The DOI matches its Crossref record; 181 of the 184 references it cites were found in a registry or an index.
The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation
Open accessAbstract
Over the last decade, decreasing effectiveness of conventional antimicrobial-drugs has caused serious problems due to the rapid emergence of multidrug-resistant pathogens. Furthermore, biofilms, which are microbial communities that cause serious chronic infections and dental plaque, form environments that enhance antimicrobial resistance. As a result, there is a continuous search to overcome or control such problems, which has resulted in antimicrobial peptides being considered as an alternative to conventional drugs. Antimicrobial peptides are ancient host defense effector molecules in living organisms. These peptides have been identified in diverse organisms and synthetically developed by using peptidomimic techniques. This review was conducted to demonstrate the mode of action by which antimicrobial peptides combat multidrug-resistant bacteria and prevent biofilm formation and to introduce clinical uses of these compounds for chronic disease, medical devices, and oral health. In addition, combinations of antimicrobial peptides and conventional drugs were considered due to their synergetic effects and low cost for therapeutic treatment.
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“Peptide-based therapies, which encompass antimicrobial peptides and growth factors, are particularly appealing for their dual ability to combat infection and promote healing [23,24].”
From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [24]
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Cited by
Sorted by citations
Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies
Pang, Z., Raudonis, R., Glick, B. R., Lin, T., & Cheng, Z. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.11.013 · Cited by 2,520
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Metadata
- Authors
- Park, S.-C., Park, Y., & Hahm, K.-S.
- Affiliations
- Chosun University (KR)
- Corresponding author
- Park, Yoonkyung
- Hahm, Kyung-Soo
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2011-09-16
- Volume
- 12
- Issue
- 9
- Pages
- 5971-5992
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3189763
- OpenAlex
- W2081930655
- Cited by
- 327
- References
- 184
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 23 · 2023: 23 · 2022: 25 · 2021: 27 · 2020: 29 · 2019: 28 · 2018: 19 · 2017: 19 · 2016: 28 · 2015: 21 · 2014: 14 · 2013: 20 · 2012: 9
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation
- National Research Foundation of Korea (2011-0017532)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- antimicrobial peptides, multidrug-resistant bacteria, biofilm formation, antimicrobial resistance, peptidomimetics, chronic infection, medical device infections, oral health, dental plaque, combination therapy, mechanism of action
- MeSH terms
- Bacteria, Bacterial Infections, Humans, Microbial Sensitivity Tests, Models, Biological, Bacterial Physiological Phenomena, Biofilms, Antimicrobial Cationic Peptides, Drug Resistance, Multiple, Bacterial
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