Effects of Soybean Agglutinin on Intestinal Barrier Permeability and Tight Junction Protein Expression in Weaned Piglets
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This study was developed to provide further information on the intestinal barrier permeability and the tight junction protein expression in weaned piglets fed with different levels of soybean agglutinin (SBA). Twenty-five weaned crossbred barrows (Duroc × Landrace × Yorkshire) were selected and randomly allotted to five groups, each group with five replicates. The piglets in the control group were not fed with leguminous products. 0.05, 0.1, 0.15 and 0.2% SBA was added to the control diet to form four experimental diets, respectively. After the experimental period of 7 days (for each group), all the piglets were anesthetized with excess procaine and slaughtered. The D-lactic acid in plasma and the Ileal mucosa diamine oxidase (DAO) was analyzed to observe the change in the intestinal permeability. The tight junction proteins occludin and ZO-1 in the jejunum tissue distribution and relative expression were detected by immunohistochemistry and Western Blot. The results illustrated that a high dose of SBA (0.1–0.2%) could increase the intestinal permeability and reduce piglet intestinal epithelial tight junction protein occludin or ZO-1 expression, while low dose of SBA (0.05% of total diet) had no significant affects. The contents of DAO, D-lactic acid, occludin or ZO-1, had a linear relationship with the SBA levels (0–0.2%) in diets. The high dose SBA (0.1–0.2%) could increase the intestinal permeability and reduce piglet intestinal epithelial tight junction protein occludin or ZO-1 expression, while low dose of SBA (0.05% of total diet) had no affects.
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Nonsurgical causes of intestinal hyperpermeability also increase absorption of D-lactate from the intestinal lumen.
“Nonsurgical causes of intestinal hyperpermeability also increase absorption of D-lactate from the intestinal lumen.63,64”
From The Gut Microbiome and the Brain (2014) · cites this paper as [63]
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Cites
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Occludin: a novel integral membrane protein localizing at tight junctions.
Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580 · see citing works
Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands
Saitou, M., Furuse, M., Sasaki, H., Schulzke, J.-D., Fromm, M., Takano, H., Noda, T., & Tsukita, S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4131 · Cited by 1,195 · see citing works
Intestinal permeability: an overview
Bjarnason, I., Macpherson, A., & Hollander, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90708-4 · Cited by 927 · see citing works
Nutritional and Health Benefits of Soy Proteins
Friedman, M., & Brandon, D. L. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0009246 · Cited by 919 · see citing works
Legume lectins — a large family of homologous proteins
Sharon, N., & Lis, H. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.14.2227211 · Cited by 470 · see citing works
Ando‐Akatsuka, Y., Saitou, M., Hirase, T., Kishi, M., Sakakibara, A., Itoh, M., Yonemura, S., Furuse, M., & Tsukita, S. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.1.43 · Cited by 332 · see citing works
Pinton, P., Nougayrède, J., Rio, J.-C. D., Moreno, C., Marin, D. E., Ferrier, L., Bracarense, A. P. F. R. L., Kolf‐Clauw, M., & Oswald, I. P. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.03.003 · Cited by 321 · see citing works
Epithelial transport and barrier function in occludin-deficient mice
Schulzke, J., Gitter, A. H., Mankertz, J., Spiegel, S., Seidler, U. E., Amasheh, S., Saitou, M., Tsukita, S., & Fromm, M. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.01.008 · Cited by 320 · see citing works
Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells
Yu, A. S. L., McCarthy, K. M., Francis, S. A., McCormack, J. M., Lai, J., Rogers, R. A., Lynch, R. D., & Schneeberger, E. E. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00581.2004 · Cited by 307 · see citing works
Protein quality of legume seeds for non-ruminant animals: a literature review
Gâtel, F. (1994) · Animal Feed Science and Technology · doi:10.1016/0377-8401(94)90036-1 · Cited by 192 · see citing works
Localization and differential expression of two isoforms of the tight junction protein ZO-1
Willott, E., Balda, M. S., Heintzelman, M. B., Jameson, B., & Anderson, J. M. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.5.c1119 · Cited by 174 · see citing works
Anti-nutritional and toxic factors in food legumes: a review
Gupta, Y. P. (1987) · Plant Foods for Human Nutrition · doi:10.1007/bf01091786 · Cited by 171 · see citing works
CONTENT AND DISTRIBUTION OF TRYPSIN INHIBITORS AND HEMAGGLUTININS IN SOME LEGUME SEEDS
Valdebouze, P., Bergeron, É., Gaborit, T., & Delort-Laval, J. (1980) · Canadian Journal of Plant Science · doi:10.4141/cjps80-097 · Cited by 161 · see citing works
Use of D-Lactic Acid Measurements in the Diagnosis of Bacterial Infections
Smith, S. M., Eng, R. H. K., & Buccini, F. (1986) · The Journal of Infectious Diseases · doi:10.1093/infdis/154.4.658 · Cited by 134 · see citing works
ANTINUTRITIONAL FACTORS IN THE PLANT PROTEINS OF DIETS FOR NON-RUMINANTS
Huisman, J., & Tolman, G. H. (1992) · Recent Advances in Animal Nutrition · doi:10.1016/b978-0-7506-0714-8.50005-9 · Cited by 107 · see citing works
Yoshida, Y., Ban, Y., & Kinoshita, S. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3046 · Cited by 90 · see citing works
Pellegrina, C. D., Perbellini, O., Scupoli, M. T., Tomelleri, C., Zanetti, C., Zoccatelli, G., Fusi, M., Peruffo, A., Rizzi, C., & Chignola, R. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.03.012 · Cited by 84 · see citing works
The effect of the route of nutrient delivery on gut structure and diamine oxidase levels
Thompson, J., Wp, V., Forst, C. F., Dl, J., Weekly, J., & Lf, R. (1987) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860718701100128 · Cited by 61 · see citing works
Plant lectins as carriers for oral drugs: Is wheat germ agglutinin a suitable candidate?
Pellegrina, C. D., Rizzi, C., Mosconi, S., Zoccatelli, G., Peruffo, A., & Chignola, R. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.01.001 · Cited by 44 · see citing works
King, T. P., Begbie, R., & Cadenhead, A. (1983) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740341214 · Cited by 42 · see citing works
Effect of Lectins on the Transport of Food Factors in Caco-2 Cell Monolayers
Ohno, Y., Naganuma, T., Ogawa, T., & Muramoto, K. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf052040y · Cited by 38 · see citing works
Zhao, J., Wang, J., Dong, L., Shi, H., Wang, Z., Ding, H., Shi, H., & Lu, X. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.12.032 · Cited by 35 · see citing works
Effects of soybean agglutinin on body composition and organ weights in rats
Zang, J., Li, D., Piao, X., & Tang, S. (2006) · Archives of Animal Nutrition · doi:10.1080/17450390600679082 · Cited by 26 · see citing works
Sharon, N., & Lis, H. (2002) · Encyclopedia of Molecular Biology · doi:10.1002/047120918x.emb0834 · Cited by 21 · see citing works
(2007) · Springer eBooks · doi:10.1007/978-1-4020-6953-6_4 · Cited by 13 · see citing works
Intestinal and pancreatic responses to dietary soyabean (Glycine max) proteins
Grant, G., Watt, W. B., Stewart, J. C., Bardócz, S., & Pusztai, A. J. (1988) · Biochemical Society Transactions · doi:10.1042/bst0160610 · Cited by 7 · see citing works
