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Cited by 252Seaweed-derived Bioactive CompoundsMarine Sponges and Natural ProductsMarine and coastal plant biology

The DOI matches its Crossref record; 111 of the 113 references it cites were found in a registry or an index.

Bioactivities from Marine Algae of the Genus Gracilaria

Open access
De Almeida, Cynthia Layse F., De S. Falcão, Heloina, De M. Lima, Gedson R., De A. Montenegro, Camila, Lira, Narlize S., De Athayde-Filho, Petrônio F., Rodrigues, Luis C., De Souza, Maria de Fátima V., Barbosa-Filho, José M., Batista, Leônia M.·2011·International Journal of Molecular Sciences
DOI 10.3390/ijms12074550PMC PMC3155369
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Abstract

Seaweeds are an important source of bioactive metabolites for the pharmaceutical industry in drug development. Many of these compounds are used to treat diseases like cancer, acquired immune-deficiency syndrome (AIDS), inflammation, pain, arthritis, as well as viral, bacterial, and fungal infections. This paper offers a survey of the literature for Gracilaria algae extracts with biological activity, and identifies avenues for future research. Nineteen species of this genus that were tested for antibacterial, antiviral, antifungal, antihypertensive, cytotoxic, spermicidal, embriotoxic, and anti-inflammatory activities are cited from the 121 references consulted.

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Registry

Crossref · 10.3390/ijms12074550

Cites

111 of 111 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Structure of the compounds found in G. foliifera, G. coronopifolia and G. edulis.
Figure 1 Structure of the compounds found in G. foliifera, G. coronopifolia and G. edulis.CC BY · PubMed Central
Figure 2 Structure composed of species of Gracilaria tested in cytotoxicity.
Figure 2 Structure composed of species of Gracilaria tested in cytotoxicity.CC BY · PubMed Central
Figure 3 Structure of the compounds found in G. verrucosa and G. chorda.
Figure 3 Structure of the compounds found in G. verrucosa and G. chorda.CC BY · PubMed Central
Figure 4 Chemical structure of the steroids isolated from G. edulis.
Figure 4 Chemical structure of the steroids isolated from G. edulis.CC BY · PubMed Central
Figure 5 Structure of compounds found in species of Gracilaria with antifungal activity.
Figure 5 Structure of compounds found in species of Gracilaria with antifungal activity.CC BY · PubMed Central
Figure 6 Structure of the steroids isolated from G. domingensis.
Figure 6 Structure of the steroids isolated from G. domingensis.CC BY · PubMed Central
Figure 7 Structure of a compound found in Gracilaria sp and G. bursa-pastoris.
Figure 7 Structure of a compound found in Gracilaria sp and G. bursa-pastoris.CC BY · PubMed Central

