Association between temperature change and outpatient visits for respiratory tract infections among children in Guangzhou, China
Open accessAbstract
The current study examined the association between temperature change and clinical visits for childhood respiratory tract infections (RTIs) in Guangzhou, China. Outpatient records of clinical visits for pediatric RTIs, which occurred from 1 January 2012 to 31 December 2013, were collected from Guangzhou Women and Children's Hospital. Records for meteorological variables during the same period were obtained from the Guangzhou Meteorological Bureau. Temperature change was defined as the difference between the mean temperatures on two consecutive days. A distributed lag non-linear model (DLNM) was used to examine the impact of temperature change on pediatric outpatient visits for RTIs. A large temperature decrease was associated with a significant risk for an RTI, with the effect lasting for ~10 days. The maximum effect of a temperature drop (-8.8 °C) was reached at lag 2~3 days. Children aged 0-2 years, and especially those aged <1 year, were particularly vulnerable to the effects of temperature drop. An extreme temperature decrease affected the number of patient visits for both upper respiratory tract infections (URTIs) and lower respiratory tract infections (LRTIs). A temperature change between consecutive days, and particularly an extreme temperature decrease, was significantly associated with increased pediatric outpatient visits for RTIs in Guangzhou.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A rapid change of temperature and humidity levels can significantly affect respiratory and infectious diseases in children.
“whereas a rapid change of temperature and humidity levels can significantly affect respiratory and infectious diseases in children.41,42”
From Climate change and child health: A scoping review and an expanded conceptual framework (2021) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Impact of regional climate change on human health
Patz, J. A., Campbell-Lendrum, D., Holloway, T., & Foley, J. A. (2005) · Nature · doi:10.1038/nature04188 · Cited by 3,103 · see citing works
Nair, H., Nokes, D. J., Gessner, B. D., Dherani, M., Madhi, S. A., Singleton, R. J., O'Brien, K. L., Roca, A., Wright, P. F., Bruce, N., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60206-1 · Cited by 2,773 · see citing works
Distributed lag non‐linear models
Gasparrini, A., Armstrong, B., & Kenward, M. G. (2010) · Statistics in Medicine · doi:10.1002/sim.3940 · Cited by 2,481 · see citing works
Distributed Lag Linear and Non-Linear Models in R : The Package dlnm
Gasparrini, A. (2011) · Journal of Statistical Software · doi:10.18637/jss.v043.i08 · Cited by 1,714 · see citing works
Model Choice in Time Series Studies of Air Pollution and Mortality
Peng, R. D., Dominici, F., & Louis, T. A. (2006) · Journal of the Royal Statistical Society Series A: Statistics in Society · doi:10.1111/j.1467-985x.2006.00410.x · Cited by 583 · see citing works
Impact of hot temperatures on death in London: a time series approach
Hajat, S., Kovats, S. R., Atkinson, R. W., & Haines, A. (2002) · Journal of Epidemiology & Community Health · doi:10.1136/jech.56.5.367 · Cited by 401 · see citing works
An Explanation for the Seasonality of Acute Upper Respiratory Tract Viral Infections
Eccles, R. (2002) · Acta Oto-Laryngologica · doi:10.1080/00016480252814207 · Cited by 396 · see citing works
Basu, R., & Ostro, B. D. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn170 · Cited by 364 · see citing works
Impact of ambient temperature on children's health: A systematic review
Xu, Z., Etzel, R. A., Su, H., Huang, C., Guo, Y., & Tong, S. (2012) · Environmental Research · doi:10.1016/j.envres.2012.07.002 · Cited by 319 · see citing works
Self-citationEffects of climate change on environmental factors in respiratory allergic diseases
D’Amato, G., & Cecchi, L. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03033.x · Cited by 286 · see citing works
Impact of diurnal temperature range on human health: a systematic review
Cheng, J., Xu, Z., Zhu, R., Wang, X., Jin, L., Song, J. G., & Su, H. (2014) · International Journal of Biometeorology · doi:10.1007/s00484-014-0797-5 · Cited by 275 · see citing works
Outdoor air pollution, climatic changes and allergic bronchial asthma
D’Amato, G., Liccardi, G., D’Amato, M., & Cazzola, M. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00401402 · Cited by 275 · see citing works
YUSUF, S., Piedimonte, G., Auais, A., Demmler, G. J., KRISHNAN, S., Caeseele, P. G. V., Singleton, R. J., Broor, S., Parveen, S., Avendaño, L. F., et al. (2007) · Epidemiology and Infection · doi:10.1017/s095026880600776x · Cited by 257 · see citing works
Yang, J., Ou, C., Ding, Y., Zhou, Y.-X., & Chen, P. (2012) · Environmental Health · doi:10.1186/1476-069x-11-63 · Cited by 244 · see citing works
Are Meteorological Parameters Associated with Acute Respiratory Tract Infections?
