The DOI matches its Crossref record; 386 of the 386 references it cites were found in a registry or an index.
Balancing the Oral Redox State: Endogenous and Exogenous Sources of Reactive Oxygen Species and the Antioxidant Role of Lamiaceae and Asteraceae
Open accessAbstract
Background/Objectives: Oral health is a complex concept involving physical, psychological, emotional, and social components. A key factor in maintaining oral tissue integrity is redox balance, which is disrupted by oxidative stress (OS) through an imbalance between reactive oxygen species (ROS) and antioxidant defenses. This study examines the contribution of endogenous and exogenous sources to OS and explores the therapeutic potential of medicinal plants from the Asteraceae and Lamiaceae families in restoring redox homeostasis and improving oral health. Methods: A literature review was conducted, analyzing the role of OS in oral diseases and the antioxidant mechanisms of selected Asteraceae species. Special attention was given to their phytochemical contents—polyphenols, flavonoids, and essential oils—and their biological relevance to oral health. Results: OS plays a critical role in the onset and progression of oral conditions such as caries, periodontitis, gingivitis, aphthous ulcers, abscesses, precancerous lesions, and oral cancers. ROS and reactive nitrogen species (RNS) cause inflammation, tissue breakdown, and salivary gland dysfunction. Asteraceae plants like Matricaria chamomilla, Calendula officinalis, Cichorium intybus, Taraxacum officinale, Arctium lappa, Achillea millefolium, and Solidago virgaurea demonstrate notable antioxidant, anti-inflammatory, and antimicrobial properties that help counteract OS and support oral homeostasis. Conclusions: Asteraceae and Lamiaceae species show high therapeutic potential in addressing OS-related oral disorders. Their bioactive compounds aid in restoring redox balance and protecting oral tissues. These findings support the integration of phytotherapeutic agents into oral healthcare and call for further clinical validation of plant-based strategies for disease prevention and management.
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“Berberine reaches high local concentrations there before absorption and, being broadly antibacterial, can act on that community [107].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [107]
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“The oral compartment, where berberine reaches its highest concentrations of all, is unexamined and belongs in the same program [103,104,105,106,107,108].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [107]
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“No study has yet measured the disposition of a co-administered drug before and after berberine while characterizing the microbiota in the same subjects, which is what would move Axis 4 from candidate to demonstrated.”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [107]
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Metadata
- Authors
- Dumitru, C. N., Mariana, L., Budacu, C. C., Mitea, G., Radu, M. D., Dumitru, A. O., Lupoae, A., Tatu, A., & Topor, G.
- Affiliations
- "Dunarea de Jos" University of Galati (RO)
- Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, 800010 Galati, Romania
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Ovidius University (RO)
- Emergency Clinical Hospital “St. Apostle Andrew”, 800010 Galati, Romania
- Corresponding author
- Budacu, Cristian Constantin
- ORCID
- Venue
- Dentistry Journal
- Publisher
- MDPI AG
- Published
- 2025-05-21
- Volume
- 13
- Issue
- 5
- Pages
- 222
- ISSN
- 2304-6767 (ISSN-L)
- PMC
- PMC12110304
- OpenAlex
- W4410564845
- Cited by
- 17
- References
- 381
- Citations by year
- 2026: 15 · 2025: 2
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Dentistry Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- oxidative stress, reactive oxygen species, reactive nitrogen species, antioxidant activity, medicinal plants, Asteraceae, Lamiaceae, oral health, periodontitis, dental caries, gingivitis, recurrent aphthous stomatitis, oral cancer, polyphenols, flavonoids, essential oils, herbal medicine, chamomile, Calendula officinalis, chicory, Taraxacum officinale, Arctium lappa, yarrow, Solidago virgaurea, anti-inflammatory activity, antimicrobial activity
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