Lyeth, B. G., & Povlishock, J. T. (1995) · Experimental Brain Research · doi:10.1007/bf00241120 · Cited by 130 · see citing works
Barnes, N. Y., Li, L., Yoshikawa, K., Schwartz, L. M., Oppenheim, R. W., & Milligan, C. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-15-05869.1998 · Cited by 129 · see citing works
Sanders, M. J., Sick, T. J., Pérez‐Pinzón, M. A., Dietrich, W. D., & Green, E. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)01986-7 · Cited by 125 · see citing works
Necrostatin-1 Suppresses Autophagy and Apoptosis in Mice Traumatic Brain Injury Model
Wang, Y.-Q., Wang, L., Zhang, M., Wang, T., Bao, H., Liu, W., Dai, D.-K., Zhang, L., Chang, P., Dong, W., et al. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0791-4 · Cited by 125 · see citing works
Onyszchuk, G., He, Y., Berman, N. E. J., & Brooks, W. M. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0430 · Cited by 120 · see citing works
Albensi, B. C., Sullivan, P. G., Thompson, M. B., Scheff, S. W., & Mattson, M. P. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7338 · Cited by 118 · see citing works
Sun, D. A., Deshpande, L. S., Sombati, S., Baranova, A., Wilson, M. S., Hamm, R. J., & DeLorenzo, R. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06156.x · Cited by 118 · see citing works
Knoblach, S. M., Nikolaeva, M. A., Huang, X., Fan, L., Krajewski, S., Reed, J. C., & Faden, A. I. (2002) · Journal of Neurotrauma · doi:10.1089/08977150260337967 · Cited by 117 · see citing works
Caspase Gene Expression in the Brain as a Function of the Clinical Progression of Alzheimer Disease
Pompl, P. N., Yemul, S., Xiang, Z., Ho, L., Haroutunian, V., Purohit, D. P., Mohs, R. C., & Pasinetti, G. M. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.369 · Cited by 117 · see citing works
Ferretti, M. T., Allard, S., Partridge, V., Ducatenzeiler, A., & Cuello, A. C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-62 · Cited by 115 · see citing works
The role of caspases in Alzheimer’s disease; potential novel therapeutic opportunities
Rohn, T. T. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0463-2 · Cited by 112 · see citing works
Ubiquitin Regulates GGA3-mediated Degradation of BACE1
Kang, E. L., Cameron, A. N., Piazza, F., Walker, K. R., & Tesco, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092742 · Cited by 111 · see citing works
Self-citationOxidative stress in head trauma in aging
Shao, C., Roberts, K. N., Markesbery, W. R., Scheff, S. W., & Lovell, M. A. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.03.007 · Cited by 111 · see citing works
Hudry, E., Wu, H.-Y., Arbel‐Ornath, M., Hashimoto, T., Matsouaka, R., Fan, Z., Spires‐Jones, T. L., Betensky, R. A., Bacskai, B. J., & Hyman, B. T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6439-11.2012 · Cited by 110 · see citing works
Gentleman, S. M., Greenberg, B., Savage, M. J., Noori, M., Newman, S. J., Roberts, G. W., Griffin, W. S. T., & Graham, D. I. (1997) · Neuroreport · doi:10.1097/00001756-199704140-00039 · Cited by 110 · see citing works
Liang, B., Duan, B.-Y., Zhou, X., Gong, J., & Luo, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.117960 · Cited by 109 · see citing works
Anti-Inflammatory Impact of Minocycline in a Mouse Model of Tauopathy
Garwood, C. J., Cooper, J. D., Hanger, D. P., & Noble, W. (2010) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2010.00136 · Cited by 106 · see citing works
Early Mitochondrial Dysfunction after Cortical Contusion Injury
Gilmer, L. K., Roberts, K. N., Joy, K. M., Sullivan, P. G., & Scheff, S. W. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0857 · Cited by 105 · see citing works
Wakade, C. G., Sukumari‐Ramesh, S., Laird, M. D., Dhandapani, K. M., & Vender, J. R. (2010) · Journal of neurosurgery · doi:10.3171/2010.3.jns091212 · Cited by 101 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Military-related traumatic brain injury and neurodegeneration
McKee, A. C., & Robinson, M. E. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.04.003 · Cited by 423 · see citing works
McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422 · see citing works
Begemann, M. J., Brand, B. A., Ćurčić-Blake, B., Aleman, A., & Sommer, I. E. (2020) · Psychological Medicine · doi:10.1017/s0033291720003670 · Cited by 368 · see citing works
Pathogenesis of Brain Edema and Investigation into Anti-Edema Drugs
Michinaga, S., & Koyama, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16059949 · Cited by 339 · see citing works
Traumatic Brain Injury Induces Tau Aggregation and Spreading
Edwards, G., Zhao, J., Dash, P. K., Soto, C., & Moreno-Gonzalez, I. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2018.6348 · Cited by 195 · see citing works
Neurological consequences of traumatic brain injuries in sports
Ling, H., Hardy, J., & Zetterberg, H. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.03.012 · Cited by 197 · see citing works
Tominaga, T., Shimada, R., Okada, Y., Kawamata, T., & Kibayashi, K. (2019) · PLOS ONE · doi:10.1371/journal.pone.0213673 · Cited by 66 · see citing works
Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury
Reifschneider, K., Auble, B., & Rose, S. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4081536 · Cited by 66 · see citing works
“Secondary injury typically develops within hours or days to weeks following the primary injury [12].”
BackgroundNIH toolbox cognition tests following traumatic brain injury: Frequency of low scores.
Holdnack, J. A., Iverson, G. L., Silverberg, N. D., Tulsky, D. S., & Heinemann, A. W. (2017) · Rehabilitation Psychology · doi:10.1037/rep0000145 · Cited by 23 · see citing works
- Authors
- Walker, K. R., & Tesco, G.
- Affiliations
- Tufts University (US)
- Corresponding author
- Tesco, Giuseppina
- ORCID
- Tesco, Giuseppina
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 5
- Pages
- 29-29
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC3705200
- OpenAlex
- W2008657247
- Cited by
- 265
- References
- 275
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 11 · 2023: 21 · 2022: 23 · 2021: 15 · 2020: 39 · 2019: 28 · 2018: 14 · 2017: 27 · 2016: 21 · 2015: 19 · 2014: 11 · 2013: 5
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Cure Alzheimer's Fund
- National Institute on Aging (R01AG033016, R01AG025952)
- Topics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- traumatic brain injury, cognitive impairment, secondary injury mechanisms, chronic traumatic encephalopathy, Alzheimer's disease, amyloid-beta, tau protein, neurodegeneration, axonal injury, synaptic dysfunction, neuronal loss, dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
