Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting
Open accessAbstract
Sepsis elicits skeletal muscle weakness and fiber atrophy. The accumulation of injured mitochondria and depressed mitochondrial functions are considered as important triggers of sepsis-induced muscle atrophy. It is unclear whether mitochondrial dysfunctions in septic muscles are due to the inadequate activation of quality control processes. We hypothesized that overexpressing Parkin, a protein responsible for the recycling of dysfunctional mitochondria by the autophagy pathway (mitophagy), would confer protection against sepsis-induced muscle atrophy by improving mitochondrial quality and content. Parkin was overexpressed for four weeks in the limb muscles of four-week old mice using intramuscular injections of adeno-associated viruses (AAVs). The cecal ligation and perforation (CLP) procedure was used to induce sepsis. Sham operated animals were used as controls. All animals were studied for 48 h post CLP. Sepsis resulted in major body weight loss and myofiber atrophy. Parkin overexpression prevented myofiber atrophy in CLP mice. Quantitative two-dimensional transmission electron microscopy revealed that sepsis is associated with the accumulation of enlarged and complex mitochondria, an effect which was attenuated by Parkin overexpression. Parkin overexpression also prevented a sepsis-induced decrease in the content of mitochondrial subunits of NADH dehydrogenase and cytochrome C oxidase. We conclude that Parkin overexpression prevents sepsis-induced skeletal muscle atrophy, likely by improving mitochondrial quality and contents.
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Parkin overexpression prevents sepsis-induced skeletal muscle atrophy.
“We also recently showed that Parkin overexpression prevents sepsis-induced skeletal muscle atrophy, likely by improving mitochondrial quality and content [159].”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [159]
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- Authors
- Leduc-Gaudet, J.-P., Mayaki, D., Reynaud, O., Broering, F. E., Chaffer, T. J., Hussain, S. N. A., & Gouspillou, G.
- Affiliations
- Meakins-Christie Laboratories and Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre; Department of Critical Care, McGill University Health Centre, Montréal, QC H4A 3J1, Canada
- McGill University Health Centre (CA)
- Université du Québec à Montréal (CA)
- Corresponding author
- Hussain, Sabah N. A.
- Gouspillou, Gilles
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2020-06-11
- Volume
- 9
- Issue
- 6
- Pages
- 1454
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC7349807
- OpenAlex
- W3034767506
- Cited by
- 54
- References
- 55
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 6 · 2021: 8 · 2020: 2
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Le dépôt institutionnel (Université du Québec à Trois-Rivières) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Sciences and Engineering Research Council of Canada (RGPIN-2014-04668)
- Canadian Institutes of Health Research (MOP-93760, MOV-409262)
- Fonds de Recherche du Québec - Santé (FRQS-35184)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- Parkin, sepsis, muscle atrophy, mitophagy, mitochondrial quality control, skeletal muscle weakness, cecal ligation and puncture, mitochondrial dysfunction, NADH dehydrogenase, cytochrome c oxidase, AAV gene delivery
- MeSH terms
- Animals, Cecum, Gene Expression Regulation, Ligation, Male, Mice, Inbred C57BL, Mitochondria, Muscular Atrophy, Signal Transduction, Muscle Fibers, Skeletal, Sepsis, Ubiquitin-Protein Ligases, Mitochondrial Dynamics
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