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Cited by 37Cardiomyopathy and Myosin StudiesViral Infections and Immunology ResearchCardiovascular Effects of Exercise

Myocardial Inflammation as a Manifestation of Genetic Cardiomyopathies: From Bedside to the Bench

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Peretto, Giovanni, Sommariva, Elena, Di Resta, Chiara, Rabino, Martina, Villatore, Andrea, Lazzeroni, Davide, Sala, Simone, Pompilio, Giulio +1 more·2023·Biomolecules
DOI 10.3390/biom13040646PMC PMC10136351
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Abstract

Over recent years, preclinical and clinical evidence has implicated myocardial inflammation (M-Infl) in the pathophysiology and phenotypes of traditionally genetic cardiomyopathies. M-Infl resembling myocarditis on imaging and histology occurs frequently as a clinical manifestation of classically genetic cardiac diseases, including dilated and arrhythmogenic cardiomyopathy. The emerging role of M-Infl in disease pathophysiology is leading to the identification of druggable targets for molecular treatment of the inflammatory process and a new paradigm in the field of cardiomyopathies. Cardiomyopathies constitute a leading cause of heart failure and arrhythmic sudden death in the young population. The aim of this review is to present, from bedside to bench, the current state of the art about the genetic basis of M-Infl in nonischemic cardiomyopathies of the dilated and arrhythmogenic spectrum in order to prompt future research towards the identification of novel mechanisms and treatment targets, with the ultimate goal of lowering disease morbidity and mortality.

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  • Lymphocytic myocarditis is primarily associated with viral infections, characterized by histological observations of myocardial infiltration predominantly by T lymphocytes.

    “Lymphocytic myocarditis is primarily associated with viral infections, characterized by histological observations of myocardial infiltration predominantly by T lymphocytes”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [144]

    The Introduction (§1.1; page unavailable) lists viral infections among the main recognized causes of myocarditis, but does not say they are the primary cause of lymphocytic myocarditis. The autopsy discussion (§2.2; page unavailable) reports T-lymphocyte staining in classic myocarditis, but does not establish that T lymphocytes predominate in its infiltrates. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Authors
Peretto, G., Sommariva, E., Di Resta, C., Rabino, M., Villatore, A., Lazzeroni, D., Sala, S., Pompilio, G., & Cooper, L. T.
Affiliations
  • Vita-Salute San Raffaele University (IT)
  • Centro Cardiologico Monzino (IT)
  • School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy
  • IRCCS Ospedale San Raffaele (IT)
  • Don Carlo Gnocchi Foundation (IT)
  • University of Milan (IT)
  • Mayo Clinic (US)
Corresponding author
Peretto, Giovanni
ORCID
Venue
Biomolecules
Publisher
MDPI AG
Published
2023-04-04
Volume
13
Issue
4
Pages
646
ISSN
2218-273X (ISSN-L)
DOI
10.3390/biom13040646
PMC
PMC10136351
OpenAlex
W4362557569
Cited by
37
References
9
Citations by year
2026: 12 · 2025: 9 · 2024: 9 · 2023: 7
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomolecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords
myocarditis, familial cardiomyopathy, dilated cardiomyopathy, arrhythmogenic cardiomyopathy, druggable targets, sudden cardiac death, heart failure
MeSH terms
Arrhythmias, Cardiac, Heart Failure, Humans, Inflammation, Cardiomyopathies, Myocarditis

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