The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy
Open accessAbstract
RATIONALE: Mutations in the intercalated disc proteins, such as plakophilin 2 (PKP2), cause arrhythmogenic cardiomyopathy (AC). AC is characterized by the replacement of cardiac myocytes by fibro-adipocytes, cardiac dysfunction, arrhythmias, and sudden death. OBJECTIVE: To delineate the molecular pathogenesis of AC. METHODS AND RESULTS: Localization and levels of selected intercalated disc proteins, including signaling molecules, were markedly reduced in human hearts with AC. Altered protein constituents of intercalated discs were associated with activation of the upstream Hippo molecules in the human hearts, in Nkx2.5-Cre:Dsp(W/F) and Myh6:Jup mouse models of AC, and in the PKP2 knockdown HL-1 myocytes (HL-1(PKP2:shRNA)). Level of active protein kinase C-α isoform, which requires PKP2 for activity, was reduced. In contrast, neurofibromin 2 (or Merlin), a molecule upstream of the Hippo pathway and that is inactivated by protein kinase C-α isoform, was activated. Consequently, the downstream Hippo molecules mammalian STE20-like protein kinases 1/2 (MST1/2), large tumor suppressor kinases 1/2 (LATS1/2), and Yes-associated protein (YAP) (the latter is the effector of the pathway) were phosphorylated. Coimmunoprecipitation detected binding of phosphorylated YAP, phosphorylated β-catenin, and junction protein plakoglobin (the latter translocated from the junction). RNA sequencing, transcript quantitative polymerase chain reaction, and reporter assays showed suppressed activity of SV40 transcriptional enhancer factor domain (TEAD) and transcription factor 7-like 2 (TCF7L2), which are transcription factors of the Hippo and the canonical Wnt signaling, respectively. In contrast, adipogenesis was enhanced. Simultaneous knockdown of Lats1/2, molecules upstream to YAP, rescued inactivation of YAP and β-catenin and adipogenesis in the HL-1(PKP2:shRNA) myocytes. CONCLUSIONS: Molecular remodeling of the intercalated discs leads to pathogenic activation of the Hippo pathway, suppression of the canonical Wnt signaling, and enhanced adipogenesis in AC. The findings offer novel mechanisms for the pathogenesis of AC.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Suppression of canonical Wnt/β-catenin signaling leads to ACM, prominently through competition with nuclear localization of JUP, rather than through β-catenin degradation.
“In a landmark study by Garcia-Gras E et al. [77], these authors demonstrated that suppression of canonical Wnt/β-catenin signaling leads to ACM, prominently through competition with nuclear localization of JUP, rather than through β-catenin degradation [77,79,80].”
From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [79]
The Results section ('Suppression of the canonical Wnt signaling'; page unavailable) reports suppressed canonical Wnt activity in ACM models. But the paper does not establish competition with nuclear JUP as the principal mechanism: its Discussion instead proposes sequestration of β-catenin through interactions with YAP and JUP. Its degradation experiments do not establish the claimed contrast between nuclear competition and β-catenin degradation. (LLM, conf=0.86)
Experimental — accuracy not yet measuredLoss of nuclear YAP in conjunction with Wnt/β-catenin suppression further drives adipogenesis and maladaptive fibrotic repair.
“The loss of nuclear YAP in conjunction with Wnt/β-catenin suppression further drives adipogenesis and maladaptive fibrotic repair [79,80].”
From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [79]
The Discussion (page not provided) links increased membrane localization of YAP and β-catenin, suppressed Hippo and canonical Wnt signaling, and enhanced adipogenesis in arrhythmogenic cardiomyopathy models. It describes Wnt suppression as a possible contributor, however, and does not establish that these changes drive maladaptive fibrotic repair. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn ACM, prior studies have demonstrated aberrant Hippo pathway activation and subsequent YAP inactivation.
“Conversely, in ACM, prior studies have demonstrated aberrant Hippo pathway activation and subsequent YAP inactivation [79].”
From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [79]
Recent evidence implicates fibro-adipogenic progenitors and epicardial-derived cells as primary sources, and they typically show epicardial to endocardial migration.
“Recent evidence implicates fibro-adipogenic progenitors and epicardial-derived cells as primary sources, and they typically show an epicardial to endocardial migration [77,79,83,84].”
