Social Stress Increases Vulnerability to High-Fat Diet-Induced Insulin Resistance by Enhancing Neutrophil Elastase Activity in Adipose Tissue

Motoyama, Shinichiro; Yamada, Hiroyuki; Yamamoto, Keita; Wakana, Noriyuki; Terada, Kensuke; Kikai, Masakazu; Wada, Naotoshi; Saburi, Makoto; Sugimoto, Takeshi; Kubota, Hiroshi; Miyawaki, Daisuke; Kami, Daisuke; Ogata, Takehiro; Ibi, Masakazu; Yabe-Nishimura, Chihiro; Matoba, Satoaki

doi:10.3390/cells9040996

Social Stress Increases Vulnerability to High-Fat Diet-Induced Insulin Resistance by Enhancing Neutrophil Elastase Activity in Adipose Tissue

Social stress (SS) has been linked to the development of cardiovascular disease (CVD), which is closely associated with insulin resistance (IR); however, the causal effect of SS on IR remains unclear. The 8-week-old male C57BL/6 mice were exposed to SS by housing with a larger CD-1 mouse in a sha…