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Recent Advances in Surface Functionalization of Magnetic Nanoparticles

Comanescu, Cezar·2023·Coatings
DOI 10.3390/coatings13101772
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Abstract

In recent years, significant progress has been made in the surface functionalization of magnetic nanoparticles (MNPs), revolutionizing their utility in multimodal imaging, drug delivery, and catalysis. This progression, spanning over the last decade, has unfolded in discernible phases, each marked by distinct advancements and paradigm shifts. In the nascent stage, emphasis was placed on foundational techniques, such as ligand exchange and organic coatings, establishing the groundwork for subsequent innovations. This review navigates through the cutting-edge developments in tailoring MNP surfaces, illuminating their pivotal role in advancing these diverse applications. The exploration encompasses an array of innovative strategies such as organic coatings, inorganic encapsulation, ligand engineering, self-assembly, and bioconjugation, elucidating how each approach impacts or augments MNP performance. Notably, surface-functionalized MNPs exhibit increased efficacy in multimodal imaging, demonstrating improved MRI contrast and targeted imaging. The current review underscores the transformative impact of surface modifications on drug delivery systems, enabling controlled release, targeted therapy, and enhanced biocompatibility. With a comprehensive analysis of characterization techniques and future prospects, this review surveys the dynamic landscape of MNP surface functionalization over the past three years (2021–2023). By dissecting the underlying principles and applications, the review provides not only a retrospective analysis but also a forward-looking perspective on the potential of surface-engineered MNPs in shaping the future of science, technology, and medicine.

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Figure 1 General schematic diagram of MNPs' synthesis and functionalization. Figure 1. General schematic diagram of MNPs' synthesis and functionalization.
Figure 1 General schematic diagram of MNPs' synthesis and functionalization. Figure 1. General schematic diagram of MNPs' synthesis and functionalization.CC-BY · From the PDF
Image 2
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Figure 3 Representative research direction in functionalized magnetic nanoparticles. Figure 3. Representative research direction in functionalized magnetic nanoparticles.
Figure 3 Representative research direction in functionalized magnetic nanoparticles. Figure 3. Representative research direction in functionalized magnetic nanoparticles.CC-BY · From the PDF
Image 4
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Figure 5 Synthesis procedure for poly(2-(diethylamino) ethylmethacrylate) brushes capped with folic acid grafted on magnetic mesoporous silica nanoparticle (MMSNs) surfaces via SI-ARGET ATRP [44]. Figure 5. Synthesis procedure for poly(2-(diethylamino) ethylmethacrylate) brushes capped with folic acid grafted on magnetic mesoporous silica nanoparticle (MMSNs) surfaces via SI-ARGET ATRP [44]. Figure 5. Synthesis procedure for poly(2-(diethylamino) ethylmethacrylate) brushes capped with folic acid grafted on magnetic mesoporous silica nanoparticle (MMSNs) surfaces via SI-ARGET ATRP [44].
Figure 5 Synthesis procedure for poly(2-(diethylamino) ethylmethacrylate) brushes capped with folic acid grafted on magnetic mesoporous silica nanoparticle (MMSNs) surfaces via SI-ARGET ATRP [44]. Figure 5. Synthesis procedure for poly(2-(diethylamino) ethylmethacrylate) brushes capped with folic acid grafted on magnetic mesoporous silica nanoparticle (MMSNs) surfaces via SI-ARGET ATRP [44]. Figure 5. Synthesis procedure for poly(2-(diethylamino) ethylmethacrylate) brushes capped with folic acid grafted on magnetic mesoporous silica nanoparticle (MMSNs) surfaces via SI-ARGET ATRP [44].CC-BY · From the PDF
Figure 6 ( A ) Synthesis of PGICLCys and SPIONs and conjugation with folic acid (FA) or methotrexate (MTX). SPION@PGlCLCys_MTX: ( B ) drug delivery assay at lysosomal pH (pH 5.3) with or without protease (ENZ); ( C ) breast carcinoma-derived MDA-MB 231 cells viability after 72 h at different MTX concentrations. Reprinted under the terms and conditions of the Creative Commons Attribution (CC BY) license from ref. [90]. Figure 6. ( A ) Synthesis of PGICLCys and SPIONs and conjugation with folic acid (FA) or methotrexate (MTX). SPION@PGlCLCys_MTX: ( B ) drug delivery assay at lysosomal pH (pH 5.3) with or without protease (ENZ); ( C ) breast carcinoma-derived MDA-MB 231 cells viability after 72 h at different MTX concentrations. Reprinted under the terms and conditions of the Creative Commons Attribution (CC BY) license from ref. [90].
Figure 6 ( A ) Synthesis of PGICLCys and SPIONs and conjugation with folic acid (FA) or methotrexate (MTX). SPION@PGlCLCys_MTX: ( B ) drug delivery assay at lysosomal pH (pH 5.3) with or without protease (ENZ); ( C ) breast carcinoma-derived MDA-MB 231 cells viability after 72 h at different MTX concentrations. Reprinted under the terms and conditions of the Creative Commons Attribution (CC BY) license from ref. [90]. Figure 6. ( A ) Synthesis of PGICLCys and SPIONs and conjugation with folic acid (FA) or methotrexate (MTX). SPION@PGlCLCys_MTX: ( B ) drug delivery assay at lysosomal pH (pH 5.3) with or without protease (ENZ); ( C ) breast carcinoma-derived MDA-MB 231 cells viability after 72 h at different MTX concentrations. Reprinted under the terms and conditions of the Creative Commons Attribution (CC BY) license from ref. [90].CC-BY · From the PDF
Image 7
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Figure 8 The main parameters and features that need to be addressed by future MNP nanoplatforms for efficient use in biomedical applications and beyond. Figure 8. The main parameters and features that need to be addressed by future MNP nanoplatforms for efficient use in biomedical applications and beyond.
Figure 8 The main parameters and features that need to be addressed by future MNP nanoplatforms for efficient use in biomedical applications and beyond. Figure 8. The main parameters and features that need to be addressed by future MNP nanoplatforms for efficient use in biomedical applications and beyond.CC-BY · From the PDF

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Metadata

Authors
Comanescu, C.
Venue
Coatings
Publisher
MDPI AG
Published
2023-10-15
Volume
13
Issue
10
Pages
1772
ISSN
2079-6412
DOI
10.3390/coatings13101772
Cited by
132
References
0
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Romanian Ministry of Research and Innovation (PN-III-P1-1.1-TE-2021-1657 (TE 84/2022), TE 91/2022, PC1-PN23080101)
  • Core Program of the National Institute of Materials Physics (PN-III-P1-1.1-TE-2021-1657 (TE 84/2022), TE 91/2022, PC1-PN23080101)

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CoChat. (2026). Citation check: Recent Advances in Surface Functionalization of Magnetic Nanoparticles. https://app.cochat.ai/papers/10.3390/coatings13101772
The paper
Comanescu, C. (2023). Recent Advances in Surface Functionalization of Magnetic Nanoparticles. Coatings. https://doi.org/10.3390/coatings13101772