From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [79]
The Results section reports Hippo-pathway changes in epicardial regions, but does not identify epicardial-derived cells or trace their migration. The References list names studies of cardiac progenitors as adipocyte sources; this paper’s text does not establish that fibro-adipogenic progenitors and epicardial-derived cells are primary sources or that they typically migrate toward the endocardium (searched: epicardial, progenitor, migration). (LLM, conf=0.75)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Wnt/β-catenin signaling and disease
Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554 · see citing works
Marcus, F. I., McKenna, W. J., Sherrill, D., Basso, C., Bauce, B., Bluemke, D. A., Calkins, H., Corrado, D., Cox, M. G. P. J., Daubert, J. P., et al. (2010) · Circulation · doi:10.1161/circulationaha.108.840827 · Cited by 2,676 · see citing works
Aragona, M., Panciera, T., Manfrin, A., Giulitti, S., Michielin, F., Elvassore, N., Dupont, S., & Piccolo, S. (2013) · Cell · doi:10.1016/j.cell.2013.07.042 · Cited by 1,651 · see citing works
Marcus, G. M., McKenna, W. J., Sherrill, D., Basso, C., Bauce, B., Bluemke, D. A., Calkins, H. G., Corrado, D., Cox, M. G. P. J., Daubert, J. P., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq025 · Cited by 1,610 · see citing works
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205 · see citing works
Phosphate-binding Tag, a New Tool to Visualize Phosphorylated Proteins
Kinoshita, E., Kinoshita‐Kikuta, E., Takiyama, K., & Koike, T. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.t500024-mcp200 · Cited by 1,105 · see citing works
McKoy, G., Protonotarios, N., Crosby, A. H., Tsatsopoulou, A., Anastasakis, A., Coonar, A. S., Norman, M. W., BABOONIAN, C., Jeffery, S., & McKenna, W. J. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02379-5 · Cited by 1,096 · see citing works
Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size
Heallen, T. R., Zhang, M., Wang, J., Bonilla-Claudio, M., Klysik, E., Johnson, R. L., & Martin, J. F. (2011) · Science · doi:10.1126/science.1199010 · Cited by 1,092 · see citing works
Corrado, D., Basso, C., Thiene, G., McKenna, W. J., Davies, M. J., Fontaliran, F., Nava, A., Silvestri, F., Blomstrom-Lundqvist, C., Wlodarska, E. K., et al. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00332-x · Cited by 978 · see citing works
Arrhythmogenic right ventricular cardiomyopathy
Basso, C., Corrado, D., Marcus, G. M., Nava, A. K., & Thiene, G. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60256-7 · Cited by 928 · see citing works
Hippo pathway effector Yap promotes cardiac regeneration
Xin, M., Kim, Y., Sutherland, L. B., Murakami, M., Qi, X., McAnally, J., Porrello, E. R., Mahmoud, A. I., Tan, W., Shelton, J. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313192110 · Cited by 895 · see citing works
Arrhythmogenic Right Ventricular Cardiomyopathy: Dysplasia, Dystrophy, or Myocarditis?
Basso, C., Thiene, G., Corrado, D., Angelini, A., Nava, A., & Valente, M. (1996) · Circulation · doi:10.1161/01.cir.94.5.983 · Cited by 890 · see citing works
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
Li, V. S. W., Ng, S. S., Boersema, P. J., Low, T. Y., Karthaus, W. R., Gerlach, J. P., Mohammed, S., Heck, A. J. R., Maurice, M. M., Mahmoudi, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.002 · Cited by 889 · see citing works
Gerull, B., Heuser, A., Wichter, T., Paul, M., Basson, C. T., McDermott, D. A., Lerman, B. B., Markowitz, S., Ellinor, P. T., MacRae, C. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1461 · Cited by 821 · see citing works
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
Kim, N.-G., Koh, E., Chen, X., & Gumbiner, B. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103345108 · Cited by 698 · see citing works
Garcia-Gras, E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27751 · Cited by 623 · see citing works
von Gise, A., Lin, Z., Schlegelmilch, K., Honor, L. B., Pan, G. M., Buck, J. N., Ma, Q., Ishiwata, T., Zhou, B., Camargo, F. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116136109 · Cited by 573 · see citing works
Xin, M., Kim, Y., Sutherland, L. B., Qi, X., McAnally, J., Schwartz, R. J., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2011) · Science Signaling · doi:10.1126/scisignal.2002278 · Cited by 549 · see citing works
Yin, F., Yu, J., Zheng, Y., Chen, Q., Zhang, N., & Pan, D. (2013) · Cell · doi:10.1016/j.cell.2013.08.025 · Cited by 506 · see citing works
A New Diagnostic Test for Arrhythmogenic Right Ventricular Cardiomyopathy
Asimaki, A., Tandri, H., Huang, H., Halushka, M. K., Gautam, S., Basso, C., Thiene, G., Tsatsopoulou, A., Protonotarios, N., McKenna, W. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808138 · Cited by 456 · see citing works
Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos
Hirate, Y., Hirahara, S., Inoue, K., Suzuki, A., Alarcón, V. B., Akimoto, K., Hirai, T., Hara, T., Adachi, M., Chida, K., et al. (2013) · Current Biology · doi:10.1016/j.cub.2013.05.014 · Cited by 418 · see citing works