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Research works printed but not linked: 1
- [19]Cereijido M Evolution of ideas on the tight junction Tight Junctions Cereijido M. CRC Press Boca Raton, FL, USA 1992 1 13
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The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Li, G., Wang, S., Deng, D., Xiao, Z., Dong, Z., Wang, Z., Lei, Q., Gao, S., Huang, G., Zhang, E., et al. (2020) · ACS Nano · doi:10.1021/acsnano.9b06689 · Cited by 235 · see citing works
Hu, C., Gu, L. Y., Luan, Z. S., Song, J., & Zhu, K. (2012) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2012.07.028 · Cited by 184 · see citing works
Li, C., Wang, N., Zheng, G., & Yang, L. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c14818 · Cited by 167 · see citing works
Ruan, Z., Liu, S., Zhou, Y., Mi, S., Liu, G., Wu, X., Kang, Y., Assaad, H., Deng, Z., Hou, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097815 · Cited by 122 · see citing works
Bested, A. C., Logan, A. C., & Selhub, E. M. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-3 · Cited by 121 · see citing works
Pan, L., Zhao, P., Ma, X. K., Shang, Q., Xu, Y., Long, S., Wu, Y., Yuan, F., & Piao, X. (2017) · Journal of Animal Science · doi:10.2527/jas.2016.1243 · Cited by 118 · see citing works
Jiang, W., Hu, K., Zhang, J.-X., Liu, Y., Jiang, J., Wu, P., Zhao, J., Kuang, S., Tang, L. Y., Tang, W., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003219 · Cited by 110 · see citing works
Impaired intestinal barrier function in a mouse model of hyperuricemia
Guo, Y., Li, H., Liu, Z., Li, C., Chen, Y., Jiang, C., Yu, Y., & Tian, Z. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10586 · Cited by 101 · see citing works
Yu, H., Ding, X., Li, N., Zhang, X., Zeng, X., Wang, S., Liu, H., Wang, Y. M., Jia, H. M., & Qiao, S. (2017) · Journal of Animal Science · doi:10.2527/jas2017.1494 · Cited by 99 · see citing works
Self-citationHao, T., Gao, Y., Li, Z.-C., Zhou, X., & Yan, B. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c08059 · Cited by 94 · see citing works
Yu, J., Song, Y., Yu, B., He, J., Zheng, P., Mao, X., Huang, Z., Luo, Y., Luo, J., Yan, H., et al. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-020-00496-5 · Cited by 92 · see citing works
Zeng, Y., Wang, Z.-R., Zou, T., Chen, J., Li, G., Zheng, L., Li, S., & You, J. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.623899 · Cited by 80 · see citing works
Zhang, J.-C., Chen, P., Zhang, C., Khalil, M. M., Zhang, N., Qi, D., Wang, Y.-W., & Sun, L. (2020) · Poultry Science · doi:10.1016/j.psj.2019.11.017 · Cited by 73 · see citing works
Li, P., Farouk, M. H., Qin, G., Zhao, Y., & Bao, N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020554 · Cited by 72 · see citing works
Self-citationNavarrete, P., Fuentes, P. D. M. J. D., la Fuente, L. D., Barros, L., Magne, F., Opazo, R., Ibacache, C., Espejo, R. T., & Romero, J. (2013) · Aquaculture Nutrition · doi:10.1111/anu.12047 · Cited by 68 · see citing works
Wan, J., Zhang, J., Chen, D., Yu, B., Huang, Z., Mao, X., Zheng, P., Yu, J., & He, J. (2018) · RSC Advances · doi:10.1039/c8ra01943f · Cited by 65 · see citing works
Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds
Basson, A. R., Ahmed, S. U. M., Almutairi, R., Seo, B., & Cominelli, F. (2021) · Foods · doi:10.3390/foods10040774 · Cited by 60 · see citing works
Yu, H., Shang, L., Zeng, X., Li, N., Liu, H., Cai, S., Huang, S., Wang, G., Wang, Y., Song, Q., et al. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03405 · Cited by 49 · see citing works
Su, W., Jiang, Z., Wang, C., Zhang, Y., Gong, T., Wang, F., Jin, M., Wang, Y., & Lu, Z. (2022) · Animal nutrition · doi:10.1016/j.aninu.2022.07.008 · Cited by 49 · see citing works
