Cited by 78Nanoparticle-Based Drug DeliveryCancer Cells and MetastasisNanoplatforms for cancer theranostics

Targeted Inhibition of Tumor Inflammation and Tumor-Platelet Crosstalk by Nanoparticle-Mediated Drug Delivery Mitigates Cancer Metastasis

Li, Shujie, Li, Lian, Lin, Xi, Chen, Cheng, Luo, Chaohui, Huang, Yuan·2022·ACS Nano

Abstract

Sowing malignant cells (the "seeds" of metastasis) to engraft secondary sites requires a conducive premetastatic niche (PMN, the "soil" of metastasis). Inflammation and tumor associated platelet (TAP) has been hijacked by primary tumors to induce PMN "soil" in distant organs, as well as facilitate the dissemination of "seeds". This study reports a combinatory strategy with activated platelet-targeting nanoparticles to aim at the dynamic process of entire cancer metastasis, which exerts robust antimetastasis efficacy by simultaneously inhibiting tumor inflammation and tumor-platelet crosstalk. Our results reveals that the PSN peptide (a P-selectin-targeting peptide) modification enriched the accumulation of nanoparticles in primary tumor, pulmonary PMN, and metastases via capturing activated platelet. Such characteristics contribute to the efficient inhibition on almost every crucial and consecutive step of the metastasis cascade by retarding epithelial-mesenchymal transition (EMT) progression within tumors, specifically blocking the tumor-platelet crosstalk to remove the platelets "protective shield" around disseminated "seeds", and reversing the inflammatory microenvironment to interfere with the "soil" formation. Consisting of inflammation inhibiting and TAP impeding nanoparticles, this approach prominently reduces various metastasis in abscopal lung, including spontaneous metastasis, disseminated tumor cells metastasis, and post-operative metastasis. This work provides a generalizable nanoplatform of parallel inflammation disturbance and tumor-TAP crosstalk blockade to resist metastatic tumors.

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Crossref · 10.1021/acsnano.1c06022

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  • The magnetic response intelligent nano system has two treatment procedures: the first uses magnetic fields to assist drug targeting, and the second uses magnetic fields to cause hyperthermia.

    “As a result, the magnetic response intelligent nano system has two treatment procedures. The first technique uses magnetic fields to assist drug targeting, whereas the second uses magnetic fields to cause hyperthermia.186–188”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [187]

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Authors
Li, S., Li, L., Lin, X., Chen, C., Luo, C., & Huang, Y.
Affiliations
Sichuan University (CN)
Corresponding author
Huang, Yuan
Venue
ACS Nano
Published
2021-12-07
Volume
16
Issue
1
Pages
50-67
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W4200265423
Cited by
78
References
87
Citations by year
2026: 8 · 2025: 22 · 2024: 27 · 2023: 18 · 2022: 3
FWCI
3.13
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Nano (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81625023)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
metastasis, pre-metastatic niche, tumor inflammation, epithelial-mesenchymal transition, lung metastasis, abscopal effect, disseminated tumor cells, nanoparticle drug delivery
MeSH terms
Blood Platelets, Humans, Inflammation, Neoplasm Metastasis, Neoplasms, Nanoparticles, Epithelial-Mesenchymal Transition, Tumor Microenvironment

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