Lloyd, A. C. (2013) · Cell · doi:10.1016/j.cell.2013.08.053 · Cited by 393 · see citing works
BURKE, A. P., Farb, A. A., Tashko, G., & Virmani, R. (1998) · Circulation · doi:10.1161/01.cir.97.16.1571 · Cited by 362 · see citing works
NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctionsPreprint
Lallemand, D., Curto, M., Saotome, I., Giovannini, M., & McClatchey, A. I. (2003) · Genes & Development · doi:10.1101/gad.1054603 · Cited by 324 · see citing works
The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila
Baumgartner, R., Poernbacher, I., Buser, N., Hafen, E., & Stocker, H. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.013 · Cited by 320 · see citing works
The Cardiac Desmosome and Arrhythmogenic Cardiomyopathies
Delmar, M., & McKenna, W. J. (2010) · Circulation Research · doi:10.1161/circresaha.110.223412 · Cited by 307 · see citing works
Dalal, D., Molin, L. H., Piccini, J. P., Tichnell, C., James, C. A., Bomma, C. S., Prakasa, K., Towbin, J. A., Marcus, G. M., Spevak, P. J., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.568642 · Cited by 246 · see citing works
Franke, W. W., Borrmann, C. M., Gründ, C., & Pieperhoff, S. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2005.11.003 · Cited by 219 · see citing works
SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage
Seo, E., Basu-Roy, U., Gunaratne, P. H., Coarfa, C., Lim, D.-S., Basilico, C., & Mansukhani, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.029 · Cited by 216 · see citing works
Rizzo, S., Lodder, E. M., Verkerk, A. O., Wolswinkel, R., Beekman, L., Pilichou, K., Basso, C., Remme, C. A., Thiene, G., & Bezzina, C. R. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs219 · Cited by 211 · see citing works
Desmosome assembly and dynamics
Nekrasova, O. E., & Green, K. J. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.06.004 · Cited by 177 · see citing works
Lombardi, R., Cabreira-Hansen, M. D. G., Bell, A., Fromm, R., Willerson, J. T., & Marian, A. J. (2011) · Circulation Research · doi:10.1161/circresaha.111.255075 · Cited by 159 · see citing works
Self-citationNoorman, M., Hakim, S., Kessler, E., Groeneweg, J. A., Cox, M. G. P. J., Asimaki, A., van Rijen, H. V. M., van Stuijvenberg, L., Chkourko, H., van der Heyden, M. A. G., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2012.11.018 · Cited by 154 · see citing works
Lombardi, R., Dong, J., Rodrı́guez, G., Bell, A., Leung, T. K., Schwartz, R. J., Willerson, J. T., Brugada, R., & Marian, A. J. (2009) · Circulation Research · doi:10.1161/circresaha.109.196899 · Cited by 148 · see citing works
Self-citationChen, S. N., Czernuszewicz, G. Z., Tan, Y., Lombardi, R., Jin, J., Willerson, J. T., & Marian, A. J. (2012) · Circulation Research · doi:10.1161/circresaha.112.270207 · Cited by 147 · see citing works
Self-citationPlakophilin 2: a critical scaffold for PKCα that regulates intercellular junction assembly
Zubek, A., Hobbs, R. P., Amargo, E. V., Garcia, N. J., Hsieh, S. N., Chen, X., Wahl, J. K., Denning, M. F., & Green, K. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712133 · Cited by 147 · see citing works
Lats2 Is a Negative Regulator of Myocyte Size in the Heart
Matsui, Y., Nakano, N., Shao, D., Gao, S., Luo, W., Hong, C., Zhai, P., Holle, E., Yu, X., Yabuta, N., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.180042 · Cited by 133 · see citing works
Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus
Li, W., Cooper, J. M., Karajannis, M. A., & Giancotti, F. G. (2012) · EMBO Reports · doi:10.1038/embor.2012.11 · Cited by 129 · see citing works
The area composita of adhering junctions connecting heart muscle cells of vertebrates.
Pieperhoff, S., & Franke, W. W. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.02.005 · Cited by 128 · see citing works
The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster
Grusche, F., Degoutin, J. L., Richardson, H. E., & Harvey, K. F. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.020 · Cited by 127 · see citing works
A study on the interactions between heparan sulfate proteoglycans and Wnt proteins
Fuerer, C., Habib, S. J., & Nusse, R. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22067 · Cited by 122 · see citing works
Kamachi, Y., & Kondoh, H. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5206-5215.1993 · Cited by 121 · see citing works
Zhou, L., Ercolano, E., Ammoun, S., Schmid, M. C., Barczyk, M., & Hanemann, C. O. (2011) · Neoplasia · doi:10.1593/neo.111060 · Cited by 91 · see citing works
Swope, D., Cheng, L., Gao, E., Li, J., & Radice, G. L. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06188-11 · Cited by 91 · see citing works
Hippo–YAP and mTOR pathways collaborate to regulate organ size
Csibi, A., & Blenis, J. (2012) · Nature Cell Biology · doi:10.1038/ncb2634 · Cited by 79 · see citing works
Mangoura, D. A., Sun, Y., Li, C., Singh, D., Gutmann, D. H., Flores, A., Ahmed, M., & Vallianatos, G. (2005) · Oncogene · doi:10.1038/sj.onc.1209113 · Cited by 79 · see citing works
The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth
Hamaratoǧlu, F., Gajewski, K. M., Sansores-García, L., Morrison, C. M., Tao, C., & Halder, G. A. (2009) · Journal of Cell Science · doi:10.1242/jcs.046482 · Cited by 78 · see citing works