du Prel, J., Puppe, W., Gröndahl, B., Knuf, M., Weigl, J. A. I., Schaaff, F., & Schmitt, H. (2009) · Clinical Infectious Diseases · doi:10.1086/605435 · Cited by 228 · see citing works
Role of environmental stress in the physiological response to chemical toxicants
Gordon, C. J. (2003) · Environmental Research · doi:10.1016/s0013-9351(02)00008-7 · Cited by 226 · see citing works
On Time Series Analysis of Public Health and Biomedical Data
Zeger, S. L., Irizarry, R. A., & Peng, R. D. (2006) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.26.021304.144517 · Cited by 216 · see citing works
Diurnal temperature range and daily mortality in Shanghai, China
Kan, H., London, S. J., Chen, H., Song, G., Chen, G., Jiang, L., Zhao, N., Zhang, Y., & Chen, B. (2007) · Environmental Research · doi:10.1016/j.envres.2006.11.009 · Cited by 201 · see citing works
Luís Ferreira Braga, A., Zanobetti, A., & Schwartz, J. (2001) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-200111000-00001 · Cited by 196 · see citing works
Climate change and respiratory disease: European Respiratory Society position statement
Ayres, J. G., Forsberg, B., Annesi‐Maesano, I., Dey, R., Ebi, K. L., Helms, P. J. B., Medina-Ramón, M., Windt, M. R., & Forastiere, F. (2009) · European Respiratory Journal · doi:10.1183/09031936.00003409 · Cited by 195 · see citing works
Exposure to cold and respiratory tract infections.
Mourtzoukou, E. G., & Falagas, M. E. (2007) · PubMed · Cited by 187 · see citing works
Inhalation of cold air increases the number of inflammatory cells in the lungs in healthy subjects
Larsson, K., Tornling, G., Gavhed, D., et al. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.12040825 · Cited by 179 · see citing works
Global climate change: Impact of diurnal temperature range on mortality in Guangzhou, China
Yang, J., Liu, H.-Z., Ou, C., Lin, G.-Z., Zhou, Q., Shen, G.-C., Chen, P.-Y., & Guo, Y. (2013) · Environmental Pollution · doi:10.1016/j.envpol.2012.12.021 · Cited by 171 · see citing works
Self-citationGlobal burden of acute respiratory infections in children: Implications for interventions
Mulholland, K. (2003) · Pediatric Pulmonology · doi:10.1002/ppul.10344 · Cited by 167 · see citing works
A Large Change in Temperature between Neighbouring Days Increases the Risk of Mortality
Guo, Y., Barnett, A. G., Yu, W., Pan, X., Ye, X., Huang, C., & Tong, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016511 · Cited by 149 · see citing works
Self-citationThe role of allergic rhinitis in nasal responses to sudden temperature changes
Graudenz, G. S., Landgraf, R. G., Jancar, S., Tribess, A., Fonseca, S. G., Fae, K. C., & Kalil, J. E. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.07.005 · Cited by 149 · see citing works
Temperature effect on the ciliary beat frequency of human nasal and tracheal ciliated cells
Clary-Meinesz, C., Cosson, J., Huitorel, P., & Blaive, B. (1992) · Biology of the Cell · doi:10.1016/0248-4900(92)90436-5 · Cited by 141 · see citing works
Diurnal temperature range and childhood asthma: a time-series study
Xu, Z., Huang, C., Su, H., Turner, L., Qiao, Z., & Tong, S. (2013) · Environmental Health · doi:10.1186/1476-069x-12-12 · Cited by 137 · see citing works
Extreme temperatures and emergency department admissions for childhood asthma in Brisbane, Australia