Rong, Y., Lu, Z., Zhang, H., Zhang, L., Song, D., & Wang, Y. (2015) · Animal nutrition · doi:10.1016/j.aninu.2015.05.006 · Cited by 47 · see citing works
Zhu, B., Lei, L., Sun, Y., Shi, X., Fu, K., Hua, J., Martyniuk, C. J., Han, J. Z., Yang, L., & Zhou, B. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c02712 · Cited by 46 · see citing works
Pan, L., Qin, G., Zhao, Y., Wang, J., Liu, F., & Che, D. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141121689 · Cited by 45 · see citing works
Self-citationSolís, C. J., Hamilton, M. K., Caruffo, M., García-López, J. P., Navarrete, P., Guillemin, K. J., & Feijóo, C. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01330 · Cited by 44 · see citing works
Zuo, T., Cao, L., Li, X., Zhang, Q., Xue, C., & Tang, Q. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.989369 · Cited by 39 · see citing works
Sun, G., Song, X., Zou, Y., Teng, T., Jiang, L., & Shi, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147730 · Cited by 37 · see citing works
Degroote, J., Vergauwen, H., Wang, W., Ginneken, C. J. V., SMET, S. D., & Michiels, J. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-020-00440-7 · Cited by 36 · see citing works
Liu, X., Wu, P., Jiang, W., Liu, Y., Jiang, J., Kuang, S., Tang, L. Y., Zhou, X., & Feng, L. (2020) · Toxins · doi:10.3390/toxins13010011 · Cited by 35 · see citing works
Ma, J., Shah, A. M., Wang, Z., Hu, R., Zou, H., Wang, Y., Cao, G., Peng, Q., Bai, X., Wang, L., et al. (2020) · PeerJ · doi:10.7717/peerj.9851 · Cited by 34 · see citing works
Wang, D., Zhou, L., Zhou, H., Hu, H., & Hou, G. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10904 · Cited by 33 · see citing works
Niu, H., Zhou, X., Gong, P., Jiao, Y., Zhang, J., Wu, Y., Lyu, L., Liang, C., Chen, S., Han, X., et al. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100619 · Cited by 33 · see citing works
Fructo-Oligosaccharide Alleviates Soybean-Induced Anaphylaxis in Piglets by Modulating Gut Microbes
Chang, M., Zhao, Y., Qin, G., & Zhang, X. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02769 · Cited by 32 · see citing works
Self-citationZhang, H., Peng, A., Guo, S., Wang, M., Loor, J. J., & Wang, H. (2019) · Food & Function · doi:10.1039/c8fo01618f · Cited by 31 · see citing works
Yu, C., Jia, G., Deng, Q., Zhao, H. Y., Chen, X., Liu, G., & Wang, K. (2015) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.15.0415 · Cited by 29 · see citing works
Peng, P., Chen, J., Kang, Y., Yin, Y., Long, L., & Fang, R. (2019) · Animal Science Journal · doi:10.1111/asj.13228 · Cited by 28 · see citing works
Zhou, J., Wang, Y., Zeng, X., Zhang, T., Li, P., Yao, B., Wang, L., Qiao, S., & Zeng, X. (2019) · Food & Function · doi:10.1039/c9fo02724f · Cited by 28 · see citing works
Mosberian‐Tanha, P., Øverland, M., Landsverk, T., Reveco, F. E., Schrama, J. W., Roem, A. J., Agger, J. W., & Mydland, L. T. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.7 · Cited by 28 · see citing works
The Integrins Involved in Soybean Agglutinin-Induced Cell Cycle Alterations in IPEC-J2
Pan, L., Zhao, Y., Yuan, Z., Farouk, M. H., Zhang, S., Bao, N., & Qin, G. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.2207 · Cited by 27 · see citing works
Self-citationChe, D., Zhao, B. X., Fan, Y., Han, R., Zhang, C., Qin, G., Adams, S., & Jiang, H. (2019) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13087 · Cited by 27 · see citing works
Self-citationHan, F., Qi, C., Lin, Z., Jia, Y., Yang, L., Lu, J., Wang, X., Li, E., Qin, J. G., & Chen, L. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.734504 · Cited by 27 · see citing works
Jiang, X., Liu, H., You, Y., Zhong, G., Ruan, Z., Liao, J., Zhang, H., Pan, J., Tang, Z., & Hu, L. (2023) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2023.109815 · Cited by 25 · see citing works
