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Cited by 4Congenital heart defects researchCardiovascular Effects of ExerciseCardiac electrophysiology and arrhythmias

Desmosomes in Cell Fate Determination: From Cardiogenesis to Cardiomyopathy

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Moazzen, Hoda, Bolaji, Mistura Dolapo, Leube, Rudolf E.·2023·Cells
DOI 10.3390/cells12172122PMC PMC10487268
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Abstract

Desmosomes play a vital role in providing structural integrity to tissues that experience significant mechanical tension, including the heart. Deficiencies in desmosomal proteins lead to the development of arrhythmogenic cardiomyopathy (AC). The limited availability of preventative measures in clinical settings underscores the pressing need to gain a comprehensive understanding of desmosomal proteins not only in cardiomyocytes but also in non-myocyte residents of the heart, as they actively contribute to the progression of cardiomyopathy. This review focuses specifically on the impact of desmosome deficiency on epi- and endocardial cells. We highlight the intricate cross-talk between desmosomal proteins mutations and signaling pathways involved in the regulation of epicardial cell fate transition. We further emphasize that the consequences of desmosome deficiency differ between the embryonic and adult heart leading to enhanced erythropoiesis during heart development and enhanced fibrogenesis in the mature heart. We suggest that triggering epi-/endocardial cells and fibroblasts that are in different “states” involve the same pathways but lead to different pathological outcomes. Understanding the details of the different responses must be considered when developing interventions and therapeutic strategies.

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  • Epicardial cells contribute by transdifferentiating into fibro-adipogenic progenitors.

    “Epicardial cells additionally contribute by transdifferentiating into fibro-adipogenic progenitors [104,105] via pathways described in Section 4.2 and Section 4.4.”

    From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [104]

    Section 3.2 says some epicardial cells undergo epithelial-to-mesenchymal transition and can differentiate into fibroblasts or mesenchymal stem cells. Section 6.2 reports adipose- and connective-tissue-associated markers in desmosome-deficient epicardial cells, but does not establish that epicardial cells transdifferentiate into fibro-adipogenic progenitors. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Moazzen, H., Bolaji, M. D., & Leube, R. E.
Affiliations
RWTH Aachen University (DE)
Corresponding author
Moazzen, Hoda
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2023-08-22
Volume
12
Issue
17
Pages
2122
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells12172122
PMC
PMC10487268
OpenAlex
W4386069988
Cited by
4
References
2
Citations by year
2026: 2 · 2025: 1 · 2023: 1
FWCI
0.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
  • RWTH Publications (RWTH Aachen)
Funders
START Program of the Faculty of Medicine RWTH Aachen University (81-02.04.2020.A323)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
desmosomes, desmosomal proteins, arrhythmogenic cardiomyopathy, heart development, epicardial cells, endocardial cells, cell fate determination, signaling pathways, erythropoiesis, myocardial fibrosis, fibroblasts
MeSH terms
Adult, Cell Differentiation, Desmosomes, Humans, Cardiomyopathies, Epirubicin, Myocytes, Cardiac

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