Rangwala, R. A., Banine, F., Borg, J., & Sherman, L. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414154200 · Cited by 69 · see citing works
Kirchner, F., Schuetz, A., Boldt, L., Martens, K., Dittmar, G., Haverkamp, W., Thierfelder, L., Heinemann, U., & Gerull, B. (2012) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.111.961854 · Cited by 68 · see citing works
Merlin, a multi‐suppressor from cell membrane to the nucleus
Zhou, L., & Hanemann, C. O. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.016 · Cited by 64 · see citing works
Lombardi, R., Bell, A., Senthil, V., Sidhu, J. S., Noseda, M., Roberts, R., & Marian, A. J. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn078 · Cited by 57 · see citing works
Self-citationGehmlich, K., Syrris, P., Peskett, E., Evans, A. L., Ehler, E., Asimaki, A., Anastasakis, A., Tsatsopoulou, A., Vouliotis, A.-I., Stefanadis, C., et al. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq353 · Cited by 57 · see citing works
Plakoglobin has both structural and signalling roles in zebrafish development
Martin, E. D., Moriarty, M. A., Byrnes, L., & Grealy, M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.11.036 · Cited by 55 · see citing works
Ruggiero, A., Chen, S. N., Lombardi, R., Rodrı́guez, G., & Marian, A. J. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs294 · Cited by 52 · see citing works
Self-citationLombardi, R., & Marian, A. J. (2011) · Pediatric Cardiology · doi:10.1007/s00246-011-9890-2 · Cited by 48 · see citing works
Self-citationBeyond cell adhesion: The role of armadillo proteins in the heart
Swope, D., Li, J., & Radice, G. L. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.09.025 · Cited by 40 · see citing works
Munkholm, J., Christensen, A. H., Svendsen, J. H., & Andersen, C. B. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.08.044 · Cited by 35 · see citing works
Laulajainen, M., Muranen, T. E., Nyman, T. A., Carpén, O., & Grönholm, M. (2011) · Neoplasia · doi:10.1593/neo.11356 · Cited by 31 · see citing works
Cell–Cell Junctions: α-Catenin and E-Cadherin Help Fence In Yap1
Robinson, B. S., & Moberg, K. H. (2011) · Current Biology · doi:10.1016/j.cub.2011.09.019 · Cited by 30 · see citing works
Hippo Signaling Goes Long Range
Codelia, V. A., & Irvine, K. D. (2012) · Cell · doi:10.1016/j.cell.2012.07.020 · Cited by 25 · see citing works
The Phosphorylation Status of Merlin Is Important for Regulating the Ras-ERK Pathway
Jung, J. R., Kim, H., Jeun, S., Lee, J., Koh, E.-J., & Ji, C. (2005) · Molecules and Cells · doi:10.1016/s1016-8478(23)13217-1 · Cited by 23 · see citing works
Flagged first, then by citations
1 of the 62 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Hippo Pathway: Biology and Pathophysiology
Ma, S., Meng, Z., Chen, R., & Guan, K.-L. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111829 · Cited by 1,387 · see citing works
The Hippo Signaling Pathway in Development and Disease
Zheng, Y., & Pan, D. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.06.003 · Cited by 867 · see citing works
Towbin, J. A., McKenna, W. J., Abrams, D. J., Ackerman, M. J., Calkins, H. G., Darrieux, F., Daubert, J. P., de Chillou, C., DePasquale, E. C., Desai, M. Y., et al. (2019) · Heart Rhythm · doi:10.1016/j.hrthm.2019.05.007 · Cited by 862 · see citing works
The Hippo signalling pathway and its implications in human health and diseases
Fu, M., Hu, Y., Lan, T., Guan, K., Luo, T., & Luo, M. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01191-9 · Cited by 767 · see citing works
Cardiomyocyte Maturation: New Phase in Development
Guo, Y., & Pu, W. T. (2020) · Circulation Research · doi:10.1161/circresaha.119.315862 · Cited by 653 · see citing works
Corrado, D., Basso, C., & Judge, D. P. (2017) · Circulation Research · doi:10.1161/circresaha.117.309345 · Cited by 462 · see citing works
Lin, Z., von Gise, A., Zhou, P., Gu, F., Ma, Q., Jiang, J., Yau, A. L., Buck, J. N., Gouin, K. A., van Gorp, P. R. R., et al. (2014) · Circulation Research · doi:10.1161/circresaha.115.303632 · Cited by 403 · see citing works
The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration
Wang, J., Liu, S., Heallen, T. R., & Martin, J. F. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0063-3 · Cited by 383 · see citing works
Mechanotransduction in Cardiac Hypertrophy and Failure
Lyon, R. C., Zanella, F., Omens, J. H., & Sheikh, F. (2015) · Circulation Research · doi:10.1161/circresaha.116.304937 · Cited by 345 · see citing works
The Hippo Pathway, YAP/TAZ, and the Plasma Membrane
Rausch, V., & Hansen, C. G. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.10.005 · Cited by 279 · see citing works
Molecular mechanisms of arrhythmogenic cardiomyopathy
Austin, K. M., Trembley, M. A., Chandler, S. F., Sanders, S. P., Saffitz, J. E., Abrams, D. J., & Pu, W. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0200-7 · Cited by 265 · see citing works
Disease implications of the Hippo/YAP pathway
Plouffe, S. W., Hong, A. W., & Guan, K. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.01.003 · Cited by 229 · see citing works
