Cited by 337Antimicrobial Peptides and ActivitiesAntimicrobial agents and applicationsBacterial biofilms and quorum sensing

The DOI matches its Crossref record; 181 of the 184 references it cites were found in a registry or an index.

The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation

Open access

Park, Seong-Cheol, Park, Yoonkyung, Hahm, Kyung-Soo·2011·International Journal of Molecular Sciences

DOI 10.3390/ijms12095971PMC PMC3189763

Open this paper in CoChat — free account Open PDF

Abstract

Over the last decade, decreasing effectiveness of conventional antimicrobial-drugs has caused serious problems due to the rapid emergence of multidrug-resistant pathogens. Furthermore, biofilms, which are microbial communities that cause serious chronic infections and dental plaque, form environments that enhance antimicrobial resistance. As a result, there is a continuous search to overcome or control such problems, which has resulted in antimicrobial peptides being considered as an alternative to conventional drugs. Antimicrobial peptides are ancient host defense effector molecules in living organisms. These peptides have been identified in diverse organisms and synthetically developed by using peptidomimic techniques. This review was conducted to demonstrate the mode of action by which antimicrobial peptides combat multidrug-resistant bacteria and prevent biofilm formation and to introduce clinical uses of these compounds for chronic disease, medical devices, and oral health. In addition, combinations of antimicrobial peptides and conventional drugs were considered due to their synergetic effects and low cost for therapeutic treatment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms12095971

Cites

181 of 181 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Three typical modes of action of antimicrobial peptides against cytoplasmic membranes. (A) barrel-stave model; (B) toroidal pore model; (C) carpet model.CC BY · PubMed Central

Figure 2 General overview of bacterial biofilm development. (1) reversible adsorption of bacteria; (2) irreversible attachment of bacteria; (3) production of extracelluar polymeric substance and biofilm growth; (4) maturation; (5) dispersion. After dispersion of the biofilm, bacteria move to other organs, tissues, or surfaces and a new biofilm is formed via stages (1)–(5).CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Bacterial biofilms: from the Natural environment to infectious diseases
Hall‐Stoodley, L., Costerton, J. W., & Stoodley, P. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro821 · Cited by 7,133
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Antibiotic resistance of bacteria in biofilms
Stewart, P. S., & Costerton, J. W. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05321-1 · Cited by 4,596
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
Hancock, R. E. W., & Sahl, H. (2006) · Nature Biotechnology · doi:10.1038/nbt1267 · Cited by 4,301
QUORUM SENSING: Cell-to-Cell Communication in Bacteria
Waters, C. M., & Bassler, B. L. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131001 · Cited by 3,989
Antibiotic resistance of bacterial biofilms
Høiby, N., Bjarnsholt, T., Givskov, M., Molin, S., & Ciofu, O. (2010) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2009.12.011 · Cited by 3,238
Mechanisms of Antimicrobial Peptide Action and Resistance
Yeaman, M. R., & Yount, N. Y. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.2 · Cited by 2,998
Estimating Health Care-Associated Infections and Deaths in U.S. Hospitals, 2002
Klevens, R. M., Edwards, J. R., Richards, C. L., Horan, T. C., Gaynes, R. P., Pollock, D. A., & Cardo, D. M. (2007) · Public Health Reports · doi:10.1177/003335490712200205 · Cited by 2,963

Show all 184 references

Research works printed but not linked: 2

Bierbaum, 2009, Lantibiotics: Mode of action, biosynthesis and bioengineering, Curr Pharm Biotechnol, 10, 2, 10.2174/138920109787048616 · DOI
Nicolas, 2009, Multifunctional host defense peptides: Intracellular-targeting antimicrobial peptides, FEBS J, 276, 6483, 10.1111/j.1742-4658.2009.07359.x · DOI

