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Bioactivities from Marine Algae of the Genus Gracilaria
Open accessAbstract
Seaweeds are an important source of bioactive metabolites for the pharmaceutical industry in drug development. Many of these compounds are used to treat diseases like cancer, acquired immune-deficiency syndrome (AIDS), inflammation, pain, arthritis, as well as viral, bacterial, and fungal infections. This paper offers a survey of the literature for Gracilaria algae extracts with biological activity, and identifies avenues for future research. Nineteen species of this genus that were tested for antibacterial, antiviral, antifungal, antihypertensive, cytotoxic, spermicidal, embriotoxic, and anti-inflammatory activities are cited from the 121 references consulted.
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“Macroalgae also produce antimicrobial compounds (de Almeida et al., 2011), so it is possible that the normal intestinal microbiota of manatees was affected by a high macroalgal intake, with an associated increase in Clostridiales.”
From Novel Lethal Clostridial Infection in Florida Manatees (Trichechus manatus latirostris): Cause of the 2013 Unusual Mortality Event in the Indian River Lagoon (2022) · cites this paper as de Almeida et al., 2011
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“Different studies [49,50] with extracts from red algae were carried out. These extracts were administrated to female rats in the first seven days of their pregnancies. As result, it was demonstrated that these extracts have post-coital contraceptive protection in the rats without showing any relevant adverse effect.”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [50]
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Flagged first, then by citations
2 of the 113 references couldn’t be matched to a known paper.
Research works printed but not linked: 24
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Cited by
Sorted by citations
Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review
EL-BELTAGI, H. S., Mohamed, A. A., Mohamed, H. I., Ramadan, K. M. A., Barqawi, A. A., & Mansour, A. T. (2022) · Marine Drugs · doi:10.3390/md20060342 · Cited by 395
Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties
Lee, J., Hou, M., Huang, H., Chang, F., Yeh, C.-C., Tang, J., & Chang, H. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-55 · Cited by 334
Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review
Ahmadi, A., Moghadamtousi, S. Z., AbuBakar, S., & Zandi, K. (2015) · BioMed Research International · doi:10.1155/2015/825203 · Cited by 309
The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value
Gomez-Zavaglia, A., Prieto Lage, M. A., Jimenez-Lopez, C., Mejuto, J. C., & Simal-Gandara, J. (2019) · Antioxidants · doi:10.3390/antiox8090406 · Cited by 280
Priyadharshini, R. I., Prasannaraj, G., Geetha, N., & Venkatachalam, P. (2014) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-014-1225-3 · Cited by 262
Metadata
- Authors
- De Almeida, C. L. F., De S. Falcão, H., De M. Lima, G. R., De A. Montenegro, C., Lira, N. S., De Athayde-Filho, P. F., Rodrigues, L. C., De Souza, M. D. F. V., Barbosa-Filho, J. M., & Batista, L. M.
- Affiliations
- Department of Pharmaceutical Sciences, Laboratory of Pharmaceutical Technology, Federal University of Paraiba, João Pessoa, PB 58051-900, Brazil
- Universidade Federal da Paraíba (BR)
- Corresponding author
- Batista, Leônia M.
- ORCID
- Batista, Leônia M.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2011-07-15
- Volume
- 12
- Issue
- 7
- Pages
- 4550-4573
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3155369
- OpenAlex
- W2080981798
- Cited by
- 252
- References
- 113
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 15 · 2023: 21 · 2022: 31 · 2021: 23 · 2020: 16 · 2019: 28 · 2018: 17 · 2017: 10 · 2016: 13 · 2015: 17 · 2014: 10 · 2013: 13 · 2012: 13
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Apoio à Pesquisa do Estado da Paraíba
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- Gracilaria, red algae, marine algae, bioactive metabolites, antibacterial activity, antiviral activity, antifungal activity, antihypertensive effect, cytotoxicity, spermicidal activity, embryotoxicity, anti-inflammatory activity, drug development
- MeSH terms
- Animals, Anti-Infective Agents, Anti-Inflammatory Agents, Anticonvulsants, Bacteria, Cell Survival, DNA Viruses, Fungi, Humans, Nervous System, Plant Extracts, Platelet Aggregation, RNA Viruses, Gracilaria
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