Systems Analysis of Transcriptomic and Proteomic Profiles Identifies Novel Regulation of Fibrotic Programs by miRNAs in Pulmonary Fibrosis Fibroblasts
Open accessAbstract
Fibroblasts/myofibroblasts are the key effector cells responsible for excessive extracellular matrix (ECM) deposition and fibrosis progression in both idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc) patient lungs, thus it is critical to understand the transcriptomic and proteomic programs underlying their fibrogenic activity. We conducted the first integrative analysis of the fibrotic programming in these cells at the levels of gene and microRNA (miRNA) expression, as well as deposited ECM protein to gain insights into how fibrotic transcriptional programs culminate in aberrant ECM protein production/deposition. We identified messenger RNA (mRNA), miRNA, and deposited matrisome protein signatures for IPF and SSc fibroblasts obtained from lung transplants using next-generation sequencing and mass spectrometry. SSc and IPF fibroblast transcriptional signatures were remarkably similar, with enrichment of WNT, TGF-β, and ECM genes. miRNA-seq identified differentially regulated miRNAs, including downregulation of miR-29b-3p, miR-138-5p and miR-146b-5p in disease fibroblasts and transfection of their mimics decreased expression of distinct sets of fibrotic signature genes as assessed using a Nanostring fibrosis panel. Finally, proteomic analyses uncovered a distinct “fibrotic” matrisome profile deposited by IPF and SSc fibroblasts compared to controls that highlights the dysregulated ECM production underlying their fibrogenic activities. Our comprehensive analyses of mRNA, miRNA, and matrisome proteomic profiles in IPF and SSc lung fibroblasts revealed robust fibrotic signatures at both the gene and protein expression levels and identified novel fibrogenesis-associated miRNAs whose aberrant downregulation in disease fibroblasts likely contributes to their fibrotic and ECM gene expression.
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Activation of myofibroblasts is part of physiological wound repair; in chronic injury and inflammatory fibrotic conditions, persistent activation exacerbates disease progression.
“Activation of myofibroblasts is itself part of physiological wound repair following tissue injury, whereas in chronic injury and inflammatory fibrotic conditions their persistent activation exacerbates the disease progression [132,133,134,135].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [133]
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- Authors
- Mullenbrock, S., Liu, F., Szak, S., Hronowski, X., Gao, B., Juhasz, P., Sun, C., Liu, M., McLaughlin, H., Xiao, Q., Feghali-Bostwick, C., & Zheng, T. S.
- Affiliations
- Biogen (United States) (US)
- Biogen, Cambridge, MA 02142, USA
- Division of Rheumatology and Immunology, Department of Medicine, The Medical University of South Carolina, Charleston, SC 29425, USA
- Corresponding author
- Zheng, Timothy S.
- Venue
- Genes
- Publisher
- MDPI AG
- Published
- 2018-11-29
- Volume
- 9
- Issue
- 12
- Pages
- 588
- ISSN
- 2073-4425 (ISSN-L)
- PMC
- PMC6316743
- OpenAlex
- W2902774925
- Cited by
- 35
- References
- 41
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 1 · 2020: 10 · 2019: 5
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Genes (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Biogen
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- idiopathic pulmonary fibrosis, systemic sclerosis, lung fibroblasts, myofibroblasts, pulmonary fibrosis, extracellular matrix deposition, matrisome, microRNA regulation, miR-29b-3p, miR-138-5p, miR-146b-5p, Wnt signaling, TGF-beta signaling, fibrogenesis
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