Sorted by citations

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies
Pang, Z., Raudonis, R., Glick, B. R., Lin, T., & Cheng, Z. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.11.013 · Cited by 2,520
Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action
Roy, R., Tiwari, M., Donelli, G., & Tiwari, V. (2017) · Virulence · doi:10.1080/21505594.2017.1313372 · Cited by 1,605
Bacteriocins, Antimicrobial Peptides from Bacterial Origin: Overview of Their Biology and Their Impact against Multidrug-Resistant Bacteria
Simons, A., Alhanout, K., & Duval, R. E. (2020) · Microorganisms · doi:10.3390/microorganisms8050639 · Cited by 587
Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing
Annabi, N., Rana, D., Sani, E. S., Lara, R. P., Gifford, J. L., Fares, M. M., Mithieux, S. M., & Weiss, A. S. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.011 · Cited by 554
Antimicrobial peptides under clinical investigation
Koo, H. B., & Seo, J. (2019) · Peptide Science · doi:10.1002/pep2.24122 · Cited by 387
Antimicrobial Peptides: A Potent Alternative to Antibiotics
Rima, M., Rima, M., Fajloun, Z., Sabatier, J., Bechinger, B., & Naas, T. (2021) · Antibiotics · doi:10.3390/antibiotics10091095 · Cited by 366
AmPEP: Sequence-based prediction of antimicrobial peptides using distribution patterns of amino acid properties and random forest
Bhadra, P., Yan, J., Li, J., Fong, S. J., & Siu, S. W. I. (2018) · Scientific Reports · doi:10.1038/s41598-018-19752-w · Cited by 357
Plant antimicrobial peptides: structures, functions, and applications
Li, J., Hu, S., Jian, W., Xie, C., & Yang, X. (2021) · Botanical studies · doi:10.1186/s40529-021-00312-x · Cited by 337
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches
Christopher, M. S., Gazdag, Z., & Melegh, S. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-022-03334-0 · Cited by 318
Self‐Assembly of Antimicrobial Peptides on Gold Nanodots: Against Multidrug‐Resistant Bacteria and Wound‐Healing Application
Chen, W., Chang, H., Lu, J., Huang, Y., Harroun, S. G., Tseng, Y., Li, Y., Huang, C., & Chang, H. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201503248 · Cited by 298
Alternatives to overcoming bacterial resistances: State-of-the-art
Rios, A. C., Moutinho, C. M. S. G., Pinto, F. C., Fiol, F. D. S. D., Jozala, Â. F., Chaud, M. V., Vila, M. M. D. C., Teixeira, J. A., & Balcão, V. M. (2016) · Microbiological Research · doi:10.1016/j.micres.2016.04.008 · Cited by 277
Characterization of Antimicrobial Peptides toward the Development of Novel Antibiotics
Aoki, W., & Ueda, M. (2013) · Pharmaceuticals · doi:10.3390/ph6081055 · Cited by 258
Polymicrobial Infections and Biofilms: Clinical Significance and Eradication Strategies
Anju, V. T., Busi, S., Imchen, M., Kumavath, R., Mohan, M. S., Salim, S. A., Pattnaik, S., & Dyavaiah, M. (2022) · Antibiotics · doi:10.3390/antibiotics11121731 · Cited by 199
An Overview of Biofilm Formation–Combating Strategies and Mechanisms of Action of Antibiofilm Agents
Asma, S. T., Imre, K., Morar, A., Herman, V., Acaröz, U., Mukhtar, H., Arslan‐Acaröz, D., Shah, S. R. A., & Gerlach, R. (2022) · Life · doi:10.3390/life12081110 · Cited by 191
dbAMP: an integrated resource for exploring antimicrobial peptides with functional activities and physicochemical properties on transcriptome and proteome data
Jhong, J.-H., Chi, Y.-H., Li, W.-C., Lin, T.-H., Huang, K., & Lee, T.-Y. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1030 · Cited by 180
A review on antimicrobial peptides databases and the computational tools
Ramazi, S., Mohammadi, N., Allahverdi, A., Khalili, E., & Abdolmaleki, P. (2022) · Database · doi:10.1093/database/baac011 · Cited by 167
Sonorensin: A new bacteriocin with potential of an anti-biofilm agent and a food biopreservative
Chopra, L., Singh, G., Jena, K. K., & Sahoo, D. K. (2015) · Scientific Reports · doi:10.1038/srep13412 · Cited by 161
New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches
Jorge, P., Lourenço, A. M. G., & Pereira, M. O. (2012) · Biofouling · doi:10.1080/08927014.2012.728210 · Cited by 161
