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Cited by 931Autophagy in Disease and TherapyMitochondrial Function and PathologyCell death mechanisms and regulation

Mitochondrial dynamics and mitochondrial quality control

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Ni, Hong-Min, Williams, Jessica A., Ding, Wen-Xing·2015·Redox Biology
DOI 10.1016/j.redox.2014.11.006PMC PMC4309858
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Abstract

Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis and function. Mitochondria are reticular organelles that have high plasticity for their dynamic structures and constantly undergo fission and fusion as well as movement through the cytoskeleton. In this review, we discuss the most recent progress on the molecular mechanisms and roles of mitochondrial fission/fusion and mitochondrial motility in mitophagy. We also discuss multiple pathways leading to the quality control of mitochondria in addition to the traditional mitophagy pathway under different conditions.

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  • Mitochondrial dynamics and mitophagy are tightly inter-connected and it has been suggested that they regulate each-other.

    “In addition, we listed mitochondria fission and fusion proteins, as well as specific transcription factors within the mitophagy category; in fact, mitochondrial dynamics and mitophagy are tightly inter-connected and it has been suggested that they regulate each-other [6, 35].”

    From A gene toolbox for monitoring autophagy transcription (2021) · cites this paper as [35]

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Cited by

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Authors
Ni, H.-M., Williams, J. A., & Ding, W.-X.
Affiliations
University of Kansas Medical Center (US)
Corresponding author
Ding, Wen-Xing
ORCID
Venue
Redox Biology
Publisher
Elsevier BV
Published
2015-04
Volume
4
Pages
6-13
ISSN
2213-2317 (ISSN-L)
DOI
10.1016/j.redox.2014.11.006
PMC
PMC4309858
OpenAlex
W2090711760
Cited by
931
References
19
Citations by year
2026: 59 · 2025: 106 · 2024: 111 · 2023: 97 · 2022: 108 · 2021: 126 · 2020: 81 · 2019: 67 · 2018: 74 · 2017: 53 · 2016: 27 · 2015: 20 · 2014: 1 · 2012: 1
FWCI
4.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Redox Biology (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • NIAAA (R01 AA020518, R01 DK102142)
  • National Center for Research Resources (5P20RR021940)
  • National Institute of General Medical Sciences (8P20 GM103549, T32 ES007079))
  • National Institutes of Health (P20 GM103418)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
mitochondrial dynamics, mitochondrial quality control, mitophagy, mitochondrial fission, mitochondrial fusion, mitochondrial motility, cytoskeleton, cellular energy homeostasis, cell death, metabolic homeostasis
MeSH terms
Animals, Cytoskeleton, Homeostasis, Humans, Lysosomes, Mammals, Mitochondria, Mitochondrial Dynamics, Mitophagy

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