Cited by 2,312Cell death mechanisms and regulationCancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

Fulda, S, Debatin, K-M·2006·Oncogene

Abstract

Apoptosis or programmed cell death is a key regulator of physiological growth control and regulation of tissue homeostasis. One of the most important advances in cancer research in recent years is the recognition that cell death mostly by apoptosis is crucially involved in the regulation of tumor formation and also critically determines treatment response. Killing of tumor cells by most anticancer strategies currently used in clinical oncology, for example, chemotherapy, gamma-irradiation, suicide gene therapy or immunotherapy, has been linked to activation of apoptosis signal transduction pathways in cancer cells such as the intrinsic and/or extrinsic pathway. Thus, failure to undergo apoptosis may result in treatment resistance. Understanding the molecular events that regulate apoptosis in response to anticancer chemotherapy, and how cancer cells evade apoptotic death, provides novel opportunities for a more rational approach to develop molecular-targeted therapies for combating cancer.

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Crossref · 10.1038/sj.onc.1209608

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Authors
Fulda, S., & Debatin, K.-M.
Affiliations
University Hospital Ulm (DE)
Corresponding author
Fulda, S
Venue
Oncogene
Published
2006-08-07
Volume
25
Issue
34
Pages
4798-4811
ISSN
  • 0950-9232 (ISSN-L)
  • 1476-5594
OpenAlex
W2009183786
Cited by
2,312
References
152
Citations by year
2026: 50 · 2025: 84 · 2024: 78 · 2023: 106 · 2022: 134 · 2021: 134 · 2020: 137 · 2019: 133 · 2018: 157 · 2017: 151 · 2016: 186 · 2015: 170 · 2014: 136 · 2013: 135 · 2012: 140
FWCI
5.11
Type
journal article
Language
en
Open access
closed
Locations
  • Oncogene (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Deutsche Krebshilfe
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
apoptosis, extrinsic apoptotic pathway, mitochondrial apoptosis, cancer chemotherapy, apoptosis signaling, treatment resistance, cancer cell death
MeSH terms
Animals, Antineoplastic Agents, Humans, Neoplasms, Signal Transduction, Apoptosis

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