Alatorre-Cruz, J. M., Pita-López, W., López-Reyes, R. G., Ferriz‐Martínez, R. A., Cervantes-Jiménez, R., Guerrero-Carrillo, M. D. J., Aranda-Vargas, P. J., López‐Herrera, G., Rodríguez-Méndez, A. J., Zamora-Arroyo, A., et al. (2017) · Toxicology Reports · doi:10.1016/j.toxrep.2017.12.008 · Cited by 24 · see citing works
Chen, Y., Jiang, W., Wu, P., Liu, Y., Ma, Y.-B., Ren, H., Jin, X., Jiang, J., Zhang, R., Li, H., et al. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01224-7 · Cited by 23 · see citing works
Ren, S., Wang, C., Chen, A., Bai, Z., Tian, Y., & Lv, W. (2023) · Food & Function · doi:10.1039/d3fo00268c · Cited by 20 · see citing works
Maggot protein ameliorates dextran sulphate sodium-induced ulcerative colitis in mice
Wang, R., Wang, L., Luo, Y., Wang, D., Du, R., Du, J., & Wang, Y. (2018) · Bioscience Reports · doi:10.1042/bsr20181799 · Cited by 19 · see citing works
Effects of Food Lectins on the Transport System of Human Intestinal Caco-2 Cell Monolayers
Yamamoto, S., Tomiyama, M., Nemoto, R., NAGANUMA, T., Ogawa, T., & Muramoto, K. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.130367 · Cited by 18 · see citing works
Integrins Were Involved in Soybean Agglutinin Induced Cell Apoptosis in IPEC-J2
Pan, L., Zhao, Y., Farouk, M. H., Bao, N., Wang, T., & Qin, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020587 · Cited by 18 · see citing works
Self-citationSong, T., Qin, Y., Ke, L., Wang, X., Wang, K., Sun, Y., & Ye, J. (2022) · Metabolites · doi:10.3390/metabo12100915 · Cited by 17 · see citing works
Fan, D., Fu, Y., Zhang, J., Bi, Y., Ma, T., Diao, Q., & Zhang, N. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.06.004 · Cited by 17 · see citing works
Jejunal Metabolic Responses to Escherichia coli Infection in Piglets
Wu, H., Liu, J., Chen, S., Zhao, Y., Zeng, S., Bin, P., Zhang, D., Tang, Z., & Zhu, G. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02465 · Cited by 16 · see citing works
Self-citationMa, L., Zhu, Y., La, A. L. T. Z., Lourenco, J. M., Callaway, T. R., & Bu, D. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23466 · Cited by 15 · see citing works
Jiang, J., Chen, D., Yu, B., He, J., Yu, J., Mao, X., Huang, Z., Luo, Y., Luo, J., & Zheng, P. (2019) · Journal of Animal Science · doi:10.1093/jas/skz134 · Cited by 15 · see citing works
Evaluation of Probiotic Lactobacillus fermentum CCM 7421 Administration with Alginite in Dogs
Strompfová, V., Kubašová, I., Farbáková, J., Maďari, A., Gancarčíková, S., Mudroňová, D., & Lauková, A. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-017-9370-y · Cited by 15 · see citing works
Grosu, I. A., Bulgaru, C. V., Pistol, G. C., Cișmileanu, A. E., Marin, D. E., & Țăranu, I. (2023) · Toxins · doi:10.3390/toxins15030206 · Cited by 14 · see citing works
Ultra-high-pressure passivation of soybean agglutinin and safety evaluations
Han, X., Sun, Y., Huangfu, B., He, X., & Huang, K. (2023) · Food Chemistry X · doi:10.1016/j.fochx.2023.100726 · Cited by 13 · see citing works
Zhou, Y., Ren, Z., Zhang, S., Wang, H., Wu, S., & Bao, W. (2021) · Animals · doi:10.3390/ani11030644 · Cited by 13 · see citing works
Anti-nutritional characteristics and mechanism of soybean agglutinin
Pan, L., Liu, J., Farouk, M. H., Qin, G., Bao, N., Zhao, Y., & Sun, H. (2021) · Biocell · doi:10.32604/biocell.2021.014289 · Cited by 13 · see citing works
Self-citationDong, X., Xu, Q., Wang, C., Zou, X., & Lu, J. (2019) · Journal of Applied Animal Research · doi:10.1080/09712119.2019.1645673 · Cited by 12 · see citing works
He, Z., Liu, S., Wen, X., Cao, S., Zhan, X., Hou, L., Li, Y., Chen, S., Zheng, H., Deng, D., et al. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1321486 · Cited by 10 · see citing works
Zhang, S., Zhang, G., Xu, J., Chen, D., Yin, C., Wang, J., Jiang, X., & Wang, C. (2026) · Veterinary Sciences · doi:10.3390/vetsci13020131 · Cited by 9 · see citing works
