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Cited by 9Sperm and Testicular FunctionBioinformatics and Genomic NetworksMale Reproductive Health Studies

A Comparative Cross-Platform Analysis to Identify Potential Biomarker Genes for Evaluation of Teratozoospermia and Azoospermia

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Das, Suchismita, Guha, Pokhraj, Nath, Monika, Das, Sandipan, Sen, Surojit, Sahu, Jagajjit, Kopanska, Marta, Dutta, Sulagna +5 more·2022·Genes
DOI 10.3390/genes13101721PMC PMC9602071
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Abstract

Male infertility is a global public health concern. Teratozoospermia is a qualitative anomaly of spermatozoa morphology, contributing significantly to male infertility, whereas azoospermia is the complete absence of spermatozoa in the ejaculate. Thus, there is a serious need for unveiling the common origin and/or connection between both of these diseases, if any. This study aims to identify common potential biomarker genes of these two diseases via an in silico approach using a meta-analysis of microarray data. In this study, a differential expression analysis of genes was performed on four publicly available RNA microarray datasets, two each from teratozoospermia (GSE6872 and GSE6967) and azoospermia (GSE145467 and GSE25518). From the analysis, 118 DEGs were found to be common to teratozoospermia and azoospermia, and, interestingly, sperm autoantigenic protein 17 (SPA17) was found to possess the highest fold change value among all the DEGs (9.471), while coiled-coil domain-containing 90B (CCDC90B) and coiled-coil domain-containing 91 (CCDC91) genes were found to be common among three of analyses, i.e., Network Analyst, ExAtlas, and GEO2R. This observation indicates that SPA17, CCDC90B, and CCDC91 genes might have significant roles to play as potential biomarkers for teratozoospermia and azoospermia. Thus, our study opens a new window of research in this area and can provide an important theoretical basis for the diagnosis and treatment of both these diseases.

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  • Advances in the genetics of male infertility have shown a significant contribution of genetics towards abnormal sperm morphology, especially in cases of severe or specific sperm morphological defects.

    “Advances in the genetics of male infertility have shown a significant contribution of genetics towards abnormal sperm morphology (35), especially in cases of severe or specific sperm morphological defects (36).”

    From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [35]

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Das, S., Guha, P., Nath, M., Das, S., Sen, S., Sahu, J., Kopanska, M., Dutta, S., Jamal, Q. M. S., Kesari, K. K., Sengupta, P., Slama, P., & Roychoudhury, S.
Affiliations
  • Assam University (IN)
  • Department of Zoology, Garhbeta College, Garhbeta 721127, India
  • Department of Zoology, Mariani College, Mariani 785634, India
  • GyanArras Academy, Gothapatna, Malipada, Bhubaneswar 751003, India
  • Department of Pathophysiology, Institute of Medical Sciences, College of Medical Sciences, University of Rzeszow, 35959 Rzeszow, Poland
  • Bharath University (IN)
  • Qassim University (SA)
  • Aalto University (FI)
  • Gulf Medical University (AE)
  • Laboratory of Animal Immunology and Biotechnology, Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, 61300 Brno, Czech Republic
Corresponding author
Roychoudhury, Shubhadeep
ORCID
Venue
Genes
Publisher
MDPI AG
Published
2022-09-25
Volume
13
Issue
10
Pages
1721
ISSN
2073-4425 (ISSN-L)
DOI
10.3390/genes13101721
PMC
PMC9602071
OpenAlex
W4297198512
Cited by
9
References
1
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 1
FWCI
0.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Genes (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Aaltodoc (Aalto University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
  • Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
Keywords
teratozoospermia, azoospermia, male infertility, biomarker genes, differentially expressed genes, sperm morphology, gene expression profiling
MeSH terms
Teratozoospermia, Humans, Infertility, Male, Male, RNA, Semen, Biomarkers, Azoospermia

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