The Hippo Pathway in Heart Development, Regeneration, and Diseases
Zhou, Q., Li, L., Zhao, B., & Guan, K. (2015) · Circulation Research · doi:10.1161/circresaha.116.303311 · Cited by 219 · see citing works
Plakophilin-2 Is Required for Transcription of Genes That Control Calcium Cycling and Cardiac Rhythm
Cerrone, M., Montnach, J., Lin, X., Zhao, Y.-T., Zhang, M., Agullo-Pascual, E., Leo-Macias, A., Alvarado, F. J., Dolgalev, I., Karathanos, T. V., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00127-0 · Cited by 210 · see citing works
Colpaert, R. M. W., & Calore, M. (2019) · Cells · doi:10.3390/cells8070737 · Cited by 198 · see citing works
Desmosomes and Intermediate Filaments: Their Consequences for Tissue MechanicsPreprint
Hatzfeld, M., Keil, R., & Magin, T. M. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029157 · Cited by 161 · see citing works
Chen, S. N., Lombardi, R., Karmouch, J. L., Tsai, J.-Y., Czernuszewicz, G., Taylor, M. R. G., Mestroni, L., Coarfa, C., Gurha, P., & Marian, A. J. (2019) · Circulation Research · doi:10.1161/circresaha.118.314238 · Cited by 152 · see citing works
Self-citationIdentification of Cadherin 2 ( CDH2 ) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy
Mayosi, B. M., Fish, M., Shaboodien, G., Mastantuono, E., Kraus, S., Wieland, T., Kotta, M., Chin, A., Laing, N., Ntusi, N., et al. (2017) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.116.001605 · Cited by 154 · see citing works
Pilichou, K., Thiene, G., Bauce, B., Rigato, I., Lazzarini, E., Migliore, F., Marra, M. P., Rizzo, S., Zorzi, A., Daliento, L., et al. (2016) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-016-0407-1 · Cited by 148 · see citing works
Arrhythmogenic Right Ventricular Cardiomyopathy
Krahn, A. D., Wilde, A. A. M., Calkins, H. G., Gerche, A. L., Cadrin‐Tourigny, J., Roberts, J. D., & Han, H. (2022) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2021.12.002 · Cited by 152 · see citing works
Akdiş, D., Saguner, A. M., Shah, K., Wei, C., Medeiros‐Domingo, A., von Eckardstein, A., Lüscher, T. F., Brunckhorst, C., Chen, H.-S. V., & Duru, F. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx011 · Cited by 144 · see citing works
Beyond the One Gene–One Disease Paradigm
Cerrone, M., Remme, C. A., Tadros, R., Bezzina, C. R., & Delmar, M. (2019) · Circulation · doi:10.1161/circulationaha.118.035954 · Cited by 140 · see citing works
Alpha-Catenins Control Cardiomyocyte Proliferation by Regulating Yap Activity
Li, J., Gao, E., Vite, A., Yi, R., Gomez, L., Goossens, S., Roy, F. M. V., & Radice, G. L. (2014) · Circulation Research · doi:10.1161/circresaha.116.304472 · Cited by 126 · see citing works
NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart
Matsuda, T., Zhai, P., Sciarretta, S., Zhang, Y., Jeong, J. I., Ikeda, S., Park, J., Hsu, C., Tian, B., Pan, D., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.308586 · Cited by 127 · see citing works
Desmosome regulation and signaling in disease
Broussard, J. A., Getsios, S., & Green, K. J. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2136-5 · Cited by 125 · see citing works
Kim, J., Pérez-Hernández, M., Alvarado, F. J., Maurya, S. R., Montnach, J., Yin, Y., Zhang, M., Lin, X., Vásquez, C., Heguy, A., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.039710 · Cited by 125 · see citing works
Arrhythmogenic cardiomyopathy: pathology, genetics, and concepts in pathogenesis
Hoorntje, E. T., Rijdt, W. P. T., James, C. A., Pilichou, K., Basso, C., Judge, D. P., Bezzina, C. R., & van Tintelen, J. P. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx150 · Cited by 119 · see citing works
Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes
Dubash, A. D., Kam, C. Y., Aguado, B. A., Patel, D. M., Delmar, M., Shea, L. D., & Green, K. J. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201507018 · Cited by 110 · see citing works
Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
Ragni, C. V., Diguet, N., Garrec, J. L., Novotová, M., Resende, T. P., Pop, S., Charon, N., Guillemot, L., Kitasato, L., Badouel, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms14582 · Cited by 109 · see citing works
The mammalian Hippo pathway: regulation and function of YAP1 and TAZ
Kodaka, M., & Hata, Y. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1742-9 · Cited by 108 · see citing works
Gillers, B. S., Chiplunkar, A. R., Aly, H., Valenta, T., Basler, K., Christoffels, V. M., Efimov, I. R., Boukens, B. J., & Rentschler, S. (2014) · Circulation Research · doi:10.1161/circresaha.116.304731 · Cited by 101 · see citing works
Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy
Sommariva, E., Brambilla, S., Carbucicchio, C., Gambini, E., Meraviglia, V., Dello Russo, A., Farina, F. M., Casella, M., Catto, V., Pontone, G., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv579 · Cited by 101 · see citing works
Wu, W., Ziemann, M., Huynh, K., She, G., Pang, Z., Zhang, Y., Duong, T., Kiriazis, H., Pu, T.-T., Bai, R., et al. (2021) · Theranostics · doi:10.7150/thno.62302 · Cited by 95 · see citing works
The Hippo signal transduction network in skeletal and cardiac muscle
