Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice
Abstract
It is well-known that chronic ultraviolet B (UVB) exposure at low-dose causes skin photoaging including increases in skin thickness and wrinkle formation and reduction in skin elasticity. This study examined the effects of total saponins and ginsenoside Rb(1) isolated from Red Ginseng roots on skin thickness, elasticity, and wrinkle formation caused by long-term, low-dose UVB irradiation in hairless mice. The topical application of total ginseng saponins (10 pg or 100 ng/mouse) and ginsenoside Rb(1) (100 fg, 10 pg, or 1 ng/mouse) significantly inhibited increases in skin thickness and wrinkle formation and the reduction in skin elasticity induced by long-term UVB irradiation. Furthermore, we examined the histological effects of total saponins and ginsenoside Rb(1) in the skin of UVB-irradiated hairless mice. The increases in apoptotic, Ki-67-, and 8-hydroxy-2'-deoxyguanosine-positive cells induced by UVB exposure were prevented by the topical application of total saponins and ginsenoside Rb(1). Furthermore, total saponins and ginsenoside Rb(1) prevented the disruption of collagen fibers induced by the long-term UVB irradiation. Ginsenoside Rb(1) (100 fg, 10 pg, and 1 ng/ml) increased the Bcl-2 expression level in UVB-treated human keratinocytes. The protective effect of ginsenoside Rb(1) on UVB-mediated apoptosis may be due to the up-regulation of Bcl-2 expression. These results suggest that the protective effect of ginsenoside Rb(1) on skin photoaging induced by chronic UVB…
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Ginsenoside Re (5) and ginsenoside Rb1 (7) have been reported to alleviate skin inflammation in animal models.
“In addition, ginsenoside Re (5) and ginsenoside Rb1 (7) have been reported to alleviate skin inflammation in animal models [32,33].”
From Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ-Induced Skin Cell Damage (2024) · cites this paper as [33]
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The Bcl2 family: regulators of the cellular life-or-death switch
Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032 · see citing works
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Lee, H.-S., Kim, M.-R., Park, Y., Park, H. J., Chang, U. J., Kim, S. Y., & Suh, H. J. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2187 · Cited by 101 · see citing works
Park, J., Pyun, H., Woo, S. W., Jeong, J., & Hwang, J. (2014) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/phpp.12097 · Cited by 74 · see citing works
Shin, D. J., Kim, J., Lim, T., Jeong, E. H., Park, G., Kang, N. J., Park, J., Yeom, M., Oh, D. K., Bode, A. M., et al. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24833 · Cited by 37 · see citing works
Kang, M., Park, S., Son, S.-R., Noh, Y., Jang, D. S., & Lee, S. (2024) · Molecules · doi:10.3390/molecules29225479 · Cited by 23 · see citing works
Lee, H. Y., Kim, E.-J., Cho, D. Y., Jung, J. G., Kim, M. J., Lee, J. H., Kim, W., Kang, S. S., Cho, K. M., & Kang, D. (2023) · Nutrients · doi:10.3390/nu15071715 · Cited by 16 · see citing works
- Authors
- Kim, Y. G., Sumiyoshi, M., Sakanaka, M., & Kimura, Y.
- Affiliations
- Ehime University (JP)
- Corresponding author
- Kimura, Yoshiyuki
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 602
- Issue
- 1
- Pages
- 148-156
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2008479537
- Cited by
- 88
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 8 · 2013: 3 · 2012: 8
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (19590694)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- ginsenosides, ginsenoside Rb1, red ginseng, photoaging, UVB irradiation, skin thickness, wrinkle formation, skin elasticity, collagen fibers, apoptosis, Bcl-2, keratinocytes, dermal fibroblasts, matrix metalloproteinases, oxidative DNA damage, topical application
- MeSH terms
- Administration, Topical, Animals, Cells, Cultured, Dose-Response Relationship, Drug, Fibroblasts, Panax, Humans, Male, Metalloendopeptidases, Mice, Hairless, Saponins, Ultraviolet Rays, Skin Aging, Keratinocytes, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Mice
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