Correlation among isolated teratozoospermia, sperm DNA fragmentation and markers of systemic inflammation in primary infertile men
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Aim: To assess the prevalence of isolated teratozoospermia (iTZS) in a cohort of infertile and fertile men; explore the relationship between iTZS, inflammatory parameters and sperm DNA fragmentation index (SDF) in the same cohort. Materials and methods: 1824 infertile men and 103 fertile controls. Semen analysis, the neutrophil-to-lymphocyte ratio (NLR) and serum hormones were investigated. DFI was tested in infertile men only. According to 2010 WHO semen analysis, patients were categorized in 3 sub-groups of isolated sperm defects: isolated oligozoospermia (iOZS), isolated asthenozoospermia (iAZS) and iTZS. Descriptive statistics and linear regression models tested the association between clinical variables and inflammatory markers. Results: Among infertile men, iAZS, iTZS, and iOZS were found in 13.9%, 11.9% and 4.1% participants, respectively. iTZS was found in 37 (35.9%) fertile men. Infertile men with iTZS had higher NLR values than those with iOZS, iAZS and men with normal semen parameters (all p<0.001). FSH and LH were higher and inhibin B lower in iOZS infertile men compared to all other groups (p≤0.001). Hormonal characteristics were similar between iTZS infertile and fertile men. Similarly, iTZS infertile men had higher SDF than all other groups (all p<0.001). Infertile men with iTZS had higher NLR values than fertile men with iTZS (p<0.01). Linear regression analysis showed that, in infertile men, iTZS was associated with SDF and NLR (all p≤0.01). Conclusions: iTZS was found in 11.9% of infertile men but it was even more prevalent in fertile controls. Infertile men with iTZS had higher NLR than fertile controls and increased SDF values than infertile participant with iAZS, iOZS, or normal semen parameters. No differences in hormonal characteristics were found between infertile and fertile men with iTZS.
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One study found that isolated teratozoospermia was more common in fertile than infertile males.
“and one study found that isolated teratozoospermia was more common in fertile than infertile males (20).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [20]
A recent study of 1,824 infertile men found that while 11.9% of infertile males had isolated teratozoospermia, the prevalence was higher in 103 fertile controls at 35.9%.
“Interestingly, a recent study of 1,824 infertile men found that while 11.9% of infertile males had isolated teratozoospermia, the prevalence was higher in 103 fertile controls at 35.9% (20).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [20]
A real-world study showed that infertile men with isolated teratozoospermia have a higher SDF rate than those without abnormalities.
“A real-world study also showed that infertile men with isolated teratozoospermia have a higher SDF rate than those without abnormalities (20).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [20]
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- Authors
- Candela, L., Boeri, L., Capogrosso, P., Cazzaniga, W., Pozzi, E., Belladelli, F., Baudo, A., Ravizzoli, A., Ventimiglia, E., Viganò, P., Alfano, M., Abbate, C., Cornelius, J., Mattei, A., Montorsi, F., & Salonia, A.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Ospedale di Circolo e Fondazione Macchi (IT)
- IRCCS Ospedale San Raffaele (IT)
- Luzerner Kantonsspital (CH)
- Corresponding author
- Salonia, Andrea
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2021-06-07
- Volume
- 16
- Issue
- 6
- Pages
- e0251608
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC8184012
- OpenAlex
- W3167553352
- Cited by
- 35
- References
- 58
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 5 · 2022: 3 · 2021: 2
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IrInSubria (University of Insubria) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- sperm DNA fragmentation, systemic inflammation, neutrophil-to-lymphocyte ratio, male infertility, semen quality, follicle-stimulating hormone, luteinizing hormone, inhibin B
- MeSH terms
- Teratozoospermia, Fertility, Humans, Infertility, Male, Inflammation, Male, Oligospermia, Semen, Sperm Motility, Spermatozoa, Biomarkers, Asthenozoospermia, DNA Fragmentation
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