Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin1
Abstract
Synopsis: The palmitoyl pentapeptide palmitoyl‐lysine‐threonine‐threonine‐lysine‐serine (pal‐KTTKS) is a synthetic material that was designed as a topical agent to stimulate collagen production and thus provide a skin anti‐wrinkle benefit. To determine if pal‐KTTKS is effective, the clinical study reported here was conducted. Caucasian female subjects (n = 93, aged 35–55) participated in a 12‐week, double‐blind, placebo‐controlled, split‐face, left–right randomized clinical study assessing two topical products: moisturizer control product vs. the same moisturizer product containing 3 ppm pal‐KTTKS. Pal‐KTTKS was well tolerated by the skin and provided significant improvement vs. placebo control for reduction in wrinkles/fine lines by both quantitative technical and expert grader image analysis. In self‐assessments, subjects also reported significant fine line/wrinkle improvements and noted directional effects for other facial improvement parameters.
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In a placebo-controlled, double-blinded randomized controlled split-face study of 93 healthy subjects with mild photodamaged skin, Pal-KTTKS significantly reduced rhytides compared with control.
“Compared to control, Pal‐KTTKS can significantly reduce the rhytides (Level Ib).”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [46]
Cites
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Molecular Mechanisms of Dermal Aging and Antiaging Approaches
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Effects of topicals on the aging skin process
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Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23 · see citing works
- Authors
- Robinson, L. R., Fitzgerald, N. C., Doughty, D. G., Dawes, N. C., Berge, C. A., & Bissett, D. L.
- Affiliations
- Procter & Gamble (United States) (US)
- Corresponding author
- Bissett, D. L.
- ORCID
- Fitzgerald, N. C.
- Venue
- International Journal of Cosmetic Science
- Publisher
- Wiley
- Published
- 2005-05-06
- Volume
- 27
- Issue
- 3
- Pages
- 155-160
- ISSN
- 0142-5463 (ISSN-L)
- 1468-2494
- OpenAlex
- W2028947341
- Cited by
- 214
- References
- 9
- Citations by year
- 2026: 21 · 2025: 15 · 2024: 12 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 12 · 2018: 5 · 2017: 12 · 2016: 13 · 2015: 16 · 2014: 3 · 2013: 11 · 2012: 4
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cosmetic Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- photodamaged skin, facial wrinkles, fine lines, collagen stimulation, emollients, wrinkle reduction
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