Wackerhage, H., Del Re, D. P., Judson, R. N., Sudol, M., & Sadoshima, J. (2014) · Science Signaling · doi:10.1126/scisignal.2005096 · Cited by 92 · see citing works
Lombardi, R., Chen, S. N., Ruggiero, A., Gurha, P., Czernuszewicz, G. Z., Willerson, J. T., & Marian, A. J. (2016) · Circulation Research · doi:10.1161/circresaha.115.308136 · Cited by 94 · see citing works
Self-citationChelko, S. P., Keceli, G., Carpi, A., Doti, N., Agrimi, J., Asimaki, A., Beti, C. B., Miyamoto, M., Amat-Codina, N., Bedja, D., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf0891 · Cited by 92 · see citing works
Desmosomes: Essential contributors to an integrated intercellular junction network
Green, K. J., Jaiganesh, A., & Broussard, J. A. (2019) · F1000Research · doi:10.12688/f1000research.20942.1 · Cited by 94 · see citing works
The role of genetics in cardiovascular disease: arrhythmogenic cardiomyopathy
James, C. A., Syrris, P., van Tintelen, J. P., & Calkins, H. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa141 · Cited by 92 · see citing works
Role of adipose tissue in the pathogenesis of cardiac arrhythmias
Samanta, R., Pouliopoulos, J., Thiagalingam, A., & Kovoor, P. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.08.016 · Cited by 91 · see citing works
Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis
Aktary, Z., Alaee, M., & Pasdar, M. (2017) · Oncotarget · doi:10.18632/oncotarget.15650 · Cited by 85 · see citing works
The Hippo Signaling Pathway in Cardiac Development and Diseases
Mia, M. M., & Singh, M. K. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00211 · Cited by 83 · see citing works
The emerging role of Hippo signaling in neurodegeneration
Sahu, M. R., & Mondal, A. C. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24551 · Cited by 80 · see citing works
Desmosomes as Signaling Hubs in the Regulation of Cell Behavior
Müller, L., Hatzfeld, M., & Keil, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.745670 · Cited by 78 · see citing works
Intercalated discs: cellular adhesion and signaling in heart health and diseases
Zhao, G., Qiu, Y., Zhang, H. M., & Yang, D. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9743-7 · Cited by 77 · see citing works
Desmoglein 2–Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function
Kant, S., Holthöfer, B., Magin, T. M., Krusche, C. A., & Leube, R. E. (2015) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000974 · Cited by 73 · see citing works
Auguste, G. E., Gurha, P., Lombardi, R., Coarfa, C., Willerson, J. T., & Marian, A. J. (2018) · Circulation Research · doi:10.1161/circresaha.117.312052 · Cited by 72 · see citing works
Self-citationNajor, N. A. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-044030 · Cited by 72 · see citing works
Ademuwagun, I. A., Rotimi, S. O., Syrbe, S., Ajamma, Y. U., & Adebiyi, E. F. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.600050 · Cited by 68 · see citing works
The Hippo pathway in disease and therapy: cancer and beyond
Gómez-Ferrer, M., Gómez, V., & Hergovich, A. (2014) · Clinical and Translational Medicine · doi:10.1186/2001-1326-3-22 · Cited by 65 · see citing works
van der Voorn, S. M., Riele, A. S. J. M. T., Basso, C., Calkins, H. G., Remme, C. A., & van Veen, T. A. B. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa084 · Cited by 63 · see citing works
Insights Into Genetics and Pathophysiology of Arrhythmogenic Cardiomyopathy
Gerull, B., & Brodehl, A. (2021) · Current Heart Failure Reports · doi:10.1007/s11897-021-00532-z · Cited by 63 · see citing works
Wnt/β-catenin pathway in arrhythmogenic cardiomyopathy
Lorenzon, A., Calore, M., Poloni, G., De Windt, L. J., Braghetta, P., & Rampazzo, A. (2017) · Oncotarget · doi:10.18632/oncotarget.17457 · Cited by 64 · see citing works
Unmasking the molecular link between arrhythmogenic cardiomyopathy and Brugada syndrome
Moncayo, J., & Brugada, R. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.103 · Cited by 64 · see citing works
Genetics of and pathogenic mechanisms in arrhythmogenic right ventricular cardiomyopathy
Vimalanathan, A. K., Ehler, E., & Gehmlich, K. (2018) · Biophysical Reviews · doi:10.1007/s12551-018-0437-0 · Cited by 59 · see citing works
Pfleger, C. M. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.12.001 · Cited by 61 · see citing works
Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury
Nakamura, M., Zhai, P., Re, D. P. D., Maejima, Y., & Sadoshima, J. (2016) · JCI Insight · doi:10.1172/jci.insight.86217 · Cited by 60 · see citing works
Intercalated Discs and Arrhythmogenic Cardiomyopathy
Rampazzo, A., Calore, M., van Hengel, J., & Roy, F. M. V. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000645 · Cited by 59 · see citing works
Calore, M., Lorenzon, A., Vitiello, L., Poloni, G., Khan, M. A. F., Beffagna, G., Dazzo, E., Sacchetto, C., Polishchuk, R., Sabatelli, P., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy253 · Cited by 59 · see citing works
Pathogenesis of Arrhythmogenic Cardiomyopathy
Asimaki, A., Kléber, A. G., & Saffitz, J. E. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.04.012 · Cited by 58 · see citing works
