The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Role of topical peptides in preventing or treating aged skin
Open accessAbstract
Ageing, a basic biological process seen in all living creatures, is not preventable. Surgical and topical modalities have been invented and substances were applied topically to alter the ageing process. Peptides and proteins, frequently used for this purpose, were categorized into four groups: signal peptides, enzyme-inhibitor peptides, neurotransmitter-inhibitor peptides and carrier peptides. We comprehensively review eligible studies -including controlled ex vivo or in vivo efficacy studies on any topical peptide or protein that has been administered to treat signs and symptoms of ageing.
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“The level of evidence for this article is categorized as Level 2b, as it is based on expert opinion or consensus.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
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“Additionally, the article is limited by its focus on theoretical considerations rather than empirical research.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
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“Furthermore, the article lacks well‐designed, randomized controlled trials that validate the clinical utility of peptide‐containing skincare products.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, despite the promising theoretical rationale behind the use of topical peptides in skincare, the evidence presented in this article is primarily based on in vitro and animal studies. The level of evidence falls short of providing conclusive proof of the efficacy of topical peptides in human subjects.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“While the authors cite numerous studies to support their claims, much of the evidence presented is anecdotal or lacks rigorous scientific validation.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
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In the citing paper
“Overall, the level of evidence presented in this article is classified as Level III according to the Oxford Centre for Evidence‐Based Medicine's hierarchy of evidence.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
Experimental — accuracy not yet measuredIn the citing paper
“Numerous studies confirmed the ability of copper peptides to improve condition of aging skin, which make them indispensable in anti-aging and protective cosmetic products [2,3].”
From Skin Regenerative and Anti-Cancer Actions of Copper Peptides (2018) · cites this paper as [2]
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Citations
Cites
1 retracted
Interventions for photodamaged skin
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A peptide carrier for the delivery of biologically active proteins into mammalian cells
Morris, M. C., Depollier, J., Méry, J., Heitz, F., & Divita, G. (2001) · Nature Biotechnology · doi:10.1038/nbt1201-1173 · Cited by 1,019
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Enhancement of Wound Healing by Topical Treatment with Epidermal Growth Factor
Brown, G. L., Nanney, L. B., Griffen, J., Cramer, A. B., Yancey, J. M., Curtsinger, L. J., Holtzin, L., Schultz, G. S., Jurkiewicz, M. J., & Lynch, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198907133210203 · Cited by 682
Hsp70 Prevents Activation of Stress Kinases
Gabai, V. L., Meriin, A. B., Mosser, D. D., Caron, A. W., Rits‐Volloch, S., Shifrin, V. I., & Sherman, M. Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18033 · Cited by 509
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Percutaneous Penetration Enhancers
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Expansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians
FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., & SANSONI, P. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-689.x · Cited by 362
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Flagged first, then by citations
Research works printed but not linked: 11
- Osborne R., 2005, Use of a facial moisturizer containing palmitoyl pentapeptide improves the appreance of aging skin, J. Am. Acad. Dermatol., 52
- Croda USA, 1998, News and News Releases
- Ghersetich I., 1992, Immunohistochemical and ultrastructural investigation of multiple common warts before and after therapy with alpha‐interferon, G. Ital. Dermatol. Venereol., 127, 207
- Botto J., 2001, Treatment of human cells with Hsp‐70‐rich yeast extract enhances cell thermotolerance and resistance to stress, J. Invest. Dermatol., 117, 452
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- Domloge N., 2002, Artemia extract toward more extensive sun protection, Cosmet. Toiletries, 2002, 69
- Bauza E., 2001, Hsp70 induction by Artemia extract exhibits anti‐inflammatory effect and down‐regulates IL‐1 and IL‐8 synthesis in human HaCaT cells, J. Invest. Dermatol., 117, 415
- 10.1111/j.1751-1097.2005.tb00229.x · DOI
- Leyden J.J., 2002, American Academy of Dermatology 60th Annual Meeting, 29
- Finkey M.B., 2005, Cosmeceuticals and Active Cosmetics, 549
- Leyden J.J., 2002, American Academy of Dermatology 60th Annual Meeting, 29
Cited by
Sorted by citations
Topical Peptide Treatments with Effective Anti-Aging Results
Schagen, S. (2017) · Cosmetics · doi:10.3390/cosmetics4020016 · Cited by 195
Skin Regenerative and Anti-Cancer Actions of Copper Peptides
Pickart, L., & Margolina, A. (2018) · Cosmetics · doi:10.3390/cosmetics5020029 · Cited by 33
Effects of topicals on the aging skin process
Thomas, J. R., Dixon, T. K., & Bhattacharyya, T. K. (2013) · Facial Plastic Surgery Clinics of North America · doi:10.1016/j.fsc.2012.11.009 · Cited by 29
Spent Yeast Waste Streams as a Sustainable Source of Bioactive Peptides for Skin Applications
Costa, E. M., Oliveira, A. S., Silva, S., Ribeiro, A. B., Pereira, C. F., Ferreira, C., Casanova, F., Pereira, J. O., Freixo, R., Pintado, M. E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032253 · Cited by 23
Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23
Metadata
- Authors
- Gorouhi, F., & Maibach, H. I.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Gorouhi, F.
- Venue
- International Journal of Cosmetic Science
- Publisher
- Wiley
- Published
- 2009-08-27
- Volume
- 31
- Issue
- 5
- Pages
- 327-345
- ISSN
- 0142-5463 (ISSN-L)
- 1468-2494
- OpenAlex
- W2131381649
- Cited by
- 193
- References
- 92
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 11 · 2023: 22 · 2022: 12 · 2021: 11 · 2020: 21 · 2019: 7 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 12 · 2014: 12 · 2013: 5 · 2012: 2
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cosmetic Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Keywords
- skin aging, signal peptide, protein delivery
- MeSH terms
- Administration, Topical, Cosmetics, Humans, Peptides, Skin, Skin Absorption, Skin Aging
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