Synthesis and characterization of biogenic selenium nanoparticles with antimicrobial properties made by Staphylococcus aureus , methicillin‐resistant Staphylococcus aureus (MRSA), Escherichia coli, and Pseudomonas aeruginosa
Medina-Cruz, D., Mi, G., & Webster, T. J. (2018) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36347 · Cited by 159
Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery
Makowski, M., Silva, Í. C., do Amaral, C. P., Gonçalves, S., & Santos, N. C. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11110588 · Cited by 158
Short Synthetic β‐Sheet Forming Peptide Amphiphiles as Broad Spectrum Antimicrobials with Antibiofilm and Endotoxin Neutralizing Capabilities
Ong, Z. Y., Gao, S. J., & Yang, Y. Y. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201202850 · Cited by 148
An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections
Patrulea, V., Borchard, G., & Jordan, O. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090840 · Cited by 148
From Antimicrobial Peptides to Antimicrobial Poly(α‐amino acid)s
Shen, W. H., He, P., Xiao, C., & Chen, X. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800354 · Cited by 146
Peptides, new tools for plant protection in eco-agriculture
Zhang, Y., Ye, D., Liu, Y., Zhang, X., Zhou, Y., Zhang, L., & Yang, X. (2023) · Advanced Agrochem · doi:10.1016/j.aac.2023.01.003 · Cited by 139
Nanoparticles Encapsulated with LL37 and Serpin A1 Promotes Wound Healing and Synergistically Enhances Antibacterial Activity
Fumakia, M., & Ho, E. A. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00099 · Cited by 132
Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145
de Breij, A., Riool, M., Kwakman, P. H. S., de Boer, L., Cordfunke, R. A., Drijfhout, J. W., Cohen, O., Emanuel, N., Zaat, S. A. J., Nibbering, P. H., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.003 · Cited by 130
Cationic Antimicrobial Peptide LL-37 Is Effective against both Extra- and Intracellular Staphylococcus aureus
Noore, J., Noore, A., & Li, B. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01650-12 · Cited by 126
An Introduction to Bacterial Biofilms and Their Proteases, and Their Roles in Host Infection and Immune Evasion
Ramírez-Larrota, J. S., & Eckhard, U. (2022) · Biomolecules · doi:10.3390/biom12020306 · Cited by 122
Deep Learning for Novel Antimicrobial Peptide Design
Wang, C. E., Garlick, S., & Zloh, M. (2021) · Biomolecules · doi:10.3390/biom11030471 · Cited by 117
Treatment of microbial biofilms in the post-antibiotic era: prophylactic and therapeutic use of antimicrobial peptides and their design by bioinformatics tools
Luca, M. D., Maccari, G., & Nifosì, R. (2014) · Pathogens and Disease · doi:10.1111/2049-632x.12151 · Cited by 107
The proteome targets of intracellular targeting antimicrobial peptides
SHAH, P. M., Hsiao, F. S., Ho, Y.-H., & Chen, C. (2015) · PROTEOMICS · doi:10.1002/pmic.201500380 · Cited by 102
Modification of Titanium Substrates with Chimeric Peptides Comprising Antimicrobial and Titanium-Binding Motifs Connected by Linkers To Inhibit Biofilm Formation
Liu, Z., Ma, S., Duan, S., Deng, X., Sun, Y., Zhang, X., Xu, X., Guan, B., Wang, C., Hu, M., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b11949 · Cited by 100
The overview of antimicrobial peptide‐coated implants against oral bacterial infections
Sun, Z., Ma, L., Sun, X., Sloan, A. J., O’brien-simpson, N. M., & Li, W. (2023) · Aggregate · doi:10.1002/agt2.309 · Cited by 97
Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines
Ratcliffe, N. A., Azambuja, P., & Neto, C. B. D. M. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/904958 · Cited by 94
Review on PLGA Polymer Based Nanoparticles with Antimicrobial Properties and Their Application in Various Medical Conditions or Infections
Shakya, A. K., Al-Sulaibi, M., Naik, R. R., Nsairat, H., Suboh, S., & Abulaila, A. (2023) · Polymers · doi:10.3390/polym15173597 · Cited by 93
Non-antibiotic antimicrobial agents to combat biofilm-forming bacteria
Cao, Y., Naseri, M., He, Y., Xu, C., Walsh, L. J., & Ziora, Z. M. (2019) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2019.11.012 · Cited by 91