Activation of Yap1/Taz signaling in ischemic heart disease and dilated cardiomyopathy
Hou, N., Wen, Y., Yuan, X., Xu, H., Wang, X., Li, F., & Ye, B. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.11.006 · Cited by 58 · see citing works
Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy
Cheedipudi, S. M., Hu, J., Fan, S., Yuan, P., Karmouch, J. L., Czernuszewicz, G., Robertson, M. J., Coarfa, C., Hong, K., Yao, Y., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz199 · Cited by 58 · see citing works
Self-citationWu, I., Zeng, A., Greer-Short, A., Aycinena, J. A., Tefera, A. E., Shenwai, R., Farshidfar, F., Van Pell, M., Xu, E., Reid, C., et al. (2024) · Communications Medicine · doi:10.1038/s43856-024-00450-w · Cited by 57 · see citing works
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes
Nielsen, M. S., van Opbergen, C. J. M., van Veen, T. A. B., & Delmar, M. (2023) · Physiological Reviews · doi:10.1152/physrev.00021.2022 · Cited by 58 · see citing works
Desmosomes in the Heart: A Review of Clinical and Mechanistic Analyses
Patel, D. M., & Green, K. J. (2014) · Cell Communication & Adhesion · doi:10.3109/15419061.2014.906533 · Cited by 57 · see citing works
Giuliodori, A., Beffagna, G., Marchetto, G., Fornetto, C., Vanzi, F., Toppo, S., Facchinello, N., Santimaria, M., Vettori, A., Rizzo, S., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy057 · Cited by 57 · see citing works
Wen, J., Wei, C.-Y., Shah, K., Wong, J., Wang, C., & Chen, H. V. (2015) · Circulation Journal · doi:10.1253/circj.cj-15-0363 · Cited by 51 · see citing works
Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy
Zhang, H., Liu, S., Dong, T., Yang, J., Xie, Y., Wu, Y., Kang, K., Hu, S., Gou, D., & Wei, Y. (2016) · Scientific Reports · doi:10.1038/srep28101 · Cited by 56 · see citing works
Rouhi, L., Cheedipudi, S. M., Chen, S. N., Fan, S., Lombardi, R., Chen, X., Coarfa, C., Robertson, M. J., Gurha, P., & Marian, A. J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa300 · Cited by 55 · see citing works
Self-citationAnkyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy
Roberts, J. D., Murphy, N. P., Hamilton, R. M., Lubbers, E. R., James, C. A., Kline, C. F., Gollob, M. H., Krahn, A. D., Sturm, A. C., Musa, H., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125538 · Cited by 56 · see citing works
Arrhythmogenic cardiomyopathy: An in-depth look at molecular mechanisms and clinical correlates
Costa, S., Cerrone, M., Saguner, A. M., Brunckhorst, C., Delmar, M., & Duru, F. (2020) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2020.07.006 · Cited by 54 · see citing works
Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity
Liu, C., Zhong, G., Zhou, Y., Yang, Y., Tan, Y., Li, Y., Gao, X., Sun, W., Li, J., Jin, X., et al. (2020) · Cell Proliferation · doi:10.1111/cpr.12783 · Cited by 52 · see citing works
Arrhythmogenic cardiomyopathy: a disease of intercalated discs
Calore, M., Lorenzon, A., Bortoli, M. D., Poloni, G., & Rampazzo, A. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-2015-5 · Cited by 52 · see citing works
Gurha, P., Chen, X., Lombardi, R., Willerson, J. T., & Marian, A. J. (2016) · Circulation Research · doi:10.1161/circresaha.116.308422 · Cited by 52 · see citing works
Self-citationCerrone, M., Marrón-Liñares, G. M., van Opbergen, C. J. M., Costa, S., Bourfiss, M., Pérez-Hernández, M., Schlamp, F., Sanchis-Gomar, F., Malkani, K., Drenkova, K., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehab772 · Cited by 51 · see citing works
ANUMONWO, J. M. B., & Herron, T. J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00002 · Cited by 51 · see citing works
Yuan, P., Cheedipudi, S. M., Rouhi, L., Fan, S., Simon, L. M., Zhao, Z., Hong, K., Gurha, P., & Marian, A. J. (2021) · Circulation · doi:10.1161/circulationaha.120.052928 · Cited by 49 · see citing works
Self-citationWnt Signaling in Cardiac Disease
Hermans, K. C. M., & Blankesteijn, W. M. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140060 · Cited by 51 · see citing works
Genetics and Genomics of Single-Gene Cardiovascular Diseases
Marian, A. J., van Rooij, E., & Roberts, R. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.09.968 · Cited by 48 · see citing works
Self-citationThe cardiac connexome: Non-canonical functions of connexin43 and their role in cardiac arrhythmias
Leo‐Macías, A., Agulló-Pascual, E., & Delmar, M. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.12.002 · Cited by 48 · see citing works
Xiao, Z., Cao, L., Liang, Y., Huang, J., Stern, A. R., Dallas, M., Johnson, M. L., & Quarles, L. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114198 · Cited by 47 · see citing works
Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration
Flinn, M. A., Link, B. A., & O'Meara, C. C. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.09.004 · Cited by 47 · see citing works
Genetic basis and molecular biology of cardiac arrhythmias in cardiomyopathies
Marian, A. J., Asatryan, B., & Wehrens, X. H. T. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa116 · Cited by 47 · see citing works
