Cited by 19Oral microbiology and periodontitis researchMedicinal Plant ResearchPhytochemicals and Antioxidant Activities

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Balancing the Oral Redox State: Endogenous and Exogenous Sources of Reactive Oxygen Species and the Antioxidant Role of Lamiaceae and Asteraceae

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Dumitru, Caterina Nela, Mariana, Lupoae, Budacu, Cristian Constantin, Mitea, Gabriela, Radu, Marius Daniel, Dumitru, Alina Oana, Lupoae, Andreea, Tatu, Alin, Topor, Gabi·2025·Dentistry Journal

DOI 10.3390/dj13050222PMC PMC12110304

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Abstract

Background/Objectives: Oral health is a complex concept involving physical, psychological, emotional, and social components. A key factor in maintaining oral tissue integrity is redox balance, which is disrupted by oxidative stress (OS) through an imbalance between reactive oxygen species (ROS) and antioxidant defenses. This study examines the contribution of endogenous and exogenous sources to OS and explores the therapeutic potential of medicinal plants from the Asteraceae and Lamiaceae families in restoring redox homeostasis and improving oral health. Methods: A literature review was conducted, analyzing the role of OS in oral diseases and the antioxidant mechanisms of selected Asteraceae species. Special attention was given to their phytochemical contents—polyphenols, flavonoids, and essential oils—and their biological relevance to oral health. Results: OS plays a critical role in the onset and progression of oral conditions such as caries, periodontitis, gingivitis, aphthous ulcers, abscesses, precancerous lesions, and oral cancers. ROS and reactive nitrogen species (RNS) cause inflammation, tissue breakdown, and salivary gland dysfunction. Asteraceae plants like Matricaria chamomilla, Calendula officinalis, Cichorium intybus, Taraxacum officinale, Arctium lappa, Achillea millefolium, and Solidago virgaurea demonstrate notable antioxidant, anti-inflammatory, and antimicrobial properties that help counteract OS and support oral homeostasis. Conclusions: Asteraceae and Lamiaceae species show high therapeutic potential in addressing OS-related oral disorders. Their bioactive compounds aid in restoring redox balance and protecting oral tissues. These findings support the integration of phytotherapeutic agents into oral healthcare and call for further clinical validation of plant-based strategies for disease prevention and management.

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Figure 1 The benefits of plants in addressing oral disorders related to oxidative stress.CC BY · PubMed Central

Figure 2 Endogenous and exogenous sources of reactive oxygen species.CC BY · PubMed Central

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Authors: Dumitru, C. N., Mariana, L., Budacu, C. C., Mitea, G., Radu, M. D., Dumitru, A. O., Lupoae, A., Tatu, A., & Topor, G.
Affiliations: "Dunarea de Jos" University of Galati (RO)
Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, 800010 Galati, Romania
Grigore T. Popa University of Medicine and Pharmacy (RO)
Ovidius University (RO)
Emergency Clinical Hospital “St. Apostle Andrew”, 800010 Galati, Romania
Corresponding author: Budacu, Cristian Constantin
ORCID: Dumitru, Caterina Nela
Mariana, Lupoae
Budacu, Cristian Constantin
Mitea, Gabriela
Radu, Marius Daniel
Dumitru, Alina Oana
Tatu, Alin
Topor, Gabi
Venue: Dentistry Journal
Publisher: MDPI AG
Published: 2025-05-21
Volume: 13
Issue: 5
Pages: 222
ISSN: 2304-6767 (ISSN-L)
DOI: 10.3390/dj13050222
PMC: PMC12110304
OpenAlex: W4410564845
Cited by: 17
References: 381
Citations by year: 2026: 15 · 2025: 2
FWCI: 2.89
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Dentistry Journal (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: oxidative stress, reactive oxygen species, reactive nitrogen species, antioxidant activity, medicinal plants, Asteraceae, Lamiaceae, oral health, periodontitis, dental caries, gingivitis, recurrent aphthous stomatitis, oral cancer, polyphenols, flavonoids, essential oils, herbal medicine, chamomile, Calendula officinalis, chicory, Taraxacum officinale, Arctium lappa, yarrow, Solidago virgaurea, anti-inflammatory activity, antimicrobial activity

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Balancing the Oral Redox State: Endogenous and Exogenous Sources of Reactive Oxygen Species and the Antioxidant Role of Lamiaceae and Asteraceae

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