Antibacterial Activity Affected by the Conformational Flexibility in Glycine–Lysine Based α-Helical Antimicrobial Peptides
Rončević, T., Vukičević, D., Ilić, N., Krce, L., Gajski, G., Tonkić, M., Goić-Barišić, I., Zoranić, L., Sonavane, Y., Benincasa, M., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01831 · Cited by 86
Coping with the ESKAPE pathogens: Evolving strategies, challenges and future prospects
Aloke, C., & Achilonu, I. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105963 · Cited by 85
Alternative therapeutics to control antimicrobial resistance: a general perspective
Singha, B., Singh, V., & Soni, V. (2024) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2024.1385460 · Cited by 83
Characterization of Antibacterial and Hemolytic Activity of Synthetic Pandinin 2 Variants and Their Inhibition against Mycobacterium tuberculosis
Rodríguez, A., Villegas, E., Montoya-Rosales, A., Rivas-Santiago, B. T., & Corzo, G. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101742 · Cited by 81
Beyond conventional antibiotics — New directions for combination products to combat biofilm
Bayramov, D. F., & Neff, J. A. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.07.010 · Cited by 81
New Insights into the Antimicrobial Properties of Hydrolysates and Peptide Fractions Derived from Chia Seed (Salvia hispanica L.)
Aguilar-Toalá, J. E., Deering, A. J., & Liceaga, A. M. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09653-8 · Cited by 80
Systematic Analysis of Intracellular-targeting Antimicrobial Peptides, Bactenecin 7, Hybrid of Pleurocidin and Dermaseptin, Proline–Arginine-rich Peptide, and Lactoferricin B, by Using Escherichia coli Proteome Microarrays
Ho, Y.-H., SHAH, P. M., Chen, Y.-W., & Chen, C. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.054999 · Cited by 76
Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32
Kerenga, B. K., McKenna, J. A., Harvey, P. J., Quimbar, P., Garcia‐Ceron, D., Lay, F. T., Phan, T. K., Veneer, P. K., Vasa, S., Parisi, K., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00795 · Cited by 74
Fluconazole-Resistant Candida auris Is Susceptible to Salivary Histatin 5 Killing and to Intrinsic Host Defenses
Pathirana, R. U., Friedman, J., Norris, H. L., Salvatori, O., McCall, A. D., Kay, J. G., & Edgerton, M. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01872-17 · Cited by 72
Investigation of the antibacterial activity of a short cationic peptide against multidrug-resistant Klebsiella pneumoniae and Salmonella typhimurium strains and its cytotoxicity on eukaryotic cells
Moghaddam, M. M., Barjini, K. A., Fasihi‐Ramandi, M., & Amani, J. (2013) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-013-1575-y · Cited by 71
Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin
de Melo, E. T., Estrela, A. B., dos Santos, E. C. G., Machado, P. R. L., Farias, K. J. S., Torres, T. M., Carvalho, E., Lima, J. P. M. S., da Silva-Júnior, A. A., Barbosa, E. G., et al. (2015) · Peptides · doi:10.1016/j.peptides.2015.03.003 · Cited by 71
Antimicrobial activity of a new synthetic peptide loaded in polylactic acid or poly(lactic-co-glycolic) acid nanoparticles against Pseudomonas aeruginosa , Escherichia coli O157:H7 and methicillin resistant Staphylococcus aureus (MRSA)
Cruz, J., Flórez, J., Torres, R. G., Urquiza, M., Gutiérrez, J. A., Guzmán, F., & Ortiz, C. C. (2017) · Nanotechnology · doi:10.1088/1361-6528/aa5f63 · Cited by 71
Pexiganan in Combination with Nisin to Control Polymicrobial Diabetic Foot Infections
Gomes, D., Santos, R., Soares, R. S., Reis, S., Carvalho, S., Rego, P., Peleteiro, M. C., Tavares, L. M., & Oliveira, M. (2020) · Antibiotics · doi:10.3390/antibiotics9030128 · Cited by 71
Antimicrobial peptide pleurocidin synergizes with antibiotics through hydroxyl radical formation and membrane damage, and exerts antibiofilm activity
Choi, H., & Lee, D. G. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.012 · Cited by 70
Effectiveness of Antimicrobial Peptide Immobilization for Preventing Perioperative Cornea Implant-Associated Bacterial Infection
