Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

Katayama, Yoshio; Battista, Michela; Kao, Wei-Ming; Hidalgo, Andrés; Peired, Anna J.; Thomas, Steven A.; Frenette, Paul S.

doi:10.1016/j.cell.2005.10.041

Cited by 1,412Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchChemokine receptors and signaling

Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

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Katayama, Yoshio, Battista, Michela, Kao, Wei-Ming, Hidalgo, Andrés, Peired, Anna J., Thomas, Steven A., Frenette, Paul S.·2006·Cell

DOI 10.1016/j.cell.2005.10.041

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Abstract

Hematopoietic stem and progenitor cells (HSPC), attracted by the chemokine CXCL12, reside in specific niches in the bone marrow (BM). HSPC migration out of the BM is a critical process that underlies modern clinical stem cell transplantation. Here we demonstrate that enforced HSPC egress from BM niches depends critically on the nervous system. UDP-galactose ceramide galactosyltransferase-deficient (Cgt(-/-)) mice exhibit aberrant nerve conduction and display virtually no HSPC egress from BM following granulocyte colony-stimulating factor (G-CSF) or fucoidan administration. Adrenergic tone, osteoblast function, and bone CXCL12 are dysregulated in Cgt(-/-) mice. Pharmacological or genetic ablation of adrenergic neurotransmission indicates that norepinephrine (NE) signaling controls G-CSF-induced osteoblast suppression, bone CXCL12 downregulation, and HSPC mobilization. Further, administration of a beta(2) adrenergic agonist enhances mobilization in both control and NE-deficient mice. Thus, these results indicate that the sympathetic nervous system regulates the attraction of stem cells to their niche.

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NE decreases the inhibitory chemokine CXCL12, and stress-induced hematopoietic stem cell differentiation is associated with decreased CXCL12 expression in the BM.
“One such way that leukocytes are stimulated by NE is by decreasing the inhibitory chemokine CXCL12 (Katayama et al, 2006;Heidt et al, 2014).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Katayama et al, 2006

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Authors: Katayama, Y., Battista, M., Kao, W.-M., Hidalgo, A., Peired, A. J., Thomas, S. A., & Frenette, P. S.
Affiliations: Okayama University Hospital (JP)
Icahn School of Medicine at Mount Sinai (US)
University of Pennsylvania (US)
Corresponding author: Frenette, Paul S.
ORCID: Kao, Wei-Ming
Hidalgo, Andrés
Peired, Anna J.
Frenette, Paul S.
Venue: Cell
Publisher: Elsevier BV
Published: 2006-01
Volume: 124
Issue: 2
Pages: 407-421
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2005.10.041
OpenAlex: W2086243699
Cited by: 1,412
References: 70
Citations by year: 2026: 46 · 2025: 44 · 2024: 50 · 2023: 57 · 2022: 65 · 2021: 79 · 2020: 92 · 2019: 84 · 2018: 68 · 2017: 93 · 2016: 81 · 2015: 90 · 2014: 95 · 2013: 91 · 2012: 85
FWCI: 28.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2790 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Blood Foundation
National Institutes of Health (DK56638, HL69438, T32 DK07792)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords: bone marrow microenvironment, sympathetic nervous system, norepinephrine signaling, CXCL12, osteoblast activity, adrenergic neurotransmission, granulocyte colony-stimulating factor, fucoidan, beta2-adrenergic agonists, UDP-galactose:ceramide galactosyltransferase, stem cell mobilization, hematopoietic stem and progenitor cells
MeSH terms: Animals, Animals, Newborn, Bone Marrow Cells, Cell Movement, Hematopoietic Stem Cells, Mice, Inbred C57BL, Osteoblasts, Radiation Chimera, Sympathetic Nervous System, Down-Regulation, Granulocyte Colony-Stimulating Factor, Mice, Knockout, Chemokines, CXC, Mice, Chemokine CXCL12

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Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

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