Xu, Z., Huang, C., Hu, W., Turner, L. R., Su, H., & Tong, S. (2013) · Occupational and Environmental Medicine · doi:10.1136/oemed-2013-101538 · Cited by 129 · see citing works
Winter mortality and its causes
Keatinge, W. R. (2002) · International Journal of Circumpolar Health · doi:10.3402/ijch.v61i4.17477 · Cited by 123 · see citing works
Lin, H., Zhang, Y., Xu, Y., Xu, X., Liu, T., Luo, Y., Xiao, J., Wu, W., & Ma, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066403 · Cited by 117 · see citing works
Lagged Effect of Diurnal Temperature Range on Mortality in a Subtropical Megacity of China
Luo, Y., Zhang, Y., Liu, T., Rutherford, S., Xu, Y., Xu, X., Wu, W., Xiao, J., Zeng, W., Chu, C. M.-Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055280 · Cited by 111 · see citing works
The self-reported health of U.S. flight attendants compared to the general population
McNeely, E., Gale, S., Tager, I., Kincl, L., Bradley, J., Coull, B., & Hecker, S. (2014) · Environmental Health · doi:10.1186/1476-069x-13-13 · Cited by 104 · see citing works
The effects of weather, air pollutants, and Asian dust on hospitalization for asthma in Fukuoka
Ueda, K., Nitta, H., & Odajima, H. (2010) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-010-0150-5 · Cited by 91 · see citing works
Influence of climate factors on emergency visits for childhood asthma attack
Hashimoto, M., Fukuda, T., Shimizu, T. M., Watanabe, S., Watanuki, S., Eto, Y., & Urashima, M. (2004) · Pediatrics International · doi:10.1111/j.1442-200x.2004.01835.x · Cited by 90 · see citing works
Koskela, H. O., & Tukiainen, H. O. (1995) · European Respiratory Journal · doi:10.1183/09031936.95.08122088 · Cited by 88 · see citing works
Zhang, D., He, Z., Xu, L., Zhu, X., Wu, J., Wen, W., Zheng, Y. P., Deng, Y., Chen, J., Hu, Y., et al. (2014) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2014.02.019 · Cited by 83 · see citing works
Temperature variability and childhood pneumonia: an ecological study
Xu, Z., Hu, W., & Tong, S. (2014) · Environmental Health · doi:10.1186/1476-069x-13-51 · Cited by 81 · see citing works
Watson, M., Gilmour, R. E., Menzies, R., Ferson, M. J., McIntyre, P. B., & New South Wales Pneumococcal Network (2005) · Clinical Infectious Diseases · doi:10.1086/498897 · Cited by 79 · see citing works
Some factors affecting the airborne survival of bacteria outdoors
Handley, B. A., & Webster, A. J. (1995) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1995.tb03150.x · Cited by 75 · see citing works
Welliver, C. (2009) · Paediatric Respiratory Reviews · doi:10.1016/s1526-0542(09)70004-1 · Cited by 71 · see citing works
Effect of meteorological variables on the incidence of respiratory tract infections
Falagas, M. E., Theocharis, G., Spanos, A., et al. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2007.12.010 · Cited by 60 · see citing works
Upper airways reactions to cold air
Cruz, Ã. A., & Togias, A. G. (2008) · Current Allergy and Asthma Reports · doi:10.1007/s11882-008-0020-z · Cited by 59 · see citing works
Yang, L., Qin, G., Zhao, N., et al. (2012) · BMC Medical Research Methodology · doi:10.1186/1471-2288-12-165 · Cited by 56 · see citing works
Buckley, J. P., & Richardson, D. B. (2012) · Environmental Health · doi:10.1186/1476-069x-11-55 · Cited by 56 · see citing works
Figueiras, A. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.3.264 · Cited by 55 · see citing works
Association between diurnal temperature range and respiratory tract infections.