Self-citationRouhi, L., Fan, S., Cheedipudi, S. M., Braza‐Boïls, A., Molina, M. S., Yao, Y., Robertson, M. J., Coarfa, C., Gimeno, J. R., Molina, P., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab197 · Cited by 45 · see citing works
Self-citationMelatonin attenuates doxorubicin‐induced cardiotoxicity through preservation of YAP expression
Li, H., Wang, C., Sun, P., Liu, D., Du, G., & Tian, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15057 · Cited by 45 · see citing works
The role of the Hippo pathway in autophagy in the heart
Maejima, Y., Zablocki, D., Nah, J., & Sadoshima, J. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac014 · Cited by 44 · see citing works
The Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response
Zheng, A., Chen, Q., & Zhang, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.971416 · Cited by 45 · see citing works
Moccia, F. D., Lodola, F., Stadiotti, I., Pilato, C. A., Bellin, M., Carugo, S., Pompilio, G., Sommariva, E., & Maione, A. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163986 · Cited by 44 · see citing works
Boogerd, C. J. J., Lacraz, G., Vértesy, Á., van Kampen, S. J., Perini, I., de Ruiter, H., Versteeg, D., Brodehl, A., van der Kraak, P. H., Giacca, M., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac072 · Cited by 44 · see citing works
Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy
Kohela, A., van Kampen, S. J., Moens, T., Wehrens, M., Molenaar, B., Boogerd, C. J. J., Monshouwer‐Kloots, J., Perini, I., Goumans, M., Smits, A. M., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf2750 · Cited by 41 · see citing works
The role of β-catenin in cardiac diseases
Ni, B., Sun, M., Zhao, J., Wang, J., & Cao, Z. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1157043 · Cited by 41 · see citing works
Sudden cardiac death: focus on the genetics of channelopathies and cardiomyopathies
Magi, S., Lariccia, V., Maiolino, M., Amoroso, S., & Gratteri, S. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0364-6 · Cited by 44 · see citing works
Trembley, M. A., Quijada, P. J., Agulló-Pascual, E., Tylock, K. M., Colpan, M., Dirkx, R. A., Myers, J. R., Mickelsen, D. M., Bentley, K. L. D. M., Rothenberg, E., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.031788 · Cited by 41 · see citing works
At the heart of inter- and intracellular signaling: the intercalated disc
Manring, H. R., Dorn, L. E., Ex-Willey, A., Accornero, F., & Ackermann, M. A. (2018) · Biophysical Reviews · doi:10.1007/s12551-018-0430-7 · Cited by 42 · see citing works
Mechanisms of Arrhythmias in the Brugada Syndrome
Blok, M., & Boukens, B. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197051 · Cited by 41 · see citing works
van Opbergen, C. J. M., Delmar, M., & van Veen, T. A. B. (2017) · Netherlands Heart Journal · doi:10.1007/s12471-017-0946-7 · Cited by 40 · see citing works
The cellular prion protein PrPcis a partner of the Wnt pathway in intestinal epithelial cells
Besnier, L., Cardot, P., Rocha, B. D., Simon, A. Y., Loew, D., Klein, C., Riveau, B., Lacasa, M., Clair, C., Rousset, M., et al. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-11-1534 · Cited by 39 · see citing works
Ding, Y., Yang, J., Chen, P., Lü, T., Jiao, K., Tester, D. J., Giudicessi, J. R., Jiang, K., Ackerman, M. J., Li, Y., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.017055 · Cited by 37 · see citing works
Inhibition of YAP/TAZ Activity in Spinal Cord Suppresses Neuropathic Pain
Xu, N., Wu, M., Deng, X., Ma, P., Li, Z., Liang, L., Xia, M.-F., Cui, D., He, D.-D., Zong, Y., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0800-16.2016 · Cited by 38 · see citing works
Zhao, W., Lu, Q., Nguyen, M., Su, Y., Ziemann, M., Wang, L., Kiriazis, H., Puthalakath, H., Sadoshima, J., Hu, H., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14674 · Cited by 37 · see citing works
Desmoplakin and clinical manifestations of desmoplakin cardiomyopathy
Yuan, Z.-Y., Cheng, L., Wang, Z., & Wu, Y. (2021) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001581 · Cited by 36 · see citing works
- Authors
- Chen, S. N., Gurha, P., Lombardi, R., Ruggiero, A., Willerson, J. T., & Marian, A. J.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Venue
- Circulation Research
- Published
- 2014-01-31
- Volume
- 114
- Issue
- 3
- Pages
- 454-468
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3946717
- OpenAlex
- W2170939446
- Cited by
- 275
- References
- 62
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 11 · 2023: 24 · 2022: 21 · 2021: 34 · 2020: 20 · 2019: 21 · 2018: 22 · 2017: 32 · 2016: 17 · 2015: 21 · 2014: 15
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R21AG038597)
- National Heart, Lung, and Blood Institute (R34HL105563, R01HL088498)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- arrhythmogenic cardiomyopathy, Hippo signaling pathway, adipogenesis, plakophilin-2, intercalated discs, protein kinase C alpha, Merlin, YAP, MST1/2, LATS1/2, Wnt/β-catenin signaling, β-catenin, plakoglobin
- MeSH terms
- Hippo Signaling Pathway, Animals, Cell Line, Humans, Signal Transduction, Protein Serine-Threonine Kinases, Mice, Knockout, Arrhythmogenic Right Ventricular Dysplasia, Adipogenesis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
