The DOI matches its Crossref record; 43 of the 49 references it cites were found in a registry or an index.
Topical Peptide Treatments with Effective Anti-Aging Results
Open accessAbstract
In the last two decades, many new peptides have been developed, and new knowledge on how peptides improve the skin has been uncovered. The spectrum of peptides in the field of cosmetics is continuously growing. This review summarizes some of the effective data on cosmeceutical peptides that work against intrinsic and extrinsic aging. Some peptides have been proven in their efficacy through clinical skin trials. Well-known and documented peptides like copper tripeptide are still under research to obtain more details on their effectiveness, and for the development of new treatments. Palmitoyl pentapeptide-4 and Carnosine are other well-researched cosmeceuticals. Additionally, there are many more peptides that are used in cosmetics. However, study results for some are sparse, or have not been published in scientific journals. This article summarizes topical peptides with proven efficacy in controlled in vivo studies.
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“Furthermore, there is a lack of clinical trials mentioned in the article to support the claims of anti‐aging results from peptide treatments.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [51]
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“However, the level of evidence provided in this article is low, as the author primarily relies on anecdotal evidence and in vitro studies.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [51]
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1 retracted
Zhou, B., Ma, L., Liu, J., Zhang, J.-A., Xu, Y., Wu, D., Permatasari, F., & Luo, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5846865 · Cited by 17
RetractedActivation of latent TGF-β by thrombospondin-1: mechanisms and physiology
Murphy-Ullrich, J. E., & Poczatek, M. H. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00029-5 · Cited by 590
Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways
Mitragotri, S. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00321-8 · Cited by 324
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin1
Robinson, L. R., Fitzgerald, N. C., Doughty, D. G., Dawes, N. C., Berge, C. A., & Bissett, D. L. (2005) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2005.00261.x · Cited by 214
Role of topical peptides in preventing or treating aged skin
Gorouhi, F., & Maibach, H. I. (2009) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2009.00490.x · Cited by 193
Ueber einige Derivate des Glykocolls
Fischer, E., & Fourneau, E. (1901) · Berichte der deutschen chemischen Gesellschaft · doi:10.1002/cber.190103402249 · Cited by 190
A synthetic hexapeptide (Argireline) with antiwrinkle activity
Blanes‐Mira, C., Clemente, J., Jodas, G., Gil, A., Fernández‐Ballester, G., Ponsati, B., Gutierrez, L., Pérez‐Payá, E., & Ferrer‐Montiel, A. (2002) · International Journal of Cosmetic Science · doi:10.1046/j.1467-2494.2002.00153.x · Cited by 187
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2015) · BioMed Research International · doi:10.1155/2015/648108 · Cited by 144
Campbell, J. D., McDonough, J. E., Zeskind, J. E., Hackett, T. L., Pechkovsky, D. V., Brandsma, C.-A., Suzuki, M., Gosselink, J. V., Liu, G., Alekseyev, Y. O., et al. (2012) · Genome Medicine · doi:10.1186/gm367 · Cited by 128
Manosroi, A., Chutoprapat, R., Abe, M., Manosroi, W., & Manosroi, J. (2012) · Pharmaceutical Biology · doi:10.3109/13880209.2011.596206 · Cited by 123
Research works printed but not linked: 8
- Imfeld, 2015, Activation of tgf a gateway to skin rejuvenation small synthetic-peptide mimics natural protein activity in skin to unlock tgf potential, H&PC Today-Househ. Pers. Care Today, 10, 6
- Guttman, 2002, Studies demonstrate value of procollagen fragment Pal-KTTKS, Dermatol. Times, 23, 68
- Rodrigues, 2009, Counter acting Ageing Phenomena by New Pure Tetrapeptides with Targeted Efficacy, Cosmet. Sci. Technol., 27, 63
- Pickart, 2015, New data of the Cosmeceutical and tripeptide GHK, SOFW J., 9, 141
- Kerscher, 2011, Update in der dermatologischen Kosmetik (Update on cosmeceuticals), JDDG, 9, 314
- Leyden, J.J., Stevens, T., Finkey, M.B., and Barkovic, S. (2002, January 22–27). Skin care benefits of copper peptide containing facial cream. Proceedings of the American Academy of Dermatology 60th Annual Meeting, New Orleans, LA, USA.
- Chhipa, N.M.R., and Chaudhari, B. (2017, April 22). Toxin as a Medicine. Available online: https://www.researchgate.net/profile/Nadim_Chhipa/publication/269037373_TOXIN_AS_A_MEDICINE/links/547dfbf70cf241bf4b5b9b40.pdf.
- Trookman, 2009, Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles, J. Clin. Aesthet. Dermatol., 2, 38
Cited by
Sorted by citations
Collagen: A review on its sources and potential cosmetic applications
Rodríguez, M. I. A., Barroso, L. G. R., & Sánchez, M. L. (2017) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12450 · Cited by 593
Zaky, A. A., Simal‐Gándara, J., Eun, J., Shim, J., & El‐Aty, A. M. A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.815640 · Cited by 475
A Global Review on Short Peptides: Frontiers and Perspectives
Apostolopoulos, V., Bojarska, J., Chai, T., Elnagdy, S. M., Kaczmarek, K., Matsoukas, J., New, R. R. C., Parang, K., Paredes‐López, O., Parhiz, H., et al. (2021) · Molecules · doi:10.3390/molecules26020430 · Cited by 459
The emerging role of nanotechnology in skincare
Salvioni, L., Morelli, L., Ochoa, E., Labra, M., Fiandra, L., Palugan, L., Prosperi, D., & Colombo, M. (2021) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2021.102437 · Cited by 344
Hu, S., Li, Z., Cores, J., Huang, K., Su, T., Dinh, P., & Cheng, K. (2019) · ACS Nano · doi:10.1021/acsnano.9b04384 · Cited by 295
Metadata
- Authors
- Schagen, S.
- Affiliations
- Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (FR)
- Corresponding author
- Schagen, Silke
- Venue
- Cosmetics
- Publisher
- MDPI AG
- Published
- 2017-05-22
- Volume
- 4
- Issue
- 2
- Pages
- 16
- ISSN
- 2079-9284 (ISSN-L)
- OpenAlex
- W2617896390
- Cited by
- 195
- References
- 49
- Citations by year
- 2026: 27 · 2025: 40 · 2024: 21 · 2023: 18 · 2022: 25 · 2021: 19 · 2020: 20 · 2019: 14 · 2018: 9 · 2017: 2
- FWCI
- 14.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cosmetics (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
- Keywords
- cosmeceuticals, skin aging, anti-aging, intrinsic aging, extrinsic aging, carnosine, in vivo efficacy
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