Postoperative Neurocognitive Disorders in Cardiac Surgery: Investigating the Role of Intraoperative Hypotension. A Systematic Review
Open accessAbstract
Perioperative neurocognitive disorders remain a challenging obstacle in patients after cardiac surgery, as they significantly contribute to postoperative morbidity and mortality. Identifying the modifiable risk factors and mechanisms for postoperative cognitive decline (POCD) and delirium (POD) would be an important step forward in preventing such adverse events and thus improving patients’ outcome. Intraoperative hypotension is frequently discussed as a potential risk factor for neurocognitive decline, due to its significant impact on blood flow and tissue perfusion, however the studies exploring its association with POCD and POD are very heterogeneous and present divergent results. This review demonstrates 13 studies found after structured systematic search strategy and discusses the possible relationship between intraoperative hypotension and postoperative neuropsychiatric dysfunction.
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Other studies conducted in the Middle East, Gulf, Asia, and Europe have also reported falls and being struck by heavy objects as common injury mechanisms in the construction sector.
“Other studies conducted in the Middle East, Gulf, Asia, and Europe have also reported these mechanisms as common ones in the construction sector (Di Domenico et al. 2022; Šoštarič et al. 2021; Papadonikolaki et al. 2021; Seo et al. 2021; Sherratt et al. 2020; Al-Bayati et al. 2020; Al-Ghamdi and Al-Kahtani 2019; Al-Kaabi and Hadipriono 2018; Li et al. 2015; Khosravi et al. 2014; Abudayyeh et al. 2”
From Impact of risk mitigation strategies on non-fatal injuries in the construction sector in qatar: a retrospective analysis (2025) · cites this paper as Papadonikolaki et al. 2021
The Introduction describes a review of intraoperative hypotension and neurocognitive disorders after cardiac surgery; the Methods likewise concern that review (pages unavailable). Searches for construction injuries, falls, and workers struck by objects found no passage addressing the claimed injury mechanisms. (LLM, conf=0.78)
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Soubra, L., Al-Mohannadi, A., Berzan, Y., Consunji, R., El‑Menyar, A., Al‑Thani, H., Al-Marri, M. A., & Al-Hajri, H. S. (2025) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-025-02126-x · Cited by 7 · see citing works
- Authors
- Czok, M., Pluta, M. P., Putowski, Z., & Krzych, Ł. J.
- Affiliations
- Medical University of Silesia (PL)
- Corresponding author
- Krzych, Łukasz J.
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2021-01-18
- Volume
- 18
- Issue
- 2
- Pages
- 786
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC7831914
- OpenAlex
- W3121630492
- Cited by
- 40
- References
- 1
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 13 · 2021: 7
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Keywords
- postoperative cognitive dysfunction, intraoperative hypotension, cardiac surgery, perioperative neurocognitive disorder, delirium, risk factors, cerebral perfusion, neuropsychiatric dysfunction
- MeSH terms
- Delirium, Cardiac Surgical Procedures, Humans, Hypotension, Postoperative Complications, Cognitive Dysfunction
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