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Citations

Cites

1 retracted

Show all 113 references

Research works printed but not linked: 24

  1. Lahaye, 1993, Marine algae as a source of dietary fibers: Determination of soluble and insoluble dietary fiber contents in some ‘sea vegetable’, J. Sci. Food Agric, 54, 523
  2. Premila, 1996, Antimicrobial activity of some marine algae of south-west coast of India, Indian J. Mar. Sci, 26, 201
  3. Jha, 2004, Biomedical compounds from marine organisms, Mar Drugs, 2, 123, 10.3390/md203123 · DOI
  4. Rehm, 2001, Marine biotechnology, Biotechnology, 10, 441
  5. Linsert, 1994, Revolution in infant formula brewing in Herman’s calves. DNA algae, Genet. Eng. Biotechnol. Monit, 1, 45
  6. Khotimchenko, 1963, Fatty acids of marine algae from the 12 substances from marine algae Puerto Rico, Antimicrob. Agents Chemother, 161, 68
  7. Combres, 1986, Fatty acid and sterol composition of red algae of the Indian ocean, Oceanol. Acta, 9, 339
  8. Castedo, 1985, Sterols from red and brown algae from the Galician coast, An. Quim. Ser. C, 8, 113
  9. Vilalta, 1984, Natural marine products from algae and cnidaria of the Galician estuaries, Cuad. Area Cienc. Mar, 2, 617
  10. Talarico, 1978, Properties and ultrastructures of r-phycoerythrin from Gracilaria verrucosa, Photosynthetica, 12, 369
  11. Chenieux, 1980, Seaweeds of French atlantic coast with antimitotic activity, Planta Med, 40, 152
  12. Avanzini, 1987, Green, red and brown algae from North Adriatic sea as source of possible cytotoxic products, Fitoterapia, 58, 391
  13. Sridhar, 1984, Biological activity of some marine algal extracts, Indian J. Mar. Sci, 13, 90
  14. Albuquerque, 1983, Detection of antimicrobial activity in marine seaweeds, Rev. Inst. Antibiot. Univ. Fed Pernambuco Recife, 21, 127
  15. Kamat, 1992, Bioactivity of marine organisms. VI. Antiviral evaluation of marine algal extracts from the Indian Coast, Bot. Mar, 35, 161, 10.1515/botm.1992.35.2.161 · DOI
  16. Nakamura, 1994, Anti-human immunodeficiency virus (HIV) activities of aqueous extracts from marine algae, Nat. Med, 48, 173
  17. Levring, T (1980). Tenth International Seaweed Symposium, Walter de Gruyter & Co.
  18. Parekh, 1984, Fatty acid content of some Indian marine algae, Indian J. Mar. Sci, 13, 45
  19. Roh, 1994, Structure of floridoside, a glycerol glycoside from the marine red alga Gracilaria verrucosa, Korean J. Pharmacogn, 25, 117
  20. Levring, T (1980). Tenth International Seaweed Symposium, Walter de Gruyter & Co.
  21. Matsuhashi, 1974, Effects of the freezing and drying method and the mechanical dehydration method by pressure on gel properties of dried agar, Reito, 49, 756
  22. Shi, 1983, Seasonal variation in yield, physical properties and chemical composition of agar from Gracilaria verrucosa, Oceanol. Limnol. Sin, 14, 272
  23. Aihara, 1968, Occurrence of antheraxanthin in two Rhodophyceae Acanthophora spicifera and Gracilaria lichenoides, Phytochemistry, 7, 497, 10.1016/S0031-9422(00)90896-3 · DOI
  24. Parekh, 1984, Fatty acid content of some Indian marine algae, Indian J. Mar. Sci, 13, 45

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Metadata

Authors
De Almeida, C. L. F., De S. Falcão, H., De M. Lima, G. R., De A. Montenegro, C., Lira, N. S., De Athayde-Filho, P. F., Rodrigues, L. C., De Souza, M. D. F. V., Barbosa-Filho, J. M., & Batista, L. M.
Affiliations
  • Department of Pharmaceutical Sciences, Laboratory of Pharmaceutical Technology, Federal University of Paraiba, João Pessoa, PB 58051-900, Brazil
  • Universidade Federal da Paraíba (BR)
Corresponding author
Batista, Leônia M.
ORCID
Batista, Leônia M.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2011-07-15
Volume
12
Issue
7
Pages
4550-4573
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms12074550
PMC
PMC3155369
OpenAlex
W2080981798
Cited by
252
References
113
Citations by year
2026: 8 · 2025: 14 · 2024: 15 · 2023: 21 · 2022: 31 · 2021: 23 · 2020: 16 · 2019: 28 · 2018: 17 · 2017: 10 · 2016: 13 · 2015: 17 · 2014: 10 · 2013: 13 · 2012: 13
FWCI
1.22
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação de Apoio à Pesquisa do Estado da Paraíba
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Keywords
Gracilaria, red algae, marine algae, bioactive metabolites, antibacterial activity, antiviral activity, antifungal activity, antihypertensive effect, cytotoxicity, spermicidal activity, embryotoxicity, anti-inflammatory activity, drug development
MeSH terms
Animals, Anti-Infective Agents, Anti-Inflammatory Agents, Anticonvulsants, Bacteria, Cell Survival, DNA Viruses, Fungi, Humans, Nervous System, Plant Extracts, Platelet Aggregation, RNA Viruses, Gracilaria

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