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Wool Keratin-Associated Protein Genes in Sheep—A Review
Open accessAbstract
The importance of sheep’s wool in making textiles has inspired extensive research into its structure and the underlying genetics since the 1960s. Wool keratin-associated proteins (KAPs) are a key structural component of the wool fibre. The characterisation of the genes encoding these proteins has progressed rapidly with advances in the nucleotide and protein sequencing. This review describes our knowledge of ovine KAPs, their categorisation into families, polymorphism in the proteins and genes, the clustering and chromosomal location of the genes, some characteristics of gene expression and some potential effects of the KAPs on wool traits. The extent and nature of genetic variation in wool KAP genes and its association with fibre characteristics, provides an opportunity for the development of gene-markers for selective breeding of sheep to produce better wool with properties highly matched to specific end-uses.
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“Keratins and the keratin-associated proteins are conserved across multiple species with family members encoding the principal structural components of hair and wool160–163.”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [162]
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Metadata
- Authors
- Gong, H., Zhou, H., Forrest, R., Li, S., Wang, J., Dyer, J., Luo, Y., & Hickford, J.
- Affiliations
- Gansu Agricultural University (CN)
- Eastern Institute of Technology (NZ)
- AgResearch (NZ)
- Corresponding author
- Luo, Yuzhu
- Hickford, Jon
- Venue
- Genes
- Publisher
- MDPI AG
- Published
- 2016-05-28
- Volume
- 7
- Issue
- 6
- Pages
- 24
- ISSN
- 2073-4425 (ISSN-L)
- PMC
- PMC4929423
- OpenAlex
- W2395447748
- Cited by
- 124
- References
- 78
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 18 · 2023: 13 · 2022: 16 · 2021: 13 · 2020: 11 · 2019: 12 · 2018: 10 · 2017: 11 · 2016: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Genes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Lincoln University Research Archive (Lincoln University) (submittedVersion, cc-by)
- Funders
- FRST (C10X0710)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- sheep, genetic polymorphism, gene clustering, chromosomal location, gene expression, wool traits, genetic markers, selective breeding, fiber properties
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