Cited by 591Cancer-related Molecular PathwaysUbiquitin and proteasome pathwaysPI3K/AKT/mTOR signaling in cancer

Signaling to p53: ribosomal proteins find their way

Open access
Zhang, Yanping, Lu, Hua·2009·Cancer Cell

Abstract

Inherently disparate cell growth and division, which are intimately coupled through a delicate network of intracellular and extracellular signaling, require ribosomal biogenesis. A number of events imparting instability to ribosomal biogenesis can cause nucleolar stress. In response to this stress, several ribosomal proteins bind to MDM2 and block MDM2-mediated p53 ubiquitination and degradation, resulting in p53-dependent cell cycle arrest. By doing so, the ribosomal proteins play a crucial role in connecting deregulated cell growth with inhibition of cell division. The ribosomal protein-MDM2-p53 signaling pathway provides a molecular switch that may constitute a surveillance network monitoring the integrity of ribosomal biogenesis.

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Crossref · 10.1016/j.ccr.2009.09.024

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  • Mdm2 and Mdmx bind many other proteins, including proteins involved in development, morphogenesis, and tumorigenesis.

    “However, both Mdm2 and Mdmx interact with many other proteins, including those involved in development, morphogenesis and tumorigenesis (Table 2; [81–92]).”

    From The p53 orchestra: Mdm2 and Mdmx set the tone (2010) · cites this paper as [82]

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Authors
Zhang, Y., & Lu, H.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • Indiana University School of Medicine (US)
Corresponding author
  • Zhang, Yanping
  • Lu, Hua
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2009-11
Volume
16
Issue
5
Pages
369-377
ISSN
1535-6108 (ISSN-L)
OpenAlex
W1992307025
Cited by
591
References
125
Citations by year
2026: 20 · 2025: 26 · 2024: 25 · 2023: 28 · 2022: 31 · 2021: 29 · 2020: 32 · 2019: 26 · 2018: 45 · 2017: 31 · 2016: 41 · 2015: 39 · 2014: 63 · 2013: 39 · 2012: 39
FWCI
3.39
Type
journal article
Language
en
Open access
Locations
  • Cancer Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • Purdue University Indianapolis (Indiana University) (submittedVersion)
  • UNC Libraries
Funders
  • American Cancer Society
  • National Cancer Institute (R01CA155235, K01CA087580, R01CA100302, R01CA127770)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
ribosomal proteins, p53, MDM2, ribosome biogenesis, nucleolar stress, p53 ubiquitination, p53 degradation, cell cycle arrest, cell growth regulation, cell division, tumor suppressor signaling
MeSH terms
Animals, Cell Cycle, Humans, Ribosomal Proteins, Signal Transduction, Tumor Suppressor Protein p53, Proto-Oncogene Proteins c-mdm2, Ubiquitination

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