Tan, X. W., Goh, T.-W., Saraswathi, P., Lwin, C. N., Setiawan, M., Riau, A. K., Lakshminarayanan, R., Liu, S., Tan, D. T.-H., Beuerman, R. W., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02859-14 · Cited by 70
Highly Synergistic Effects of Melittin with Conventional Antibiotics Against Multidrug-Resistant Isolates of Acinetobacter baumannii and Pseudomonas aeruginosa
Akbari, R., Hakemi-Vala, M., Fatemeh, P., Bevalian, P., Hashemi, A., & Bagheri, K. P. (2018) · Microbial Drug Resistance · doi:10.1089/mdr.2018.0016 · Cited by 69
Controlling biofilms using synthetic biology approaches
Fang, K., Park, O.-J., & Hong, S. H. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107518 · Cited by 69
In situ and real time investigation of the evolution of a Pseudomonas fluorescens nascent biofilm in the presence of an antimicrobial peptide
Quilès, F., Saadi, S., Francius, G., Bacharouche, J., & Humbert, F. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.10.015 · Cited by 68
Antibiofilm agents and implant-related infections in orthopaedics: where are we?
Romanò, C. L., Toscano, M., Romanò, D., & Drago, L. (2013) · Journal of Chemotherapy · doi:10.1179/1973947812y.0000000045 · Cited by 68
Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtilis, and Staphylococcus aureus
Sieberi, B. M., Omwenga, G., Wambua, R. K., Samoei, J. C., & Ngugi, M. P. (2020) · The Scientific World JOURNAL · doi:10.1155/2020/6378712 · Cited by 67
Evolution of Antimicrobial Peptides to Self-Assembled Peptides for Biomaterial Applications
McCloskey, A. P., Gilmore, B., & Laverty, G. (2014) · Pathogens · doi:10.3390/pathogens3040791 · Cited by 67
Using adjuvants and environmental factors to modulate the activity of antimicrobial peptides
Walkenhorst, W. F. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.12.034 · Cited by 67
Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties
Han, H. M., Gopal, R., & Park, Y. (2015) · Amino Acids · doi:10.1007/s00726-015-2104-0 · Cited by 65
Self-citation
Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health
Khurshid, Z., Naseem, M., Asiri, F. Y. I., Mali, M., Khan, R. S., Sahibzada, H. A., Zafar, M. S., Moin, S. F., & Khan, E. (2017) · Biomolecules · doi:10.3390/biom7040080 · Cited by 65
Individual and Combined Effects of Engineered Peptides and Antibiotics on Pseudomonas aeruginosa Biofilms
Mishra, B., & Wang, G. (2017) · Pharmaceuticals · doi:10.3390/ph10030058 · Cited by 64
Association of biofilm formation with multi drug resistance in clinical isolates of Pseudomonas aeruginosa
Abdulhaq, N., Nawaz, Z., Zahoor, M. A., & Siddique, A. B. (2019) · EXCLI journal · doi:10.17179/excli2019-2049 · Cited by 63
Novel therapeutic strategies for treatingPseudomonas aeruginosainfection
Shao, X., Xie, Y., Zhang, Y., Liu, J., Ding, Y., Wu, M., Wang, X., & Deng, X. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1803274 · Cited by 62
Conjugates and nano-delivery of antimicrobial peptides for enhancing therapeutic activity
Faya, M. A., Kalhapure, R. S., Kumalo, H. M., Waddad, A. Y., Omolo, C. A., & Govender, T. (2017) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2017.12.010 · Cited by 59
Antimicrobial Peptides and Their Analogs: Searching for New Potential Therapeutics
Midura‐Nowaczek, K., & Markowska, A. (2014) · Perspectives in Medicinal Chemistry · doi:10.4137/pmc.s13215 · Cited by 58
Applications of antimicrobial peptides (AMPs) as an alternative to antibiotic use in aquaculture – A mini-review
Naiel, M. A. E., Ghazanfar, S., Negm, S. S., Shukry, M., & Abdel‐Latif, H. M. R. (2023) · Annals of Animal Science · doi:10.2478/aoas-2022-0090 · Cited by 57
In vitro antibacterial effects of Cinnamomum extracts on common bacteria found in wound infections with emphasis on methicillin-resistant Staphylococcus aureus
Buru, A. S., Pichika, M. R., Neela, V., & Mohandas, K. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.02.044 · Cited by 57
Breaking the frontiers of cosmetology with antimicrobial peptides
Alencar‐Silva, T., Braga, M. C., Santana, G. O. S., Saldanha‐Araújo, F., Pogue, R. E., Dias, S. C., Franco, O. L., & Carvalho, J. L. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.08.005 · Cited by 57
