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Cited by 20Liver physiology and pathologyTissue Engineering and Regenerative MedicineMesenchymal stem cell research

Alternative Cell Sources for Liver Parenchyma Repopulation: Where Do We Stand?

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Tricot, Tine, De Boeck, Jolan, Verfaillie, Catherine·2020·Cells
DOI 10.3390/cells9030566PMC PMC7140465
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Abstract

Acute and chronic liver failure is a highly prevalent medical condition with high morbidity and mortality. Currently, the therapy is orthotopic liver transplantation. However, in some instances, chiefly in the setting of metabolic diseases, transplantation of individual cells, specifically functional hepatocytes, can be an acceptable alternative. The gold standard for this therapy is the use of primary human hepatocytes, isolated from livers that are not suitable for whole organ transplantations. Unfortunately, primary human hepatocytes are scarcely available, which has led to the evaluation of alternative sources of functional hepatocytes. In this review, we will compare the ability of most of these candidate alternative cell sources to engraft and repopulate the liver of preclinical animal models with the repopulation ability found with primary human hepatocytes. We will discuss the current shortcomings of the different cell types, and some of the next steps that we believe need to be taken to create alternative hepatocyte progeny capable of regenerating the failing liver.

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  • Autologous MSCs are considered a potentially clinically relevant cell type for hepatic tissue engineering due to their availability, expandability, and safety profile, along with possible beneficial immune modulation effects.

    “Autologous MSCs are considered as a potentially clinically relevant cell type for hepatic tissue engineering due to their availability, expandability, and safety profile, along with possible beneficial immune modulation effects [209,210].”

    From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [209]

    Section 5.2 describes MSCs as clinically relevant to liver regeneration and attributes potential benefits to their immunomodulatory effects. It does not establish expandability or a favorable safety profile; it also says common MSC sources can be difficult to access and some cannot be obtained autologously. No page number is available in our copy. (LLM, conf=0.88)

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Authors
Tricot, T., De Boeck, J., & Verfaillie, C.
Affiliations
  • Leuven Stem Cell Institute (BE)
  • Stem Cell Institute Leuven, KU Leuven, 3000 Leuven, Belgium
Corresponding author
Verfaillie, Catherine
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2020-02-28
Volume
9
Issue
3
Pages
566
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells9030566
PMC
PMC7140465
OpenAlex
W3010355081
Cited by
20
References
166
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 1
FWCI
0.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Lirias (submittedVersion, other-oa)
Funders
  • Fonds Wetenschappelijk Onderzoek (1185918N, 1189120N, G067314N, G0D9917N)
  • Agentschap voor Innovatie door Wetenschap en Technologie (SBO-HILIM3D)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
alternative cell sources, hepatocyte repopulation, liver regeneration, primary human hepatocytes, hepatocyte transplantation, acute liver failure, chronic liver failure, hepatic progenitor cells, cell engraftment, metabolic liver disease, preclinical animal models
MeSH terms
Animals, Cell Differentiation, Disease Models, Animal, Humans, Liver, Organ Specificity, Cell Transplantation, Hepatocytes

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