Ge, W. Z., Xu, F., Zhao, Z. H., Zhao, J., & Kan, H. D. (2013) · PubMed · doi:10.3967/0895-3988.2013.03.009 · Cited by 43 · see citing works
Effect of Meteorological Parameters on Acute Laryngitis in Adults
Danielides, V. G., Nousia, C., Patrikakos, G., et al. (2002) · Acta Oto-Laryngologica · doi:10.1080/000164802320396358 · Cited by 43 · see citing works
Human adenovirus infection in children with acute respiratory tract disease in G uangzhou, C hina
Zou, L., Zhou, J., Li, H., et al. (2012) · Apmis · doi:10.1111/j.1600-0463.2012.02890.x · Cited by 42 · see citing works
Effect of ambient temperature on emergency department visits in Shanghai, China: a time series study
Zhang, Y., Yan, C., Kan, H., Cao, J., Li, P., Xu, J., & Wang, W. (2014) · Environmental Health · doi:10.1186/1476-069x-13-100 · Cited by 32 · see citing works
Nelson, E. A. S., Tam, J. S. L., Yu, L., et al. (2007) · PubMed · Cited by 25 · see citing works
Li, T., Yang, Z., & Wang, M. (2013) · International Journal of Biometeorology · doi:10.1007/s00484-013-0734-z · Cited by 24 · see citing works
Identifying the Probable Timing and Setting of Respiratory Virus Infections
Lessler, J., Brookmeyer, R., Reich, N. G., et al. (2010) · Infection Control and Hospital Epidemiology · doi:10.1086/655023 · Cited by 23 · see citing works
[Analysis of death causes among infants in Guangzhou from 2010 to 2013].
Shen, J., Wang, M., Dong, H., et al. (2014) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Climate change and child health: A scoping review and an expanded conceptual framework
Helldén, D., Andersson, C., Nilsson, M., Ebi, K. L., Friberg, P., & Alfvén, T. (2021) · The Lancet Planetary Health · doi:10.1016/s2542-5196(20)30274-6 · Cited by 332 · see citing works
Health impact of climate change in cities of middle-income countries: the case of China
Chan, E. Y. Y., Ho, J. Y., Hung, H. H. Y., Liu, S., & Lam, H. C. Y. (2019) · British Medical Bulletin · doi:10.1093/bmb/ldz011 · Cited by 41 · see citing works
- Authors
- Liu, Y., Guo, Y., Wang, C., Li, W., Lu, J., Shen, S., Xia, H., He, J., & Qiu, X.
- Affiliations
- Sun Yat-sen University (CN)
- Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Sun Yat-sen University, 9 Jinsui Road, Guangzhou 510623, China
- Corresponding author
- Qiu, Xiu
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2015-01-06
- Volume
- 12
- Issue
- 1
- Pages
- 439-454
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC4306872
- OpenAlex
- W2039234383
- Cited by
- 63
- References
- 55
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 14 · 2020: 5 · 2019: 10 · 2018: 4 · 2017: 3 · 2015: 1
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Guangzhou Science and Technology Bureau, Guangzhou, China (2012J5100038)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Climate Change and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
- Keywords
- temperature change, respiratory infections, pediatric outpatient visits, temperature drop, upper respiratory tract infection, lower respiratory tract infection, Guangzhou
- MeSH terms
- Adolescent, Child, Child, Preschool, China, Female, Humans, Infant, Infant, Newborn, Male, Outpatients, Respiratory Tract Infections, Seasons, Temperature, Nonlinear Dynamics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review