Anti-Biofilm Effects of Synthetic Antimicrobial Peptides Against Drug-Resistant Pseudomonas aeruginosa and Staphylococcus aureus Planktonic Cells and Biofilm
Park, S., Lee, M. Y., Kim, J., Kim, H., Jung, M., Shin, M., Lee, W., Cheong, G., Lee, J. R., & Jang, M.-K. (2019) · Molecules · doi:10.3390/molecules24244560 · Cited by 55
Self-citation
Antimicrobial Action of Water-Soluble β-Chitosan against Clinical Multi-Drug Resistant Bacteria
Park, S., Nam, J.-P., Kim, J., Kim, Y., Nah, J., & Jang, M.-K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047995 · Cited by 55
Self-citation
Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine
Bacalum, M., Janosi, L., Zorilă, F. L., Țepeş, A.-M., Ionescu, C., Bogdan, E., Hădade, N. D., Craciun, L. S., Grosu, I., Turcu, I., et al. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.03.024 · Cited by 54
Development, dynamics and control of antimicrobial-resistant bacterial biofilms: a review
Singh, B. P., Ghosh, S., & Chauhan, A. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-020-01169-5 · Cited by 54
Antimicrobial activity and mechanisms of multiple antimicrobial peptides isolated from rockfish Sebastiscus marmoratus
Bo, J., Yang, Y., Zheng, R., Fang, C., Jiang, Y., Liu, J., Chen, M., Hong, F., Bailey, C., Segner, H. E., et al. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.08.054 · Cited by 53
Pro-Moieties of Antimicrobial Peptide Prodrugs
Forde, É., & Devocelle, M. C. (2015) · Molecules · doi:10.3390/molecules20011210 · Cited by 53
Targeted Modification of a Novel Amphibian Antimicrobial Peptide from Phyllomedusa tarsius to Enhance Its Activity against MRSA and Microbial Biofilm
Gao, Y., Wu, D., Wang, L., Chen, L., Ma, C., Xi, X., Zhou, M., Duan, J., Bininda‐Emonds, O. R. P., Chen, T., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00628 · Cited by 52
Potential of Cell-Free Supernatant from Lactobacillus plantarum NIBR97, Including Novel Bacteriocins, as a Natural Alternative to Chemical Disinfectants
Kim, S. W., Kang, S. I., Shin, D. H., Oh, S. Y., Lee, C. W., Yang, Y., Son, Y. K., Yang, H., Lee, B., An, H., et al. (2020) · Pharmaceuticals · doi:10.3390/ph13100266 · Cited by 52
Lights and Shadows on the Therapeutic Use of Antimicrobial Peptides
Bellotti, D., & Remelli, M. (2022) · Molecules · doi:10.3390/molecules27144584 · Cited by 52
Design, expression and characterization of the hybrid antimicrobial peptide LHP7, connected by a flexible linker, against Staphylococcus and Streptococcus
Xi, D., Teng, D., Wang, X., Mao, R., Yang, Y., Xiang, W., & Wang, J. (2013) · Process Biochemistry · doi:10.1016/j.procbio.2013.01.008 · Cited by 52
Symbiotic Plant Peptides Eliminate Candida albicans Both In Vitro and in an Epithelial Infection Model and Inhibit the Proliferation of Immortalized Human Cells
Ördögh, L., Vörös, A., Nagy, I., Kondorosi, É., & Kereszt, A. (2014) · BioMed Research International · doi:10.1155/2014/320796 · Cited by 52
Antimicrobial nanomaterials against biofilms: an alternative strategy
Liu, C., Guo, J., Yan, X., Tang, Y., Mazumder, A., Wu, S., & Liang, Y. (2016) · Environmental Reviews · doi:10.1139/er-2016-0046 · Cited by 52
Multidrug-Resistant Microbial Therapy Using Antimicrobial Peptides and the CRISPR/Cas9 System
Getahun, Y. A., Ali, D. A., Taye, B. W., & Alemayehu, Y. A. (2022) · Veterinary Medicine Research and Reports · doi:10.2147/vmrr.s366533 · Cited by 50
Anti-Microbial, Anti-Biofilm Activities and Cell Selectivity of the NRC-16 Peptide Derived from Witch Flounder, Glyptocephalus cynoglossus
Gopal, R., Lee, J. H., Kim, Y., Kim, M.-S., Seo, C., & Park, Y. (2013) · Marine Drugs · doi:10.3390/md11061836 · Cited by 49
Self-citation
The role of nanocomposites against biofilm infections in humans
Varma, A., Warghane, A. J., Dhiman, N. K., Paserkar, N., Upadhye, V. J., Modi, A., & Saini, R. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1104615 · Cited by 48
Disease prevention and mitigation in US finfish aquaculture: A review of current approaches and new strategies
Wright, A., Li, X., Yang, X., Soto, E., & Gross, J. A. (2023) · Reviews in Aquaculture · doi:10.1111/raq.12807 · Cited by 48
Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges
Dho, M., Candian, V., & Tedeschi, R. (2023) · Antibiotics · doi:10.3390/antibiotics12060952 · Cited by 47
Multidrug resistance crisis during COVID-19 pandemic: Role of anti-microbial peptides as next-generation therapeutics
Sharma, S., Barman, P., Joshi, S., Preet, S., & Saini, A. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112303 · Cited by 47
Biofilm inhibition/eradication: exploring strategies and confronting challenges in combatting biofilm
Srivastava, A., Verma, N., Kumar, V., Apoorva, P., & Agarwal, V. K. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-03938-0 · Cited by 46
Fabrication of charge reversible graphene oxide-based nanocomposite with multiple antibacterial modes and magnetic recyclability
Li, Q., Yong, C., Cao, W., Wang, X., Wang, L., Zhou, J., & Xing, X. (2017) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2017.10.002 · Cited by 45
A novel hybrid peptide composed of LfcinB6 and KR-12-a4 with enhanced antimicrobial, anti-inflammatory and anti-biofilm activities
Ajish, C., Yang, S., Kumar, S. D., Kim, E. Y., Min, H. J., Lee, C. W., Shin, S., & Shin, S. Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-08247-4 · Cited by 45
Anionic Antimicrobial and Anticancer Peptides from Plants
Prabhu, S., Dennison, S. R., Lea, B., Snape, T. J., Nicholl, I. D., Radecka, I., & Harris, F. (2013) · Critical Reviews in Plant Sciences · doi:10.1080/07352689.2013.773238 · Cited by 45
Antibacterial Properties of Gold Nanoparticles in the Modification of Medical Implants: A Systematic Review
Zhan, X., Yan, J., Tang, H., Xia, D., & Lin, H. Q. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122654 · Cited by 42
Protegrin-1 cytotoxicity towards mammalian cells positively correlates with the magnitude of conformational changes of the unfolded form upon cell interaction
Soundrarajan, N., Park, S. H., Le, Q. V. C., Cho, H., Raghunathan, G., Ahn, B., Song, H., Kim, J., & Park, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-47955-2 · Cited by 42
Self-citation
Anti-biofilm properties of the antimicrobial peptide temporin 1Tb and its ability, in combination with EDTA, to eradicate Staphylococcus epidermidis biofilms on silicone catheters
Maisetta, G., Grassi, L. C., Luca, M. D., Bombardelli, S., Medici, C., Brancatisano, F. L., Esin, S., & Batoni, G. (2016) · Biofouling · doi:10.1080/08927014.2016.1194401 · Cited by 41
Whether a novel drug delivery system can overcome the problem of biofilms in respiratory diseases?
Dua, K., Shukla, S. D., Tekade, R. K., & Hansbro, P. M. (2016) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0349-0 · Cited by 41
Human Antimicrobial Peptides: Spectrum, Mode of Action and Resistance Mechanisms
Bazzaz, B. S. F., Seyedi, S., Goki, N. H., & Khameneh, B. (2020) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-020-10127-2 · Cited by 41
New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing
Simonetti, O., Rizzetto, G., Radi, G., Molinelli, E., Cirioni, O., Giacometti, A., & Offidani, A. (2021) · Antibiotics · doi:10.3390/antibiotics10111377 · Cited by 41
Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption
Rončević, T., Gerdol, M., Mardirossian, M., Maleš, M., Cvjetan, S., Benincasa, M., Maravić, A., Gajski, G., Krce, L., Aviani, I., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.04.025 · Cited by 40
Identification and Antimicrobial Activity of Medium-Sized and Short Peptides from Yellowfin Tuna (Thunnus albacares) Simulated Gastrointestinal Digestion
Cerrato, A., Capriotti, A. L., Capuano, F., Cavaliere, C., Montone, A. M. I., Montone, C. M., Piovesana, S., Chiozzi, R. Z., & Laganà, A. (2020) · Foods · doi:10.3390/foods9091185 · Cited by 40
Chloride-Inducible Expression Vector for Delivery of Antimicrobial Peptides Targeting Antibiotic-Resistant Enterococcus faecium
Geldart, K., Borrero, J., & Kaznessis, Y. N. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.00227-15 · Cited by 40
Novel Strategies to Combat Antimicrobial Resistance
Kaur, I. (2016) · Journal of Infectious Diseases and Therapy · doi:10.4172/2332-0877.1000292 · Cited by 40