Wang, K., Chen, X., Zuo, L., Pan, C.-Y., Liu, G., Zhang, X., Du, J., Zhang, C., Zhang, B., Wang, Z., et al. (2021) · Italian Journal of Animal Science · doi:10.1080/1828051x.2021.1955627 · Cited by 9 · see citing works
Self-citationTian, X.-P., Zhao, H., Zhang, Z., Guo, Z., & Li, W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223651 · Cited by 9 · see citing works
Pan, L., Liu, Y., Lan, H., Bao, N., Zhao, Y., Sun, H., Qin, G., & Farouk, M. H. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.639792 · Cited by 9 · see citing works
Self-citationRen, Z., Fan, H., Deng, H., Yao, S., Jia, G., Zuo, Z., Hu, Y., Shen, L., Ma, X., Zhong, Z., et al. (2022) · Food Science & Nutrition · doi:10.1002/fsn3.2828 · Cited by 9 · see citing works
Zhao, B. X., Che, D., Adams, S., Guo, N., Han, R., Zhang, C., Qin, G., Farouk, M. H., & Jiang, H. (2019) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13091 · Cited by 9 · see citing works
Self-citationLi, W., & Hakkak, R. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1278158 · Cited by 8 · see citing works
Marzorati, M., den Abbeele, P. V., Verstrepen, L., Medts, J. D., & Ekmay, R. D. (2023) · Nutraceuticals · doi:10.3390/nutraceuticals3010013 · Cited by 8 · see citing works
Zeamer, K. M., Samuel, R. S., Pierre, B. S., Thaler, R. C., Woyengo, T. A., Hymowitz, T., & Levesque, C. L. (2020) · Livestock Science · doi:10.1016/j.livsci.2020.104369 · Cited by 8 · see citing works
Wang, H., Li, P., Du, T., Pu, G., Fan, L., Chen, G., Niu, P., Wu, C., Zhou, W., & Huang, R. (2019) · Animals · doi:10.3390/ani9121039 · Cited by 7 · see citing works
Pan, L., Tianjiao, E., Xu, C., Fan, X., Xia, J., Liu, Y., Liu, J., Zhao, J., Bao, N., Zhao, Y., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-32951-4 · Cited by 6 · see citing works
Self-citationRetractedCho, E., Yoo, Y., & Yoon, Y. (2024) · Journal of Animal Science and Technology · doi:10.5187/jast.2024.e47 · Cited by 6 · see citing works
Pita-López, W., Gomez-Garay, M., Blanco‐Labra, A., Barreyro, A. A., de Souza, T. C. R., Olvera-Ramírez, A. M., Ferriz‐Martínez, R. A., & García-Gasca, T. (2020) · Toxicology Research · doi:10.1093/toxres/tfaa062 · Cited by 6 · see citing works
Oral plant-derived exosome-like nanovesicles: a new therapeutic perspective for intestinal diseases
Zhang, L. Y., Zubair, M., & Chu, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1827379 · Cited by 6 · see citing works
Westmark, C. J. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1520211 · Cited by 5 · see citing works
First report of significant growth improvement of Totoaba macdonaldi using Bacillus and soy
Mercado, V., Olmos, J., López, L. M., & Galavíz, M. A. (2024) · Aquaculture International · doi:10.1007/s10499-024-01753-4 · Cited by 4 · see citing works
Kovanda, L. L., Rengman, S., Tawde, S. N., Pos, J., Park, S., Sun, S., Park, J., Kim, K., Li, X., & Liu, Y. (2024) · Journal of Animal Science · doi:10.1093/jas/skae322 · Cited by 4 · see citing works
Bacillus pumilus SMU5927 protect mice from damage caused by Salmonella Enteritidis colonization
Ran, L., Lei, J., Liu, H., Wang, D., Liu, J., Yang, F., & Chen, D. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123291 · Cited by 4 · see citing works
Analysis of the sensitization activity of Moringa oleifera leaves protein
Lu, J., Liu, X., Li, W., Xi, C., Feng, D., & Song, S. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1509343 · Cited by 4 · see citing works
Zhao, B. X., Fan, Y., Li, H., Chun, Z., Han, R., & Che, D. (2022) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13677 · Cited by 4 · see citing works
Self-citationTianjiao, E., Xu, C., Fan, X., Liu, J., Zhao, J., Bao, N., Zhao, Y., Farouk, M. H., Ji, Y. S., Wu, Z., et al. (2024) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.14051 · Cited by 2 · see citing works
Self-citationZheng, J., Li, C., Li, S., & Zheng, X. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.177364 · Cited by 2 · see citing works
Effect of the Addition of Xianglian Granules to PD-1 Monoclonal Antibodies in Pancancer Patients
Wu, T.-T., Li, S. Y., Shuang, H., Li, Y., Fu, S., Jiang, H., Zhang, S., Du, B., Lv, J., Xiaoting, X., et al. (2025) · Biological Procedures Online · doi:10.1186/s12575-025-00309-x · Cited by 1 · see citing works
Restructuring Schools as Families: Report of a Conference
Elrod, L. D., Podell, J., & Nolan, L. C. (2016) · Cited by 1 · see citing works
Gastrointestinal Tract Barrier Efficiency: Function and Threats
Yakout, H. M., & Eckhardt, E. R. M. (2022) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-030-90303-9_2 · Cited by 1 · see citing works
Changes of diamine oxidase and D-lactate in human breast and gynecologic cancers after chemotherapy
Hu, L., Kong, F., Yuan, Q., Huang, M., & Huang, Y. (2025) · Medicine · doi:10.1097/md.0000000000041442 · Cited by 1 · see citing works
Tian, X.-P., Zhang, Z., & Li, W. (2019) · Current Molecular Medicine · doi:10.2174/1566524019666190820141331 · Cited by 1 · see citing works
Pan, L., Liu, Y., Farouk, M. H., Bao, N., Zhao, Y., Sun, H., & Qin, G. (2020) · Research Square · doi:10.21203/rs.3.rs-62411/v1
Self-citationFan, Z., Xia, Z., Cozannet, P., de Nanclares, M. P., Xin, H., Wang, M., Chen, D., Yu, B., He, J., Yu, J., et al. (2022) · Agriculture · doi:10.3390/agriculture12121984
Degroote, J., Vergauwen, H., Wang, W., Ginneken, C. J. V., SMET, S. D., & Michiels, J. (2020) · Figshare · doi:10.6084/m9.figshare.12186255
Su, W., Jiang, Z., Gong, T., Du, M. K., Wang, F., Lu, Z., Jin, M., & Wang, Y. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250168
Liu, N., Fu, X., Zhang, B., Zhong, Q., Bao, N., & Sun, Z. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1646816
Self-citationDegroote, J., Vergauwen, H., Wang, W., Ginneken, C. J. V., De Smet, S., & Michiels, J. (2020) · Figshare · doi:10.6084/m9.figshare.12186246
Risks for human health related to the presence of plant lectins in food
Chain, E. P. O. C. I. T. F., Knutsen, H. K., Åkesson, A., Bampidis, V., Bignami, M., Bodin, L., Chipman, J. K., Degen, G., Hernández, A. F., Hofer, T., et al. (2026) · EFSA Journal · doi:10.2903/j.efsa.2026.9850
Therapeutic Potential of Ruberythric Acid in Intestinal Inflammation and Barrier Function Reduction
Jo, H. J., Kim, S., & Jung, S. K. (2026) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2025.236
Jin, H., Zhang, A., Xu, L., Tang, D., & Qin, S. (2026) · Animals · doi:10.3390/ani16060946
- Authors
- Zhao, Y., Qin, G., Sun, Z., Che, D., Bao, N., & Zhang, X.
- Affiliations
- Jilin Agricultural University (CN)
- Jilin University (CN)
- Corresponding author
- Qin, Guixin
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2011-11-29
- Volume
- 12
- Issue
- 12
- Pages
- 8502-8512
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3257084
- OpenAlex
- W1969812442
- Cited by
- 94
- References
- 28
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 8 · 2021: 8 · 2020: 12 · 2019: 12 · 2018: 7 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31101719)
- Jilin Agricultural University
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- soybean agglutinin, intestinal permeability, tight junction proteins, occludin, ZO-1, weaned piglets, diamine oxidase, D-lactate, jejunum, dose-dependent effects
- MeSH terms
- Animals, Amine Oxidase (Copper-Containing), Ileum, Intestinal Absorption, Intestinal Mucosa, Jejunum, Phytohemagglutinins, Swine, Lactic Acid, Soybean Proteins, Plant Lectins, Occludin, Zonula Occludens-1 Protein
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