Authors: Park, S.-C., Park, Y., & Hahm, K.-S.
Affiliations: Chosun University (KR)
Corresponding author: Park, Yoonkyung
Hahm, Kyung-Soo
ORCID: Park, Seong-Cheol
Park, Yoonkyung
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2011-09-16
Volume: 12
Issue: 9
Pages: 5971-5992
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms12095971
PMC: PMC3189763
OpenAlex: W2081930655
Cited by: 327
References: 184
Citations by year: 2026: 18 · 2025: 22 · 2024: 23 · 2023: 23 · 2022: 25 · 2021: 27 · 2020: 29 · 2019: 28 · 2018: 19 · 2017: 19 · 2016: 28 · 2015: 21 · 2014: 14 · 2013: 20 · 2012: 9
FWCI: 1.65
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Research Foundation
National Research Foundation of Korea (2011-0017532)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: antimicrobial peptides, multidrug-resistant bacteria, biofilm formation, antimicrobial resistance, peptidomimetics, chronic infection, medical device infections, oral health, dental plaque, combination therapy, mechanism of action
MeSH terms: Bacteria, Bacterial Infections, Humans, Microbial Sensitivity Tests, Models, Biological, Bacterial Physiological Phenomena, Biofilms, Antimicrobial Cationic Peptides, Drug Resistance, Multiple, Bacterial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks